Endoscopic surveillance strategy after endoscopic resection for early gastric cancer

Table 1 Incidence of synchronous gastric cancers in the surgically resected stomach

Ref.	Overall		Missed lesion
Noguchi et al[42], 1985	6.50%	468/7220
Ezaki et al[24], 1987	14.60%	75/512
Honmyo et al[43], 1989	4.80%	40/839	53%	21/40
Mitsudomi et al[44], 1989	8.30%	83/997	23%	42/182
Kosaka et al[25], 1990	5.80%	49/852
Kodera et al[26], 1995	5.70%	160/2790	53%	85/160
Kodama et al[45], 1996	6.80%	107/1458	64%	69/107
Fujita et al[46], 2009	8.70%	266/3042
Lee et al[27], 2010	5.20%	51/986	28%	14/51
Total	6.90%	1299/18696	39%	210/540

Table 2 Incidence of synchronous gastric cancers in the endoscopically resected stomach within 1 yr of the initial endoscopic resection

Ref.	Overall		Missed lesion
Arima et al[23], 1999	6.60%	5/76	NA
Nasu et al[10], 2005	11%	16/143	NA
Nakajima et al[9], 2006	9.20%	581/633	NA
Kobayashi et al[28], 2010	19.20%	45/234	NA
Han et al[29], 2011	4%	7/176	NA
Kato et al[19], 2013	8.70%	110/1258	19% (21/110)
Kim et al[47], 2013	2%	122/602	NA
Total	8.10%	253/3122

¹Including 14 adenomas;

²Including 5 adenomas. NA: Not available.

Table 3 Metachronous cancer rate after endoscopic resection

Ref.	Rate		Follow up period (yr)
Arima et al[23], 1999	7.90%	6/76	71
Nasu et al[10], 2005	14%	20/143	4.8 (median)
Nakajima et al[9], 2006	8.40%	53/633	4.4 (mean)
Kim et al[48], 2007	2.70%	13/479	3.3 (median)
Kobayashi et al[28], 2010	12.80%	30/234	5 (median)
Lee et al[49], 2011	3.30%	15/458	2.2 (median)
Kato et al[19], 2013	5.20%	65/1258	2.2 (mean)
Total	6.70%	202/3281

¹All patients were followed up for 7 yr.

Table 4 Local recurrence rate after endoscopic resection

Ref.	Local recurrence rate
	EMR		ESD
	Curative	Not curative	Curative	Not curative
Oka et al[50], 2006	2.90%	4.40%	0%	0%
Kim et al[48], 20071	6.0% (24/399)	15% (10/68)
Park et al[11], 2010	18% (9/50, not en bloc; 18)		3.7% (7/189, not en bloc: 25)
Lee et al[49], 2011	NA	NA	0.7% (2/276, not en bloc: 3)2
	NA	NA	0% (0/182, not en bloc: 22)3
Kato et al[19], 2013	NA	NA	0.4% (5/1258)
Tanabe et al[51], 20134	4.2%(15/359)5		0.2% (1/421)

“Not curative” includes piecemeal resection or marginal positive resection.

¹Including 34 lesions treated by ESD (6.6%);

²Guideline group;

³Expanded guideline group;

⁴For lesions meeting the JGCA criteria, the local recurrence rates were 2.9% in the EAM group and 0% in the ESD group;

⁵Treated by endoscopic aspiration mucosectomy (EAM). EMR: Endoscopic mucosal resection; ESD: Endoscopic submucosal dissection; NA: Not available.