Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats

Figure 1 Microphotographs showing expression of CK19 from oval cells (arrows) in livers of group III (A) and group IV (B) and α-fetoprotein mRNA expression from oval cells (arrows) in group III (C) and group IV (D). In group IV there is higher oval cell presence as demonstrated by both markers [CK19: streptavidin biotin peroxidase (A) × 250, (B) × 100, α-fetoprotein mRNA: in situ hybridization × 250]. PT: Portal tract.

Figure 2 Microphotographs showing Ki67 (+) hepatocytes (arrows) from livers of group III (A) and group IV (B) and TUNEL (+) hepatocytes (arrows) in group III (C) and group IV (D). In group IV there are more Ki67 (+) hepatocytes (streptavidin biotin peroxidase × 100) and less TUNEL (+) hepatocytes (streptavidin biotin peroxidase and hematoxylin eosin × 250). PT: Portal tract.