Retrospective Study
Copyright ©The Author(s) 2016.
World J Radiol. Jan 28, 2016; 8(1): 90-97
Published online Jan 28, 2016. doi: 10.4329/wjr.v8.i1.90
Table 1 Patient characteristics
CharacteristicsValue
Total patients19
Demographics
Mean age (yr)57
Age range (yr)41-74
Male/female3/16
Location of primary tumor
Oropharynx19
Stages
Stage III15
Stage IV4
Tumor size (cm3)0.615-14.879
Therapy typeChemo-radiation
Outcome
Locoregional control17
Locoregional failure2
Table 2 Paired student’s t test on tumor volume, Ktrans and ve between pretreatment and intra-treatment scans (n = 19)
ParametersMeasuresPre (n = 19) (mean ± SD)Intra (n = 19) (mean ± SD)P values
Tumor volume (cm3)9.02 ± 6.877.23 ± 6.220.02a
Ktrans (volume transfer rate, min-1)Mean0.34 ± 0.180.37 ± 0.220.36
SD0.25 ± 0.110.25 ± 0.110.99
E0.34 ± 0.140.38 ± 0.190.18
H0.84 ± 0.040.83 ± 0.050.61
ve (volume fraction of the extravascular extracellular space)Mean0.29 ± 0.120.34 ± 0.190.09
SD0.15 ± 0.040.17 ± 0.070.26
E0.30 ± 0.110.41 ± 0.220.041
H0.84 ± 0.040.83 ± 0.060.78
Table 3 Mann-Whitney U test of tumor volume, Ktrans and ve between groups of patients with locoregional control (n = 17) and locoregional failure (n = 2)
Measures for patient groups (LC and LF)PreIntraDifference between intra and pre
Tumor volume (cm3)LC9.68 ± 7.037.70 ± 6.45-1.97 ± 3.13
LF3.79 ± 0.733.42 ± 0.91-0.37 ± 0.17
P value0.150.540.64
MeanLC0.34 ± 0.190.38 ± 0.230.04 ± 0.15
LF0.34 ± 0.010.26 ± 0.13-0.08 ± 0.14
P valueP = 0.84P = 0.42P = 0.42
Ktrans (min-1)SDLC0.26 ± 0.110.25 ± 0.11-0.007 ± 0.12
LF0.20 ± 0.050.27 ± 0.16-0.08 ± 0.14
P valueP = 0.49P = 0.74P = 0.49
ELC0.35 ± 0.150.38 ± 0.190.02 ± 0.11
LF0.27 ± 0.080.41 ± 0.300.14 ± 0.22
P valueP = 0.74P = 1.00P = 0.57
HLC0.84 ± 0.040.83 ± 0.06-0.01 ± 0.04
LF0.82 ± 0.030.85 ± 0.040.03 ± 0.04
P valueP = 0.35P = 0.57P = 0.35
veMeanLC0.29 ± 0.130.35 ± 0.200.05 ± 0.12
LF0.28 ± 0.100.26 ± 0.01-0.01 ± 0.11
P valueP = 0.94P = 0.42P = 0.35
SDLC0.16 ± 0.040.17 ± 0.070.01 ± 0.07
LF0.14 ± 0.010.22 ± 0.010.08 ± 0.02
P valueP = 0.23P = 0.14P = 0.10
ELC0.31 ± 0.120.38 ± 0.210.07 ± 0.16
LF0.28 ± 0.020.65 ± 0.210.37 ± 0.23
P valueP = 0.94P = 0.10P = 0.07
HLC0.84 ± 0.040.82 ± 0.06-0.01 ± 0.06
LF0.84 ± 0.020.91 ± 0.060.06 ± 0.06
P valueP = 0.74P = 0.14P = 0.18