Role of TNFSF15 in the intestinal inflammatory response

Figure 1 Effect of tumor necrosis factor ligand-related molecule 1 (TL1A) signaling across different subtypes of leukocytes. TL1A acts by promoting cytokine signaling, cell differentiation, and proliferation. These effects vary between different subtypes. While TL1A promotes natural killer T cells and T helper Th1/Th17 proliferation, it can also suppress regulatory T cell functions and forkhead box P3 positive expression. Regardless, TL1A is not associated exclusively with any form. CD: Crohn’s disease; DC: Dendritic cell; DD: Diverticular disease; IFN-γ: Interferon gamma; IL: Interleukin; NKT: Natural killer T cells; TL1A: Tumor necrosis factor Ligand-related molecule 1; Th: T helper; T_reg: Regulatory T cell; Foxp3: Forkhead box P3; UC: Ulcerative colitis.