Positron emission tomography tracers in medullary thyroid carcinoma: Current evidence and emerging targets

doi:10.4329/wjr.v18.i5.120146

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World Journal of Radiology

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1949-8470

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Radiol. May 28, 2026; 18(5): 120146
Published online May 28, 2026. doi: 10.4329/wjr.v18.i5.120146

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Figure 1 The “flip-flop” phenomenon in medullary thyroid carcinoma imaging. As tumours dedifferentiate along the spectrum from well-differentiated (left) to poorly-differentiated (right), ¹⁸F-fluorodihydroxyphenylalanine uptake (blue curve) progressively decreases while ¹⁸F-fluorodeoxyglucose uptake (orange curve) reciprocally increases. The crossover point represents the transition where fluorodeoxyglucose becomes more informative than fluorodihydroxyphenylalanine. MTC: Medullary thyroid carcinoma; PET: Positron emission tomography; ¹⁸F-FDOPA: ¹⁸F-fluorodihydroxyphenylalanine; ¹⁸F-FDG: ¹⁸F-fluorodeoxyglucose; AADC: Aromatic L-amino acid decarboxylase; NE: Neuroendocrine.

Citation: Ahmed FW, Ahmed F. Positron emission tomography tracers in medullary thyroid carcinoma: Current evidence and emerging targets. World J Radiol 2026; 18(5): 120146
URL: https://www.wjgnet.com/1949-8470/full/v18/i5/120146.htm
DOI: https://dx.doi.org/10.4329/wjr.v18.i5.120146

Ahmed FW, Ahmed F. Positron emission tomography tracers in medullary thyroid carcinoma: Current evidence and emerging targets. World J Radiol 2026; 18(5): 120146 [PMID: 42238228 DOI: 10.4329/wjr.v18.i5.120146]

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