Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar

For: Halliday BP, Gulati A, Ali A, Guha K, Newsome S, Arzanauskaite M, Vassiliou VS, Lota A, Izgi C, Tayal U, Khalique Z, Stirrat C, Auger D, Pareek N, Ismail TF, Rosen SD, Vazir A, Alpendurada F, Gregson J, Frenneaux MP, Cowie MR, Cleland JGF, Cook SA, Pennell DJ, Prasad SK. Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction. Circulation 2017;135:2106-2115. [PMID: 28351901 PMCID: PMC5444425 DOI: 10.1161/circulationaha.116.026910] [Citation(s) in RCA: 269] [Impact Index Per Article: 33.6] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/17/2016] [Accepted: 03/13/2017] [Indexed: 12/11/2022]

For:	Halliday BP, Gulati A, Ali A, Guha K, Newsome S, Arzanauskaite M, Vassiliou VS, Lota A, Izgi C, Tayal U, Khalique Z, Stirrat C, Auger D, Pareek N, Ismail TF, Rosen SD, Vazir A, Alpendurada F, Gregson J, Frenneaux MP, Cowie MR, Cleland JGF, Cook SA, Pennell DJ, Prasad SK. Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction. Circulation 2017;135:2106-2115. [PMID: 28351901 PMCID: PMC5444425 DOI: 10.1161/circulationaha.116.026910] [Citation(s) in RCA: 269] [Impact Index Per Article: 33.6] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/17/2016] [Accepted: 03/13/2017] [Indexed: 12/11/2022]

Number

Cited by Other Article(s)

Evertz R, Beukema R, Westra S, Nijveldt R, Vernooy K. Primary prevention ICD in non-ischaemic cardiomyopathy: an ongoing search for improvement of current indications : A retrospective study analysing the impact of the new Dutch guideline on the use of ICDs. Neth Heart J 2025:10.1007/s12471-025-01960-5. [PMID: 40354022 DOI: 10.1007/s12471-025-01960-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/14/2025] [Indexed: 05/14/2025] Open

Liao TWE, Xu L, Khoshknab MP, Mather PJ, Bravo PE, Desjardins B, Nazarian S. Quantitative cardiac magnetic resonance standardized signal intensity comparison in dilated cardiomyopathy vs. cardiac sarcoidosis. J Interv Card Electrophysiol 2025:10.1007/s10840-025-02042-7. [PMID: 40327245 DOI: 10.1007/s10840-025-02042-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/15/2025] [Accepted: 03/31/2025] [Indexed: 05/07/2025]

Paudel B, Pan J, Singulane CC, Wang S, Thomas M, Ayers M, Philips S, Patel AR. Cardiac Magnetic Resonance Guidance for the Pathogenetic Definition of Cardiomyopathies. Curr Cardiol Rep 2025;27:85. [PMID: 40238040 PMCID: PMC12003507 DOI: 10.1007/s11886-025-02233-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 04/01/2025] [Indexed: 04/18/2025]

Abstract

PURPOSE OF REVIEW

Pathogenetics is the study of genetics in disease pathogenesis. Many abnormal gene alleles have been identified in cardiomyopathies, but their clinical utility remains limited. This review aims to examine the integration of cardiac MRI (CMR) with genetic data to enhance early detection, prognostication, and treatment strategies for cardiomyopathies.

RECENT FINDINGS

CMR is the gold standard imaging modality for cardiomyopathy evaluation, capable of detecting subtle structural and functional changes throughout the disease course. When applied to patients with genetic mutations, with or without phenotypic expression, CMR aids in early diagnosis and risk stratification. Cardiomyopathies can be categorized into at least seven clinical groups based on morphology, function, and genetic associations: (1) Dilated cardiomyopathy (DCM), (2) Hypertrophic cardiomyopathy (HCM), (3) Restrictive cardiomyopathy, including transthyretin amyloidosis (ATTR-CM), iron overload, and Anderson-Fabry disease, (4) Arrhythmogenic cardiomyopathy (ACM), (5) Non-dilated left ventricular cardiomyopathy (NDLVC), (6) Peripartum cardiomyopathy, and (7) Muscular dystrophy-related cardiomyopathy. We have described left ventricular noncompaction (LVNC) as a morphological trait rather than a distinct cardiomyopathy. Emerging CMR and genetic data suggest an inflammatory component in DCM and ACM, with potential therapeutic implications for immunotherapy. Advanced CMR techniques, such as quantitative perfusion, can distinguish cardiomyopathies from ischemic heart disease and detect early microvascular dysfunction, particularly in ATTR-CM and HCM. Late gadolinium enhancement (LGE) and parametric mapping (T1 and extracellular volume [ECV]) further enhance early diagnosis, prognostication and treatment response by assessing fibrosis and myocardial composition. The integration of CMR and genetic insights improves our understanding of cardiomyopathy pathogenesis, aiding in early diagnosis and prognostic assessment. Future research should leverage artificial intelligence (AI) to analyze genetic and radiomic CMR features, including perfusion data, to establish a comprehensive pathogenetic framework. This approach could refine disease classification, identify novel therapeutic targets, and advance precision medicine in cardiomyopathy management.

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Malomo S, Oswald T, Stephenson E, Yip A, Alway T, Hadjivassilev S, Coombs S, Ellery S, Lee J, James R, Phillips C, Philips B, Hildick-Smith D, Parish V, Liu A. Characterisation of Post-Sepsis Cardiomyopathy Using Cardiovascular Magnetic Resonance. Diagnostics (Basel) 2025;15:997. [PMID: 40310393 PMCID: PMC12025626 DOI: 10.3390/diagnostics15080997] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/04/2025] [Revised: 03/26/2025] [Accepted: 04/04/2025] [Indexed: 05/02/2025] Open

Abstract

Background: Post-sepsis cardiomyopathy is associated with an increased risk of adverse cardiovascular outcomes. It remains poorly understood, which limits therapeutic development. This study characterised post-sepsis cardiomyopathy using cardiovascular magnetic resonance (CMR) imaging. Methods: Patients admitted with acute sepsis and suspected cardiac injury or heart failure who subsequently (47 days [IQR: 22-122]) underwent CMR at a UK tertiary cardiac centre were included. Age- and gender-matched controls (n = 16) were also included. Subjects underwent CMR at 1.5 Tesla with cines, native T1- and T2-mapping, and late gadolinium enhancement (LGE) imaging. Results: Of the 22 post-sepsis patients (age 50 ± 13 years; 64% males), 13 patients (59%) had left ventricular (LV) dilatation. Patients had significantly elevated left ventricular (LV) end-diastolic and end-systolic volume indices compared to controls (p = 0.011 and p = 0.013, respectively). Eleven patients (50%) had LV systolic dysfunction (ejection fraction < 50%), most of whom (8/11) had non-ischaemic patterns of LGE (n = 7 mid-wall; n = 1 mid-wall/patchy). In the eleven patients with preserved LV systolic function (ejection fraction ≥ 50%), three patients (27%) had significant LGE (n = 1 mid-wall; n = 1 subepicardial/mid-wall; n = 1 patchy). Compared to controls, patients had elevated septal native myocardial T1 values (p < 0.001) but similar septal native myocardial T2 values (p = 0.090), suggesting the presence of myocardial fibrosis without significant oedema. Conclusions: Post-sepsis cardiomyopathy is characterised by LV dilatation, systolic dysfunction, and myocardial fibrosis in a non-ischaemic distribution. Significant myocardial oedema is not prominent several weeks post-recovery. Further work is needed to test these findings on a multi-centre basis and to develop novel therapies for post-sepsis cardiomyopathy.

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Affiliation(s)

Samuel Malomo Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Thomas Oswald Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Edward Stephenson Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Anthony Yip Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Thomas Alway Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Stanislav Hadjivassilev Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Steven Coombs Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Susan Ellery Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Joon Lee Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Rachael James Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Claire Phillips Intensive Care Unit, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (C.P.); (B.P.)
Barbara Philips Intensive Care Unit, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (C.P.); (B.P.) Brighton and Sussex Medical School, Brighton BN1 9PX, UK
David Hildick-Smith Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Victoria Parish Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)
Alexander Liu Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK; (S.M.); (T.O.); (E.S.); (A.Y.); (T.A.); (S.H.); (S.C.); (S.E.); (J.L.); (R.J.); (D.H.-S.); (V.P.)

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Russo AM, Desai MY, Do MM, Butler J, Chung MK, Epstein AE, Guglin ME, Levy WC, Piccini JP, Bhave NM, Russo AM, Desai MY, Do MM, Ambardekar AV, Berg NC, Bilchick KC, Dec GW, Gopinathannair R, Han JK, Klein L, Lampert RJ, Panjrath GS, Reeves RR, Yoerger Sanborn DM, Stevenson LW, Truong QA, Varosy PD, Villines TC, Volgman AS, Zareba KM. ACC/AHA/ASE/HFSA/HRS/SCAI/SCCT/SCMR 2025 Appropriate Use Criteria for Implantable Cardioverter-Defibrillators, Cardiac Resynchronization Therapy, and Pacing. J Am Coll Cardiol 2025;85:1213-1285. [PMID: 39808105 PMCID: PMC11998028 DOI: 10.1016/j.jacc.2024.11.023] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/16/2025]

Abstract

This appropriate use criteria (AUC) document is developed by the American College of Cardiology along with key specialty and subspecialty societies. It provides a comprehensive review of common clinical scenarios where implantable cardioverter-defibrillator (ICD), cardiac resynchronization therapy (CRT), cardiac contractility modulation, leadless pacing, and conduction system pacing therapies are frequently considered. The 335 clinical scenarios covered in this document address ICD indications including those related to secondary prevention, primary prevention, comorbidities, generator replacement at elective replacement indicator, dual-chamber, and totally subcutaneous ICDs, as well as device indications related to CRT, conduction system pacing, leadless pacing, cardiac contractility modulation, and ICD therapy in the setting of left ventricular assist devices (LVADs).

The indications (clinical scenarios) were derived from common applications or anticipated uses, as well as from current clinical practice guidelines and results of studies examining device implantation. The indications in this document were developed by a multidisciplinary writing group and scored by a separate independent rating panel on a scale of 1 to 9 to designate care that is considered “Appropriate” (median 7 to 9), “May Be Appropriate” (median 4 to 6), and “Rarely Appropriate” (median 1 to 3). The final ratings reflect the median score of the 17 rating panel members.

In general, Appropriate designations were assigned to scenarios for which clinical trial evidence and/or clinical experience was available that supported device implantation. In contrast, scenarios for which clinical trial evidence was limited or device implantation seemed reasonable for extenuating or practical reasons were categorized as May Be Appropriate. Scenarios for which there were data showing harm, or no data were available, and medical judgment deemed device therapy was illadvised were categorized as Rarely Appropriate. For example, comorbidities including reduced life expectancy related to noncardiac conditions or severe cognitive dysfunction would negatively impact appropriateness ratings.

The appropriate use criteria for ICD, CRT, and pacing have the potential to enhance clinician decision making, healthcare delivery, and payment policy. Furthermore, recognition of clinical scenarios rated as May Be Appropriate facilitates the identification of areas where there may be gaps in evidence that would benefit from future research.

The American College of Cardiology (ACC) has a long history of developing documents (eg, expert consensus decision pathways, health policy statements, AUC documents) to provide members with guidance on both clinical and nonclinical topics relevant to cardiovascular care. In most circumstances, these documents have been created to complement clinical practice guidelines and to inform clinicians about areas where evidence is new and evolving or where sufficient data are more limited. Despite this, numerous gaps persist, highlighting the need for more streamlined and efficient processes to implement best practices in patient care.

Central to the ACC’s strategic plan is the generation of actionable knowledge —a concept that places emphasis on making clinical information easier to consume, share, integrate, and update. To this end, the ACC has shifted from developing isolated documents to creating integrated “solution sets.” These are groups of closely related activities, policy, mobile applications, decision-support tools, and other resources necessary to transform care and/or improve heart health. Solution sets address key questions facing care teams and attempt to provide practical guidance to be applied at the point of care. They use both established and emerging methods to disseminate information for cardiovascular conditions and their related management. The success of solution sets rests firmly on their ability to have a measurable impact on the delivery of care. Because solution sets reflect current evidence and ongoing gaps in care, the associated tools will be refined across time to match changing evidence and member needs.

AUC represent a key component of solution sets. They consist of common clinical scenarios associated with given disease states and ratings that define when it is reasonable to perform testing or provide therapies and, importantly, when it is not. AUC methodology relies on content development work groups, which create patient scenarios, and independent rating panels that employ a modified Delphi process to rate the relevant options for testing and intervention as Appropriate, May Be Appropriate, or Rarely Appropriate. AUC should not replace clinician judgment and practice experience but should function as tools to improve patient care and health outcomes in a cost-effective manner.

I extend sincere gratitude to the writing group for their invaluable contributions to the development of this document’s structure and clinical scenarios; to the rating panelists—a distinguished group of professionals with diverse expertise—for their thoughtful deliberation of the merits of device implantation across various clinical contexts; and to the reviewers for their thoughtful evaluation of the clinical scenarios and evidence mapping. Additionally, I am grateful to the members of the Solution Set Oversight Committee, which provided insight and guidance, and to ACC staff members María Velásquez and Lara Gold, for their support in bringing this document to fruition.

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Akkuş ÖF, Gürdoğan M. Effect of Global Longitudinal Strain at Discharge Period on Predicting Cardiac Defibrillator Implantation in STEMİ Patients with Impaired Left Ventricle Systolic Functions. MEDICINA (KAUNAS, LITHUANIA) 2025;61:545. [PMID: 40142356 PMCID: PMC11943911 DOI: 10.3390/medicina61030545] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 02/09/2025] [Revised: 03/07/2025] [Accepted: 03/18/2025] [Indexed: 03/28/2025]

Leo I, Dellegrottaglie S, Scatteia A, Torella D, Abete R, Aquaro GD, Baggiano A, Barison A, Bogaert J, Calo' L, Camastra G, Carigi S, Carrabba N, Casavecchia G, Censi S, Cicala G, De Cecco CN, De Lazzari M, Di Giovine G, Dobrovie M, Focardi M, Fusini L, Gaibazzi N, Gismondi A, Gravina M, Guglielmo M, Lanzillo C, Lombardi M, Lorenzoni V, Lozano-Torres J, Margonato D, Martini C, Marzo F, Masci PG, Masi A, Moro C, Muscogiuri G, Mushtaq S, Nese A, Palumbo A, Pavon AG, Pedrotti P, Perazzolo Marra M, Pradella S, Presicci C, Rabbat MG, Raineri C, Rodriguez-Palomares JF, Sbarbati S, Schoepf UJ, Squeri A, Sverzellati N, Symons R, Tat E, Timpani M, Todiere G, Valentini A, Varga-Szemes A, Volpe A, Guaricci AI, Schwitter J, Pontone G. CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Dilated Left Ventricular Cardiomyopathy: a sub-study from the DERIVATE Registry. Eur Heart J Cardiovasc Imaging 2025:jeaf043. [PMID: 39899463 DOI: 10.1093/ehjci/jeaf043] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/24/2024] [Revised: 01/04/2025] [Accepted: 01/10/2025] [Indexed: 02/05/2025] Open

Abstract

BACKGROUND

Accurate risk stratification for patients with non-dilated left ventricular cardiomyopathy (NDLVC) remains challenging due to lack of dedicated clinical trials. This post-hoc analysis aims to delineate the arrhythmic risk and assess the incremental value of cardiac magnetic resonance (CMR) imaging in the DERIVATE (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy) study cohort meeting the NDLVC diagnostic criteria.

METHODS

Patients with NDLVC from DERIVATE registry were identified in the absence of left ventricular (LV) dilatation and in the presence of non-ischaemic LV scarring ("fibrotic NDLVC") or isolated LV systolic dysfunction (LV ejection fraction <50%) without fibrosis ("hypokinetic NDLVC"). The primary endpoint was all-cause mortality. Major adverse arrhythmic cardiac events (MAACE) were the secondary endpoint and included sudden cardiac death (SCD) and aborted SCD.

RESULTS

One hundred ninety-seven NDLVC patients were identified from the cohort of the DERIVATE study (Mean age: 59±14 years; Male: 135). Over a median follow-up of 2.7 years, 15 (8%) patients died, and 8 (4%) experienced MAACE. Patients with "hypokinetic" NDLVC had significantly lower rates of MAACE than non-ischaemic dilated cardiomyopathy (NIDCM) (p=0.001), while patients with "fibrotic" NDLVC had same rate of both primary (p=0.48) and secondary endpoints (p= 0.616) compared to NIDMC patients. Multivariable analysis identified LGE with midwall distribution as an independent predictor of MAACE in NDLVC patients (Hazard Ratio 6.7, 95% Confidence Interval: 1.33-33.67; p=0.021).

CONCLUSIONS

NDLVC patients exhibit a heterogeneous risk profile for arrhythmic events. The presence of midwall LGE, similarly to NIDCM, is a significant predictor of MAACE, highlighting the importance of CMR imaging for risk stratification.

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Affiliation(s)

Isabella Leo Advanced Cardiovascular Imaging Unit, Clinica Villa dei Fiori, Acerra (Naples), Italy Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy
Santo Dellegrottaglie Advanced Cardiovascular Imaging Unit, Clinica Villa dei Fiori, Acerra (Naples), Italy
Alessandra Scatteia Advanced Cardiovascular Imaging Unit, Clinica Villa dei Fiori, Acerra (Naples), Italy
Daniele Torella Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy
Raffaele Abete Department of Cardiology, Policlinico di Monza, Monza, Italy
Giovanni Donato Aquaro U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy
Andrea Baggiano Centro Cardiologico Monzino IRCCS, Milan, Italy
Andrea Barison U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy
Jan Bogaert Department of Radiology, University Hospital Leuven, Leuven, Belgium
Leonardo Calo' Cardiology Department, Policlinico Casilino, Rome, Italy
Giovanni Camastra Cardiac Department, Vannini Hospital Rome, Rome, Italy
Samuela Carigi Department of Cardiology, Infermi Hospital, Rimini, Italy
Nazario Carrabba Cardiotoracovascular Department, Careggi Hospital, Florence, Italy
Grazia Casavecchia Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
Stefano Censi MariaCecilia Hospital, GVM Care & Research, Cotignola, RA, Italy
Gloria Cicala Department of Diagnostic, Parma University Hospital, Parma, Italy, Parma University Hospital, Via Gramsci, Parma, Italy
Carlo N De Cecco Division of Cardiothoracic Imaging, Emory University, Atlanta, GA, USA
Manuel De Lazzari Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Medical School, Padova, Italy
Gabriella Di Giovine Department of Cardiology, Policlinico di Monza, Monza, Italy
Monica Dobrovie Department of Radiology, University Hospital Leuven, Leuven, Belgium
Marta Focardi Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
Laura Fusini Centro Cardiologico Monzino IRCCS, Milan, Italy Department of Electronics, Information and Bioengineering, Politecnico di Milano, Italy
Nicola Gaibazzi Department of Cardiology, Azienda Ospedaliero- Universitaria, Parma, Italy
Annalaura Gismondi Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
Matteo Gravina Department of Radiology, University of Foggia, Foggia, Italy
Marco Guglielmo Department of Cardiology, Division of Heart and Lungs, Utrecht University, Utrecht, The Netherlands Department of Cardiology, Haga Teaching Hospital, The Hague, Netherlands
Chiara Lanzillo Cardiology Department, Policlinico Casilino, Rome, Italy
Massimo Lombardi Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
Valentina Lorenzoni Institute of Management, Scuola Superiore Sant'Anna, Pisa, Italy
Jordi Lozano-Torres Department of Cardiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER-CV, Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Davide Margonato Department of Cardiology, Policlinico di Monza, Monza, Italy
Chiara Martini Department of Diagnostic, Parma University Hospital, Parma, Italy, Parma University Hospital, Via Gramsci, Parma, Italy Department of Medicine and Surgery, University of Parma, Parma, Italy
Francesca Marzo Department of Cardiology, Infermi Hospital, Rimini, Italy
Pier-Giorgio Masci School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK
Ambra Masi De Gasperis' Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
Claudio Moro Department of Cardiology, ASST Monza, P.O. Desio, Italy
Giuseppe Muscogiuri ASST Papa Giovanni XXIII, 24127 Bergamo, Italy
Saima Mushtaq Centro Cardiologico Monzino IRCCS, Milan, Italy
Alberto Nese Dipartimento Neuro-Cardiovascolare, Ospedale Ca' Foncello Treviso, Treviso, Italy
Alessandro Palumbo Department of Diagnostic, Parma University Hospital, Parma, Italy, Parma University Hospital, Via Gramsci, Parma, Italy
Anna Giulia Pavon Cardiovascular Department, Division of Cardiology, and CMR Center, University Hospital Lausanne, CHUV, Lausanne, Switzerland
Patrizia Pedrotti De Gasperis' Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
Martina Perazzolo Marra Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Medical School, Padova, Italy
Silvia Pradella Department of Radiology, Careggi Hospital, Florence, Italy
Cristina Presicci Department of Diagnostic, Parma University Hospital, Parma, Italy, Parma University Hospital, Via Gramsci, Parma, Italy
Mark G Rabbat Division of Cardiology, Loyola University of Chicago, Chicago, IL, USA Edward Hines Jr. VA Hospital, Hines, Illinois
Claudia Raineri Department of Cardiology, Citta` della salute e della Scienza - Ospedale Molinette, Turin, Italy
Jose' F Rodriguez-Palomares Department of Cardiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER-CV, Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Stefano Sbarbati Radiology Department, Vannini Hospital Rome, Rome, Italy
U Joseph Schoepf Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA
Angelo Squeri MariaCecilia Hospital, GVM Care & Research, Cotignola, RA, Italy
Nicola Sverzellati Department of Medicine and Surgery, University of Parma, Parma, Italy
Rolf Symons Department of Radiology, Imelda Hospital, Bonheiden, Belgium
Emily Tat Division of Cardiology, Loyola University of Chicago, Chicago, IL, USA
Mauro Timpani UOC Radiologia, Ospedale "F. Spaziani", Frosinone, Italy
Giancarlo Todiere U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy
Adele Valentini Department of Radiology, Fondazione IRCCS Policlinico S.Matteo, Pavia, Italy
Akos Varga-Szemes Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA
Alessandra Volpe Centro Cardiologico Monzino IRCCS, Milan, Italy
Andrea Igoren Guaricci University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Bari, Italy
Juerg Schwitter Cardiovascular Department, Division of Cardiology, and CMR Center, University Hospital Lausanne, CHUV, Lausanne, Switzerland Faculty of Medicine and Biology, University of Lausanne, UniL, Lausanne, Switzerland
Gianluca Pontone Centro Cardiologico Monzino IRCCS, Milan, Italy Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

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Parlati ALM, Nardi E, Marzano F, Madaudo C, Di Santo M, Cotticelli C, Agizza S, Abbellito GM, Perrone Filardi F, Del Giudice M, Annunziata FR, Martone I, Prastaro M, Paolillo S, Perrone Filardi P, Gargiulo P. Advancing Cardiovascular Diagnostics: The Expanding Role of CMR in Heart Failure and Cardiomyopathies. J Clin Med 2025;14:865. [PMID: 39941536 PMCID: PMC11818251 DOI: 10.3390/jcm14030865] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/13/2025] [Revised: 01/25/2025] [Accepted: 01/26/2025] [Indexed: 02/16/2025] Open

Affiliation(s)

Antonio Luca Maria Parlati Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Ermanno Nardi Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Federica Marzano Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Cristina Madaudo Cardiology Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University Hospital P. Giaccone, University of Palermo, 90127 Palermo, Italy
Mariafrancesca Di Santo Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Ciro Cotticelli Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Simone Agizza Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Giuseppe Maria Abbellito Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Fabrizio Perrone Filardi Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Mario Del Giudice Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Francesco Ruggiero Annunziata Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Isabel Martone Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Maria Prastaro Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Stefania Paolillo Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Pasquale Perrone Filardi Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Paola Gargiulo Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy

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Frodi DM, Diederichsen SZ, Xing LY, Spona DC, Jacobsen PK, Risum N, Svendsen JH. Incidence and risk factors for first and recurrent ICD shock therapy in patients with an implantable cardioverter defibrillator. J Interv Card Electrophysiol 2025;68:125-139. [PMID: 39168942 PMCID: PMC11832632 DOI: 10.1007/s10840-024-01873-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/20/2024] [Accepted: 07/09/2024] [Indexed: 08/23/2024]

Feng XY, Zheng YC, Yang YX, He WF, Yang F, Wang LL, Yang HF, Li CP, Xu XX, Li R. Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy. Rev Cardiovasc Med 2025;26:25654. [PMID: 39867184 PMCID: PMC11759975 DOI: 10.31083/rcm25654] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/10/2024] [Revised: 09/02/2024] [Accepted: 09/05/2024] [Indexed: 01/28/2025] Open

Hammersley DJ, Mukhopadhyay S, Chen X, Jones RE, Ragavan A, Javed S, Rajabali H, Androulakis E, Curran L, Mach L, Khalique Z, Baruah R, Guha K, Gregson J, Zhao S, De Marvao A, Tayal U, Lota AS, Ware JS, Pennell DJ, Prasad SK, Halliday BP. Precision prediction of heart failure events in patients with dilated cardiomyopathy and mildly reduced ejection fraction using multi-parametric cardiovascular magnetic resonance. Eur J Heart Fail 2024;26:2553-2562. [PMID: 39143936 PMCID: PMC7616534 DOI: 10.1002/ejhf.3425] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/21/2024] [Revised: 07/08/2024] [Accepted: 07/24/2024] [Indexed: 08/16/2024] Open

Affiliation(s)

Daniel J. Hammersley King's College Hospital NHS Foundation TrustLondonUK National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Srinjay Mukhopadhyay National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Xiuyu Chen Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
Richard E. Jones National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK Essex Cardiothoracic CentreBasildonUK Anglia Ruskin UniversityChelmsfordUK
Aaraby Ragavan National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Saad Javed National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Husein Rajabali Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Emmanuel Androulakis King's College Hospital NHS Foundation TrustLondonUK
Lara Curran National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Lukas Mach National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Zohya Khalique National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Resham Baruah Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Kaushik Guha Portsmouth Hospital University TrustPortsmouthUK
John Gregson London School of Hygiene and Tropical MedicineLondonUK
Shihua Zhao Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
Antonio De Marvao King's College Hospital NHS Foundation TrustLondonUK British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine and Sciences, King's College LondonLondonUK Department of Women and Children's HealthKing's College LondonLondonUK MRC Laboratory of Medical Sciences, Imperial College LondonLondonUK
Upasana Tayal National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Amrit S. Lota National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
James S. Ware National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK MRC Laboratory of Medical Sciences, Imperial College LondonLondonUK
Dudley J. Pennell National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Sanjay K. Prasad National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK
Brian P. Halliday National Heart and Lung Institute, Imperial College LondonLondonUK Royal Brompton & Harefield Hospital, Guy's & St Thomas' NHS Foundation TrustLondonUK

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Parisi V, Graziosi M, Lopes LR, De Luca A, Pasquale F, Tini G, Targetti M, Cueto MR, Moura AR, Ditaranto R, Torlasco C, Taglieri N, Nardi E, Lovato L, Augusto JB, Galiè N, Crotti L, Gasperetti A, Biffi M, Autore C, Merlo M, Olivotto I, Sinagra G, Elliott PM, Biagini E. Arrhythmic risk stratification in patients with left ventricular ring-like scar. Eur J Prev Cardiol 2024:zwae353. [PMID: 39486037 DOI: 10.1093/eurjpc/zwae353] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/29/2024] [Revised: 07/28/2024] [Accepted: 10/30/2024] [Indexed: 11/03/2024]

Affiliation(s)

Vanda Parisi Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart
Maddalena Graziosi Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart
Luis R Lopes Barts Heart Centre, St Bartholomew's Hospital, London, UK Institute of Cardiovascular Science, University College London, London, UK
Antonio De Luca Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy
Ferdinando Pasquale Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart
Giacomo Tini Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy
Mattia Targetti Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy
Maria R Cueto Barts Heart Centre, St Bartholomew's Hospital, London, UK Heart Failure and Cardiomyopathies Clinic, Germans Trias i Pujol University Hospital, Badalona, Spain
Ana R Moura Barts Heart Centre, St Bartholomew's Hospital, London, UK Unidade Local de Saúde de Matosinhos, Portugal
Raffaello Ditaranto Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart
Camilla Torlasco IRCCS, Istituto Auxologico Italiano, Department of Cardiology, Cardiomyopathy Unit, San Luca Hospital, Milan, Italy
Nevio Taglieri Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart
Elena Nardi Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy
Luigi Lovato Pediatric and Adult Cardio-Thoracic and Vascular, Onco-Hematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna
João B Augusto Institute of Cardiovascular Science, University College London, London, UK Cardiology Department, Hospital Prof Doutor Fernando Fonseca, Amadora, Portugal Católica Medical School, Universidade Católica Portuguesa, Lisbon, Portugal
Nazzareno Galiè Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart
Lia Crotti European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart IRCCS, Istituto Auxologico Italiano, Department of Cardiology, Cardiomyopathy Unit, San Luca Hospital, Milan, Italy Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
Alessio Gasperetti Division of Cardiology, School of Medicine, Johns Hopkins University, 600 N. Wolfe St. Blalock 545, Baltimore, MD 21287, USA
Mauro Biffi Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart
Camillo Autore Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy
Marco Merlo Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy
Iacopo Olivotto Meyer Children Hospital and Careggi University Hospital, University of Florence, Florence, Italy
Gianfranco Sinagra Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy
Perry M Elliott Barts Heart Centre, St Bartholomew's Hospital, London, UK Institute of Cardiovascular Science, University College London, London, UK
Elena Biagini Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart

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Ipek R, Holland J, Cramer M, Rider O. CMR to characterize myocardial structure and function in heart failure with preserved left ventricular ejection fraction. Eur Heart J Cardiovasc Imaging 2024;25:1491-1504. [PMID: 39205602 PMCID: PMC11522877 DOI: 10.1093/ehjci/jeae224] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/21/2024] [Revised: 07/21/2024] [Accepted: 07/29/2024] [Indexed: 09/04/2024] Open

Hammersley DJ, Mukhopadhyay S, Chen X, Cheng L, Jones RE, Mach L, Curran L, Yazdani M, Iacob A, Lota AS, Khalique Z, De Marvao A, Baruah R, Guha K, Ware JS, Gregson J, Zhao S, Pennell DJ, Tayal U, Prasad SK, Halliday BP. Comparative prognostic importance of measures of left atrial structure and function in non-ischaemic dilated cardiomyopathy. Eur Heart J Cardiovasc Imaging 2024;25:1566-1574. [PMID: 38492215 PMCID: PMC11522868 DOI: 10.1093/ehjci/jeae080] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/13/2023] [Revised: 02/12/2024] [Accepted: 02/24/2024] [Indexed: 03/18/2024] Open

Affiliation(s)

Daniel J Hammersley National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Srinjay Mukhopadhyay National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Xiuyu Chen State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Fuwai Hospital, Beijing, China
Leanne Cheng National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Richard E Jones National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK Essex Cardiothoracic Centre, Basildon, UK Anglia Ruskin University, Chelmsford, UK
Lukas Mach National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Lara Curran National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Momina Yazdani National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Alma Iacob National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Amrit S Lota National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Zohya Khalique National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Antonio De Marvao British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK Department of Women and Children's Health, King’s College London, London, UK Medical Research Council Laboratory of Medical Sciences, Imperial College London, UK
Resham Baruah Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Kaushik Guha Portsmouth Hospitals NHS Trust, Portsmouth, UK
James S Ware National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK Medical Research Council Laboratory of Medical Sciences, Imperial College London, UK
John Gregson London School of Hygiene and Tropical Medicine, London, UK
Shihua Zhao State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Fuwai Hospital, Beijing, China
Dudley J Pennell National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Upasana Tayal National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Sanjay K Prasad National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK
Brian P Halliday National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK Royal Brompton and Harefield Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK

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Dalili M, Dastafshan M, Mahdavi M, Shahzadi H, Mortaz Hejri G, Rashidighader F, Brugada P. The Influence of Arrhythmia on the Outcomes of Pediatric Patients with Idiopathic Dilated Cardiomyopathy. Pediatr Cardiol 2024:10.1007/s00246-024-03684-6. [PMID: 39432098 DOI: 10.1007/s00246-024-03684-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/18/2024] [Accepted: 10/11/2024] [Indexed: 10/22/2024]

Abstract

Children diagnosed with dilated cardiomyopathy (DCM) are at an increased risk of developing arrhythmias, which can significantly affect their overall prognosis. However, the implantation and effectiveness of implantable cardioverter-defibrillators (ICDs) pose challenges in the pediatric population. Therefore, it is crucial to determine the prevalence of arrhythmia-related death in pediatric patients with DCM. This study investigated the correlation between arrhythmias and mortality in pediatric patients with DCM. This retrospective cohort study examined children with idiopathic DCM referred to Rajaie Cardiovascular, Medical, and Research Institute in Tehran, Iran, from 2017 to 2023. All patients underwent a standard 12-lead electrocardiogram, 24-h Holter monitoring, cardiac magnetic resonance imaging, and echocardiography. Patient outcomes, including death, heart transplantation, and survival, were evaluated within one year of Holter monitoring. A total of 178 children (79 males) with a mean age of 83.06 ± 56.41 months were included in the study. Overall, 72 deaths (40.4%) and 46 heart transplants (25.8%) were recorded and 60 patients (33.7%) survived. There was no significant association between patients' outcomes with ventricular arrhythmias, late gadolinium enhancement, corrected QT interval, and QRS interval prolongation; however, a significantly higher proportion of dead patients had abnormal heart rate variability (P = 0.034). Heart failure was the leading cause of death, with ventricular arrhythmia accounting for two out of 72 deaths. Both cases of ventricular arrhythmia were associated with severe cardiac dysfunction. Arrhythmia-related mortality is rare in children with idiopathic DCM, with severe heart failure being the primary cause of death in this population. Life-threatening arrhythmias primarily occur in DCM children with more compromised cardiac function.

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Verdonschot JAJ, Fuster JJ, Walsh K, Heymans SRB. The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy. Eur Heart J 2024;45:ehae682. [PMID: 39417710 PMCID: PMC11638724 DOI: 10.1093/eurheartj/ehae682] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/21/2024] [Revised: 07/30/2024] [Accepted: 09/24/2024] [Indexed: 10/19/2024] Open

Hammersley DJ, Zegard A, Androulakis E, Jones RE, Okafor O, Hatipoglu S, Mach L, Lota AS, Khalique Z, de Marvao A, Gulati A, Baruah R, Guha K, Ware JS, Tayal U, Pennell DJ, Halliday BP, Qiu T, Prasad SK, Leyva F. Arrhythmic Risk Stratification by Cardiovascular Magnetic Resonance Imaging in Patients With Nonischemic Cardiomyopathy. J Am Coll Cardiol 2024;84:1407-1420. [PMID: 39217566 PMCID: PMC11444937 DOI: 10.1016/j.jacc.2024.06.046] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/11/2024] [Revised: 05/30/2024] [Accepted: 06/14/2024] [Indexed: 09/04/2024]

Affiliation(s)

Daniel J Hammersley National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; Kings College Hospital NHS Foundation Trust, London, United Kingdom
Abbasin Zegard University Hospitals Birmingham Queen Elizabeth, Birmingham, United Kingdom; Aston Medical School, Aston University, Birmingham, United Kingdom
Emmanuel Androulakis Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Richard E Jones National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; Anglia Ruskin Medical School, Chelmsford, United Kingdom; Essex Cardiothoracic Centre, Basildon, Essex, United Kingdom
Osita Okafor University Hospitals Birmingham Queen Elizabeth, Birmingham, United Kingdom; Aston Medical School, Aston University, Birmingham, United Kingdom
Suzan Hatipoglu Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Lukas Mach National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Amrit S Lota National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Zohya Khalique National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Antonio de Marvao MRC Laboratory of Medical Sciences, Imperial College London, London, United Kingdom; Department of Women and Children's Health, King's College London, London, United Kingdom; British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, United Kingdom
Ankur Gulati Lewisham and Greenwich NHS Trust, London, United Kingdom
Resham Baruah Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Kaushik Guha Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom
James S Ware National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; MRC Laboratory of Medical Sciences, Imperial College London, London, United Kingdom
Upasana Tayal National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Dudley J Pennell National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Brian P Halliday National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Tian Qiu University Hospitals Birmingham Queen Elizabeth, Birmingham, United Kingdom
Sanjay K Prasad National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton & Harefield Clinical Group, part of Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Francisco Leyva University Hospitals Birmingham Queen Elizabeth, Birmingham, United Kingdom; Aston Medical School, Aston University, Birmingham, United Kingdom.

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Buch MH, Mallat Z, Dweck MR, Tarkin JM, O'Regan DP, Ferreira V, Youngstein T, Plein S. Current understanding and management of cardiovascular involvement in rheumatic immune-mediated inflammatory diseases. Nat Rev Rheumatol 2024;20:614-634. [PMID: 39232242 DOI: 10.1038/s41584-024-01149-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 07/22/2024] [Indexed: 09/06/2024]

Abstract

Immune-mediated inflammatory diseases (IMIDs) are a spectrum of disorders of overlapping immunopathogenesis, with a prevalence of up to 10% in Western populations and increasing incidence in developing countries. Although targeted treatments have revolutionized the management of rheumatic IMIDs, cardiovascular involvement confers an increased risk of mortality and remains clinically under-recognized. Cardiovascular pathology is diverse across rheumatic IMIDs, ranging from premature atherosclerotic cardiovascular disease (ASCVD) to inflammatory cardiomyopathy, which comprises myocardial microvascular dysfunction, vasculitis, myocarditis and pericarditis, and heart failure. Epidemiological and clinical data imply that rheumatic IMIDs and associated cardiovascular disease share common inflammatory mechanisms. This concept is strengthened by emergent trials that indicate improved cardiovascular outcomes with immune modulators in the general population with ASCVD. However, not all disease-modifying therapies that reduce inflammation in IMIDs such as rheumatoid arthritis demonstrate equally beneficial cardiovascular effects, and the evidence base for treatment of inflammatory cardiomyopathy in patients with rheumatic IMIDs is lacking. Specific diagnostic protocols for the early detection and monitoring of cardiovascular involvement in patients with IMIDs are emerging but are in need of ongoing development. This Review summarizes current concepts on the potentially targetable inflammatory mechanisms of cardiovascular pathology in rheumatic IMIDs and discusses how these concepts can be considered for the diagnosis and management of cardiovascular involvement across rheumatic IMIDs, with an emphasis on the potential of cardiovascular imaging for risk stratification, early detection and prognostication.

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Khan M, Jahangir A. The Uncertain Benefit from Implantable Cardioverter-Defibrillators in Nonischemic Cardiomyopathy: How to Guide Clinical Decision-Making? Heart Fail Clin 2024;20:407-417. [PMID: 39216926 DOI: 10.1016/j.hfc.2024.06.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 09/04/2024]

Lampert R, Chung EH, Ackerman MJ, Arroyo AR, Darden D, Deo R, Dolan J, Etheridge SP, Gray BR, Harmon KG, James CA, Kim JH, Krahn AD, La Gerche A, Link MS, MacIntyre C, Mont L, Salerno JC, Shah MJ. 2024 HRS expert consensus statement on arrhythmias in the athlete: Evaluation, treatment, and return to play. Heart Rhythm 2024;21:e151-e252. [PMID: 38763377 DOI: 10.1016/j.hrthm.2024.05.018] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/09/2024] [Accepted: 05/09/2024] [Indexed: 05/21/2024]

Trimarchi G, Pizzino F, Paradossi U, Gueli IA, Palazzini M, Gentile P, Di Spigno F, Ammirati E, Garascia A, Tedeschi A, Aschieri D. Charting the Unseen: How Non-Invasive Imaging Could Redefine Cardiovascular Prevention. J Cardiovasc Dev Dis 2024;11:245. [PMID: 39195153 DOI: 10.3390/jcdd11080245] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/11/2024] [Revised: 08/02/2024] [Accepted: 08/03/2024] [Indexed: 08/29/2024] Open

Dai M, Peterson C, Chorin U, Leiva O, Katz M, Sliman H, Aizer A, Barbhaiya C, Bernstein S, Holmes D, Knotts R, Park D, Spinelli M, Chinitz L, Jankelson L. Risk of malignant ventricular arrhythmias in patients with mildly to moderately reduced ejection fraction after permanent pacemaker implantation. Heart Rhythm 2024;21:1308-1316. [PMID: 38490597 DOI: 10.1016/j.hrthm.2024.03.026] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/08/2024] [Revised: 02/22/2024] [Accepted: 03/10/2024] [Indexed: 03/17/2024]

Galis P, Bartosova L, Farkasova V, Bartekova M, Ferenczyova K, Rajtik T. Update on clinical and experimental management of diabetic cardiomyopathy: addressing current and future therapy. Front Endocrinol (Lausanne) 2024;15:1451100. [PMID: 39140033 PMCID: PMC11319149 DOI: 10.3389/fendo.2024.1451100] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/18/2024] [Accepted: 07/12/2024] [Indexed: 08/15/2024] Open

Mistrulli R, Ferrera A, Salerno L, Vannini F, Guida L, Corradetti S, Addeo L, Valcher S, Di Gioia G, Spera FR, Tocci G, Barbato E. Cardiomyopathy and Sudden Cardiac Death: Bridging Clinical Practice with Cutting-Edge Research. Biomedicines 2024;12:1602. [PMID: 39062175 PMCID: PMC11275154 DOI: 10.3390/biomedicines12071602] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/17/2024] [Revised: 07/10/2024] [Accepted: 07/16/2024] [Indexed: 07/28/2024] Open

Affiliation(s)

Raffaella Mistrulli Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy; (A.F.); (L.S.); (F.V.); (L.G.); (S.C.); (F.R.S.); (G.T.); (E.B.) OLV Hospital Aalst, 9300 Aalst, Belgium; (L.A.); (S.V.)
Armando Ferrera Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy; (A.F.); (L.S.); (F.V.); (L.G.); (S.C.); (F.R.S.); (G.T.); (E.B.)
Luigi Salerno Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy; (A.F.); (L.S.); (F.V.); (L.G.); (S.C.); (F.R.S.); (G.T.); (E.B.)
Federico Vannini Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy; (A.F.); (L.S.); (F.V.); (L.G.); (S.C.); (F.R.S.); (G.T.); (E.B.)
Leonardo Guida Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy; (A.F.); (L.S.); (F.V.); (L.G.); (S.C.); (F.R.S.); (G.T.); (E.B.)
Sara Corradetti Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy; (A.F.); (L.S.); (F.V.); (L.G.); (S.C.); (F.R.S.); (G.T.); (E.B.) OLV Hospital Aalst, 9300 Aalst, Belgium; (L.A.); (S.V.)
Lucio Addeo OLV Hospital Aalst, 9300 Aalst, Belgium; (L.A.); (S.V.) Department of Advanced Biomedical Sciences, University of Naples Federico II, Corso Umberto I, 40, 80138 Naples, Italy
Stefano Valcher OLV Hospital Aalst, 9300 Aalst, Belgium; (L.A.); (S.V.) Cardiovascular Department, Humanitas University, Via Alessandro Manzoni, 56, 20089 Rozzano, Italy
Giuseppe Di Gioia Institute of Sports Medicine and Science, National Italian Olympic Committee, Largo Piero Gabrielli, 1, 00197 Rome, Italy;
Francesco Raffaele Spera Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy; (A.F.); (L.S.); (F.V.); (L.G.); (S.C.); (F.R.S.); (G.T.); (E.B.)
Giuliano Tocci Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy; (A.F.); (L.S.); (F.V.); (L.G.); (S.C.); (F.R.S.); (G.T.); (E.B.)
Emanuele Barbato Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy; (A.F.); (L.S.); (F.V.); (L.G.); (S.C.); (F.R.S.); (G.T.); (E.B.)

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Nishigake D, Yamasaki Y, Hida T, Shirasaka T, Funatsu R, Kato T, Ishigami K. Influence of cardiac cycle on myocardial extracellular volume fraction measurements with dual-layer computed tomography. Quant Imaging Med Surg 2024;14:4714-4722. [PMID: 39022251 PMCID: PMC11250292 DOI: 10.21037/qims-23-1647] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/20/2023] [Accepted: 05/22/2024] [Indexed: 07/20/2024]

Abstract

Background

In cardiac computed tomography (CT), the best image quality is obtained at mid-diastole at low heart rates (HRs) and at end-systole at high HRs. On the other hand, extracellular volume (ECV) measurements may be influenced by the cardiac phase. Therefore, we aimed to clarify the influence of the cardiac phase on the image quality and ECV values obtained using dual-layer spectral computed tomography (DLCT).

Methods

Fifty-five patients (68.0±14.5 years; 26 men) with cardiac diseases who underwent retrospective electrocardiogram-gated myocardial CT delayed enhancement (CTDE) between February 2019 to April 2022 were enrolled. The ECVs at the right ventricle (RV) and left ventricle (LV) walls in the end-systolic and mid-diastolic phases were calculated using iodine-density measurements from CTDE spectral data. Iodine-density image quality was classified on a 4-point scale. ECV and image quality across cardiac phases were compared using the t-test and Wilcoxon signed-rank test, respectively. Inter- and intraobserver variability were evaluated using intraclass correlation coefficient (ICC) values.

Results

The ECV of the septal regions during mid-diastole was significantly higher than that during end-systole. Other regions showed similar ECV measurements in both groups (P=0.13-0.97), except for the LV anterior wall and LV posterior wall at the base-ventricular level. The image-quality score in end-systole was significantly higher than that in mid-diastole (systole vs. diastole: 3.6±0.5 vs. 3.2±0.7; P=0.0195). Intra- and interobserver variabilities for RV ECV measurements at the end-systolic phase were superior to those at the mid-diastolic phase, whereas the corresponding values for LV ECV measurements were similar.

Conclusions

Septal ECV showed small but significant differences while other region ECV showed no difference during the cardiac cycle. RV ECV measurements in the end-systolic phase were more reproducible than those in the mid-diastolic phase.

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Kolk MZH, Ruipérez-Campillo S, Allaart CP, Wilde AAM, Knops RE, Narayan SM, Tjong FVY. Multimodal explainable artificial intelligence identifies patients with non-ischaemic cardiomyopathy at risk of lethal ventricular arrhythmias. Sci Rep 2024;14:14889. [PMID: 38937555 PMCID: PMC11211323 DOI: 10.1038/s41598-024-65357-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/28/2024] [Accepted: 06/19/2024] [Indexed: 06/29/2024] Open

Ailoaei S, Sorodoc L, Ureche C, Sandu G, Sîtari N, Ceasovschih A, Grecu M, Sascău RA, Stătescu C. Role of Cardiac Magnetic Resonance in the Assessment of Patients with Premature Ventricular Contractions: A Narrative Review. Anatol J Cardiol 2024;28:467-478. [PMID: 38832526 PMCID: PMC11460551 DOI: 10.14744/anatoljcardiol.2024.4314] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/07/2024] [Accepted: 05/07/2024] [Indexed: 06/05/2024] Open

Karur GR, Aneja A, Stojanovska J, Hanneman K, Latchamsetty R, Kersting D, Rajiah PS. Imaging of Cardiac Fibrosis: An Update, From the AJR Special Series on Imaging of Fibrosis. AJR Am J Roentgenol 2024;222:e2329870. [PMID: 37753860 DOI: 10.2214/ajr.23.29870] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/28/2023]

van der Lingen ALCJ, Verstraelen TE, van Erven L, Meeder JG, Theuns DA, Vernooy K, Wilde AAM, Maass AH, Allaart CP. Assessment of ICD eligibility in non-ischaemic cardiomyopathy patients: a position statement by the Task Force of the Dutch Society of Cardiology. Neth Heart J 2024;32:190-197. [PMID: 38634993 DOI: 10.1007/s12471-024-01859-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 01/30/2024] [Indexed: 04/19/2024] Open

Ismail TF. Understanding heart failure and cardiomyopathy in Africa: Insights from cardiovascular magnetic resonance. Int J Cardiol 2024;402:131847. [PMID: 38354982 DOI: 10.1016/j.ijcard.2024.131847] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/31/2024] [Accepted: 02/09/2024] [Indexed: 02/16/2024]

Popa OA, Amzulescu M, Bugeac C, Tomescu L, Slavu IM, Gheorghita V, Andrei R, Tulin A. Cardiovascular Magnetic Resonance Imaging in Myocardial Disease. Cureus 2024;16:e58688. [PMID: 38774162 PMCID: PMC11107957 DOI: 10.7759/cureus.58688] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/21/2024] [Indexed: 05/24/2024] Open

Amemiya K, Matsuyama TA, Ishibashi-Ueda H, Morita Y, Matsumoto M, Ohta-Ogo K, Ikeda Y, Tsukamoto Y, Fukushima N, Fukushima S, Fujita T, Hatakeyama K. Can right ventricular endomyocardial biopsy predict left ventricular fibrosis beforehand in dilated cardiomyopathy? ESC Heart Fail 2024;11:1001-1008. [PMID: 38234242 DOI: 10.1002/ehf2.14642] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/05/2023] [Revised: 10/18/2023] [Accepted: 12/05/2023] [Indexed: 01/19/2024] Open

Tsunamoto H, Yamamoto H, Masumoto A, Taniguchi Y, Takahashi N, Onishi T, Takaya T, Kawai H, Hirata KI, Tanaka H. Efficacy of Native T₁ Mapping for Patients With Non-Ischemic Cardiomyopathy and Ventricular Functional Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair. Circ J 2024;88:519-527. [PMID: 38325820 DOI: 10.1253/circj.cj-23-0777] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/09/2024]

Liu X, Li M, Chen J, Wu J, Zhang L, Hu J, Li F, Fan X, Yang H, Yan L, Liu J. Association between left bundle branch block and ventricular septal mid-wall fibrosis in patients with preserved left ventricular ejection fraction. J Electrocardiol 2024;83:21-25. [PMID: 38241779 DOI: 10.1016/j.jelectrocard.2024.01.002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/09/2023] [Revised: 11/29/2023] [Accepted: 01/07/2024] [Indexed: 01/21/2024]

Perone F, Dentamaro I, La Mura L, Alifragki A, Marketou M, Cavarretta E, Papadakis M, Androulakis E. Current Insights and Novel Cardiovascular Magnetic Resonance-Based Techniques in the Prognosis of Non-Ischemic Dilated Cardiomyopathy. J Clin Med 2024;13:1017. [PMID: 38398330 PMCID: PMC10889760 DOI: 10.3390/jcm13041017] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/19/2023] [Revised: 01/29/2024] [Accepted: 02/02/2024] [Indexed: 02/25/2024] Open

Kim D, Collins JD, White JA, Hanneman K, Lee DC, Patel AR, Hu P, Litt H, Weinsaft JW, Davids R, Mukai K, Ng MY, Luetkens JA, Roguin A, Rochitte CE, Woodard PK, Manisty C, Zareba KM, Mont L, Bogun F, Ennis DB, Nazarian S, Webster G, Stojanovska J. SCMR expert consensus statement for cardiovascular magnetic resonance of patients with a cardiac implantable electronic device. J Cardiovasc Magn Reson 2024;26:100995. [PMID: 38219955 PMCID: PMC11211236 DOI: 10.1016/j.jocmr.2024.100995] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/13/2023] [Accepted: 01/09/2024] [Indexed: 01/16/2024] Open

Affiliation(s)

Daniel Kim Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jeremy D Collins Department of Radiology, Mayo Clinic, Rochester, MN, USA
James A White Departments of Cardiac Sciences and Diagnostic Imaging, Cummings School of Medicine, University of Calgary, Calgary, Canada
Kate Hanneman Department of Medical Imaging, University Medical Imaging Toronto, Toronto General Hospital and Peter Munk Cardiac Centre, University of Toronto, Toronto, Canada
Daniel C Lee Department of Medicine (Division of Cardiology), Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Amit R Patel Cardiovascular Division, University of Virginia, Charlottesville, VA, USA
Peng Hu School of Biomedical Engineering, ShanghaiTech University, Shanghai, China
Harold Litt Department of Radiology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA
Jonathan W Weinsaft Department of Medicine (Division of Cardiology), Weill Cornell Medicine, New York, NY, USA
Rachel Davids SHS AM NAM USA DI MR COLLAB ADV-APPS, Siemens Medical Solutions USA, Inc., Chicago, Il, USA
Kanae Mukai Salinas Valley Memorial Healthcare System, Ryan Ranch Center for Advanced Diagnostic Imaging, Monterey, CA, USA
Ming-Yen Ng Department of Diagnostic Radiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, the Hong Kong Special Administrative Region of China
Julian A Luetkens Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany
Ariel Roguin Department of Cardiology, Hillel Yaffe Medical Center, Hadera and Faculty of Medicine. Technion - Israel Institute of Technology, Israel
Carlos E Rochitte Heart Institute, InCor, University of São Paulo Medical School, São Paulo, SP, Brazil
Pamela K Woodard Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA
Charlotte Manisty Institute of Cardiovascular Science, University College London, London, UK
Karolina M Zareba Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA
Lluis Mont Cardiovascular Institute, Hospital Clínic, University of Barcelona, Catalonia, Spain
Frank Bogun Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
Daniel B Ennis Department of Radiology, Stanford University, Stanford, CA, USA
Saman Nazarian Section of Cardiac Electrophysiology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA
Gregory Webster Department of Pediatrics (Cardiology), Ann & Robert H. Lurie Children's Hospital, Chicago, IL, USA
Jadranka Stojanovska Department of Radiology, Grossman School of Medicine, New York University, New York, NY, USA

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Ma HY, Xie GY, Tao J, Li ZZ, Liu P, Zheng XJ, Wang RP. Identification of patients with nonischemic dilated cardiomyopathy at risk of malignant ventricular arrhythmias: insights from cardiac magnetic resonance feature tracking. BMC Cardiovasc Disord 2024;24:29. [PMID: 38172720 PMCID: PMC10765793 DOI: 10.1186/s12872-023-03655-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/04/2023] [Accepted: 12/04/2023] [Indexed: 01/05/2024] Open

Abstract

BACKGROUND

Patients with nonischemic dilated cardiomyopathy (NIDCM) are prone to arrhythmias, and the cause of mortality in these patients is either end-organ dysfunction due to pump failure or malignant arrhythmia-related death. However, the identification of patients with NIDCM at risk of malignant ventricular arrhythmias (VAs) is challenging in clinical practice. The aim of this study was to evaluate whether cardiovascular magnetic resonance feature tracking (CMR-FT) could help in the identification of patients with NIDCM at risk of malignant VAs.

METHODS

A total of 263 NIDCM patients who underwent CMR, 24-hour Holter electrocardiography (ECG) and inpatient ECG were retrospectively evaluated. The patients with NIDCM were allocated to two subgroups: NIDCM with VAs and NIDCM without VAs. From CMR-FT, the global peak radial strain (GPRS), global longitudinal strain (GPLS), and global peak circumferential strain (GPCS) were calculated from the left ventricle (LV) model. We investigated the possible predictors of NIDCM combined with VAs by univariate and multivariate logistic regression analyses.

RESULTS

The percent LGE (15.51 ± 3.30 vs. 9.62 ± 2.18, P < 0.001) was higher in NIDCM patients with VAs than in NIDCM patients without VAs. Furthermore, the NIDCM patients complicated with VAs had significantly lower GPCS than the NIDCM patients without VAs (- 5.38 (- 7.50, - 4.22) vs.-9.22 (- 10.73, - 8.19), P < 0.01). Subgroup analysis based on LGE negativity showed that NIDCM patients complicated with VAs had significantly lower GPRS, GPCS, and GPLS than NIDCM patients without VAs (P < 0.05 for all). Multivariate analysis showed that both GPCS and %LGE were independent predictors of NIDCM combined with VAs.

CONCLUSIONS

CMR global strain can be used to identify NIDCM patients complicated with VAs early, specifically when LGE is not present. GPCS < - 13.19% and %LGE > 10.37% are independent predictors of NIDCM combined with VAs.

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Gil KE, Mikrut K, Mazur J, Black AL, Truong VT, Smart S, Zareba KM. Risk stratification in patients with structurally normal hearts: Does fibrosis type matter? PLoS One 2023;18:e0295519. [PMID: 38117807 PMCID: PMC10732365 DOI: 10.1371/journal.pone.0295519] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/28/2023] [Accepted: 11/26/2023] [Indexed: 12/22/2023] Open

Abstract

OBJECTIVES

The study sought to assess the prognostic significance of nonischemic myocardial fibrosis (MF) on cardiovascular magnetic resonance (CMR)-both macroscopic MF assessed by late gadolinium enhancement (LGE) and diffuse microscopic MF quantified by extracellular volume fraction (ECV)-in patients with structurally normal hearts.

BACKGROUND

The clinical relevance of tissue abnormalities identified by CMR in patients with structurally normal hearts remains unclear.

METHODS

Consecutive patients undergoing CMR were screened for inclusion to identify those with LGE imaging and structurally normal hearts. ECV was calculated in patients with available T1 mapping. The associations between myocardial fibrosis and the outcomes of all-cause mortality, new-onset heart failure [HF], and an arrhythmic outcome were evaluated.

RESULTS

In total 525 patients (mean age 43.1±14.2 years; 30.5% males) were included. Over a median follow-up of 5.8 years, 13 (2.5%) patients died and 18 (3.4%) developed new-onset HF. Nonischemic midwall /subepicardial LGE was present in 278 (52.9%) patients; isolated RV insertion fibrosis was present in 80 (15.2%) patients. In 276 patients with available T1 mapping, the mean ECV was 25.5 ± 4.4%. There was no significant association between LGE and all-cause mortality (HR: 1.36, CI: 0.42-4.42, p = 0.61), or new-onset HF (HR: 0.64, CI: 0.25-1.61, p = 0.34). ECV (per 1% increase) correlated with all-cause mortality (HR: 1.19, CI: 1.04-1.36, p = 0.009), but not with new-onset HF (HR: 0.97, CI: 0.86-1.10, p = 0.66). There was no significant association between arrhythmic outcomes and LGE (p = 0.60) or ECV (p = 0.49). In a multivariable model after adjusting for covariates, ECV remained significantly associated with all-cause mortality (HR per 1% increase in ECV: 1.26, CI: 1.06-1.50, p = 0.009).

CONCLUSION

Nonischemic LGE in patients with structurally normal hearts is common and does not appear to be associated with adverse outcomes, whereas elevated ECV is associated with all-cause mortality and may be an important risk stratification tool.

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Argentiero A, Carella MC, Mandunzio D, Greco G, Mushtaq S, Baggiano A, Fazzari F, Fusini L, Muscogiuri G, Basile P, Siena P, Soldato N, Napoli G, Santobuono VE, Forleo C, Garrido EC, Di Marco A, Pontone G, Guaricci AI. Cardiac Magnetic Resonance as Risk Stratification Tool in Non-Ischemic Dilated Cardiomyopathy Referred for Implantable Cardioverter Defibrillator Therapy-State of Art and Perspectives. J Clin Med 2023;12:7752. [PMID: 38137821 PMCID: PMC10743710 DOI: 10.3390/jcm12247752] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/31/2023] [Revised: 12/12/2023] [Accepted: 12/15/2023] [Indexed: 12/24/2023] Open

Affiliation(s)

Adriana Argentiero University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Maria Cristina Carella University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Donato Mandunzio University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Giulia Greco University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Saima Mushtaq Perioperative and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy; (S.M.); (A.B.); (F.F.); (L.F.); (G.P.)
Andrea Baggiano Perioperative and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy; (S.M.); (A.B.); (F.F.); (L.F.); (G.P.)
Fabio Fazzari Perioperative and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy; (S.M.); (A.B.); (F.F.); (L.F.); (G.P.)
Laura Fusini Perioperative and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy; (S.M.); (A.B.); (F.F.); (L.F.); (G.P.)
Giuseppe Muscogiuri Department of Radiology, ASST Papa Giovanni XIII, 24127 Bergamo, Italy;
Paolo Basile University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Paola Siena University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Nicolò Soldato University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Gianluigi Napoli University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Vincenzo Ezio Santobuono University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Cinzia Forleo University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)
Eduard Claver Garrido Bio-Heart Cardiovascular Diseases Research Group, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, 08907 Barcelona, Spain; (E.C.G.); (A.D.M.) Department of Cardiology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
Andrea Di Marco Bio-Heart Cardiovascular Diseases Research Group, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, 08907 Barcelona, Spain; (E.C.G.); (A.D.M.) Department of Cardiology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
Gianluca Pontone Perioperative and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy; (S.M.); (A.B.); (F.F.); (L.F.); (G.P.) Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy
Andrea Igoren Guaricci University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy; (A.A.); (M.C.C.); (D.M.); (G.G.); (P.B.); (P.S.); (N.S.); (G.N.); (V.E.S.); (C.F.)

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Polovina M, Tschöpe C, Rosano G, Metra M, Crea F, Mullens W, Bauersachs J, Sliwa K, de Boer RA, Farmakis D, Thum T, Corrado D, Bayes-Genis A, Bozkurt B, Filippatos G, Keren A, Skouri H, Moura B, Volterrani M, Abdelhamid M, Ašanin M, Krljanac G, Tomić M, Savarese G, Adamo M, Lopatin Y, Chioncel O, Coats AJS, Seferović PM. Incidence, risk assessment and prevention of sudden cardiac death in cardiomyopathies. Eur J Heart Fail 2023;25:2144-2163. [PMID: 37905371 DOI: 10.1002/ejhf.3076] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/18/2023] [Revised: 10/17/2023] [Accepted: 10/22/2023] [Indexed: 11/02/2023] Open

Affiliation(s)

Marija Polovina Faculty of Medicine, Belgrade University, Belgrade, Serbia Department of Cardiology, University Clinical Centre of Serbia, Belgrade, Serbia
Carsten Tschöpe Berlin Institute of Health (BIH), Charité-Universitätsmedizin Berlin, Berlin, Germany German Centre for Cardiovascular Research, Charité-Universitätsmedizin Berlin, Berlin, Germany Department of Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany
Giuseppe Rosano IRCCS San Raffaele Pisana, Rome, Italy
Marco Metra Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
Filippo Crea Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy
Wilfried Mullens Hasselt University, Hasselt, Belgium Ziekenhuis Oost-Limburg, Genk, Belgium
Johann Bauersachs Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Karen Sliwa Cape Heart Institute. Division of Cardiology, Groote Schuur Hospital, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Rudolf A de Boer Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands
Dimitrios Farmakis University of Cyprus Medical School, Nicosia, Cyprus
Thomas Thum Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany
Domenico Corrado Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy
Antoni Bayes-Genis Servicio de Cardiología, Hospital Universitari Germans Trias i Pujol, CIBERCV, Universidad Autónoma de Barcelona, Badalona, Spain
Biykem Bozkurt Section of Cardiology, Winters Center for Heart Failure, Department of Medicine, Baylor College of Medicine, Houston, TX, USA Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA
Gerasimos Filippatos National and Kapodistrian University of Athens, School of Medicine, Department of Cardiology, Attikon University Hospital, Athens, Greece
Andre Keren Hadassah-Hebrew University Medical Center Jerusalem, Clalit Services District of Jerusalem, Jerusalem, Israel
Hadi Skouri Division of Cardiology, American University of Beirut Medical Center, Beirut, Lebanon
Brenda Moura Armed Forces Hospital, Porto, & Faculty of Medicine, University of Porto, Porto, Portugal
Maurizio Volterrani IRCCS San Raffaele Pisana, Rome, Italy Department of Human Science and Promotion of Quality of Life, San Raffaele Open University of Rome, Rome, Italy
Magdy Abdelhamid Department of Cardiovascular Medicine, Faculty of Medicine, Kasr Al Ainy, Cairo University, Giza, Egypt
Milika Ašanin Faculty of Medicine, Belgrade University, Belgrade, Serbia Department of Cardiology, University Clinical Centre of Serbia, Belgrade, Serbia
Gordana Krljanac Faculty of Medicine, Belgrade University, Belgrade, Serbia Department of Cardiology, University Clinical Centre of Serbia, Belgrade, Serbia
Milenko Tomić Department of Cardiology, University Clinical Centre of Serbia, Belgrade, Serbia
Gianluigi Savarese Division of Cardiology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden
Marianna Adamo Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
Yuri Lopatin Volgograd Medical University, Cardiology Centre, Volgograd, Russian Federation
Ovidiu Chioncel Emergency Institute for Cardiovascular Diseases 'Prof. Dr. C.C. Iliescu', Bucharest, Romania University for Medicine and Pharmacy 'Carol Davila', Bucharest, Romania
Andrew J S Coats University of Warwick, Coventry, UK
Petar M Seferović Faculty of Medicine, Belgrade University, Belgrade, Serbia Serbian Academy of Sciences and Arts, Belgrade, Serbia

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Hespe S, Isbister JC, Duflou J, Puranik R, Bagnall RD, Semsarian C, Gray B, Ingles J. A case series of patients with filamin-C truncating variants attending a specialized cardiac genetic clinic. Eur Heart J Case Rep 2023;7:ytad572. [PMID: 38116480 PMCID: PMC10729912 DOI: 10.1093/ehjcr/ytad572] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/14/2023] [Revised: 09/25/2023] [Accepted: 11/15/2023] [Indexed: 12/21/2023]

Affiliation(s)

Sophie Hespe Genomics and Inherited Disease Program, Garvan Institute of Medical Research, and University of New South Wales, 384 Victoria Street, Darlinghurst, 2010 NSW, Australia Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050 NSW, Australia
Julia C Isbister Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050 NSW, Australia Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, 2050 NSW, Australia Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, The University of Sydney, Sydney, 2050 NSW, Australia
Johan Duflou Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050 NSW, Australia
Raj Puranik Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050 NSW, Australia Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, 2050 NSW, Australia
Richard D Bagnall Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050 NSW, Australia Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, The University of Sydney, Sydney, 2050 NSW, Australia
Christopher Semsarian Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050 NSW, Australia Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, 2050 NSW, Australia Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, The University of Sydney, Sydney, 2050 NSW, Australia
Belinda Gray Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050 NSW, Australia Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, 2050 NSW, Australia
Jodie Ingles Genomics and Inherited Disease Program, Garvan Institute of Medical Research, and University of New South Wales, 384 Victoria Street, Darlinghurst, 2010 NSW, Australia Faculty of Medicine and Health, The University of Sydney, Camperdown, 2050 NSW, Australia Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, 2050 NSW, Australia

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Cha MJ, Hong YJ, Park CH, Cha YJ, Kim TH, Kim C, Park CH. Utilities and Limitations of Cardiac Magnetic Resonance Imaging in Dilated Cardiomyopathy. Korean J Radiol 2023;24:1200-1220. [PMID: 38016680 PMCID: PMC10700999 DOI: 10.3348/kjr.2023.0531] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/05/2023] [Revised: 08/08/2023] [Accepted: 08/15/2023] [Indexed: 11/30/2023] Open

Feng J, Zhao X, Huang B, Wu Y, Wang J, Guan J, Huang L, Li X, Zhang Y, Zhang J. Prognostic Value of QRS Duration in Patients with Dilated Cardiomyopathy According to Left Ventricular Ejection Fraction. Rev Cardiovasc Med 2023;24:362. [PMID: 39077076 PMCID: PMC11272873 DOI: 10.31083/j.rcm2412362] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/16/2023] [Revised: 07/19/2023] [Accepted: 07/27/2023] [Indexed: 07/31/2024] Open

Affiliation(s)

Jiayu Feng State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China
Xuemei Zhao State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China
Boping Huang State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China
Yihang Wu State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China
Jing Wang State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China
Jingyuan Guan State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China
Liyan Huang State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China
Xinqing Li State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China
Yuhui Zhang State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China
Jian Zhang State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 10000 Beijing, China Key Laboratory of Clinical Research for Cardiovascular Medications, National Health Committee, 10000 Beijing, China

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Kan A, Fang Q, Li S, Liu W, Tao X, Huang K, Hu M, Feng Z, Gong L. The potential predictive value of cardiac mechanics for left ventricular reverse remodelling in dilated cardiomyopathy. ESC Heart Fail 2023;10:3340-3351. [PMID: 37697922 PMCID: PMC10682859 DOI: 10.1002/ehf2.14529] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2023] [Revised: 06/21/2023] [Accepted: 08/30/2023] [Indexed: 09/13/2023] Open

Abstract

AIMS

Left ventricular reverse remodelling (LVRR) is an important objective of optimal medical management for dilated cardiomyopathy (DCM) patients, as it is associated with favourable long-term outcomes. Cardiac magnetic resonance (CMR) can comprehensively assess cardiac structure and function. We aimed to assess the CMR parameters at baseline and investigate independent variables to predict LVRR in DCM patients.

METHODS AND RESULTS

Nighty-eight initially diagnosed DCM patients who underwent CMR and echocardiography examinations at baseline were included. CMR parameters and feature tracking (FT) based left ventricular (LV) global strain (nStrain) and nStrain indexed to LV cardiac mass index (rStrain) were measured. The predictors of LVRR were determined by multivariate logistic regression analyses. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of CMR parameters and were compared by the DeLong test. At a median follow-up time of 9 [interquartile range, 7-12] months, 35 DCM patients (36%) achieved LVRR. The patients with LVRR had lower LV volume, mass, LGE extent and stroke volume index (LVSVi) and higher left ventricular remodelling index (LVRI), nStrains, rStrains, and peak systolic strain rate (PSSR) in the longitudinal direction and rStrains in the circumferential direction at baseline (all P < 0.05). In the multivariate logistic regression analyses, LVRI [per SD, odds ratio (OR) 1.79; 95% confidence interval (CI) 1.08-2.98; P = 0.024] and the ratio of global longitudinal peak strain (rGLPS) (per SD, OR 1.88; 95% CI 1.18-3.01; P = 0.008) were independent predictors of LVRR. The combination of LVSVi, LVRI, and rGLPS had a greater area under the curve (AUC) than the combination of LVSVi and LVRI (0.75 vs. 0.68), but not significantly (P = 0.09).

CONCLUSIONS

Patients with LVRR had a lower LV volume index, lower LVSV index, lower LGE extent, higher LVRI, and preserved myocardial deformation in the longitudinal direction at baseline. LVRI and rGLPS at baseline were independent determinants of LVRR.

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Feng XY, He WF, Zhang TY, Wang LL, Yang F, Feng YL, Li CP, Li R. Association between late gadolinium enhancement and outcome in dilated cardiomyopathy: A meta-analysis. World J Radiol 2023;15:324-337. [PMID: 38058605 PMCID: PMC10696187 DOI: 10.4329/wjr.v15.i11.324] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/17/2023] [Revised: 09/29/2023] [Accepted: 10/23/2023] [Indexed: 11/24/2023] Open

Khan M, Jahangir A. The Uncertain Benefit from Implantable Cardioverter-Defibrillators in Nonischemic Cardiomyopathy: How to Guide Clinical Decision-Making? Cardiol Clin 2023;41:545-555. [PMID: 37743077 DOI: 10.1016/j.ccl.2023.06.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 09/26/2023]

Hammersley DJ, Jones RE, Owen R, Mach L, Lota AS, Khalique Z, De Marvao A, Androulakis E, Hatipoglu S, Gulati A, Reddy RK, Yoon WY, Talukder S, Shah R, Baruah R, Guha K, Pantazis A, Baksi AJ, Gregson J, Cleland JG, Tayal U, Pennell DJ, Ware JS, Halliday BP, Prasad SK. Phenotype, outcomes and natural history of early-stage non-ischaemic cardiomyopathy. Eur J Heart Fail 2023;25:2050-2059. [PMID: 37728026 PMCID: PMC10946699 DOI: 10.1002/ejhf.3037] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/09/2023] [Revised: 09/03/2023] [Accepted: 09/15/2023] [Indexed: 09/21/2023] Open

Abstract

AIMS

To characterize the phenotype, clinical outcomes and rate of disease progression in patients with early-stage non-ischaemic cardiomyopathy (early-NICM).

METHODS AND RESULTS

We conducted a prospective observational cohort study of patients with early-NICM assessed by late gadolinium enhancement cardiovascular magnetic resonance (CMR). Cases were classified into the following subgroups: isolated left ventricular dilatation (early-NICM H-/D+), non-dilated left ventricular cardiomyopathy (early-NICM H+/D-), or early dilated cardiomyopathy (early-NICM H+/D+). Clinical follow-up for major adverse cardiovascular events (MACE) included non-fatal life-threatening arrhythmia, unplanned cardiovascular hospitalization or cardiovascular death. A subset of patients (n = 119) underwent a second CMR to assess changes in cardiac structure and function. Of 254 patients with early-NICM (median age 46 years [interquartile range 36-58], 94 [37%] women, median left ventricular ejection fraction [LVEF] 55% [52-59]), myocardial fibrosis was present in 65 (26%). There was no difference in the prevalence of fibrosis between subgroups (p = 0.90), however fibrosis mass was lowest in early-NICM H-/D+, higher in early-NICM H+/D- and highest in early-NICM H+/D+ (p = 0.03). Over a median follow-up of 7.9 (5.5-10.0) years, 28 patients (11%) experienced MACE. Non-sustained ventricular tachycardia (hazard ratio [HR] 5.1, 95% confidence interval [CI] 2.36-11.00, p < 0.001), myocardial fibrosis (HR 3.77, 95% CI 1.73-8.20, p < 0.001) and diabetes mellitus (HR 5.12, 95% CI 1.73-15.18, p = 0.003) were associated with MACE in a multivariable model. Only 8% of patients progressed from early-NICM to dilated cardiomyopathy with LVEF <50% over a median of 16 (11-34) months.

CONCLUSION

Early-NICM is not benign. Fibrosis develops early in the phenotypic course. In-depth characterization enhances risk stratification and might aid clinical management.

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Affiliation(s)

Daniel J. Hammersley National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Richard E. Jones National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK Anglia Ruskin Medical School, UKCambridgeUK Essex Cardiothoracic CentreBasildonUK
Ruth Owen London School of Hygiene and Tropical MedicineLondonUK
Lukas Mach National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Amrit S. Lota National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Zohya Khalique National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Antonio De Marvao Department of Women and Children's HealthKing's College LondonLondonUK British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine and SciencesKing's College LondonLondonUK
Emmanuel Androulakis Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Suzan Hatipoglu Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Ankur Gulati Lewisham and Greenwich NHS TrustLondonUK
Rohin K. Reddy National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Won Young Yoon Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Suprateeka Talukder Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Riya Shah Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Resham Baruah Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Kaushik Guha Portsmouth Hospitals NHS TrustPortsmouthUK
Antonis Pantazis Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
A. John Baksi Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
John Gregson London School of Hygiene and Tropical MedicineLondonUK
John G.F. Cleland British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic HealthUniversity of GlasgowGlasgowUK
Upasana Tayal National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Dudley J. Pennell National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
James S. Ware National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK MRC London Institute of Medical SciencesImperial College LondonLondonUK
Brian P. Halliday National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK
Sanjay K. Prasad National Heart and Lung InstituteImperial College LondonLondonUK Royal Brompton & Harefield HospitalGuy's and St Thomas' NHS Foundation TrustLondonUK

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Xiang X, Zhao K, Chen X, Song Y, Yang K, Yu S, Yang S, Wang J, Dong Z, Lu M, Ma L, Zhao S. Prediction of adverse outcomes in nonischemic dilated cardiomyopathy: A CMR-based nomogram. Int J Cardiol 2023;390:131136. [PMID: 37356732 DOI: 10.1016/j.ijcard.2023.131136] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/29/2023] [Revised: 05/23/2023] [Accepted: 06/20/2023] [Indexed: 06/27/2023]

Affiliation(s)

Xiaorui Xiang MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Kankan Zhao Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Xiuyu Chen MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Yanyan Song MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Kai Yang MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Shiqin Yu MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Shujuan Yang MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Jiaxin Wang MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Zhixiang Dong MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Minjie Lu MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Likun Ma First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui 230036, China.
Shihua Zhao MR Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

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Basharat SA, Hsiung I, Garg J, Alsaid A. Arrhythmogenic Cardiomyopathy: Evolving Diagnostic Criteria and Insight from Cardiac Magnetic Resonance Imaging. Heart Fail Clin 2023;19:429-444. [PMID: 37714585 DOI: 10.1016/j.hfc.2023.03.006] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 09/17/2023]

Song Y, Chen X, Yang K, Dong Z, Cui C, Zhao K, Cheng H, Ji K, Lu M, Zhao S. Cardiac MRI-derived Myocardial Fibrosis and Ventricular Dyssynchrony Predict Response to Cardiac Resynchronization Therapy in Patients with Nonischemic Dilated Cardiomyopathy. Radiol Cardiothorac Imaging 2023;5:e220127. [PMID: 37908550 PMCID: PMC10613947 DOI: 10.1148/ryct.220127] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/20/2022] [Revised: 06/05/2023] [Accepted: 08/22/2023] [Indexed: 11/02/2023]

Abstract

Purpose

To determine the association of myocardial fibrosis and left ventricular (LV) dyssynchrony measured using cardiac MRI with late gadolinium enhancement (LGE) and feature tracking (FT), respectively, with response to cardiac resynchronization therapy (CRT) for nonischemic dilated cardiomyopathy (DCM).

Materials and Methods

This retrospective study included 98 patients (mean age, 59 years ± 10 [SD]; 54 men) who had nonischemic DCM, as assessed with LGE cardiac MRI before CRT. Cardiac MRI FT-derived dyssynchrony was defined as the SD of the time-to-peak strain (TTP-SD) of the LV segments in three directions (longitudinal, radial, and circumferential). CRT response was defined as a 15% increase in LV ejection fraction (LVEF) at echocardiography at 6-month follow-up, and then, long-term cardiovascular events were assessed. The likelihood ratio test was used to evaluate the incremental prognostic value of LGE and dyssynchrony parameters.

Results

Seventy-one (72%) patients showed a favorable LVEF response following CRT. LGE presence (odds ratio: 0.14 [95% CI: 0.04, 0.47], P = .002; and hazard ratio: 3.52 [95% CI: 1.37, 9.07], P = .01) and lower circumferential TTP-SD (odds ratio: 1.04 [95% CI: 1.02, 1.07], P = .002; and hazard ratio: 0.98 [95% CI: 0.96, 1.00], P = .03) were independently associated with LVEF nonresponse and long-term outcomes. Combined LGE and circumferential TTP-SD provided the highest discrimination for LVEF nonresponse (area under the receiver operating characteristic curve [AUC]: 0.89 [95% CI: 0.81, 0.94], sensitivity: 84.5% [95% CI: 74.0%, 92.0%], specificity: 85.2% [95% CI: 66.3%, 95.8%]) and long-term outcomes (AUC: 0.84 [95% CI: 0.75, 0.91], sensitivity: 76.9% [95% CI: 56.4%, 91.0%], specificity: 87.0% [95% CI: 76.7%, 93.9%]).

Conclusion

Myocardial fibrosis and lower circumferential dyssynchrony assessed with pretherapy cardiac MRI were independently associated with unfavorable LVEF response and long-term events following CRT in patients with nonischemic DCM and may provide incremental value in predicting prognosis.Keywords: MR Imaging, Cardiac, Outcomes Analysis Supplemental material is available for this article. © RSNA, 2023.

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Affiliation(s)

Yanyan Song
Xiuyu Chen
Kai Yang From the Department of Magnetic Resonance Imaging (Y.S., X.C., K.Y., Z.D., C.C., K.J., M.L., S.Z.), Department of Function Test Center (H.C.), and Department of Radiology Imaging Center (S.Z.), Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xi Cheng District, Beijing 100037, China; and Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China (K.Z.)
Zhixiang Dong From the Department of Magnetic Resonance Imaging (Y.S., X.C., K.Y., Z.D., C.C., K.J., M.L., S.Z.), Department of Function Test Center (H.C.), and Department of Radiology Imaging Center (S.Z.), Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xi Cheng District, Beijing 100037, China; and Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China (K.Z.)
Chen Cui From the Department of Magnetic Resonance Imaging (Y.S., X.C., K.Y., Z.D., C.C., K.J., M.L., S.Z.), Department of Function Test Center (H.C.), and Department of Radiology Imaging Center (S.Z.), Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xi Cheng District, Beijing 100037, China; and Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China (K.Z.)
Kankan Zhao From the Department of Magnetic Resonance Imaging (Y.S., X.C., K.Y., Z.D., C.C., K.J., M.L., S.Z.), Department of Function Test Center (H.C.), and Department of Radiology Imaging Center (S.Z.), Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xi Cheng District, Beijing 100037, China; and Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China (K.Z.)
Huaibing Cheng From the Department of Magnetic Resonance Imaging (Y.S., X.C., K.Y., Z.D., C.C., K.J., M.L., S.Z.), Department of Function Test Center (H.C.), and Department of Radiology Imaging Center (S.Z.), Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xi Cheng District, Beijing 100037, China; and Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China (K.Z.)
Keshan Ji From the Department of Magnetic Resonance Imaging (Y.S., X.C., K.Y., Z.D., C.C., K.J., M.L., S.Z.), Department of Function Test Center (H.C.), and Department of Radiology Imaging Center (S.Z.), Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xi Cheng District, Beijing 100037, China; and Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China (K.Z.)
Minjie Lu From the Department of Magnetic Resonance Imaging (Y.S., X.C., K.Y., Z.D., C.C., K.J., M.L., S.Z.), Department of Function Test Center (H.C.), and Department of Radiology Imaging Center (S.Z.), Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xi Cheng District, Beijing 100037, China; and Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China (K.Z.)
Shihua Zhao From the Department of Magnetic Resonance Imaging (Y.S., X.C., K.Y., Z.D., C.C., K.J., M.L., S.Z.), Department of Function Test Center (H.C.), and Department of Radiology Imaging Center (S.Z.), Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xi Cheng District, Beijing 100037, China; and Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China (K.Z.)

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