Observational Study
Copyright ©The Author(s) 2016.
World J Radiol. Feb 28, 2016; 8(2): 200-209
Published online Feb 28, 2016. doi: 10.4329/wjr.v8.i2.200
Table 1 Patient characteristics (n = 45)
Demography
Age (yr)61 ± 10
Stage at diagnosis
I5
II21
III14
IV5
Histology
Ductal35
Lobular8
Other2
Tumor receptor (+/-/unknown)
Estrogen receptor39/2/4
PgR29/11/5
c-erb B214/24/7
Site of metastatic disease other than bone
Lung27%
Liver20%
Lymph nodes30%
Systemic therapy
First-line81%
Second-line62%
Third-line36%
Bisphosphonates22%
Follow-up (mean 28 mo range 22-39)
Patients with disease progression58%
Patients dead from disease30%
Table 2 Patient-based analysis: Performance comparisons between 2-deoxy-2-(18F)fluoro-D-glucose and 18F-sodium positron emission tomography/computed tomography
18F-FDG18F-NaF
Sensitivity (%)75.00 (55.10-88.00)91.67 (74.15-97.68)
Specificity (%)99.00 (84.54-100)76.19 (54.91-89.37)
Positive predictive value (%)99.00 (82.41-100)81.48 (63.3 91.82)
Negative predictive value (%)77.78 (59.24-89.39)88.89 (67.2-96.90)
Error rate (%)13.33 (6.26-26.18)15.56 (7.75-28.78)
Accuracy (%)86.67 (73.82-93.74)84.44 (71.22-92.25)
Youden's index0.75 (0.75-0.74)0.6786 (0.68-0.6718)
Table 3 Sites and density characteristics showing different performance between 2-deoxy-2-(18F)fluoro-D-glucose and 18F-sodium positron emission tomography/computed tomography
n18F-FDG18F-NaFP
Density
Osteosclerotic890.005
Sensitivity (%):42.86 (15.82-74.95)99.00 (64.57-99.00)
Specificity (%):97.00 (60.97-97.00)48.15 (35.39-61.15)
No lesion/bone marrow290.002
Sensitivity(%):100.00 (60.97-100.00)48.15 (30.74-66.01)
Specificity(%):100.00 (34.24-100.00)100.00 (34.24-100.00)
Site
Spine810.002
Sensitivity (%):65.38 (51.80-76.85)100.00 (93.12-100.00)
Specificity (%):98.00 (88.30-98.00)13.45 (0.61-27.18)
Ribs1180.04
Sensitivity (%):83.96 (75.81-89.74)96.23 (90.70-98.52)
Specificity (%):78.37 (52.33-92.50)78.57 (52.41-92.43)

  • Citation: Capitanio S, Bongioanni F, Piccardo A, Campus C, Gonella R, Tixi L, Naseri M, Pennone M, Altrinetti V, Buschiazzo A, Bossert I, Fiz F, Bruno A, DeCensi A, Sambuceti G, Morbelli S. Comparisons between glucose analogue 2-deoxy-2-(18F)fluoro-D-glucose and 18F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions. World J Radiol 2016; 8(2): 200-209
  • URL: https://www.wjgnet.com/1949-8470/full/v8/i2/200.htm
  • DOI: https://dx.doi.org/10.4329/wjr.v8.i2.200