Mindfulness based interventions (MBIs) are increasingly recognised for their efficacy in treating depressive disorders. Depressive symptoms are prevalent across various disorders and can significantly impact outcomes, therefore being an important transdiagnostic target. Multiple randomized controlled Trials (RCTs) have explored this question in discrete disorders; however, evidence has never been meta-analysed transdiagnostically. The Prospero-registered (CRD42022352046) systematic review has been conducted on EMBASE, MEDLINE and PsychINFO using terms related to Randomised controlled trials, mindfulness and depression in clinical samples aged between 18 and 65. Random-effects models were performed to assess the effectiveness of MBIs, including Mindfulness based Cognitive Therapy (MBCT), Acceptance and Commitment Therapy (ACT), and Dialectical Behavioural Therapy (DBT), on depressive symptoms transdiagnostically. We conducted sensitivity, heterogeneity analyses, publication bias assessments, meta-regressions and assessed quality. Thirty-five studies, including participants from 12 different diagnostic categories, were included. The results revealed that MBCT, ACT, DBT and others are efficacious in treating depressive symptoms across psychiatric diagnoses compared to active control conditions, all with significant effect sizes. MBIs are effective in reducing depressive symptoms across psychiatric disorders. They should be considered as a potential cost-effective tool to be systematically implemented, not only in those with depression but across mental health disorders.

Law enforcement is a high-stress profession, with officers frequently exposed to traumatic events, leading to mental health challenges such as communication anxiety, post-traumatic stress disorder (PTSD), anger management difficulties, and mood disorders. Mindfulness meditation (MM), particularly when guided through short video applications, has shown promise in addressing these issues by enhancing emotional regulation and resilience.

This study explores the effects of an 8-week MM intervention, delivered via short video apps, on communication anxiety, PTSD, anger management, and mood disorders in police officers.

A randomized controlled trial (RCT) was conducted with 110 full-time police officers aged 25-55 in China. The final 92 eligible participants were divided into two groups: the MM group (n = 46) and the control group (n = 46). The intervention consisted of daily 10-15 min video-guided MM sessions. Pre- and post-intervention measures included validated questionnaires assessing communication anxiety (PRCA-24), PTSD (PCL-5), anger management (STAXI-2), and mood disorders (DASS-21). Data analysis was performed using MANOVA.

The intervention group showed significant improvements in communication anxiety (F = 8.505, p = 0.004), PTSD (F = 25.831, p < 0.001), anger management (F = 4.968, p = 0.027), and mood disorders (F = 13.058, p < 0.001) compared to the control group. These improvements were supported by significant interaction effects between group and time, indicating that the MM intervention had a positive impact on these mental health variables.

Video-guided MM delivered via short video apps significantly reduced communication anxiety, PTSD symptoms, and mood disorders, and improved anger management among police officers. These findings highlight the potential of digital MM interventions as a scalable and accessible tool for enhancing mental well-being and resilience in law enforcement personnel.

During the pandemic, a randomized controlled trial (RCT) of Mindfulness-Based Stress Reduction (MBSR) versus the antidepressant, escitalopram (ESC) added a second phase using a synchronous, videoconference (VC) format for both interventions, enabling randomized and naturalistic comparisons. The original in-person RCT demonstrated non-inferiority of MBSR to ESC. In the second phase, we hypothesized that MBSR-VC would be non-inferior to ESC-VC, and that MBSR-VC would be non-inferior to in-person MBSR (MBSR-IN).

Adults with anxiety disorders were recruited for a 3-center RCT. Primary (Clinical Global Impression of Severity: CGIS) and secondary outcomes (satisfaction, other measures for anxiety subtypes) were compared between MBSR-IN vs MBSR-VC, ESC-IN vs ESC-VC and MBSR-VC vs ESC-VC.

MBSR-VC (n = 100) and ESC-VC (n = 102) did not significantly differ in mean CGI-S change at endpoint (1.39 vs 1.51, p = 0.17) but non-inferiority of MBSR-VC was not supported. MBSR did not vary by delivery format (VC: 1.3 vs. IN: 1.3, p = 0.77) and MBSR-VC's non-inferiority to MBSR-IN was demonstrated within the pre-specified margin of -0.40 (95 % CI: -0.34 to 0.25). ESC-IN and ESC-VC were not significantly different in CGI-S change in unadjusted comparisons (1.4 vs 1.5, p = 0.53), but the average CGI-S at endpoint was significantly lower in the ESC-VC group in a multivariable longitudinal model. Other findings included in-person treatments having a greater impact on social anxiety compared to their VC version, ESC-VC having higher satisfaction ratings and a greater impact on panic symptoms than MBSR-VC.

Remotely delivered MBSR demonstrated comparable effectiveness to in-person MBSR for anxiety disorders, providing support for this delivery approach. Social anxiety symptoms improved more with in-person care.

Clinicaltrials.gov: NCT03522844.

Mindfulness and cognitive reappraisal have been recognized as two useful ways to regulate emotions. The former tends to cultivate an attitude of being open and accepting of emotional events; whereas the latter involves a top-down process of re-interpreting emotional events. However, it is unclear how mindfulness influences cognitive reappraisal. Hence, the current study mainly addressed this research issue by exploring the mediating role of emotional and interoceptive awareness. 372 participants were asked to report dispositional mindfulness, cognitive reappraisal, emotional awareness, and interoceptive awareness by means of corresponding questionnaires. First, we performed the Pearson Correlations among the four factors, then assessed the mediating role of emotional awareness and interoceptive awareness in the link between mindfulness and cognitive reappraisal in separated models. Last, we used structural equation modeling (SEM) to investigate the link when both emotional and interoceptive awareness acted as the mediating variables. Results showed that mindfulness was negatively correlated with cognitive reappraisal, emotional awareness, and interoceptive awareness; whereas emotional awareness, interoceptive awareness, and cognitive reappraisal were positively correlated with each other. Moreover, increased mindfulness had a significantly negative effect on cognitive reappraisal, by reducing emotional and interoceptive awareness separately or successively. Except for the No-worrying factor, the remaining seven factors of interoceptive awareness were significantly loaded onto the latent variable. The result reveals the negative relationship between mindfulness and cognitive reappraisal. This link is mediated by one's emotional awareness and interoceptive awareness independently or successively, which may reflect the intensity of externally-emotional reactivity that signify the need to regulate emotions by means of cognitive reappraisal.

Body dysmorphic disorder presents in up to 2% of the general population, yet less than half seek psychological support. Some treatment barriers include poor illness insight, low body dysmorphic disorder awareness among mental health professionals and a lack of accessibility to body dysmorphic disorder-specific treatments. Currently available treatments for body dysmorphic disorder, including psychopharmacology and psychotherapy, show modest results in improving body dysmorphic disorder symptoms. With the reduced quality of life and increased risks of suicide among individuals with body dysmorphic disorder, there is a need for new and easily accessible therapeutic approaches specific to body dysmorphic disorder. Emerging research has suggested that mindfulness-based interventions show promise as an addition to available body dysmorphic disorder treatments. Clinical evidence of mindfulness-based interventions demonstrates efficacy in improving symptoms in eating disorders, social anxiety disorder and obsessive-compulsive disorder, conditions that have similar clinical presentations as body dysmorphic disorder. Mindfulness strategies, such as increasing interoceptive awareness, non-judgement and non-reactivity, are also suggested to reduce body image disturbances, anxiety and repetitive thoughts, and cognitive rigidity, clinical characteristics of body dysmorphic disorder. This perspective piece aims to provide evidences for integrating mindfulness into treatment protocols to support mental health professionals better address the challenges faced by individuals with body dysmorphic disorder.

There is evidence to suggest that individuals with the personality trait of shyness are more prone to depression, and a possible key factor in the process of shyness leading to depression is core self-evaluation. Given the prevalence and cross-cultural nature of shyness in humans, it is crucial to understand the factors that reduce shyness, enhance core self-evaluation, and ultimately lower depression. This study aims to examine whether mindfulness affects depression through sequential pathways involving shyness and core self-evaluation.

We adopted a two-phase sampling method, recruiting an initial sample of 646 college students (Sample 1). We conducted a questionnaire survey using the Chinese version of the Five Factor Mindfulness Scale, the revised Cheek and Buss Shyness Scale, the Core Self-Evaluation Scale, and the Chinese version of the Beck Depression Inventory-II. We constructed a chain mediation model to examine the relationship between mindfulness and depressive symptoms, with shyness and core self-evaluation as mediating variables. Subsequently, based on Sample 1, we purposively selected a subsample of 269 college students with higher shyness scores (Sample 2) and re-examined the chain mediation effect.

Higher levels of mindfulness were associated with lower levels of depressive symptoms, and this relation was mediated through shyness and core self-evaluation.

These results highlight that mindfulness can influence depression through the sequential pathway of shyness and core self-evaluation, and the importance of considering mindfulness practices in psychological interventions to help college students, especially shy college students, to reduce their shyness levels, improve core self-evaluation levels, and ultimately prevent and/or treat their depressive symptoms.

The Default Mode Network has been extensively studied in recent decades due to its central role in higher cognitive processes and its relevance for understanding mental disorders. This neural network, characterized by synchronized and coherent activity at rest, is intrinsically linked to self-reflection, mental exploration, social interaction, and emotional processing. Our understanding of the DMN extends beyond humans to non-human animals, where it has been observed in various species, highlighting its evolutionary basis and adaptive significance throughout phylogenetic history. Additionally, the DMN plays a crucial role in brain development during childhood and adolescence, influencing fundamental cognitive and emotional processes. This literature review aims to provide a comprehensive overview of the DMN, addressing its structural, functional, and evolutionary aspects, as well as its impact from infancy to adulthood. By gaining a deeper understanding of the organization and function of the DMN, we can advance our knowledge of the neural mechanisms that underlie cognition, behavior, and mental health. This, in turn, can lead to more effective therapeutic strategies for a range of neuropsychiatric conditions.

Anxiety and depression reduce autonomic system activity, as measured by Heart Rate Variability (HRV), and exacerbate cardiac morbidity. Both music and mindfulness have been shown to increase HRV, and clinical approaches incorporating these interventions show promise as effective treatments for symptoms of anxiety and depression. Music mindfulness, which combines music listening with mindfulness activities, may provide unique and synergistic therapeutic benefits for stress management. However, to date, no studies have evaluated the physiological mechanisms underlying a community-based music mindfulness paradigm.

We used wearable technology to record electrocardiography and electroencephalography signals from participants with moderate symptoms of anxiety and depression during a community-based music mindfulness paradigm. We also assessed the impact of our music mindfulness session on participant's psychological state.

We found that music mindfulness sessions acutely enhanced multiple measures of HRV and altered EEG power spectral density across various frequency bands in frontotemporal electrodes. Both live and virtual music mindfulness sessions also acutely reduced stress and altered participants' state of consciousness; however, only live sessions fostered social connection. Additionally, the physiological and psychological effects of music mindfulness varied based on participants' self-reported sex. Overall, our findings demonstrate that music mindfulness effectively engages autonomic and frontotemporal neural mechanisms, which may contribute to the treatment of anxiety and depression symptoms.

The content of mindfulness-based social-emotional learning (MBSEL) concentrates on conscious attention to thoughts, emotions, and bodily senses, which reduces test stress and anxiety and also leads to an increase in students' performance regarding stress management and improving responsible behaviors. This study aimed to explore the relationship between the degree of test anxiety and the level of students' mindfulness and the academic performance of nursing students.

This descriptive cross-sectional study was conducted during 2021-2022, and the target population included all nursing students of the Faculty of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran. The sample size is determined by Cochran's formula (151 participants). The sampling method was also simple random. The Sarason's test anxiety questionnaire and the short form of the Freiburg Mindfulness Inventory were used to collect data. The student's academic performance was also evaluated based on their previous academic semester scores. Data were analyzed by SPSS version 23 software through descriptive statistics, Pearson correlation coefficient, and an independent t-test.

According to the Pearson correlation coefficient, there was an inverse and significant correlation between the variable of mindfulness and the level of test anxiety in nursing students (r = -170, P = 0.033), a positive and significant correlation between academic performance and mindfulness (r = 0.284, P = 0.001), and a negative and significant correlation between academic performance and test anxiety level (r = -0.170, P = 0.037).

Mindfulness-based cognitive therapy is effective in reducing negative thoughts, ineffective attitudes, depression, stress, and anxiety, and this therapy strategy can be used to reduce or treat anxiety and worry in students.

This study investigates the relationships between mindfulness, employees' well-being, and intentions to quit their jobs and further examines the mediating role of perceived stress in these relationships. Drawing on the Job Demand-Resources model, we aim to contribute to understanding how mindfulness can impact employee well-being and turnover intentions in a non-Western organizational setting.

A cross-sectional survey study was conducted with 205 full-time white-collar employees. The study used an online questionnaire consisting of the Perceived Stress Scale, the Mindful Attention Awareness Scale, the Intention to Quit Scale, and the Employee Well-Being Scale. The data were analyzed using a full-latent model with structural equation modeling to investigate the relationships between the variables.

The findings indicate that mindfulness is crucial in influencing employees' turnover intentions and well-being through perceived stress levels. Mindfulness is associated with lower levels of perceived stress, which in turn is positively linked to employee well-being and negatively linked to turnover intentions.

This study underscores the significance of mindfulness in the workplace, particularly in non-western organizational settings. By promoting mindfulness, organizations can potentially enhance employee well-being and reduce turnover intentions, fostering a more positive and productive work environment. The implications of these findings suggest that mindfulness interventions could be beneficial for organizations aiming to improve employee mental health and retention.

The timely alleviation and healing of anxiety is crucial for preventing anxiety disorders. This study explores innovative digital approaches for anxiety relief by integrating virtual reality (VR) and multimodal interaction theories and technologies with psychodrama therapy and breathing therapy from psychology. The research proposes an innovative method of breathing interaction based on olfactory interaction modalities and designs breathing interaction semantics aimed at anxiety healing through three types of breathing therapy. Using the Unreal Engine, VR gamified scenarios and interaction logic for levels were constructed, leading to the development of a multimodal immersive software interaction system and a prototype for VR hardware interaction that extends the breathing interaction modality. The effectiveness of the system for anxiety relief was validated through an EEG experiment involving 38 participants, supported by analysis of Topographic Maps, Band-Power Reports, ERP analysis, and qualitative data from the USE scale. This research confirms that the innovative integration of VR and breathing interaction modalities is effective for anxiety therapy, aiding users in promptly alleviating anxiety and simplifying the psychological healing process.

Among the strategies people can use to regulate their emotions, there is increasing interest in mindfulness. Although prior reviews support that mindful acceptance (equanimity) is an effective strategy, other components of mindfulness (monitoring/ mindful awareness) have received less attention. Further, a recent theoretical framework-the Dual-mode Model of Mindful Emotion Regulation-proposed that mindfulness has two "modes" of action in emotion regulation: (1) implementation to regulate emotions as time-limited strategies and (2) acting as a moderator that facilitates effective emotion regulation. The present systematic review and meta-analysis aimed to evaluate the implementation of mindfulness-based strategies and facilitation effects of mindfulness on emotion reactivity and strategy implementation. A total of 2037 records were screened, from which 110 studies with 767 effects (N = 8,105) were analyzed. There was a significant effect of mindfulness-based strategies (g = .28, 95% CI [.18, .38], I 2 = 83.3%). Components of monitoring (g = .17, 95% CI [.02, .32]) and equanimity (g = .3, 95% CI [.19, .41]) were also effective, although monitoring alone was significantly less effective than other strategies. The effect size was greater for within-subjects designs, text-based emotional stimuli, personally relevant stimuli, and behavioral outcomes (e.g., pain tolerance). Despite small-study effects and publication bias, the estimate was robust to sensitivity analyses (between .15 and .3). Meta-regression of facilitation supported that greater study-level equanimity was associated with reduced reactivity. As hypothesized, mindfulness-based strategies can effectively regulate emotions. Methodological considerations and directions for future study are discussed.

The online version contains supplementary material available at 10.1007/s42761-024-00281-x.

Mobile health apps are proving to be an important tool for increasing access to psychological therapies early on, particularly with rising rates of anxiety and depression in young people.

We aimed to assess the usability, acceptability, safety, and effectiveness of a new app, Clear Fear, developed to help young people manage symptoms of anxiety using the principles of cognitive behavioral therapy.

The Clear Fear app was developed to provide cognitive behavioral strategies to suit anxiety disorders. An uncontrolled pre- and post-follow-up design over a 9-week period was used to assess the app and its effects. This study comprised 3 phases: baseline (stage 1), post-app familiarization phase (stage 2), and follow-up (stage 3). Eligible participants were aged between 16 and 25 years with mild to moderate anxiety but not currently receiving treatment or in contact with specialist mental health services or using other interventions or apps to help monitor or manage their mental health. A community sample was recruited via advertisements, relevant websites, and social media networks. Eligible participants completed standardized self-report tools and questionnaires at each study stage. These measured probable symptoms of anxiety (7-item Generalized Anxiety Disorder scale) and depression (Mood and Feelings Questionnaire); emotional and behavioral difficulties (Strengths and Difficulties Questionnaire); and feedback on the usability, accessibility, and safety of the app. Mean scores at baseline and follow-up were compared using paired 2-tailed t tests or Wilcoxon signed rank tests. Qualitative data derived from open-ended questions were coded and entered into NVivo (version 10) for analysis.

A total of 48 young people entered the study at baseline, with 37 (77%) completing all outcome measures at follow-up. The sample was mostly female (37/48, 77%). The mean age was 20.1 (SD 2.1) years. In total, 48% (23/48) of the participants reached the threshold for probable anxiety disorder, 56% (27/48) had positive scores for probable depression, and 75% (36/48) obtained a total score of "very high" on the Strengths and Difficulties Questionnaire for emotional and behavioral difficulties. The app was well received, offering reassurance, practical and immediate help to manage symptoms, and encouragement to seek help, and was generally found easy to use. A small minority (3/48, 6%) found the app difficult to navigate. The Clear Fear app resulted in statistically significant reductions in probable symptoms of anxiety (t36=2.6, 95% CI 0.41-3.53; P=.01) and depression (z=2.3; P=.02) and behavioral and emotional difficulties (t47=4.5, 95% CI 3.67-9.65; P<.001), representing mostly medium to large standardized effect sizes.

The Clear Fear app was found to be usable, acceptable, safe, and effective in helping manage symptoms of anxiety and depression and emotional and behavioral difficulties.

Fear acquisition is an essential survival mechanism for humans; however, the role and mechanisms of mindfulness training in this process remain unclear. This study employed a discriminative fear conditioning paradigm to investigate the effects and mechanisms of short-term mindfulness training, exemplified by the breath-counting task, on fear acquisition. The experiment consisted of three consecutive phases: intervention, habituation, and acquisition. During the intervention phase, each participant was assigned to one of two conditions: the breath-counting task group (experimental group) or the free reading group (control group). The results indicated that the mindfulness group exhibited significantly lower expectancy ratings for shocks to the CS- compared to the control group, while no significant difference was found in the shock ratings for CS+. Regarding skin conductance responses, although the mindfulness group showed a significantly reduced fear response to CS relative to the free reading group, there was no significant difference in overall fear acquisition effects between the two groups. The above findings indicate that breath-counting tasks enhance sensitivity to the acquisition of conditioned fear by reducing exaggerated fear responses to safety signals. The conclusions of this study further elucidate the conflicting results regarding the effects of mindfulness training on fear acquisition and provide novel perspectives for the prevention of anxiety spectrum disorders.

Health is a multidimensional phenomenon encompassing physical, mental, and social well-being, all of which are deeply interconnected. The COVID-19 pandemic highlighted the importance of mental and social health, as rates of loneliness, depression, and anxiety surged. Mindfulness practices, such as Shambhavi Mahamudra Kriya (SMK), have gained attention for their potential to enhance well-being by integrating breath regulation, meditation, and cognitive reframing techniques. During the COVID-19 pandemic, the Inner Engineering Completion Online (IECO) program was created to effectively teach SMK with global travel restrictions in effect. This study examines the long-term effects of SMK, taught through the IECO, on various measures of well-being over a one-year follow-up period.

Participants were recruited from the January 2020 IECO course. Participants completed surveys at consent, post-IECO, and 6 weeks, 6 months, and 1-year post-IECO. The surveys consisted of 4 validated neuropsychological scales: Perceived Stress Scale (PSS), Positive Emotion/Relationship/Engagement Scale (PERMA) Profiler, Pittsburgh Sleep Quality Index (PSQI), and Mindful Attention Awareness Scale (MAAS). Survey data was analyzed using linear mixed effect modeling. Two-sided p-values of <0.05 were considered statistically significant.

Hundred and eighty-eight participants were enrolled. Hundred and sixty-four participants completed baseline measurements, and 41 participants completed surveys at all timepoints. The baseline median [IQR] PSS score in participants was 13 [8, 18]; post-IECO median [IQR] PSS was 11 [8, 16] and 6-week median [IQR] PSS was 7 [4, 12], suggesting that consistent practice of Shambhavi Mahamudra Kriya resulted in reduced stress. This score was sustained up to a year post-IECO with a median [IQR] of 7 [3, 12]. The mean mindfulness scale (MAAS) score increased by 0.97 (95% C.I. 0.7-1.2 p < 0.01, η2 p = 0.30) at the 1-year timepoint compared to baseline. The global PSQI score reduced at the week 6 timepoint by 1.3 (95% C.I. 0.49-2.0, p < 0.01) with medium effect size and was sustained until 1 year.

Within 6 weeks of participating in IECO, regular practice of SMK significantly reduced stress, improved sleep quality, and boosted mindfulness. These benefits were sustained for at least a year with continued practice, suggesting that this practice is an effective path to maintaining general well-being.

ClinicalTrials.gov, trial identification number NCT04189146.

Anxiety disorders are among the most prevalent mental disorders, and stress plays a significant role in their development. Ecological momentary interventions (EMIs) hold great potential to help people manage stress and anxiety by training emotion regulation and coping skills in real-life settings. InsightApp is a gamified EMI and research tool that incorporates elements from evidence-based therapeutic approaches. It is designed to strengthen people's metacognitive skills for coping with challenging real-life situations and embracing anxiety and other emotions.

This randomized controlled trial aims to examine the effectiveness of InsightApp in (1) improving individuals' metacognitive strategies for coping with stress and anxiety and (2) promoting value-congruent action. It also evaluates how long these effects are retained. This experiment advances our understanding of the role of metacognition in emotional and behavioral reactivity to stress.

We conducted a randomized controlled trial with 228 participants (completion rate: n=197, 86.4%; mean age 38, SD 11.50 years; age range 20-80 years; female: n=101, 52.6%; and White: n=175, 91.1%), who were randomly assigned to either the treatment or the active placebo control group. During the 1-week intervention phase, the treatment group engaged with InsightApp, while participants in the control group interacted with a placebo version of the app that delivered executive function training. We assessed the differences between the 2 groups in posttest and follow-up assessments of mental health and well-being while controlling for preexisting differences. Moreover, we used a multilevel model to analyze the longitudinal data, focusing on the within-participant causal effects of the intervention on emotional and behavioral reactivity to daily stressors. Specifically, we measured daily anxiety, struggle with anxiety, and value-congruent action.

The intervention delivered by InsightApp yielded mixed results. On one hand, we found no significant posttest scores on mental health and well-being measures directly after the intervention or 7 days later (all P>.22). In contrast, when confronted with real-life stress, the treatment group experienced a 15% lower increase in anxiety (1-tailed t test, t197=-2.4; P=.009) and a 12% lower increase in the struggle with anxiety (t197=-1.87; P=.031) than the control group. Furthermore, individuals in the treatment group demonstrated a 7% higher tendency to align their actions with their values compared to the control group (t197=3.23; P=.002). After the intervention period, InsightApp's positive effects on the struggle with anxiety in reaction to stress were sustained, and increased to an 18% lower reactivity to stress (t197=-2.84; P=.002).

As our study yielded mixed results, further studies are needed to obtain an accurate and reliable understanding of the effectiveness of InsightApp. Overall, our findings tentatively suggest that guiding people to apply adaptive metacognitive strategies for coping with real-life stress daily with a gamified EMI is a promising approach that deserves further evaluation.

OSF Registries osf.io/k3b5d; https://osf.io/k3b5d.

Research into brain mechanisms and their impact on quality of life has gained significant traction, emphasising stress management, cognitive enhancement, and emotional well-being as essential components.

This study explores the relationship between brain health and overall wellness, focusing on neurobiological mechanisms and evidence-based interventions that enhance stress resilience in neurodivergent populations.

A comprehensive review of neuroscience and psychological literature was conducted, including neuroimaging and behavioural studies to assess the effectiveness of various interventions.

Findings indicate that targeted strategies - such as Acceptance and Commitment Therapy (ACT), cognitive training, and lifestyle modifications - significantly improve stress resilience, cognitive abilities, and emotional regulation. Key brain regions involved include the amygdala, prefrontal cortex, and hippocampus.

Implementing evidence-based interventions fosters improved quality of life through enhanced brain wellness. Future research should focus on scalable approaches that are inclusive of diverse populations.

Chronic kidney disease (CKD) is characterized by overactivation of the sympathetic nervous system (SNS) that leads to increased risk of cardiovascular disease. This study was conducted to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) programme on SNS activity in CKD patients. Participants with CKD stages III-IV were randomized to the 8 week MBSR programme or Health Enhancement Program (HEP; a structurally parallel, active control group). Intraneural measures of SNS activity directed to muscle [muscle sympathetic nerve activity (MSNA)] via microneurography was recorded at rest and during stress manoeuvres (mental arithmetic, handgrip exercise and cold pressor test). Data analyses were performed based on the intent-to-treat principle. In total, 29 participants (64 ± 9 years; 86% males) completed the intervention with 17 in the MBSR and 12 in the HEP groups. There was a significant Group (MBSR vs. HEP) by Time (baseline vs. post-intervention) interaction in MSNA reactivity to mental stress (P = 0.029), with a significant reduction in the mean ∆MSNA over 3 min of mental arithmetic at post-intervention (10.3 ± 4.2-5.9 ± 5.6 bursts/min, P < 0.001; Hedges' g = -0.858, 95% confidence interval [-1.578, -0.167]), while no change was observed within the HEP group (P = 0.818). Reduced ∆MSNA during handgrip exercise was also observed, while ∆MSNA during the cold pressor test and resting MSNA remained unchanged in both groups from baseline to post-intervention. In this randomized controlled trial, patients with CKD had a reduction of sympathetic reactivity during mental stress and static handgrip exercise following 8 weeks of MBSR but not after HEP. Our findings demonstrate that mindfulness training is feasible and may have clinically beneficial effects on autonomic function in CKD. KEY POINTS: Question: Does the Mindfulness-Based Stress Reduction (MBSR) programme reduce sympathetic activity in patients with chronic kidney disease (CKD)? Finding: In this randomized controlled trial including 29 patients with CKD, 8 weeks of MBSR decreased sympathetic reactivity to mental stress compared to the control Health Enhancement Program (HEP). Meaning: These finding suggest that mindfulness training may have clinically beneficial effects on autonomic function in CKD.

Accelerated neuronavigation-guided high-dose repetitive transcranial magnetic stimulation (NH-rTMS) can rapidly reduce suicidal ideation and alleviate depressive symptoms in one week. Exploring accelerated NH-rTMS-related biomarkers will enhance the precision of treatment decisions for patients with major depressive disorder (MDD). This study aimed to establish predictive models of treatment response to accelerated NH-rTMS in MDD based on multimodal large-scale brain networks.

In this study, morphological, structural, and functional brain networks were constructed for untreated MDD patients with suicidal ideation before accelerated NH-rTMS treatment. Linear support vector regression methods were utilized to examine the ability of multimodal brain networks in predicting antidepressant and anti-suicidal effects of accelerated NH-rTMS.

We found that both the morphological and structural networks predicted the percentage changes of total Beck Scale of Suicidal Ideation and 24-item Hamilton Depression Rating Scale (HAMD-24) scores. Additionally, the functional networks predicted the percentage changes of total HAMD-24 scores. Further analyses revealed that the structural networks outperformed the morphological and functional networks and the somatomotor module outperformed other subnetworks in the prediction.

In summary, our study provides brain connectome-based predictive models of treatment response to accelerated NH-rTMS in MDD patients with suicidal ideation.

Introduction: The Mindfulness-Based Stress Reduction (MBSR) Program for breast cancer survivors (BCS) is designed to enhance cognitive training through formal and informal meditational practices. This randomized clinical trial (RCT) aimed to evaluate if BCS assigned to either the MBSR(BC), Breast Cancer Education Support (BCES), or Usual Care (UC) regimens experienced greater improvements at 6, 12, and 26 weeks on objective and subjective cognitive performance. Methods: BCS (n = 212) randomized to a three-group RCT: MBSR(BC) (n = 91), BCES (n = 90), or UC (n = 31) were assessed on cognitive performance and symptoms at baseline, 6, 12, and 26 weeks. Linear mixed models were fit to evaluate the effects of the MBSR(BC) program, hypothesizing ordered effect improvements: (MBSR[BC] highest, BCES intermediate, UC lowest) along with baseline characteristics evaluated as moderators. Results: Of the BCS (mean age of 57), 73% were White, and non-Hispanic, and 77% received both chemotherapy (CT) and radiation. Cognitive performance improved in all groups. Although there were no statistically significant between-group differences in cognitive outcomes, significant symptom reductions occurred for the MBSR(BC) group (p = 0.003). Within-group effect size analysis at 26 weeks showed substantial improvements in all three groups (effect sizes >0.50) in subjective impairments and quality of life (effect size >0.50) and objective measures of cognitive performance. MBSR(BC) showed the largest within-group effect size in the reduction of fatigue (effect size = 0.81). Effect sizes occurred in the hypothesized direction for 10 of the 18 outcomes. Discussion: Although the MBSR(BC) program did not show significant differences in cognitive performance compared with BCES and UC, all groups improved and reductions in fatigue were beneficial for MBSR(BC). Results suggest that cognitive performance may improve after CT over time considering one's natural history. Furthermore, BCS enrolled in RCTs may be more motivated to improve their health status (NCT02786797).

The phenomenon of neural plasticity pertains to the intrinsic capacity of neurons to undergo structural and functional reconfiguration through learning and experiential interaction with the environment. These changes could manifest themselves not only as a consequence of various life experiences but also following therapeutic interventions, including the application of noninvasive brain stimulation (NIBS) and psychotherapy. As standalone therapies, both NIBS and psychotherapy have demonstrated their efficacy in the amelioration of psychiatric disorders' symptoms, with a certain variability in terms of effect sizes and duration. Consequently, scholars suggested the convenience of integrating the two interventions into a multimodal treatment to boost and prolong the therapeutic outcomes. Such an approach is still in its infancy, and the physiological underpinnings substantiating the effectiveness and utility of combined interventions are still to be clarified. Therefore, this opinion paper aims to provide a theoretical framework consisting of compelling arguments as to why adding NIBS to psychotherapy can promote therapeutic change. Namely, we will discuss the physiological effects of the two interventions, thus providing a rationale to explain the potential advantages of a combined approach.

With the advent of human neuroimaging, researchers were drawn to the idea that by better understanding the human brain, more effective mental health interventions could be developed. It has been more than 20 years since the first functional magnetic resonance imaging (fMRI) studies were conducted to examine changes in brain activation with anxiety-related treatments and more than 60 studies have since been published in this vein. For the current review, we conduct a systematic review of this literature, focusing on adult studies using task-based fMRI to measure brain activation changes with pharmacologic or psychotherapy interventions for phobia, social anxiety disorder, panic disorder, generalized anxiety disorder, posttraumatic stress disorder, and obsessive-compulsive disorder. Neuroscientific theories of anxiety-related disorders and their treatment have focused on prefrontal-insula-amygdala networks. Treatment-related decreases in amygdala and/or anterior insula activation were identified as the most consistent finding across disorders, with the most consistent results reported for specific phobia. Directionality of change and specific regions implicated in the prefrontal cortex were inconsistent across studies. The potential importance for probing other networks and processes as mechanisms of anxiety treatment was recognized, such as striatal regions underlying inhibitory learning or reward responsivity. Future treatment-fMRI research related to anxiety disorders would benefit from larger sample sizes, use of more nuanced computational approaches, and increased focus on replication. There is continued promise that fMRI research will enhance our understanding of how treatments work and inform the evolution of more effective or personalized mental health treatment.

This study aimed to investigate the effectiveness of a training program based on cognitive emotion regulation strategies to reduce social anxiety and improve social self-efficacy among Hashemite University students.

The study sample comprised 57 students randomly divided into two groups: The experimental group consisted of 28 students, and the control group consisted of 29 students. The experimental group was exposed to the training program consisting of 18 sessions, while the control group did not receive any experimental treatment. The students in both experimental and control groups completed the social anxiety scale and social self-efficacy scales before and after the training program.

The study found differences in the mean score of the experimental group on the post-test of the social anxiety level in favor of the experimental group and in the mean score of the experimental group on the post-test of the social self-efficacy scale in favor of the experimental group.

The training program based on cognitive emotion regulation strategies is very effective in reducing the social anxiety and improving social self-efficacy.

Understanding the underpinnings of pro-environmental behavior is key to mitigating the socio-ecological crisis. Climate emotions have a critical albeit complex role in modulating pro-environmental behavior. Moreover, ideological frames, particularly those from world religions, exert strong influence on pro-environmental behavior, covering most of humanity. Among these, Buddhism has long been argued to contain elements suited to a green transition. However, empirical research on Buddhism and ecology is scarce, and little is known about the dynamics between climate emotions and behavior among Buddhists. In this article, we increase knowledge about the complex dynamics of climate action by analyzing findings from a case study investigating thirteen Western Buddhist climate activists, who operate at the intersection of Buddhism and environmentalism. Life history and thematic interview data shows that interpretations of Buddhism shape attitudes toward climate emotions in profound ways, with respondents manifesting high levels of emotional reflexivity. Interpretations of compassion and interconnectedness facilitate various levels of care for non-human nature. Some participants reported climate anxiety. Teachings on impermanence and cultivation of equanimity affect engagement with climate grief, anger, despair, and hope. Interpretations on karma allow negotiating a balance between individual guilt and allocation of responsibility to social structures, although the role of climate guilt emerges as somewhat conflicted among participants. Furthermore, emotion norms on avoiding anger and conflict can prevent individual and collective activation, and some participants were critical about traditional Buddhist interpretations of anger. Withdrawal into Buddhist practice with an inner focus was used to cope with uncertainty and burnout, and when seen to address the psychological roots of the climate crisis this could facilitate social disengagement. Our study contributes to interdisciplinary research on climate emotions, environmental activism, and religion.

Psychiatry is an area of medicine that is particularly exposed to the risks of cognitive bias, notably because diagnosis is subjective. However, psychiatrists may develop psycho-cognitive skills that protect against bias, as the reflective approach to their patients favors the activation of system 2 (logical) as opposed to system 1 (intuitive) processes. Furthermore, the collegial practices found in psychiatry, a consequence of the ethical questions psychiatrists must address, can also mitigate the impact of bias. On the other hand, clinical ethics committees have adopted structured deliberation practices that aim to improve collective decision-making and limit the cognitive biases associated with groupthink.

The primary aim was to compare blind spot bias in a group of psychiatrists and a group of 'ethicists', experts in group deliberation. The secondary objective was to study the distribution of skills influencing the balance between systems 1 and 2 (notably, ethical deliberation, feeling of efficacy, mindfulness, and values) in both groups. The general hypothesis is that psychiatrists are less prone to blind spot bias and are more competent in the skills studied.

This descriptive, cross-sectional study was conducted from April 2022 to May 2023. Thirty-two psychiatrists were recruited from several French hospitals, along with 20 'ethicists'. All participants completed the following self-administered questionnaires: the Bias Blind Spot Scale (French version), the Euro Moral Case Deliberation (Euro-MCD, ethical skills), Bandura's self-efficacy scale (self and collective efficacy), the Freiburg Mindfulness Inventory (mindfulness), and the Schwartz Value Survey (values).

The ratio of self/other blind spot bias was lower in the 'ethicists' group than the psychiatrists' group (P<0.001). Euro-MCD scores were higher (P<0.001) and psychiatrists tended to have a better sense of collective efficacy (P=0.08). No significant difference was found between the two groups for total mindfulness or presence and acceptance sub-scores. Scores for hedonic value were higher among psychiatrists (P<0.02).

The results do not confirm our hypotheses. There is less evidence of blind spot bias among our sample of 'ethicists', who are experts in group deliberation, than psychiatrists, who have experience of the patient/physician dyad. The ethical skills that are developed within the formal deliberation process seem particularly interesting in terms of reducing cognitive bias.

The neuroscience of meditation is providing insight into meditation's beneficial effects on well-being and informing understanding of consciousness. However, further research is needed to explicate mechanisms linking brain activity and meditation. Non-invasive brain stimulation (NIBS) presents a promising approach for causally investigating neural mechanisms of meditation. Prior NIBS-meditation research has predominantly targeted frontal and parietal cortices suggesting that it might be possible to boost the behavioral and neural effects of meditation with NIBS. Moreover, NIBS has revealed distinct neural signatures in long-term meditators. Nonetheless, methodological variations in NIBS-meditation research contributes to challenges for definitive interpretation of previous results. Future NIBS studies should further investigate core substrates of meditation, including specific brain networks and oscillations, and causal neural mechanisms of advanced meditation. Overall, NIBS-meditation research holds promise for enhancing meditation-based interventions in support of well-being and resilience in both non-clinical and clinical populations, and for uncovering the brain-mind mechanisms of meditation and consciousness.

Urodynamics (UDS) assesses voiding dysfunction using intravesical, vaginal, or rectal catheters, which can be distressing. This study was aimed at utilizing mindfulness to reduce anxiety and pain in patients undergoing UDS.

A single-institution randomized controlled trial was conducted on 60 patients who underwent UDS. Patients were assigned to a mindfulness group (n = 30) or a control group (n = 30). Before UDS testing, all patients completed validated questionnaires assessing lower urinary tract symptoms (Urogenital Distress Inventory 6, UDI-6), anxiety (State-Trait Anxiety Inventory 6, STAI-6), and pain (Visual Analog Scale, VAS). The mindfulness group listened to a mindfulness audio prompt before UDS. All patients received standardized UDS education before UDS testing in a calm environment. After UDS testing, all patients completed validated UDS-perception questionnaires, STAI-6, Likert scale, and VAS surveys. Statistical analysis was performed using paired t tests, independent t tests, Wilcoxon, and Chi-squared tests.

Both groups had similar demographics, history of prior UDS, anxiety, and baseline UDI-6 and STAI-6. Post-UDS, anxiety scores decreased in both groups, with the mindfulness group reporting significant improvement in "calmness" (mean 1.7, SD = 0.84) compared with the control group (mean 2.3, SD = 1.0, p < 0.05). The mindfulness group reported increased relaxation whereas the control group reported decreased relaxation post-UDS. Patients in both groups without a history of UDS had a significant improvement in total anxiety compared with those with a history of UDS.

Mindfulness meditation may improve calmness and relaxation for patients undergoing UDS.

Cancer frequently leads to psychological challenges, among them emotion regulation problems. These can be alleviated with the help of mindfulness therapies or neurofeedback (NF) interventions. Possible intervention effects on emotion procession can be detected in clinical EEG studies by exploring event-related potentials, e.g., early posterior negativity (EPN), which recently has been established to investigate emotional processing and represents very early attention to affective stimuli. Therefore, this clinical-experimental study investigated the efficacy of mindfulness and NF (10 sessions each) on the EPN in oncology patients.

The study enrolled 42 cancer patients (age: 31-73 years; gender: 28 female, 14 male). The study design was an RCT with a parallel group [NF (n = 21) versus mindfulness (n = 21)] waitlist paradigm. EEG recordings in an oddball task with neutral, rare positive and negative valence and high and low arousal stimuli were performed at three measurement time points (T0 = before waitlist, T1 = before intervention, T2 = after intervention). Following preprocessing, data from electrodes O1, Oz and O2 were analyzed for EPN amplitudes.

Response time did not differ across groups and conditions. Comparing EPN at T1 and T2, there was a significant interaction of time, valence, and intervention (p = 0.042). Descriptive statistics showed increased EPN for negative stimuli after the NF intervention (T1 to T2), while EPN for positive stimuli only slightly increased. For mindfulness, positive stimuli evoked stronger amplitudes after the intervention, while EPN for negative stimuli increased from T1 to T2.

Distinct effects were observed for the EPN for pictures with negative valence. Here, it is presumed that mindfulness treatment led to a refocusing of attention with a focus on positive valence, whereas NF seems to entail a different processing of images with negative valence and is therefore to be seen more in the sense of a confrontational approach. Our results suggest that both interventions are suitable for modulating EPN. However, it is not clear to what extent the effects are due to the interventions alone and how other factors might have affected the amplitudes, which highlights the need for further research in this area.

This study aimed to examine longitudinal associations of Type D personality and smartphone addiction, while also exploring the mediating roles of nomophobia and metacognitions about smartphone use.

Type D Personality Scale-14 (T1), Nomophobia Questionnaire (T2), Metacognitions about Smartphone Use Questionnaire (T2) and Smartphone Addiction Scale Short Version (T2) were applied at two time points. 653 university freshmen (Mage= 18.56, SD = 0.65) from a university in China were surveyed.

(1) Type D personality was significantly and positively correlated with nomophobia, negative metacognition, and smartphone addiction. In contrast, the correlation between Type D personality and positive metacognition did not reach the significant level. (2) Compared with individuals with non-Type D personality, those with Type D personality scored significantly higher on nomophobia, negative metacognition, and smartphone addiction. However, the difference was not significant for positive metacognition. (3) Nomophobia and metacognitions about smartphone use fully mediated the relationship between Type D personality and smartphone addiction. While the mediating effects of nomophobia and negative metacognition were significant, the mediating effect of positive metacognition was not significant.

Type D personality can not only affect smartphone addiction directly but also indirectly through nomophobia and negative metacognition. Therefore, to prevent and intervene in smartphone addiction, we can start from both affect (nomophobia) and metacognition (negative metacognitions about smartphone use).

Anxiety disorders significantly reduce patients' quality of life. Current pharmacological treatments, primarily benzodiazepines and antidepressants, are associated with numerous side effects. Consequently, there is a continual search for alternative methods to traditional therapies that are less burdensome for patients and broaden their therapeutic options. Our objective was to determine the role of selected alternative methods in the treatment of anxiety disorders.

In this review, we examined recent evidence on alternative treatments for anxiety disorders, including physical activity, mindfulness, virtual reality (VR) technology, biofeedback, herbal remedies, transcranial magnetic stimulation (TMS), cryotherapy, hyperbaric therapy, vagus nerve stimulation (VNS), 3,4-methylenedioxymethamphetamine (MDMA), electroconvulsive therapy (ECT), and eye movement desensitization and reprocessing (EMDR) therapy. For this purpose we reviewed PubMed and after initial search, we excluded works unrelated to our aim, non-orginal data and animal studies. We conducted second search to cover all minor methods.

We included 116 studies, which data is presented in Tables. We have investigated which methods can support treatment and which can be used as a stand-alone treatment. We assessed the risks to benefits of using alternative treatments.

Alternative treatments significantly expand the options available to patients and clinicians, with many serving as adjuncts to traditional therapies. Among the methods presented, mindfulness has the most significant therapeutic potential.

Dental anxiety and dental neglect are interconnected constructs with profound consequences for oral health and corresponding challenges for dental professionals. Meanwhile, other literature has indicated that mindfulness and self-compassion relate negatively to different forms of anxiety, and propose elements of potential interventions. This study aimed to explore the potential impact of dental anxiety as a mediator on the relationships between mindfulness or self-compassion and dental neglect. The results showed significant negative associations between mindfulness and self-compassion with dental anxiety and dental neglect. Mediation analyses supported the hypothesis that dental anxiety mediates the positive associations between mindfulness or self-compassion and dental neglect, providing preliminary evidence for the potential effectiveness of mindfulness and self-compassion interventions in addressing dental anxiety and dental neglect. Future research and potential clinical implications are discussed.

Stage IV colorectal cancer is a highly challenging condition to treat, with 5-year survival rates of 13% in Australia, improving to 40% for those patients with locally recurrent rectal cancer who are suitable for total neoadjuvant therapy and pelvic exenterative surgery. This study reports a unique case of a patient with Stage IV locally recurrent rectal cancer (LRRC), who designed and implemented a holistic integrative oncology intervention.

The patient was 59-years-old when diagnosed with Stage IV locally recurrent rectal cancer, and referred to a highly specialised centre for colorectal cancer care at a tertiary teaching hospital in Sydney, Australia. Treatment included chemo/radiotherapy, liver resection and posterior pelvic exenteration surgery. The patient's background as a health researcher and clinician optimised her ability to design and implement an integrative oncology model of care, including yoga, mindfulness, Buddhist meditation and study, social connection, exercise, psychotherapeutic and nutritional support. This paper describes these mind-body practices and lifestyle modifications and outlines her experiences and outcomes at each stage of her extensive and radical treatment.

This case provides a unique perspective into how the integration of mind-body practices and lifestyle modifications with conventional treatment can support those living with colorectal cancer.

In daily life, we must dynamically and flexibly deploy strategies to regulate our emotions, which depends on awareness of emotions and internal bodily signals. Variability in emotion-regulation strategy use may predict fewer negative emotions, especially when people pay more attention to their bodily states-or have greater "interoceptive attention" (IA). Using experience sampling, this study aimed to test whether IA predicts variability in strategy use and whether this variability and IA together predict negative affect.

University student participants ( n = 203; 165 females; Mage = 20.68, SD age = 1.84) completed trait questionnaires and reported state levels of IA, emotional awareness, negative affect, and emotion-regulation strategies, seven times daily for 1 week.

State IA significantly predicted between-strategy variability, which was mediated by emotional awareness (indirect effect = 0.002, 95% confidence interval = <0.001-0.003). Between-strategy variability was associated with lower negative affect, particularly when individuals had higher state IA (simple slope = -0.83, t = -5.87, p < .001) versus lower IA (simple slope = -0.31, t = -2.62, p = .009).

IA appears to facilitate adaptative emotion regulation and help alleviate negative affect. Findings underscore the key roles of IA and emotion-regulation flexibility in mental health.

Complementary and integrative health (CIH) approaches are increasingly popular among patients with gastrointestinal (GI) disorders. Whole person health has been identified as an important perspective in integrative health. While complementary approaches have been discussed in the GI literature, the whole person health framework has not yet been incorporated. Whole person health is particularly relevant as we shift to patient-centered care to facilitate holistic healing for this population. The aim of this paper is to apply a conceptualization of whole person health and its relevance in understanding how CIH approaches can be utilized for patients with stress-sensitive GI disorders, such as disorders of gut-brain interaction (DGBI) and inflammatory bowel disease (IBD).

Between July 2023 and December 2023 numerous major databases were reviewed to identify relevant articles for this narrative review. Keywords searched included (but not limited to) complementary alternative medicine, integrative medicine, DGBI, IBD, whole person health, and CIH categories (nutritional, mind-body, psychological). We limited our search to peer-reviewed English language articles. Studies were also cross-referenced to incorporate additional relevant studies.

This narrative review describes how to integrate CIH approaches with whole person health for patients with some of the most common stress-sensitive GI disorders, including DGBIs and IBD. In each section, we highlight how each domain of the whole person health framework (biological, behavioral, social, environmental) can be addressed through CIH approaches: psychological, mind-body practices, and nutritional.

The integration of CIH approaches into the treatment of GI disorders is a growing area of interest that holds promise for enhancing patient outcomes. The two concepts of CIH and whole person health are harmonizing, and their integration serves to support patients who are already using CIH approaches, and providers who can facilitate shared-decision-making and patient-centered care. While not exhaustive, this review demonstrates positive associations between the use of CIH and beneficial outcomes across all whole person health domains for patients with GI disorders.

Mindfulness has been linked to a range of positive social-emotional and cognitive outcomes, but the underlying mechanisms are unclear. As one of the few traits or dispositions that are associated with both affective and cognitive benefits, we asked whether mindfulness is associated with affective and cognitive outcomes through a shared, unitary process or through two dissociable processes. We examined this in adolescents using behavioral measures and also reanalyzed previously reported neuroimaging findings relating mindfulness training to either affect (negative emotion, stress) or cognition (sustained attention). Using multivariate regression analyses, our findings suggest that the relationships between dispositional mindfulness and affective and cognitive processes are behaviorally dissociable and converge with neuroimaging data indicating that mindfulness modulates affect and cognition through separate neural pathways. These findings support the benefits of trait mindfulness on both affective and cognitive processes, and reveal that those benefits are at least partly dissociable in the mind and brain.

While there exists an ample body of research in international contexts focused on the characterization and quantification of infertility psychological distress, the level of scholarly scrutiny directed towards this phenomenon within the context of China remains scant.

To investigate the formation and developmental processes of psychological distress associated with infertility and infertility treatment among women within the Chinese cultural context and to construct a theoretical framework that elucidates this phenomenon.

Qualitative approach with grounded theory methodology.

This study was conducted within the reproductive medicine department of a tertiary-level hospital located in central China from May to August 2023. Twenty-seven women who experienced infertility and underwent assisted reproductive treatment (ART) were interviewed. The interview sessions spanned durations ranging from 20 min to 1 h and 35 min. Data analysis included open coding, axial coding and selective coding. The study is reported using the COREQ checklist.

The infertility psychological distress experienced by women undergoing ART is a socially constructed phenomenon influenced by a dynamic interplay of forces that construct and conciliate it. The formation and progression of infertility psychological distress are rooted in the process of self-construction. A Middle-Ranged Theory titled 'self-reconstruction under the dome of infertility and infertility treatment' (SUDIT theory) was developed to explain this phenomenon. Within this framework, infertility psychological distress manifests across three distinct phases under the gambling of the constructive force and conciliative force: (1) distress of disrupting the former self; (2) distress linked to the struggling present self; and (3) the renewed-self harmonized with distress.

It is imperative for healthcare professionals and policymakers to acknowledge the socially constructed nature of infertility psychological distress, and proactively implement measures aimed at ameliorating it.

No patient or public contribution.

Adopting lifestyle interventions is pivotal in coronary artery disease (CAD) management and prevention to amplify cardiovascular and mental well-being. This study aims to quantify the effect of mindfulness-based interventions (MBIs) on anxiety, depression and stress in CAD patients.

A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted by searching four electronic databases (PubMed, CENTRAL, Scopus, and Science Direct) through December 2023. The risk of bias was assessed using the PEDro tool, and the study outcomes were expressed as standard mean difference at 95% CI.

Out of 1838 yielded results, eight RCTs involving 623 participants with a mean age of 56.96 ± 4.89 met the prespecified eligibility criteria. The pooled results showed a statistically significant and beneficial effect of MBIs on CAD patients' mental health status in regards to anxiety (SMD = -0.83; 95% CI [-1.19, -0.46], p < 0.001), depression (SMD = - 0.86; 95% CI [-1.14, -0.58], p < 0.001), and stress (SMD = -0.69; 95% CI [-1.27, -0.12], p = 0.02). The subgroup sensitivity analyses based on the region (Asia vs. Europe) indicated a statistically non-significant subgroup effect of MBIs on anxiety (I 2 = 63.9%, p = 0.10) and depression (I 2 = 25.8%, p = 0.25), and a significant effect on stress (I 2 = 80.0%, p = 0.03). Although the methodological quality of the trials was generally satisfactory, all studies lacked allocation concealment and blinding. Additionally, gender imbalances, and inadequate follow-up may have potentially compromised the validity of the trials.

Mindfulness-based interventions are beneficial for improving CAD patients' anxiety, depression and stress symptoms. Nevertheless, it is imperative to conduct more rigorous and robust studies with an equal gender ratio and long-term follow-up.

This study aimed to explore the time-varying impact of the Mindfulness-Based Stress Reduction (MBSR) program, specifically examining its effects on various variables 3 months, 1 year, and 3 years after program completion. Additionally, the study aimed to identify the barriers and facilitators in maintaining mindfulness practice over time and the preferred mindfulness practices among participants in three distinct time groups.

The study utilized a qualitative research design, conducting semi-structured interviews with 45 participants who had completed the 8-week MBSR program at different time points. Thematic analysis was employed to analyze the qualitative data obtained from the interviews, allowing for the identification of key themes and patterns.

The findings revealed that the effectiveness of the MBSR program varied at different times and across different variables. Immediately after completing the program, participants experienced a significant decrease in stress levels and an increase in awareness. One year later, the program continued to have positive effects on inner calm, coping mechanisms, and relationships. Three years after completing the program, its long-term impact was observed in the adoption of a mindful lifestyle, increased compassion and kindness, and ongoing personal growth.

The study highlights the transformative potential of the MBSR program beyond short-term symptom relief. The long-term effects observed in overall wellbeing emphasize the sustained efficacy of mindfulness-based interventions. The identified barriers and facilitators in maintaining mindfulness practice provide insights for program implementation and individual engagement. By understanding the long-term impact and preferences of participants, tailored interventions can be developed to maximize the benefits of the MBSR program for individuals over time.

Meditation, mental training that aims to improve one's ability to regulate their cognition, has been widely applied in clinical medicine. However, the mechanism by which meditation affects brain activity is still unclear. To explore this question, electroencephalogram data were recorded in 20 long-term meditators and 20 nonmeditators during 2 high-level cognitive tasks (meditation and mental calculation) and a relaxed resting state (control). Then, the power spectral density and phase synchronization of the electroencephalogram were extracted and compared between these 2 groups. In addition, machine learning was used to discriminate the states within each group. We found that the meditation group showed significantly higher classification accuracy and calculation efficiency than the control group. Then, during the calculation task, both the power and global phase synchronism of the gamma response decreased in meditators compared to their relaxation state; yet, no such change was observed in the control group. A potential explanation for our observations is that meditation improved the flexibility of the brain through neural plastic mechanism. In conclusion, we provided robust evidence that long-term meditation experience could produce detectable neurophysiological changes in brain activity, which possibly enhance the functional segregation and/or specialization in the brain.

This meta-analysis evaluated the effectiveness of mindfulness-based interventions (MBIs) on test anxiety across diverse age groups and intervention modalities.

Rigorous inclusion criteria were applied to select studies focusing on MBIs as the independent variable, with test anxiety as the outcome. A comprehensive search across multiple databases yielded 18 primary studies, contributing 20 comparisons. Data were extracted on study characteristics, sample sizes, and intervention details, and were analyzed using a random-effects model.

The analyses incorporated 1,275 participants, with MBIs demonstrating a moderate to large negative effect on test anxiety (effect size = -0.716; 95% CI: -1.383 to -0.049). Moderation analysis indicated that mean age, number of sessions, and intervention delivery mode did not significantly influence effect sizes. Publication bias assessment suggested the presence of bias via Egger's regression (p = 0.025), though Begg and Mazumdar's test and Duval and Tweedie's trim and fill method indicated no missing studies.

MBIs are effective in reducing test anxiety, though results should be interpreted with caution due to potential publication bias and unexplained heterogeneity. The impact of MBIs did not vary significantly with participant age, number of sessions, or delivery mode.

The prevalence of sleep quality problems and depression in the college student population has attracted widespread attention. However, the factors influencing this are still unclear. The objective of this study was to investigate the associations between self-compassion (S-C), sleep quality (SQ), and depression (DEP) among college students and examine the mediating effects of coping style (CS) between the variables.

A total of 1,038 Chinese university students were recruited for the study. The study used the Self-Compassion Scale (SCS), Simplified Coping Style Questionnaire (SCSQ), Depression Anxiety Stress Scale 21 (DASS-21), and Pittsburgh Sleep Quality Index (PSQI) to conduct the survey.

The self-compassion and coping style showed significant negative correlations with sleep quality and depression. Coping style partially mediated the relationship between self-compassion and sleep quality. The coping style also fully mediated the relationship between self-compassion and depression.

This study reveals the associations between self-compassion and sleep quality and depression, and the mediating role of coping style among college students. This study provides valuable insights for improving sleep quality and alleviating depression problems among college students. It emphasizes the importance of self-compassion and positive coping style.

This study aimed to determine if motivations to use alcohol (coping and social motivations) mediate the relationship between trait mindfulness and a variety of alcohol-related consequences and to determine if the relationship between motivations to use alcohol and alcohol-related consequences is moderated by alcohol use. We determined the factor structure of positive and negative consequences of alcohol use and used this structure as outcomes across eight moderated mediation models.

Data were obtained from 296 undergraduate students to confirm the alcohol-related consequences factor structure and to test eight moderated-mediation models.

Four alcohol-related consequences scales (romantic/sexual, positive, mild negative, and severe negative consequences) were confirmed. The motive of drinking to cope significantly mediated the relationship between trait mindfulness and all four of the alcohol-related consequences scales. Drinking to socialize did not significantly mediate the relationship between trait mindfulness and all of the alcohol-related consequences scales.

The identified four-factor structure suggests that alcohol-related consequences should be assessed in a more specific manner. Additionally, different motivations for alcohol use relate differentially to trait mindfulness and different alcohol-related consequences; drinking to cope is particularly problematic for this population. Future research on the usefulness of promoting mindfulness to reduce problematic drinking appears warranted.

Patients often experience pain and psychological distress when undergoing elective surgeries. Mindfulness-based interventions have been proposed as potential strategies to address these challenges. This meta-analysis aims to evaluate the efficacy of preoperative mindfulness-based interventions on several outcomes for patients undergoing elective surgery, including preoperative anxiety/depression, postoperative anxiety/depression, postoperative pain, and quality of life (QOL).

This meta-analysis encompassed randomized controlled trials published in the database PubMed, Cochrane, and Embase to August 2023. Mindfulness-based interventions were compared to control groups, who received treatment as usual (TAU). The RevMan software was employed to assess each outcome by using standardized mean difference based on patient-reported data. Subgroup analyses were further performed according to different categories of surgical types.

Eight RCTs with a total of 685 patients were identified. This meta-analysis demonstrated significant difference in preoperative anxiety (SMD:-0.36, 95% CI: -0.62 to -0.11, p = .006) and postoperative pain immediately (SMD:-0.65,95% CI: -1.09 to -0.20, p = .004), 2-3 days (SMD:-0.40, 95% CI:-0.78 to -0.02, p = .04),at 14 days (SMD:-0.48,95% CI: -0.85 to -0.12, p = .009) and 28 days (SMD:-0.89,95% CI: -1.55 to -0.23, p = .008) postoperatively. However, there were no differences between postoperative anxiety, preoperative/postoperative depression, and QOL.

Our findings suggest preoperative mindfulness-based interventions can effectively manage preoperative anxiety and postoperative pain in patients scheduled for elective surgery. Further research is warranted to explore the different timing and types of mindfulness-based intervention.

Abnormalities in emotion recognition (ER) are frequently reported in depression, with lower recognition accuracy in patients with major depressive disorder (MDD) when compared to healthy individuals. Mindfulness was found to directly impact the severity of depressive symptoms, by recognizing negative cognitions and dysfunctional reactions. The aims of this study were to compare ER and mindfulness levels between MDD patients and healthy controls (HCs), as well as to examine whether ER and mindfulness are related to symptom severity in MDD patients. Sixty-eight patients with MDD and 93 HCs participated in the study. A sociodemographic form, reading the mind in the eyes test (RMET), five facet mindfulness questionnaire-short form (FFMQ-S) and the Montgomery-Asberg depression scale (MADRS) were administered. Group comparison in ER and mindfulness was performed using the multivariate analysis of covariance (MANCOVA). Bivariate correlations and hierarchical linear regression analyses were performed to assess the associations between depression severity, ER and mindfulness in the patient group. Higher level of mindfulness was found in HCs relative to MDD group, however, no ER difference was present between the groups. A positive association between depression severity and the non-reactivity facet of mindfulness was found. On the other hand, ER was not significantly associated with symptom severity among individuals with MDD. Non-reactivity, unlike other dimensions of mindfulness, seems to increase with the severity of depressive symptoms among MDD patients. A particular focus on this subdimension in mindfulness techniques may yield better outcomes in alleviation of depressive symptoms.