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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastrointest Pathophysiol. Nov 15, 2014; 5(4): 405-415
Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.405
Table 1 Classification system of drug-induced acute pancreatitis according to Badalov et al[11]
DefinitionExample
Class I drugIa: at least one case report, evidence of a positive re-challenge, and exclusion of other causes of APCodeine, cytarabine, dapsone, enalapril, furosemide, isoniazid, mesalamine, metronidazole, pentamidine, pravastatin, procainamide, simvastatin, sulfamethoxazole, sulindac, tetracycline, valproic acid
Ib: similar to class Ia, except that other causes of AP could not be ruled outAmiodarone, azathioprine, dexamethasone, ifosfaide, lamivudine, losartan, 6-MP, premarin, TMP-SMZ
Class II drugsInclude at least four case reports with a consistent latency period for at least 75% of the casesAcetaminophen, Clozapine, DDI, erythromycin, estrogen, l-asparaginase, propofol, tamoxifen
Class III drugAt least two case reports but do not have re-challenge data or a consistent latency periodAlendronate, carbamazepine, ceftriaxone, clarithromycin, cyclosporin, hydrochlorothiazide, interferone/ribavirin, metformin, minocycline, naproxen, paclitaxel, prednisone, prednisolone
Class IV drugOne case report without re-challenge dataAmpicillin, cisplatin, colchicine, cyclophosphamide, diclofenac, doxorubicin, interleukin-2, octreotide, propoxyphene, rifampin, risperidone, sertaline, tacrolimus, vincristine