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Mariani P, Russo D, Russo LL, Liberti G, Menditti D, Laino L. Spontaneous Bone Regeneration of Post-Enucleation Defects of Osteolytic Lesions in the Mandible: A Digital Three-Dimensional Morphometric Analysis. JOURNAL OF STOMATOLOGY, ORAL AND MAXILLOFACIAL SURGERY 2025:102411. [PMID: 40414599 DOI: 10.1016/j.jormas.2025.102411] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/20/2025] [Revised: 04/23/2025] [Accepted: 05/15/2025] [Indexed: 05/27/2025]
Abstract
BACKGROUND Spontaneous bone regeneration after enucleation of osteolytic lesions in the mandible is crucial for healing bone defects. understanding when spontaneous bone regeneration suffices can help clinicians make informed decisions. PURPOSE This study aimed to assess the extent of spontaneous bone regeneration in post-enucleation mandibular osteolytic lesion cavities using a 3D digital approach. Secondary objectives included identifying factors like age, lesion size, and anatomical site that could influence regeneration. STUDY DESIGN The study included patients aged 18-65 years who underwent enucleation of an osteolytic mandibular lesion, with available pre-treatment and follow-up CBCT scans. MAIN OUTCOMES The primary outcome was the percentage of regenerated bone volume (%RBV), calculated using 3D-volumetric analysis. Secondary outcomes included age, gender, lesion volume and site, number of extracted teeth, bone-wall involvement, and follow-up. RESULTS The study involved 20 patients, with a mean age of 40.1 ± 16.06 years. %RBV ranged from 32% to 97%, with a mean of 66.95%. Significant predictors of regeneration included age, lesion site, and bone wall involvement. CONCLUSIONS Spontaneous bone regeneration can often achieve significant healing even in large defects; understanding the factors influencing this process can guide treatment strategies and improve clinical outcomes.
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Affiliation(s)
- Pierluigi Mariani
- Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania, "Luigi Vanvitelli", Naples, Italy.
| | - Diana Russo
- Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania, "Luigi Vanvitelli", Naples, Italy
| | - Lucio Lo Russo
- Department of Clinical and Experimental Medicine, School of Dentistry, University of Foggia, Foggia, Italy
| | - Gabriele Liberti
- Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania, "Luigi Vanvitelli", Naples, Italy
| | - Dardo Menditti
- Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania, "Luigi Vanvitelli", Naples, Italy
| | - Luigi Laino
- Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania, "Luigi Vanvitelli", Naples, Italy
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Humbert-Vidan L, Castelo AH, He R, van Dijk LV, Rhee DJ, Wang C, Wang HC, Wahid KA, Joshi S, Gerafian P, West N, Kaffey Z, Mirbahaeddin S, Curiel J, Acharya S, Shekha A, Oderinde P, Ali AMS, Hope A, Watson E, Wesson-Aponte R, Frank SJ, Barbon CEA, Brock KK, Chambers MS, Walji M, Hutcheson KA, Lai SY, Fuller CD, Naser MA, Moreno AC. Image-based Mandibular and Maxillary Parcellation and Annotation using Computer Tomography (IMPACT): A Deep Learning-based Clinical Tool for Orodental Dose Estimation and Osteoradionecrosis Assessment. MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES 2025:2025.03.18.25324199. [PMID: 40166584 PMCID: PMC11957087 DOI: 10.1101/2025.03.18.25324199] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 04/02/2025]
Abstract
Background Accurate delineation of orodental structures on radiotherapy CT images is essential for dosimetric assessments and dental decisions. We propose a deep-learning auto-segmentation framework for individual teeth and mandible/maxilla sub-volumes aligned with the ClinRad ORN staging system. Methods Mandible and maxilla sub-volumes were manually defined, differentiating between alveolar and basal regions, and teeth were labelled individually. For each task, a DL segmentation model was independently trained. A Swin UNETR-based model was used for the mandible sub-volumes. For the smaller structures (e.g., teeth and maxilla sub-volumes) a two-stage segmentation model first used the ResUNet to segment the entire teeth and maxilla regions as a single ROI that was then used to crop the image input of the Swin UNETR. In addition to segmentation accuracy and geometric precision, a dosimetric comparison was made between manual and model-predicted segmentations. Results Segmentation performance varied across sub-volumes - mean Dice values of 0.85 (mandible basal), 0.82 (mandible alveolar), 0.78 (maxilla alveolar), 0.80 (upper central teeth), 0.69 (upper premolars), 0.76 (upper molars), 0.76 (lower central teeth), 0.70 (lower premolars), 0.71 (lower molars) - and exhibited limited applicability in segmenting teeth and sub-volumes often absent in the data. Only the maxilla alveolar central sub-volume showed a statistically significant dosimetric difference (Bonferroni-adjusted p-value = 0.02). Conclusion We present a novel DL-based auto-segmentation framework of orodental structures, enabling spatial localization of dose-related differences in the jaw. This tool enhances image-based bone injury detection, including ORN, and improves clinical decision-making in radiation oncology and dental care for head and neck cancer patients.
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Affiliation(s)
- Laia Humbert-Vidan
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Austin H Castelo
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Renjie He
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Lisanne V van Dijk
- Department of Radiation Oncology, University Medical Center Groningen, Groningen, Netherlands
| | - Dong Joo Rhee
- Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Congjun Wang
- Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - He C Wang
- Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Kareem A Wahid
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Sonali Joshi
- California University of Science and Medicine, Cerritos, California, USA
| | | | - Natalie West
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Zaphanlene Kaffey
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Sarah Mirbahaeddin
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Jaqueline Curiel
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Samrina Acharya
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Amal Shekha
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Praise Oderinde
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Alaa M S Ali
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Andrew Hope
- Department of Radiation Oncology, Princess Margaret Cancer Center, Toronto, CA
| | - Erin Watson
- Department of Dental Oncology, Princess Margaret Cancer Center, Toronto, CA
| | - Ruth Wesson-Aponte
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Steven J Frank
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Carly E A Barbon
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Kristy K Brock
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Mark S Chambers
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Muhammad Walji
- Department of Clinical and Health Informatics, Texas Center of Oral Health Care Quality & Safety, Houston, Texas, USA
| | - Katherine A Hutcheson
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Stephen Y Lai
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Clifton D Fuller
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Mohamed A Naser
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
| | - Amy C Moreno
- Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Varshney S, Dwivedi A, Pandey V. Bioprinting techniques for regeneration of oral and craniofacial tissues: Current advances and future prospects. J Oral Biol Craniofac Res 2025; 15:331-346. [PMID: 40027866 PMCID: PMC11870160 DOI: 10.1016/j.jobcr.2025.01.019] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/17/2024] [Revised: 12/12/2024] [Accepted: 01/18/2025] [Indexed: 03/05/2025] Open
Abstract
Background Regenerative dentistry aims to reinstate, fix, renew, and regrow tissues within the oral and craniofacial domain. Existing regenerative methods are based on insights into tissue biology or disease processes that lead to tissue degradation. However, achieving complete and functional Tissue regeneration remains a primary challenge in real-world medical scenarios. Aim The review focuses on the application of bioprinting techniques for rejuvenating intricate Oral and craniofacial tissues, such as craniofacial bone, periodontal ligament, cementum, dental pulp, temporomandibular joint cartilage, and whole teeth. Methods Bioprinting, a cutting-edge technology in regenerative dentistry, strives to create entirely new Functional tissues and organs. This approach merges principles from engineering and biology to produce three-dimensional biologically operational constructs containing bioactive substances, Living cells and cell clusters using automated bioprinters. The review summarizes the outcomes achieved through bioprinting techniques in both in vitro (laboratory experiments) and in vivo (Studies on living organisms) experiments. Result The emergence of this innovative tissue engineering technology has yielded highly promising outcomes during the experimental stages. Conclusion These promising experimental results necessitate replication through human clinical trials to ascertain the viability of bioprinting techniques for mainstream clinical implementation in regenerative dentistry.
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Affiliation(s)
- Shailesh Varshney
- Department of Periodontology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India
| | - Anshuman Dwivedi
- ,Department of Stem Cells & Regenerative Medicine, Santosh, University, Ghaziabad, Uttar Pradesh, India
| | - Vibha Pandey
- ,Department of Psychology, Himalayan, Garhwal University, Uttarakhand, India
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Son CH, An JS, Yi WJ, Ahn SJ. Bone mineral density and anatomic limitations of miniscrew placement at buccal interradicular sites: A quantitative computed tomography study. Am J Orthod Dentofacial Orthop 2025:S0889-5406(25)00051-4. [PMID: 40029233 DOI: 10.1016/j.ajodo.2025.01.014] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/14/2024] [Revised: 01/09/2025] [Accepted: 01/13/2025] [Indexed: 03/05/2025]
Abstract
INTRODUCTION This study aimed to evaluate the bone mineral density (BMD) and anatomic limitations of miniscrew placement at buccal interradicular sites. METHODS Virtual miniscrews were placed at the interradicular sites from the canines to the second molars of 139 patients who underwent quantitative computed tomography. Mixed-effects modeling and logistic regression were used to test the differences in BMD and the odds of root proximity, sinus invasion, and bicortical perforation according to sex, growth status, and interradicular site. RESULTS No significant interradicular BMD differences were observed between the sexes. Adults had higher interradicular BMDs than adolescents only in the mandible. There were no significant BMD differences among the maxillary interradicular sites, whereas the mandibular interradicular BMD tended to increase from the anterior to the posterior regions. All interradicular bones belonged to the same category according to Misch's classification, and BMD differences of <0.05 g/cc were observed in most sites except between mandibular molars. The interradicular BMD measurements were unavailable for 41.9% and 24.6% of the maxilla and mandible, respectively, mostly because of root proximity. The most anatomically favorable site was between the mandibular premolars, whereas the most unfavorable site was between the maxillary molars. The odds of anatomic limitations were not significantly affected by growth state or sex. CONCLUSIONS Regarding BMD, all interradicular sites from the canines to the second molars may be adequate candidates for miniscrew placement, regardless of growth state and sex. Anatomic limitations should be carefully considered when placing miniscrews, specifically between the maxillary molars.
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Affiliation(s)
- Chang-Han Son
- Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, South Korea
| | - Jung-Sub An
- Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, South Korea; Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea
| | - Won-Jin Yi
- Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, South Korea; Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea
| | - Sug-Joon Ahn
- Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, South Korea; Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea.
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Eid FY, Ghaleb SI, Badr FF, Marzouk ES. Three-dimensional assessment of the skeletal characteristics accompanying unilateral maxillary canine impaction: a retrospective cone-beam computed tomography study. BMC Oral Health 2024; 24:1249. [PMID: 39427130 PMCID: PMC11489996 DOI: 10.1186/s12903-024-04974-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/27/2024] [Accepted: 09/27/2024] [Indexed: 10/21/2024] Open
Abstract
BACKGROUND Environmental and genetic factors associated with canine impaction have been extensively researched, whereas the bone characteristics in the impaction area have not been thoroughly studied. Accordingly, the objective of this investigation was to provide a skeletal assessment in terms of bone density, bone microstructure, bone volume, and palatal volume in subjects with unilaterally impacted maxillary canines. METHODS A retrospective design has been employed to address the aim of this study, where the initial pre-treatment cone-beam computed tomography (CBCT) scans of 30 patients with unilateral maxillary canine impaction were assessed. The obtained patients' data were equally divided according to the location of the impaction into 2 groups, one with buccally impacted canines, and another with palatal impactions, with the contra-lateral sides in both groups serving as the controls. Skeletal measurements such as bone density (BD), bone microstructure in terms of fractal dimension (FD), maxillary bone volume (MBV), and palatal volume (PV) were evaluated from the acquired CBCTs in both groups and compared to the controls. RESULTS With buccal impactions, significantly greater BD and FD have been reported (p < 0.001), whereas non-significant differences were found regarding the PV when compared with controls (p = 0.56). MBV was significantly greater on the non-impaction side in comparison with buccal impaction sides (p < 0.001). For palatal impactions: BD, FD, and MBV were significantly greater on the impaction sides (p < 0.001), and conversely with PV which has been reported to be significantly greater on the non-impaction sides (p < 0.001). CONCLUSIONS As per the obtained results, buccally impacted canines are associated with greater BD and FD, and less MBV, whereas palatally impacted canines are accompanied with greater BD, FD, and MBV, in addition to less PV, when both conditions are compared with the non-impaction sides.
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Affiliation(s)
- Farah Y Eid
- Department of Orthodontics, Faculty of Dentistry, Alexandria University, Champolion street, Alexandria, Egypt.
| | - Sherifa I Ghaleb
- Department of Orthodontics, Faculty of Dentistry, Alexandria University, Champolion street, Alexandria, Egypt
| | - Fatma F Badr
- Oral Diagnostic Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
| | - Eiman S Marzouk
- Department of Orthodontics, Faculty of Dentistry, Alexandria University, Champolion street, Alexandria, Egypt
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Felicita AS, Thomas LA, Uma Maheswari TN. Influence of the maxillary third molars and the surrounding cortical plate during maxillary tooth movement with TADS- A CBCT Study. Oral Maxillofac Surg 2024; 28:1169-1179. [PMID: 38480618 DOI: 10.1007/s10006-024-01229-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/10/2023] [Accepted: 02/18/2024] [Indexed: 08/18/2024]
Abstract
OBJECTIVE To determine the influence of the presence/absence of third molars and intact/loss of cortical plate of the maxillary tuberosity on the amount of distal movement of the maxillary first permanent molar during distal movement of the maxillary dentition with mini-implants. MATERIALS AND METHODS Thirty six maxillary tuberosity sites were evaluated in eighteen young adult patients. The distal movement of the entire maxillary dentition was performed with mini-implants with 200 g of distalising force applied from the mini-implant placed in the maxillary posterior buccal region to attachments placed on the arch wire between the maxillary lateral incisor and canine bilaterally. The distal movement of the maxillary first permanent molars was measured on lateral cephalograms. The maxillary tuberosity sites with intact cortical plate due to congenitally missing third molars or atraumatic extraction of third molars (G1), partial loss of cortical plate due to surgical removal of third molars (G2), fully erupted third molars (G4), third molars located at (G3), and below the cementoenamel junction (G5) were evaluated with cone beam computed tomography. One way Anova and Fisher LSD test was done. RESULTS The order of greater to lesser amount of distal movement of the maxillary first permanent molar depending on the integrity of maxillary of tuberosity was partial loss of cortical plate, third molars at the cementoenamel junction, third molars below the cementoenamel junction, intact cortical plate and fully erupted third molars. CONCLUSION The integrity of the cortical plate and the relative position of the maxillary third molar to the second molar influence the amount of distal movement of the maxillary first permanent molar during distal movement of the maxillary teeth with TADS. CLINICAL RELEVANCE The amount of distal movement of the maxillary dentition appears to depend on the presence or absence of the third molars and the condition of the cortical plate in the region of the maxillary tuberosity and thereby greatly influence the outcome of treatment.
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Affiliation(s)
- A Sumathi Felicita
- Department of Orthodontics, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162 Poonamallee High Road, Chennai, 600 077, Tamil Nadu, India.
| | - Lirin Ann Thomas
- Department of Orthodontics, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162 Poonamallee High Road, Chennai, 600 077, Tamil Nadu, India
| | - T N Uma Maheswari
- Department of Oral Medicine, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
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Andraws Yalda F, Chawshli OF, Al-Talabani SZ, Ali SH, Shihab OI. Evaluation of Palatal Thickness for the Placement of MARPE Device among a Cohort of Iraqi-Kurdish Population: A Retrospective CBCT Study. Int J Dent 2024; 2024:6741187. [PMID: 39234263 PMCID: PMC11374425 DOI: 10.1155/2024/6741187] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/15/2023] [Revised: 06/17/2024] [Accepted: 08/03/2024] [Indexed: 09/06/2024] Open
Abstract
Objectives This study aimed to evaluate and compare palatal thickness in adults for the placement of mini-implants for miniscrew-assisted rapid palatal expansion (MARPE) appliances using cone-beam computed tomography (CBCT) in a sample of Iraqi-Kurdish people. Materials and Methods CBCT scans from 68 Kurdish patients, aged between 18 and 30 years, were assessed retrospectively. Of these, 37 were males and 31 were females. The measurements were performed at 3 mm from the mid-palatal suture. T-zone was selected for the anterior points, at the level of the palatal cusps of 2nd premolars, and the posterior point at the level of mesio-palatal cusps of 1st molars bilaterally. Palatal thickness of males and females bilaterally, as well as anterior and posterior areas, were measured and compared. An independent t-test was applied for comparison for normally distributed data, and the Mann-Whitney test was utilized for nonnormally distributed data. Additionally, Bonferroni correction was implemented for p-value adjustment. Results The mean palatal thickness at the anterior area was 6.06 mm for males, 6.17 mm for females on the right side, 5.94 mm for males, and 5.99 mm for females on the left side. The mean palatal thickness at the posterior area was almost the same for both genders (4.40 mm for males and 4.44 mm for females) on the right side, 4.35 mm for males, and 4.54 mm for females on the left side. Statistically, no significant difference was recorded between males and females, as well as right and left sides in both anterior and posterior regions; however, a very highly statistically significant difference (p < 0.001) was recorded when comparing total thickness, including both hard and soft tissue, between anterior and posterior regions. Conclusions CBCT proves a highly effective modality in assessing palatal thickness and suggesting ideal locations for orthodontic mini-screw placement. Our examination of palatal thickness in a sample of Iraqi-Kurdish individuals revealed no statistical difference between genders or sides, but significant variations were noted between anterior and posterior thicknesses. Comprehensive clinical and pre-expansion CBCT evaluations are crucial for precisely determining the optimal placement of MARPE devices in each patient, ensuring successful outcomes.
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Affiliation(s)
- Fedil Andraws Yalda
- The Department of Oral Diagnosis College of Dentistry Hawler Medical University, Erbil, Iraq
| | - Omar Fawzi Chawshli
- The Department of Pedodontics Orthodontics and Preventive Dentistry College of Dentistry Hawler Medical University, Erbil, Iraq
| | - Shaho Ziyad Al-Talabani
- The Department of Pedodontics Orthodontics and Preventive Dentistry College of Dentistry Hawler Medical University, Erbil, Iraq
| | - Sarkawt Hamad Ali
- The Department of Oral Diagnosis College of Dentistry Hawler Medical University, Erbil, Iraq
| | - Omed Ikram Shihab
- The Department of Oral and Maxillofacial Surgery College of Dentistry Hawler Medical University, Erbil, Iraq
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Ciklacandir S, Gokce Kara G, Isler Y. A biomechanical investigation of miniscrews placed on a mandible for temporary anchorage; a patient-specific finite element analysis. Comput Methods Biomech Biomed Engin 2024:1-10. [PMID: 38907647 DOI: 10.1080/10255842.2024.2365909] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/28/2024] [Accepted: 06/04/2024] [Indexed: 06/24/2024]
Abstract
Miniscrews are temporary skeletal anchorage devices that are widely used in orthodontic treatment, and their success depends on the placement area, angle, technique, and screw dimensions. This study aimed to investigate the effects of miniscrew lengths, insertion angles, and force directions on a mandible model consisting of teeth, cortical and cancellous bones. One Dental Volumetric Tomography (DVT) scan from a patient who had miniscrews were used for mandibular bone modeling to perform finite element analysis. The model variables included miniscrew lengths (6, 8, and 10 mm), insertion angles (-15°, 45°, 60°, and 90°), and force directions (30°, 45°, and 60°). The minimum and maximum stresses were calculated as 18.61 and 37.11 MPa at 6 mm and 10 mm, respectively. According to the insertion angles, the lowest stress was observed at 60°, while the highest stress was found at 15° in the ventral direction. At force directions, the lowest stress was at 60°, and the highest stress was at 45°. However, there were no significant differences in insertion angles and force directions. A statistically significant difference was determined in miniscrew length. As a result, the best result was calculated to be 6 mm inserted at a 60° angle, which could induce the lowest stress. Increasing the miniscrew length will increase the stress on the mandible. In addition, because of the higher force direction, stress decreases with shorter power arms.
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Affiliation(s)
- Samet Ciklacandir
- Department of Biomedical Engineering, Izmir Katip Celebi University, Izmir, Turkey
| | - Gokcenur Gokce Kara
- Faculty of Dentistry, Department of Orthodontics, Marmara University, Istanbul, Turkey
| | - Yalcin Isler
- Department of Biomedical Engineering, Izmir Katip Celebi University, Izmir, Turkey
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da Silva AAF, Lima CAA, Montano-Pedroso JC, Pereira MD. Bone Density of the Midpalatal Suture After Surgically Assisted Rapid Maxillary Expansion: A Retrospective Cohort Study. J Craniofac Surg 2024:00001665-990000000-01693. [PMID: 38856203 DOI: 10.1097/scs.0000000000010402] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/03/2024] [Accepted: 05/17/2024] [Indexed: 06/11/2024] Open
Abstract
OBJECTIVES To evaluate the bone density in the midpalatal suture after 10 months of surgically assisted rapid maxillary expansion (SARME) with the separation of the maxilla into 2 segments. METHODS Sixty multislice computed tomography (MCT) from 20 patients undergoing SARME were analyzed in 3 periods of time (1 MCT per patient on each occasion): (1) 1 week before surgery, (2) postsurgery immediately after completing the expander activation, and (3) 10 months after the expander activation. On all occasions, the bone density was measured in Hounsfield units on MCT scans in axial and coronal sections, in the anterior (A1), middle (A2), and posterior (A3) regions of the midpalatal suture. RESULTS The mean percentage values of bone density in Hounsfield units, from the 10-month postactivation period to preoperative in the A1, A2, and A3 regions were 68.38%, 38.21%, and 55.90%, respectively, in the axial norm, and 64.06%, 36.81%, and 55.50% in coronal norm (A1 = A3>A2), with no significant difference in the tomographic cuts (P >0.05). There was no correlation between patient age or amount of expansion in the expander and bone density. CONCLUSIONS The bone density in the midpalatal suture 10 months after SARME is lower than preexpansion. A denser new bone formation along the suture concentrates closer to the extremities rather than in the central region. Although the maturation of the new bone formation in the midpalatal suture is lower 10 months after SARME, it appears to be sufficient for satisfactory clinical results, regardless of patient age or the amount of expansion in the expander.
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Affiliation(s)
- Alexandre Augusto Ferreira da Silva
- Department of Craniomaxillofacial Surgery, Division of Plastic Surgery, Postgraduate Program in Translational Surgery, Federal University of São Paulo São Paulo, Brazil
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Gupta S, Khera AK, Raghav P, Wadhawan A, Wadhwa P, Sharma N. Comparative evaluation of effectiveness of three versus four mini-implants for simultaneous intrusion and retraction of maxillary anterior teeth: A 3D FEM study. J Orthod Sci 2024; 13:19. [PMID: 38784074 PMCID: PMC11114455 DOI: 10.4103/jos.jos_57_23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/18/2023] [Revised: 10/17/2023] [Accepted: 02/16/2024] [Indexed: 05/25/2024] Open
Abstract
OBJECTIVE To evaluate and compare the displacement pattern of maxillary anterior teeth in the sagittal and vertical planes and evaluate the stress distribution in pdl, bone, teeth of the maxillary anterior region, and around the mini-implants during simultaneous en-masse retraction and intrusion using two, three, and four mini-implants combinations. METHODS A three-dimensional FEM model of maxillary teeth and periodontal ligament housed in the alveolar bone with extracted first premolarswasgenerated. The models were broadly divided into three groups according to the number of mini-implants. Mini-implants were placed bilaterally between the second premolar and molar in group I, and along with bilateral implants, an additional mid-implant was placed between the central incisors as in group II, whereas in group III, anterior mini-implants were placed in between lateral incisors and canine bilaterally. RESULTS The two mini-implant model showed the maximum amount of retraction in the sagittal plane followed by three and four mini-implant models. In the vertical plane, all six anterior teeth showed intrusion only in the four mini-implant model. The stress in cortical bone, cancellous bone, PDL, around the mini-implants, and in lateral incisor was maximum in the three mini-implant model, followed by four mini-implants with the least stress in the two mini-implant model. CONCLUSION The four mini-implant model is better than the three and two mini-implants model as there is a more even distribution of force in the four mini-implants model as compared to the three mini-implants model.
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Affiliation(s)
- Sajal Gupta
- Department of Orthodontics, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
| | - Amit Kr. Khera
- Department of Orthodontics, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
| | - Pradeep Raghav
- Department of Orthodontics, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
| | - Ashutosh Wadhawan
- Department of Orthodontics, Kalka Dental College, Meerut, Uttar Pradesh, India
| | - Pankaj Wadhwa
- Department of Orthodontics, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
| | - Nupur Sharma
- Department of Orthodontics, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
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Germanò F, Guarnieri R, Mezio M, Barbato E, Cassetta M. The Use of CAD/CAM Technology in Mandibular Canine Disimpaction: A Case Report. Dent J (Basel) 2024; 12:79. [PMID: 38534303 DOI: 10.3390/dj12030079] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/16/2024] [Revised: 03/14/2024] [Accepted: 03/18/2024] [Indexed: 03/28/2024] Open
Abstract
This case report of an 11-year-old subject shows the digital workflow for the management of an impacted mandibular canine using Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) technology along with Temporary Anchorage Devices (TADs). The miniscrew insertion site was planned using software, and a surgical guide was digitally designed and 3D printed. Orthodontic traction was performed using a 3D-designed and -printed device. In a single sitting, the miniscrew was inserted and the disimpaction device was also delivered. The primary objective of recovery and the repositioning of the impacted mandibular canine in the axis with its eruptive path was achieved. The space available and the subject's early stage of mixed dentition was considered favourable to a spontaneous eruption. This case report shows how CAD/CAM digital technology, combined with 3D printing, enables the creation of a surgical guide to position the miniscrew and the customized devices used for mandibular canine disimpaction. CAD/CAM surgical guides can help clinicians to position TADs with more accuracy and predictability, ensuring high quality bone support offering primary stability. Although orthodontic traction is the most complex therapeutic choice to implement, with the aid of CAD/CAM technology it is possible to proceed with accurate and minimally invasive orthodontic traction in order to recover a mandibular canine.
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Affiliation(s)
- Francesca Germanò
- Department of Oral and Maxillofacial Sciences, School of Dentistry, "Sapienza" University of Rome, 00161 Rome, Italy
| | - Rosanna Guarnieri
- Department of Oral and Maxillofacial Sciences, School of Dentistry, "Sapienza" University of Rome, 00161 Rome, Italy
| | - Martina Mezio
- Department of Oral and Maxillofacial Sciences, School of Dentistry, "Sapienza" University of Rome, 00161 Rome, Italy
| | - Ersilia Barbato
- Department of Oral and Maxillofacial Sciences, School of Dentistry, "Sapienza" University of Rome, 00161 Rome, Italy
| | - Michele Cassetta
- Department of Oral and Maxillofacial Sciences, School of Dentistry, "Sapienza" University of Rome, 00161 Rome, Italy
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12
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Pareek PK, Kumar A, Bhariya BS, Bamal R, Yadav L, Jaswal A. Influence of the Curve of Spee on Tooth Displacement Patterns: A Finite Element Analysis at Varying Implant Heights. Cureus 2024; 16:e54283. [PMID: 38496186 PMCID: PMC10944568 DOI: 10.7759/cureus.54283] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 02/13/2024] [Indexed: 03/19/2024] Open
Abstract
Background Monocortical mini-screw-type temporary anchorage devices (TADs), or mini-screws, have significantly impacted orthodontic treatment strategies, especially in severe crowding and protrusion cases. These devices offer flexibility in placement sites, but the chosen location can considerably influence tooth displacement patterns. Key factors include the 'line of force' and the biomechanical properties of orthodontic tools. By analyzing tension distribution and three-dimensional displacements, the finite element method (FEM) provides a thorough means to comprehend these patterns. The Curve of Spee (COS) is a crucial factor potentially affecting displacement. Objective This study aimed to leverage finite element analysis (FEA) to understand the impact of varying mini-implant heights (10 mm, 13 mm, and 16 mm) on the displacements of different tooth types under a consistent force of 150 gm and compare these displacements both in the presence and absence of the COS. Materials and methods A CAD model of the jaw and teeth was developed using CT scan data and a Rexcan III 3D White Light Scanner. This model was meshed in Altair HyperMesh using tetrahedral elements, resulting in a Finite Element Model. The model incorporated various components, including teeth, the periodontal ligament (PDL), alveolar bone, brackets, a titanium mini-screw, and an archwire measuring 0.019 x 0.025 inches. Unique material properties were assigned to the PDL, and the assembly accurately replicated the clinical alignment of the archwire and brackets. Subsequently, stress and strain analyses were conducted on the model using the FEM. Results The displacement patterns of various teeth at implant heights of 10 mm, 13 mm, and 16 mm under a 150-gm force were analyzed in relation to the COS. Notably, for the central incisor, the COS significantly affected displacements in the Y and Z directions. Similarly, the Lateral Incisor and Canine exhibited marked changes in the Z direction with the presence of the COS. The Second Premolar's apex displacement showed significant variation due to the COS, while the First Molar displayed notable changes in the X direction. Generally, the presence of the COS either maintained or slightly increased Z-directional displacements across teeth, particularly at the apices. Conclusion The presence of COS significantly influences tooth displacement patterns when using mini-screws at different implant heights. Central incisors, lateral incisors, and canines are particularly sensitive to changes in the Z direction with the COS. The biomechanical analysis emphasizes the importance of considering COS in treatment planning for optimal results with mini-implants in orthodontics.
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Affiliation(s)
- Pankaj K Pareek
- Department of Orthodontics, Rajasthan Dental College and Hospital, Jaipur, IND
| | - Ashish Kumar
- Department of Orthodontics, Rajasthan Dental College and Hospital, Jaipur, IND
| | | | - Renuka Bamal
- Department of Orthodontics, NIMS Dental College and Hospital, Jaipur, IND
| | - Lucky Yadav
- Department of Dental and Oral Surgery, Lady Hardinge Medical College, Delhi, IND
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13
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Sri HK, Ahmed N, Sasanka LK. Association of Age, Gender, and Site of Implant Placement: An Institution-Based Retrospective Study. J Long Term Eff Med Implants 2024; 34:75-82. [PMID: 38505896 DOI: 10.1615/jlongtermeffmedimplants.2023039184] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/21/2024]
Abstract
Tooth loss is an undesirable condition that leads to functional, esthetic and social damage, having an impact on an individual's quality of life. Dental implants are man-made tooth root replacements that are increasingly used to replace a missing tooth. It is important to gather demographic data in order to take precautions before the possible failures. Hence the objective of this study was to retrospectively determine the association between age, gender, and site of implant placement in patients reporting to a private dental institution. This study was carried out from the data obtained from the case records of 1281 patients who had undergone implant therapy. Chi-square test was applied to see associations of gender, age and implant site. The results show that a maximum number of 348 implants (27.7%) were placed in patients aged between 41-50 years. The patient pool consisted of 705 (55%) females and 576 (45%) males. A maximum of 228 implants (17.80%) were placed in region 46 and 224 implants (17.49%) in region 36. Only 2 implants (0.2%) were placed in region 41. There was a positive association between age, gender and site of implant. In those aged 20-30 years, 20.53% of implants were placed, 26.23% in 31-40 years, 27.1% in 41-50 years, 17.95% in 51-60 years and 8.11% in 61-70 years of age. In male, a maximum of 124 implants (54.4%) were placed in region 46 and only 1 implant (50%) in region 41. In females, region 36 had a maximum of 110 implants (49.1%), and the least number of implants were placed in regions 31 and 41. In this study, it can be concluded that general factors such as age and gender had a significant effect on the site of implant placement.
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Affiliation(s)
- Harini K Sri
- Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India
| | - Nabeel Ahmed
- Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India
| | - L Keerthi Sasanka
- Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India
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14
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Saleh HO, Moussa BG, Salah Eddin KA, Noman SA, Salah AM. Assessment of CAD/CAM Customized V Pattern Plate Versus Standard Miniplates Fixation in Mandibular Angle Fracture (Randomized Clinical Trial). J Maxillofac Oral Surg 2023; 22:995-1005. [PMID: 38105847 PMCID: PMC10719228 DOI: 10.1007/s12663-023-02027-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/13/2023] [Accepted: 09/22/2023] [Indexed: 12/19/2023] Open
Abstract
Background Mandibular angle is the most common site for fractures, accounting for 23-42% of all cases of mandibular fractures. A customized fixation system is designed directly for a specific patient, which reduces the time spent bending and fixing the plate during the operation. This study was designed to assess the effect of CAD/CAM customized V pattern plate versus standard miniplates fixation in mandibular angle fracture. Materials and Methods This prospective randomized clinical trial included 26 patients suffering from mandibular angle fracture. Patients were selected from Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University and Ahmed Maher Teaching Hospital. Study group (13) needed open reduction and internal fixation by using CAD/CAM V plate with surgical guide, while control group (13) needed open reduction and internal fixation by using standard superior-inferior miniplate fixation. The patients were then followed up for one year postoperatively. Results It showed that there was a statistical difference between the study group and the control group regarding postoperative pain, occlusion, and maximal interincisal opening (p value < 0.05%). There was no statistical difference (p value > 0.05%) in the postoperative panoramic radiograph that was taken within the postoperative 1st week in both groups, while the increase in mean bone density was statistically significant (p value < 0.05%) from 6 months to one year postoperatively. Conclusion CAD/CAM customized V pattern plate is a suitable plate design because it offers sufficient stability for normal bone healing, the creation of an ideal occlusion, an early return to function, and adequate postoperative radiographic outcomes. Trial Registration It was registered at ClinicalTrials.gov. Registration number: NCT03761524. Registration date: 03.12.2018.
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Affiliation(s)
- Hiba Obad Saleh
- Department Oral & Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt
- Department of Oral & Maxillofacial Surgery, Ahmed Maher Teaching Hospital, Cairo, Egypt
| | - Basma Gamal Moussa
- Department Oral & Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt
| | - Khaled Amr Salah Eddin
- Department Oral & Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt
| | - Samer Abduljabar Noman
- Department Oral & Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt
| | - Ahmed Mohammed Salah
- Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Sana’a University, Sana’a, Yemen
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15
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Banerjee A, Basu B, Saha S, Chowdhury AR. Design and development of a patient-specific temporomandibular joint implant: Probing the influence of bone condition on biomechanical response. J Biomed Mater Res B Appl Biomater 2023; 111:2089-2097. [PMID: 37624362 DOI: 10.1002/jbm.b.35311] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/29/2022] [Revised: 06/23/2023] [Accepted: 07/31/2023] [Indexed: 08/26/2023]
Abstract
Total temporomandibular joint (TMJ) replacement is widely recognized as an effective treatment for TMJ disorders. The long-term stability of TMJ implants depends on two important factors which are design concepts for fixation to anatomical locations in the mandible and bone conditions. Other factors include stress distribution, microstrain in the peri-implant, bone attributes like bone conditions leading to the clinical complications and failures. This study addresses these limitations by examining the influence of patient-specific design concepts and bone conditions on TMJ implant performance. Clinical evidences support the importance of implant design on healing ability. Previous studies have focused on achieving precise implant fit based on geometric considerations, however those published studies did not explore the impact of such. Against this perspective, the present study reports the extensive finite element analysis (FEA) results, while analyzing the impact of a newly designed patient-specific TMJ implant to address clinical complications associated with various bone conditions, particularly osteoporotic bone. In validating the FEA results, the performance of additively manufactured patient-specific TMJ implants was compared with designs resembling two commonly used clinically approved implant designs. By addressing the limitations of previous research and emphasizing the importance of bone conditions, the study provides valuable guidelines for the development of next-generation TMJ implants. These findings contribute to enhanced clinical outcomes and long-term success in the treatment of TMJ disorders.
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Affiliation(s)
- Anik Banerjee
- Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Shibpur, India
| | - Bikramjit Basu
- Laboratory for Biomaterials, Materials Research Centre Indian Institute of Science, Bangalore, India
| | - Subrata Saha
- Department of Restorative Dentistry, University of Washington, Seattle, Washington, USA
| | - Amit Roy Chowdhury
- Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Shibpur, India
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16
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Kim Y, Ku JK. Rat Calvaria Model Mimicking the Intraoral Lesion of Medication-Related Osteonecrosis in the Jaw: A Preliminary Test. J Clin Med 2023; 12:6731. [PMID: 37959197 PMCID: PMC10649854 DOI: 10.3390/jcm12216731] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/29/2023] [Revised: 10/17/2023] [Accepted: 10/24/2023] [Indexed: 11/15/2023] Open
Abstract
Numerous preclinical intraoral models have been proposed to study medication-related osteonecrosis of the jaws (MRONJ). However, an extraoral animal model is necessary to investigate the effects of interventions such as grafts or direct therapeutics. This study aimed to establish a MRONJ rat model on the calvaria. Seven rats were allocated to either the control or MRONJ group. The MRONJ group received injections of zoledronic acid and dexamethasone to induce osteonecrosis over 4 weeks. Two weeks after these injections, the maxillary first molar was extracted, and two calvaria defects were created using a 4 mm trephine burr. One defect was left untreated, while the other was filled with harvested calvaria bone. A histological examination of all calvaria in the MRONJ group revealed avascular necrosis and the destruction of cortical bone. An independent t-test and Pearson's correlation coefficient were used for statistical analysis and the evaluation of alveolar and calvaria defects. The total alveolar and calvaria defect volume in the control group was significantly smaller than that in the MRONJ group. A statistically significant correlation was observed between alveolar and calvaria defects (Pearson correlation = 0.6, p = 0.023). The autogenous grafts showed poor results in the MRONJ group since they failed to revascularize and exhibited necrosis. The calvaria in this study successfully mimicked MRONJ lesions with avascular necrosis. This preclinical model could be used to develop treatments that are applicable to MRONJ.
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Affiliation(s)
- Yesel Kim
- Department of Dental Hygiene, Jeonju Kijeon College, Jeonju 54989, Republic of Korea
| | - Jeong-Kui Ku
- Department of Oral and Maxillofacial Surgery, School of Dentistry and Institute of Oral Bioscience, Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University, Jeonju 54907, Republic of Korea
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17
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Konstantinović VS, Abd-Ul-Salam H, Jelovac D, Ivanjac F, Miličić B. Pterygoid and tuberosity implants in the atrophic posterior maxilla: A retrospective cohort study. J Prosthet Dent 2023; 130:219.e1-219.e10. [PMID: 37481400 DOI: 10.1016/j.prosdent.2023.06.007] [Citation(s) in RCA: 6] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/16/2022] [Revised: 06/09/2023] [Accepted: 06/09/2023] [Indexed: 07/24/2023]
Abstract
STATEMENT OF PROBLEM Rehabilitation of the partially or completely edentulous posterior maxilla using dental implants is a clinical challenge because of the presence of the maxillary sinus, as well as the low quality and quantity of bone in that region. In addition to bone augmentation procedures, posterior maxillary rehabilitation using implants includes their anchoring in bones such as the zygoma, pterygoid, and maxillary tuberosity, as well as in short implants. However, the performance of pterygoid and tuberosity implants in the atrophic posterior maxilla is unclear. PURPOSE The purpose of this retrospective cohort study was to evaluate the survival of tuberosity and pterygoid implants in patients with posterior maxillary atrophy. MATERIAL AND METHODS A nonprobability convenient sample of patients who had received fixed prostheses on implants placed in the maxillary tuberosity or pterygoid regions was analyzed retrospectively. Demographic variables included sex (male, female) and age. Implant-related variables included surface characteristics, site of placement, implant design, length, diameter, and anteroposterior insertion angle. Prosthetic-related variables included the type of reconstruction for rehabilitation and loading protocols. Implant survival, complications, crestal bone loss, and follow-up intervals were also documented. Collected data were analyzed at both patient and implant levels. The demographics and implant characteristics of patients receiving pterygoid or tuberosity implants were analyzed with a statistical software program (α=.05). Survival analysis was estimated by using the nonparametric Kaplan-Meier curve. RESULTS A total of 119 patients had 183 pterygoid or tuberosity implants inserted. Most implants in the pterygoid region (71.5%) were Ø4.1 mm (87.4%) and 15 mm in length (60.1%). The most common prostheses were complete maxillary reconstructions (49.2%) with late loading (74.3%). The average implant anteroposterior insertion angle was 60.8 degrees. The cumulative survival rate was 97.3% (n=178) during the mean follow-up period of 57 months (range 1 to 168 months). Among all implants placed, 2.7% failed (n=5) within 2 months of their placement. The statistically significant differences noted between tuberosity and pterygoid implants were related to design, surface characteristics, and loading. The average crestal bone loss was 1.5 mm. CONCLUSIONS The survival of the implants placed in the maxillary tuberosity and pterygoid regions was high in patients with posterior maxillary atrophy.
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Affiliation(s)
- Vitomir S Konstantinović
- Professor, Clinic of Maxillofacial Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia
| | - Hani Abd-Ul-Salam
- Adjunct Professor, Department of Population Oral Health, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Canada; and Professor, Department of Diagnostic and Oral Surgical Dental Sciences, Faculty of Dentistry, Gulf Medical University, College of Dentistry, Ajman, Ajman, United Arab Emirates.
| | - Drago Jelovac
- Associate Professor, Clinic of Maxillofacial Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia
| | - Filip Ivanjac
- Research Associate, Clinic of Maxillofacial Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia
| | - Biljana Miličić
- Professor, Department of Medical Statistics and Informatics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia
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Ayele S, Sharo N, Chrcanovic BR. Marginal bone loss around dental implants: comparison between diabetic and non-diabetic patients-a retrospective clinical study. Clin Oral Investig 2023; 27:2833-2841. [PMID: 36715774 PMCID: PMC10264467 DOI: 10.1007/s00784-023-04872-z] [Citation(s) in RCA: 8] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/09/2022] [Accepted: 01/22/2023] [Indexed: 01/31/2023]
Abstract
OBJECTIVES The aim of the present retrospective study was to compare the marginal bone loss (MBL) around dental implants in a group of diabetic patients in relation to a matched group of non-diabetic patients. MATERIALS AND METHODS The present dental record-based retrospective study included patients selected from individuals treated with dental implants at one specialist clinic in Malmö, Sweden. Patients were excluded if they had history of periodontitis and/or were treated for periodontal disease. The study group included 710 implants installed in 180 patients (mean age 60.3±13.0 years), 349 implants in 90 diabetic (21 T1DM and 69 T2DM patients), and 361 implants in 90 non-diabetic patients. RESULTS The results suggested that jaw (greater MBL in the maxilla), diabetes (greater MBL for diabetic patients, and worse for T1DM patients), bruxism (greater MBL for bruxers), and smoking (greater MBL for smokers and former smokers) had a statistically significant influence on MBL over time. CONCLUSIONS Patients with diabetes have an estimated greater MBL over time compared to non-diabetic patients. The difference was greater in patients with diabetes type 1 compared to patients with diabetes type 2. Bruxism, smoking, and implant location (maxilla) were also associated with a higher loss of marginal bone around implants over time. CLINICAL RELEVANCE Awareness of the possible influence of diabetes on the long-term outcomes of dental implant treatment is important, in order to be able to minimize the possibility of a high MBL with time, which can eventually lead to the loss of the implant.
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Affiliation(s)
- Sarah Ayele
- Faculty of Odontology, Malmö University, Malmö, Sweden
| | - Nora Sharo
- Faculty of Odontology, Malmö University, Malmö, Sweden
| | - Bruno Ramos Chrcanovic
- Department of Prosthodontics, Faculty of Odontology, Malmö University, Carl Gustafs väg 34, SE-214 21 Malmö, Sweden
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Alhaija ESA, Al-Areqi MM, AlShami R, Al Maaitah EF, Wahadni AA. Effect of piezocision-assisted lower second molar protraction on periodontal tissues, alveolar bone height, and lower second molar root resorption. Angle Orthod 2023; 93:306-312. [PMID: 36762903 PMCID: PMC10117208 DOI: 10.2319/090622-621.1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/01/2022] [Accepted: 12/01/2022] [Indexed: 02/11/2023] Open
Abstract
OBJECTIVES To assess the effect of piezocision on periodontal tissues and alveolar bone height and to detect lower second molar root resorption in piezocision-assisted mandibular second molar protraction compared to no-piezocision molar protraction. MATERIALS AND METHODS Twenty-one subjects (four males, 17 females, aged 22.43 ± 2.83 years) who presented with bilateral extraction of lower first molars were included. The patients were divided into two groups; Group 1: Piezocision-assisted molar protraction (right or left side of subjects) in which piezocision was performed immediately before lower second molar protraction and, Group 2: No-piezocision molar protraction in which lower second molar protraction was not surgically assisted. Plaque index (PI), gingival index (GI), periodontal pocket depth (PPD), width of keratinized gingiva (WKG), gingival recession (GR), lower second molar mesial root resorption, alveolar bone height, and mandibular bone height were recorded at T1 (immediately before molar protraction) and at T2 (after second molar space closure). RESULTS In the piezocision-assisted molar protraction group, significant changes were detected in the WKG (P < .001), GR (P < .05), and the mandibular bone height (P < .001). Compared to the no-piezocision group, piezocision-assisted molar protraction resulted in an increased WKG (P < .001) and less second molar mesial root resorption (P < .01). CONCLUSIONS Piezocision does not have any detrimental effect on the periodontium and produces less root resorption.
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Lemos CAA, de Oliveira AS, Faé DS, Oliveira HFFE, Del Rei Daltro Rosa CD, Bento VAA, Verri FR, Pellizzer EP. Do dental implants placed in patients with osteoporosis have higher risks of failure and marginal bone loss compared to those in healthy patients? A systematic review with meta-analysis. Clin Oral Investig 2023:10.1007/s00784-023-05005-2. [PMID: 37043030 DOI: 10.1007/s00784-023-05005-2] [Citation(s) in RCA: 24] [Impact Index Per Article: 12.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/12/2022] [Accepted: 03/28/2023] [Indexed: 04/13/2023]
Abstract
PURPOSE This systematic review and meta-analysis aimed to compare the dental implant survival rate and marginal bone loss between patients with and without osteoporosis. MATERIALS AND METHODS This systematic review was registered in PROSPERO (CRD42022356377). A systematic search was performed using five databases: MEDLINE/PubMed, Web of Science, Scopus, Embase, and ProQuest for articles published up to July 2022. Additional searches in ClinicalTrials.gov and the reference lists of included studies were performed. The eligibility criteria comprised observational studies with a direct comparison between patients with and without osteoporosis, with a minimum follow-up of 1 year and 10 implants placed in each group, which consider data analysis based on implant level, without restrictions on period or language of publication. The meta-analysis was performed using RevMan 5.4 program. Risk of bias analysis of the included studies was performed using the Newcastle-Ottawa scale (NOS). RESULTS Twelve studies met the eligibility criteria, totaling 1132 patients with a mean age range from 54 to 76.6 years. Most of the included patients were women (73.6%). A total of 3505 implants were evaluated-983 in patients with osteoporosis and 2522 in patients without osteoporosis. The meta-analysis indicated no difference in implant survival rates between patients with and without osteoporosis (OR, 1.78; 95% confidence interval [CI], 0.86-3.70; P = 0.12). However, significant bone loss was observed around dental implants placed in patients with osteoporosis (SMD, 0.71 mm; 95% CI, 0.06-0.87 mm). The NOS indicated a low risk of bias in the studies included. However, the certainty of the evidence was classified as very low and low for implant survival rates and bone loss, respectively. CONCLUSION According to the limitations of the present review, the data suggest that dental implants are a viable treatment option for the rehabilitation of patients with osteoporosis. However, clinical care by professionals is necessary to ensure the maintenance of peri-implant bone stability, as these patients may be susceptible to increased bone loss.
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Affiliation(s)
- Cleidiel Aparecido Araujo Lemos
- Department of Dentistry, Federal University of Juiz de Fora (UFJF), Campus Avançado Governador Valadares, Governador Valadares, Minas Gerais, Brazil.
| | - Andreza Soares de Oliveira
- Department of Dentistry, Federal University of Juiz de Fora (UFJF), Campus Avançado Governador Valadares, Governador Valadares, Minas Gerais, Brazil
| | - Daniele Sorgatto Faé
- Postgraduate Program in Applied Health Sciences (PPGCAS), Federal University of Juiz de Fora (UFJF), Campus Avançado Governador Valadares, Governador Valadares, Minas Gerais, Brazil
| | | | - Cleber Davi Del Rei Daltro Rosa
- Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba, SP, Brazil
| | - Victor Augusto Alves Bento
- Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba, SP, Brazil
| | - Fellippo Ramos Verri
- Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba, SP, Brazil
| | - Eduardo Piza Pellizzer
- Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP-Univ Estadual Paulista, Araçatuba, SP, Brazil
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Zhao J, Zhou YH, Zhao YQ, Gao ZR, Ouyang ZY, Ye Q, Liu Q, Chen Y, Tan L, Zhang SH, Feng Y, Hu J, Dusenge MA, Feng YZ, Guo Y. Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering. Stem Cell Res Ther 2023; 14:39. [PMID: 36927449 PMCID: PMC10022059 DOI: 10.1186/s13287-023-03265-z] [Citation(s) in RCA: 18] [Impact Index Per Article: 9.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/17/2022] [Accepted: 03/06/2023] [Indexed: 03/18/2023] Open
Abstract
BACKGROUND Jaw-bone defects caused by various diseases lead to aesthetic and functional complications, which can seriously affect the life quality of patients. Current treatments cannot fully meet the needs of reconstruction of jaw-bone defects. Thus, the research and application of bone tissue engineering are a "hot topic." As seed cells for engineering of jaw-bone tissue, oral cavity-derived stem cells have been explored and used widely. Models of jaw-bone defect are excellent tools for the study of bone defect repair in vivo. Different types of bone defect repair require different stem cells and bone defect models. This review aimed to better understand the research status of oral and maxillofacial bone regeneration. MAIN TEXT Data were gathered from PubMed searches and references from relevant studies using the search phrases "bone" AND ("PDLSC" OR "DPSC" OR "SCAP" OR "GMSC" OR "SHED" OR "DFSC" OR "ABMSC" OR "TGPC"); ("jaw" OR "alveolar") AND "bone defect." We screened studies that focus on "bone formation of oral cavity-derived stem cells" and "jaw bone defect models," and reviewed the advantages and disadvantages of oral cavity-derived stem cells and preclinical model of jaw-bone defect models. CONCLUSION The type of cell and animal model should be selected according to the specific research purpose and disease type. This review can provide a foundation for the selection of oral cavity-derived stem cells and defect models in tissue engineering of the jaw bone.
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Affiliation(s)
- Jie Zhao
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Ying-Hui Zhou
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China.,National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China
| | - Ya-Qing Zhao
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Zheng-Rong Gao
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Ze-Yue Ouyang
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Qin Ye
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Qiong Liu
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Yun Chen
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Li Tan
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Shao-Hui Zhang
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Yao Feng
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Jing Hu
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Marie Aimee Dusenge
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China
| | - Yun-Zhi Feng
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China.
| | - Yue Guo
- Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China.
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Hassan NA, Al-Jaboori ASK, Al-Radha ASD, Ali MQ, Albayati RM. CBCT Analysis of Edentulous Mandibular Symphysis in Iraqi Patients for Treatment with Implant-Supported Overdentures. Cross-Sectional Single-Center Study. Clin Cosmet Investig Dent 2023; 15:79-87. [PMID: 37162817 PMCID: PMC10164380 DOI: 10.2147/ccide.s410620] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/14/2023] [Accepted: 04/29/2023] [Indexed: 05/11/2023] Open
Abstract
Background Overdentures supported by dental implants are a useful treatment strategy for patients with edentulous mandibles. The aim of this study was to evaluate certain characteristics of the mandibular symphyseal edentulous cases for dental implant treatment using CBCT; and if it is associated with gender differences. Methods Ninety patients (45 females and 45 males) were included in this investigation. A section along the midline of each CBCT image was chosen for the edentulous symphyseal area. Symphysis height, width, and cortical thickness was measured for each patient. Bone density were calculated at four points A two-sample Student's t-test and Pearson correlation were used for statistical analysis. Results Males had a considerably greater symphysis height (26.66±6.21 mm) than females (24.07±5.00 mm) (p = 0.02). Similar results were found for bone width; males had greater means than females. In case of cortical bone thickness; males had thicker bone cortex in the buccal region than females (p = 0.01). While the difference in bone density between genders was small. However, a positive relationship was recorded between symphysis height and width. Conclusion Height and width of the mandibular symphysis were influenced by gender in edentulous patients, with men showing higher measurements. The reduction of symphyseal height decreased concurrently with the width after teeth were lost, while bone density was maintained in both genders with no difference between them. The lingual cortical bone is significantly thicker than the buccal cortex at the lower part of the symphysis.
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Affiliation(s)
- Nuhad A Hassan
- Department of Oral Medicine, College of Dentistry, Mustansiriyah University, Baghdad, Iraq
| | | | - Afya Sahib Diab Al-Radha
- Oral Surgery and Periodontology Department, College of Dentistry, Mustansiriyah University, Baghdad, Iraq
- Correspondence: Afya Sahib Diab Al-Radha, Oral Surgery and Periodontology Department; College of Dentistry, Al- Mustansiriyah University, Central Baghdad Post Office, Post Box (P.o.) 55418, Baghdad, Iraq, Tel +964(0)7816883387, Fax +964(0)0115372237, Email ;
| | - Maisaa Q Ali
- Department of Dental Radiology, Al-Falah Center, Ministry of Health, Baghdad, Iraq
| | - Raya M Albayati
- Department of Dental Radiology, Al-Falah Center, Ministry of Health, Baghdad, Iraq
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Finite-Element Analysis of the Effect of Utilizing Various Material Assemblies in “All on Four” on the Stresses on Mandible Bone and Prosthetic Parts. INT J POLYM SCI 2022. [DOI: 10.1155/2022/4520250] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022] Open
Abstract
Background. Fixed prostheses often utilize the “All-on-four” technique, in which four implants are inserted into the jaw bone, and a framework supports them. Titanium is usually used in the fabrication of “All-on-four” parts, due to its superior mechanical properties; however, it has drawbacks such as aesthetic impairment, casting issues, stress shielding, and incompatibility with imaging techniques. These drawbacks have motivated researchers to find alternative materials such as polymers. Recently, the new polymeric material PEEK has a major role in most areas of dentistry, and therefore, it can represent an alternative biomaterial to overcome the drawbacks of titanium. The density of bone is expected to influence the choice of “All-on-four” materials. Purpose. This research applied finite-element investigations to evaluate the stresses on bone tissues and prosthetic parts in “All on four,” utilizing three assemblies of materials, in normal and low bone densities. These assemblies were titanium (Type 1), titanium/PEEK (Type 2), and PEEK (Type 3). Materials and Methods. A 3D Mandibular model was constructed with a fixed prosthesis, and three assemblies of materials were stimulated, under 300 N unilateral force. The von Mises stresses were computed for the prosthetic parts and mucosa, while the maximum and minimum principal stresses/strains were computed for bone tissues due to their brittle and ductile properties. Moreover, the displacements of implants were extracted to check the prosthesis stability. Results. Type 2 and Type 3 minimized the stresses on frameworks, implants, abutments, and bone tissues, however, increased the mucosal stress, in comparison to Type 1. In the low-density model, Type 3 was recommended to reduce the stresses/strains on bone tissues and decrease the implant displacement, avoiding bone failure and increasing prosthesis stability. Conclusions. The bone density influenced the choice of “All-on-four” assembly. Moreover, further research on PEEK implants and abutments is required in the future.
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Parrish J, Gohel-Andrews K, Ganesan K. Management of palatally ectopic canines part 1: Importance of histological developmental understanding in improving outcomes. ADVANCES IN ORAL AND MAXILLOFACIAL SURGERY 2022. [DOI: 10.1016/j.adoms.2022.100348] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/14/2022] Open
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Ku JK, Han M, Yongvikul A, Huh JK, Kim JY. Volumetric analysis of spontaneous bone healing after jaw cyst enucleation. Sci Rep 2022; 12:14953. [PMID: 36056044 PMCID: PMC9440199 DOI: 10.1038/s41598-022-16921-w] [Citation(s) in RCA: 12] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/09/2021] [Accepted: 07/18/2022] [Indexed: 11/08/2022] Open
Abstract
The purpose of this study is to evaluate the degree of spontaneous bone healing after cyst enucleation as well as its contributing factors. Pre- and post-operative computed tomography (CT) scans of consecutive patients who had undergone jaw cyst enucleation were retrospectively analyzed. The outcome variable was healing ratio, which was calculated using the volume of the cyst before surgery and the volume of the defect in the bone after surgery. Predictor variables including duration of observation, pre-operative cyst size, age, gender, and involved jaw were analyzed to determine their influence. Forty-four subjects (30 Male and 14 Female, average 40.7 ± 15.7 years) were included in this study. Healing ratio was significantly lower during the first year (33.5 ± 32.8%) compared to the second (74.5 ± 24.2%) and subsequent years (74.2 ± 17.8%). In 35 patients who had follow-ups of over 1 year, the healing ratio was not affected by the pre-operative cyst size and upper/lower jaw except gender (p = 0.037, female > male) and age (p = 0.021, younger than 30 years > 30 years and older). The residual defect was significant larger in cysts 3 cc or larger (1.64 ± 1.54 cc) compared to smaller cysts (0.43 ± 0.42 cc, p = 0.006). The residual defect volume of large cysts was similar to those of the pre-operative volume of small cysts (1.47 ± 0.72 cc). In conclusion, spontaneous bone healing ratio of post-enucleation defects was about 73.5% after 12 months. Large cysts (> 3 cc) had larger defect, comparable to the volume of small cysts, but with altered contour. Additional treatment such as a bone graft may be considered especially in large cysts.
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Affiliation(s)
- Jeong-Kui Ku
- Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University Health Service, Seoul, Republic of Korea
| | - Michael Han
- Department of Oral and Maxillofacial Surgery, University of Illinois Chicago, Illinois, USA
| | - Atapol Yongvikul
- Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University College of Dentistry, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea
- Department of Oral and Maxillofacial Surgery, Masterpiece Hospital, Bangkok, Thailand
| | - Jong-Ki Huh
- Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University College of Dentistry, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea
| | - Jae-Young Kim
- Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University College of Dentistry, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea.
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Enteghad S, Golfeshan F, Sardarian A, Navaei H. A Comparison of Lower Dental Arch Changes Using Two Types of Space Regainers: A Removable Appliance with a Distalizing Screw and a Fixed Double-Banded Appliance. Int J Dent 2022; 2022:4699516. [PMID: 35469344 PMCID: PMC9034949 DOI: 10.1155/2022/4699516] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/18/2022] [Accepted: 03/31/2022] [Indexed: 11/29/2022] Open
Abstract
Aim The aim of this study was to compare lower dental arch changes using two types of space regainers, including a removable appliance with a distalizing screw and a fixed double-banded appliance. Methods and Materials In this case-control study, the study sample was comprised of thirty-eight children with mixed dentitions, all of whom had unilateral space deficiency due to premature loss of the second deciduous molar in the mandibular arch. Patients were treated with either a removable appliance with a distalizing screw or a fixed double-banded space regainer (DBSR) (n = 19). Pre- and posttreatment dental casts and lateral cephalograms of patients were evaluated to compare the effects of the two space-regaining devices on the mandibular dental arch. The data were analyzed using paired and independent t-tests. Results Available space, molar angle, IMPA, and the first molar distance to the mandibular plane and symphysis increased significantly in both groups (P < 0.001). The mean amount of IMPA changes was significantly greater in the distalizing screw group than in the DBSR group (P < 0.05). But, there were no statistically significant differences between the mean changes of available space, molar angle, and the first molar distance to the mandibular plane and symphysis in the distalizing screw and the DBSR group (P < 0.05). The DBSR group's treatment time was significantly shorter (P < 0.001). Conclusion The removable device with a distalizing screw and the DBSR were both able to regain mild-to-moderate unilateral space loss, achieving an increase in molar angle, IMPA, and molar extrusion. However, treatment time with the DBSR was shorter and with less incisor tipping as a side effect.
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Affiliation(s)
- Shabnam Enteghad
- Orthodontics Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Farzaneh Golfeshan
- Orthodontics Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Ahmadreza Sardarian
- Orthodontics Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Hooman Navaei
- Dental Students' Research Committee, Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
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Kim HJ, Park HS. Influence of late removal after treatment on the removal torque of microimplants. Korean J Orthod 2022; 52:201-209. [PMID: 35418519 PMCID: PMC9117795 DOI: 10.4041/kjod21.217] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/11/2021] [Revised: 12/02/2021] [Accepted: 12/08/2021] [Indexed: 12/04/2022] Open
Abstract
Objective To compare the removal torque of microimplants upon post-use removal and post-retention removal and to assess the influencing factors. Methods The sample group included 241 patients (age, 30.25 ± 12.2 years) with 568 microimplants. They were divided into the post-use (microimplants removed immediately after use or treatment) and post-retention (microimplants removed during the retention period) removal groups. The removal torque in both groups was assessed according to sex, age, placement site and method, and microimplant size. Pearson correlation and multiple linear regression analyses were performed for evaluating variables influencing the removal torque. Results The mean period of total in-bone stay of microimplants in the post-retention removal group (1,237 days) was approximately two times longer than that in the post-use removal group (656.28 days). The removal torques in the post-retention removal group (range, 4–5 N cm) were also higher than those in the post-use removal group. The mandible and pre-drilling groups demonstrated higher placement and removal torques than did the maxilla and no-drilling groups, respectively. In the no-drilling post-use removal group, the placement torque and microimplant length positively correlated with the removal torque. In the post-retention removal group, unloading in-bone stay period and microimplant diameter positively correlated with the removal torque in the no-drilling and pre-drilling methods, respectively. Conclusions The removal torques differed according to the orthodontic loading and removal time of microimplants. With prolonged retention of microimplants inserted using the no-drilling method, the removal torque was clinically acceptable and positively correlated with the unloading in-bone stay period.
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Affiliation(s)
- Ho-Jin Kim
- Department of Orthodontics, School of Dentistry, Kyungpook National University, Daegu, Korea
| | - Hyo-Sang Park
- Department of Orthodontics, School of Dentistry, Kyungpook National University, Daegu, Korea
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Al-Tawachi A, Abu Alhaija ES, Al-Jamal GA. Evaluation of maxillary canine root and maxillary bone thickness and density in patients with displaced maxillary canines: A cone-beam tomography study. Am J Orthod Dentofacial Orthop 2022; 162:318-330. [DOI: 10.1016/j.ajodo.2021.03.025] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/01/2020] [Revised: 03/01/2021] [Accepted: 03/01/2021] [Indexed: 11/01/2022]
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Abu Alhaija ES, Al Shayeb RA, Al-Khateeb S, Daher HO, Daher SO. A comparative assessment of the amount and rate of orthodontic space closure toward a healed vs recent lower premolar extraction site. Angle Orthod 2022; 92:463-470. [PMID: 35344007 DOI: 10.2319/102921-797.1] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/01/2021] [Accepted: 02/01/2022] [Indexed: 11/23/2022] Open
Abstract
OBJECTIVES To investigate and compare the amount and rate of space closure and tooth tipping during orthodontic space closure toward a recent vs healed first premolar extraction site. MATERIALS AND METHODS The mandibular arches of 23 patients were included. Treatment plans included lower first premolar extractions. After reaching 0.019 × 0.025-inch stainless-steel archwires (SSAW), patients were subdivided into two groups (Group 1: space closure was carried out toward a healed first premolar extraction space and Group 2: space closure was carried out immediately after first premolar extraction). Elastomeric power chain from second molar to second molar was used to close lower extraction spaces. The following time points were defined: T1: just before space closure; T2-T4: 1-3 months after initial space closure. Records consisted of dental study models. The amount and rate of extraction space closure were evaluated at each time point. RESULTS In Group 1 (healed socket), a total amount of 1.98 mm (coronally) and 1.75 mm (gingivally) of space closure was achieved. The rate of space closure was 0.66 mm/month coronally and 0.58 mm/month gingivally. In Group 2 (recent socket), the total amount of space closure was 3.02 mm coronally and 2.68 mm gingivally. The rate of space closure was 1.01 mm/month coronally and 0.89 mm/month gingivally. Differences between the two groups were significant (P < .01). Tipping of adjacent teeth during space closure was similar in both groups (P > .05). CONCLUSIONS In the lower arch, the amount and rate of space closure toward a recent extraction site were higher than that toward a healed extraction socket with similar tipping of teeth in both groups.
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Ting M, Alluri LSC, Sulewski JG, Suzuki JB, Paes Batista da Silva A. Laser Treatment of Peri-Implantitis: A Systematic Review of Radiographic Outcomes. Dent J (Basel) 2022; 10:dj10020020. [PMID: 35200245 PMCID: PMC8870827 DOI: 10.3390/dj10020020] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/07/2021] [Revised: 01/18/2022] [Accepted: 01/18/2022] [Indexed: 02/04/2023] Open
Abstract
(1) Background: This systematic review aimed to evaluate the effects of laser therapy on radiographic bone level (RBL) changes in peri-implantitis defects. (2) Methods: A literature search with defined inclusion criteria was performed. PubMed, Web of Science, Cochrane Library, and Google Scholar were searched through September 2020. The evaluated primary outcomes were RBL changes. In studies that reported RBL data, corresponding secondary clinical outcomes were probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL). (3) Results: Thirteen articles were selected for data extraction and risk of bias assessment. Eight studies showed evidence of RBL gain in the laser groups compared to baseline, but did not report the statistical significance. Eight of these 13 studies reported comparisons to control. Five of the eight studies did not show RBL gain in the laser groups compared to control. In the laser groups compared to baseline, 11 of 13 reported reduced PD, and 6 of 13 reported significantly reduced BOP. Compared to the control, eight of the eight reported reduction of PD, and three of six reported significantly reduced BOP. Statistical significance was not consistently reported. (4) Conclusions: Within the limits of this systematic review, laser treatment may promote bone gain in peri-implantitis defects, may reduce BOP and PDs, and may be comparable to mechanical therapy. However, definitive conclusions can only be made with statistically significant data, which were found lacking in the currently available studies. This systematic review was registered with the National Institute for Health Research, international prospective register of systematic reviews (PROSPERO): CRD42020207972.
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Affiliation(s)
- Miriam Ting
- Think Dental Learning Institute, Paoli, PA 19301, USA
- Correspondence:
| | | | - John G. Sulewski
- The Institute for Advanced Dental Technologies, Huntington Woods, MI 48070, USA;
| | - Jon B. Suzuki
- University of Maryland, Baltimore, MD 21201, USA;
- University of Washington, Seattle, WA 98015, USA
- Nova Southeastern University, Ft. Lauderdale, FL 33314, USA
| | - Andre Paes Batista da Silva
- Department of Periodontics, Case Western Reserve University School of Dental Medicine, Cleveland, OH 44106, USA;
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Salar Amoli M, EzEldeen M, Jacobs R, Bloemen V. Materials for Dentoalveolar Bioprinting: Current State of the Art. Biomedicines 2021; 10:biomedicines10010071. [PMID: 35052751 PMCID: PMC8773444 DOI: 10.3390/biomedicines10010071] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/29/2021] [Revised: 12/25/2021] [Accepted: 12/27/2021] [Indexed: 12/19/2022] Open
Abstract
Although current treatments can successfully address a wide range of complications in the dentoalveolar region, they often still suffer from drawbacks and limitations, resulting in sub-optimal treatments for specific problems. In recent decades, significant progress has been made in the field of tissue engineering, aiming at restoring damaged tissues via a regenerative approach. Yet, the translation into a clinical product is still challenging. Novel technologies such as bioprinting have been developed to solve some of the shortcomings faced in traditional tissue engineering approaches. Using automated bioprinting techniques allows for precise placement of cells and biological molecules and for geometrical patient-specific design of produced biological scaffolds. Recently, bioprinting has also been introduced into the field of dentoalveolar tissue engineering. However, the choice of a suitable material to encapsulate cells in the development of so-called bioinks for bioprinting dentoalveolar tissues is still a challenge, considering the heterogeneity of these tissues and the range of properties they possess. This review, therefore, aims to provide an overview of the current state of the art by discussing the progress of the research on materials used for dentoalveolar bioprinting, highlighting the advantages and shortcomings of current approaches and considering opportunities for further research.
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Affiliation(s)
- Mehdi Salar Amoli
- Surface and Interface Engineered Materials (SIEM), Campus Group T, KU Leuven, Andreas Vesaliusstraat 13, 3000 Leuven, Belgium;
- OMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven and Oral and Maxillofacial Surgery, University Hospitals Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium; (M.E.); (R.J.)
| | - Mostafa EzEldeen
- OMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven and Oral and Maxillofacial Surgery, University Hospitals Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium; (M.E.); (R.J.)
- Department of Oral Health Sciences, KU Leuven and Paediatric Dentistry and Special Dental Care, University Hospitals Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
| | - Reinhilde Jacobs
- OMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven and Oral and Maxillofacial Surgery, University Hospitals Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium; (M.E.); (R.J.)
- Department of Dental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden
| | - Veerle Bloemen
- Surface and Interface Engineered Materials (SIEM), Campus Group T, KU Leuven, Andreas Vesaliusstraat 13, 3000 Leuven, Belgium;
- Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
- Correspondence: ; Tel.: +32-16-30-10-95
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Kim HJ, Park HS. Long-term evaluation of factors affecting removal torque of microimplants. Prog Orthod 2021; 22:42. [PMID: 34778924 PMCID: PMC8590991 DOI: 10.1186/s40510-021-00383-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/25/2021] [Accepted: 08/31/2021] [Indexed: 11/20/2022] Open
Abstract
Background The current study aimed to evaluate factors affecting the long-term stability of microimplants using removal torque and the correlation between removal torque and clinical variables. Materials and methods This research evaluated 703 microimplants placed in 354 patients (mean age: 30.4 ± 12.1 years). The removal torque was evaluated according to various clinical variables including sex, age, placement site, microimplant size, and placement method (self-drilling versus pre-drilling). Pearson correlation and stepwise multiple linear regression analyses were performed to investigate different variables and their association with removal torque. Results The mean removal torque was significantly higher in the mandible (4.46 N cm) than in the maxilla (3.73 N cm). The values in the posterior teeth/retromolar areas were significantly higher than those in the anterior teeth area. There were no significant difference in terms of sex. Teenagers had a lower removal torque than older adults in the mandible, but not in the maxilla. Microimplants with a greater length and diameter, except for those with a greater diameter in the maxilla, was associated with a higher removal torque. Regardless of placement torque, the removal torque convergently reached approximately 4 N cm in both placement methods. The removal torque was significantly correlated with screw length in the self-drilling group and with diameter in the pre-drilling group. Conclusions Removal torque was related with placement site, age, placement method, and length and diameter of microimplants.
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Affiliation(s)
- Ho-Jin Kim
- Department of Orthodontics, School of Dentistry, Kyungpook National University, 2175, Dalgubeoldae-ro, Jung-Gu, Daegu, 41940, Korea
| | - Hyo-Sang Park
- Department of Orthodontics, School of Dentistry, Kyungpook National University, 2175, Dalgubeoldae-ro, Jung-Gu, Daegu, 41940, Korea.
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Cha C, Huang D, Kang Q, Yin M, Yan X. The effects of dehiscence and fenestration before orthodontic treatment on external apical root resorption in maxillary incisors. Am J Orthod Dentofacial Orthop 2021; 160:814-824. [PMID: 34481683 DOI: 10.1016/j.ajodo.2020.06.043] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/01/2019] [Revised: 06/01/2020] [Accepted: 06/01/2020] [Indexed: 12/15/2022]
Abstract
INTRODUCTION The objective of this study was to investigate the effects of dehiscence and fenestration on external apical root resorption (EARR) in maxillary incisors. METHODS Seventy-eight patients were selected for this study. We set dehiscence, fenestration, sex, extraction, or nonextraction, tooth position, initial age, and duration of treatment as independent variables and EARR as the dependent variable. General statistical descriptions for these variables were made by mean, standard deviation and occurrence rates, etc. To make the data visualization and find more information, 2 heat maps were made. Generalized estimation equation analysis was performed to determine associations between EARR and independent variables. RESULTS The occurrence rates of dehiscence and fenestration in maxillary incisors were 14.77% and 10.74%, respectively. The average value of EARR was 1.09 ± 0.87 mm in this study. Dehiscence, tooth position, extraction, initial age, and duration had significant correlations with EARR. The ratio of exponent B was 1:1.643 for dehiscence and nondehiscence, whereas fenestration and sex had no significant association with EARR. CONCLUSIONS The amount of EARR at maxillary incisors in patients with dehiscence before orthodontic treatment might be less than that in patients without it, and different incisors might have different contributions to it. However, the low value of exponent B for dehiscence meant that there might be other unknown factors that were involved in this study.
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Affiliation(s)
- Chang Cha
- Department of Orthodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, Liaoning, China
| | - Desheng Huang
- Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning, China
| | - Qichao Kang
- Department of Orthodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, Liaoning, China
| | - Manman Yin
- Department of Orthodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, Liaoning, China
| | - Xiulin Yan
- Department of Orthodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, Liaoning, China.
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Li QL, Yao MF, Cao RY, Zhao K, Wang XD. Survival Rates of Splinted and Nonsplinted Prostheses Supported by Short Dental Implants (≤8.5 mm): A Systematic Review and Meta-Analysis. J Prosthodont 2021; 31:9-21. [PMID: 34160869 DOI: 10.1111/jopr.13402] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 06/20/2021] [Indexed: 12/15/2022] Open
Abstract
PURPOSE To evaluate and compare the implant survival rates, marginal bone loss, and mechanical complications of prostheses supported by splinted and nonsplinted short implants (≤8.5 mm). MATERIAL AND METHODS Electronic database (MEDLINE, CENTRAL, Web of Science, and EMBASE) and manual searches up to May 2021 were conducted to identify studies comparing splinted and nonsplinted short implants (≤8.5 mm). The primary outcome was implant survival rate. Secondary outcomes were marginal bone loss and mechanical complications. The quality of included studies and risk-of-bias were assessed according to the Newcastle-Ottawa Scale. A random-effects model was used to analyze the data. RESULTS Twelve studies fulfilled the inclusion criteria and featured 1506 short implants (596 nonsplinted and 910 splinted) with a follow-up time ranging from 1 to 16 years. Quantitative analysis found no statistically significant differences between splinted and nonsplinted short implants (≤8.5 mm) for survival rate (RR = 0.98; 95% CI 0.96, 1.01; p = 0.26)) and marginal bone loss (SMD = -0.08; 95% CI - 0.23, 0.07; p = 0.28). Veneer chipping, abutment screw breakage, screw loosening, and loss of retention were reported in the selected studies as common complications. However, no statistically significant difference was found between splinted and nonsplinted short implants (RR = 0.56; 95% CI 0.20, 1.54; p = 0.26). CONCLUSIONS Within the limitations of the present meta-analysis, it might be concluded that splinted short implants (≤8.5 mm) do not present superior performance in survival rate, marginal bone maintenance and prevention of mechanical complications compared with single-unit prostheses.
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Affiliation(s)
- Qiu-Lan Li
- Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong, China.,Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, China
| | - Mian-Feng Yao
- Xiangya Hospital Central South University, Department of Stomatology, Changsha, Hunan, China
| | - Ruo-Yan Cao
- Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong, China.,Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, China
| | - Ke Zhao
- Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong, China.,Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, China
| | - Xiao-Dong Wang
- Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong, China.,Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, China
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Michelogiannakis D, Jabr L, Barmak AB, Rossouw PE, Kotsailidi EA, Javed F. Influence of low-level-laser therapy on the stability of orthodontic mini-screw implants. A systematic review and meta-analysis. Eur J Orthod 2021; 44:11-21. [PMID: 34114609 DOI: 10.1093/ejo/cjab016] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/11/2022]
Abstract
BACKGROUND The influence of low-level-laser therapy (LLLT) on the stability of orthodontic mini-screw implants (MSIs) has not been systematically reviewed. OBJECTIVES The aim was to assess the influence of LLLT on the stability of orthodontic MSIs. METHODS An unrestricted search of indexed databases was performed. SELECTION CRITERIA Randomized controlled clinical trials (RCTs) investigating the influence of LLLT on orthodontic MSI stability. DATA COLLECTION AND ANALYSIS Two authors independently performed study retrieval and selection, and data extraction. The risk of bias (RoB) of individual studies was assessed using the Cochrane RoB Tool for RCTs. Meta-analyses were performed separately for RCTs using periotest and resonance frequency analysis (RFA) to measure MSI stability; and a random effects model was applied. Subgroup analyses were performed based on the time-points of MSI stability evaluation. The quality of available evidence was evaluated using the Grades of Recommendation, Assessment, Development, and Evaluation approach. RESULTS Initially, 1332 articles were screened. Six RCTs with a split-mouth design were included. The periotest was used in 4 RCTs and 2 RCTs used RFA to measure MSI stability. All RCTs had a low RoB. Subgroup analyses based on periotest indicated that MSIs treated with LLLT had significantly higher stability than untreated MSIs at 21 and 30 days [weighted mean difference (MD) = -2.76, confidence interval (CI): [-4.17, -1.36], P-value = 0.0001) and at 60 days (weighted MD = -3.47, CI: [-4.58, -2.36], P < 0.00001); and the level of certainty was high. Subgroup analyses based on RFA showed higher stability of MSIs treated with than without LLLT at 56 and 60 days (standardized MD = 0.82, CI: [0.32, 1.32], P = 0.001), and at 70 and 90 days (standardized MD = 0.86, CI: [0.36, 1.36], P = 0.0007); and the level of certainty was moderate. LIMITATIONS Due to limited number of relevant studies, it was not possible to perform sensitivity analysis, subgroup analyses for patient and intervention-related characteristics, and reporting biases assessment. CONCLUSIONS The role of LLLT on the secondary stability of MSIs placed in patients undergoing OT remains debatable. CLINICAL TRIAL REGISTRATION PROSPERO (CRD42021230291).
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Affiliation(s)
- Dimitrios Michelogiannakis
- Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, New York, USA
| | - Luay Jabr
- Department of Dentistry, Eastman Institute for Oral Health, University of Rochester, New York, USA
| | - Abdul Basir Barmak
- Department of Dentistry, Eastman Institute for Oral Health, University of Rochester, New York, USA
| | - Paul Emile Rossouw
- Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, New York, USA
| | - Elli Anna Kotsailidi
- Department of Periodontology, Eastman Institute for Oral Health, University of Rochester, New York, USA
| | - Fawad Javed
- Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, New York, USA
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A Parametric Study on a Dental Implant Geometry Influence on Bone Remodelling through a Numerical Algorithm. PROSTHESIS 2021. [DOI: 10.3390/prosthesis3020016] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/26/2022]
Abstract
To ensure the long-term success of a dental implant, it is imperative to understand how chewing loads are transferred through the implant prosthetic components to the surrounding bone tissue. The stress distribution depends on several factors, such as load type, bone–implant interface, shape and materials of the fixture and quality and quantity of the bone. These aspects are of fundamental importance to ensure implant stability and to evaluate the remodelling capacity of the bone tissue to adapt to its biomechanical environment. A bone remodelling algorithm was formulated by the authors and implemented by means of finite element simulations on four different implants with several design characteristics. Internal bone microstructure and density, apposition/resorption of tissue and implant stability were evaluated over a period of 12 months, showing the influence of the geometry on bone tissue evolution over time. Bone remodelling algorithms may be a useful aid for clinicians to prevent possible implant failures and define an adequate implant prosthetic rehabilitation for each patient. In this work, for the first time, external bone remodelling was numerically predicted over time.
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Mishra SK, Nahar R, Gaddale R, Chowdhary R. Identification of anterior loop in different populations to avoid nerve injury during surgical procedures-a systematic review and meta-analysis. Oral Maxillofac Surg 2021; 25:159-174. [PMID: 33118108 DOI: 10.1007/s10006-020-00915-x] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/02/2020] [Accepted: 10/21/2020] [Indexed: 11/29/2022]
Abstract
Exact recognition of the anterior loop is very important to avert any injury to the neurovascular bundle during surgical procedures. The purpose of this review was to evaluate the prevalence and length of the anterior loop in different populations. A comprehensive search of Medline/Pubmed and Cochrane database was done. The focused question was the presence of anterior loop (including loop length) of the inferior alveolar nerve in mental foramen region in CBCT images of the various subjects. Articles related to the presence of anterior loop (including loop length) were only included. Initial literature search resulted in 3024 papers, after removing duplicate articles, 2821 articles were left. Two thousand seven hundred eighty-four articles were further excluded by the reviewers after screening the abstracts which resulted in 37 studies. Hand searching resulted in 2 additional papers. Seven full-text articles were excluded for not fulfilling the inclusion criteria. Finally, 32 articles were included in the review. Two thousand five hundred three subjects with anterior loop were found, which approximates 38% with 48.4% bilateral, 27.8% right side, and 23.8% left side. The loop distribution in males and females was also found to be different. There was highly significant (P < 0.001; I2 = 98.81%) heterogeneity found in the included studies. Variations were found in the prevalence, length, gender, and side distribution of anterior loop in various populations. This systematic review highly recommends not relying on any average values and the clinician should compulsorily make use of imaging modalities available in each and every case, wherever surgical procedure is to be performed near mental foramen region.
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Affiliation(s)
- Sunil Kumar Mishra
- Department of Prosthodontics, Peoples College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
| | - Rajvi Nahar
- Department of Prosthodontics, Peoples College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India
| | - Reetika Gaddale
- Department of Periodontology, AME'S Dental College and Hospital, Raichur, Karnataka, India
| | - Ramesh Chowdhary
- Department of Prosthodontics, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India
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Arvind Tr P, Jain RK. Computed tomography assessment of maxillary bone density for orthodontic mini-implant placement with respect to vertical growth patterns. J Orthod 2021; 48:392-402. [PMID: 34053366 DOI: 10.1177/14653125211020015] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]
Abstract
OBJECTIVE To quantitatively measure and report bone density of maxilla in the interradicular (alveolar and basal bone) and infrazygomatic crest (IZC) region in various growth patterns among Dravidian individuals. DESIGN This was a retrospective spiral computed tomography (CT) study. SETTING The study was conducted at the Department of Orthodontics, Saveetha Dental College and Hospital, Tamil Nadu, India. METHODS Sixty CT scans (24 men, 36 women; mean age = 25.3 years and 23.8 years, respectively) divided equally into three groups based on vertical facial proportions were included. Bone density measurements in Hounsfield units (HU) were performed using Philips and RadiAnt DICOM viewers. Buccal cortical, palatal cortical and cancellous bone regions were analysed in a Philips DICOM viewer and IZC region was analysed in a RadiAnt DICOM viewer. Statistical analysis with one-way ANOVA and post-hoc Tukey HSD test was done. RESULTS The hypodivergent group had a significantly higher bone density at the buccal cortex in posterior region (P < 0.05) when compared to the normodivergent and hyperdivergent groups. Buccal basal bone was denser than buccal alveolar bone (P < 0.05) in all three groups. In the IZC region, hypodivergent groups had significantly higher density values when compared to the normodivergent and hyperdivergent groups (P < 0.05). CONCLUSION The present study concluded that cancellous bone density in the interradicular regions was greatest in the anterior sites and was not influenced by growth pattern. Hypodivergent groups tend to have higher density in the posterior regions (buccal and palatal cortical bone) and at the IZC region compared to normodivergent and hyperdivergent groups.
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Affiliation(s)
- Prasanna Arvind Tr
- Department of Orthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, India
| | - Ravindra Kumar Jain
- Department of Orthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, India
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Choi JY, Kim MJ, Kim SH, Chung KR, Nelson G. Effect of Different Head Hole Position on the Rotational Resistance and Stability of Orthodontic Miniscrews: A Three-Dimensional Finite Element Study. SENSORS 2021; 21:s21113798. [PMID: 34070904 PMCID: PMC8198358 DOI: 10.3390/s21113798] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 04/26/2021] [Revised: 05/26/2021] [Accepted: 05/27/2021] [Indexed: 12/26/2022]
Abstract
The orthodontic miniscrew is driven into bone in a clockwise direction. Counter-clockwise rotational force applied to the implanted miniscrew can degrade the stability. The purpose of this three-dimensional finite element study was to figure out the effect of shifting the miniscrew head hole position from the long axis. Two miniscrew models were developed, one with the head hole at the long axis and the other with an eccentric hole position. One degree of counter-clockwise rotation was applied to both groups, and the maximum Von-Mises stress and moment was measured under various wire insertion angles from −60° to +60°. All Von-Mises stress and moments increased with an increase in rotational angle or wire insertion angle. The increasing slope of moment in the eccentric hole group was significantly higher than that in the centric hole group. Although the maximum Von-Mises stress was higher in the eccentric hole group, the distribution of stress was not very different from the centric hole group. As the positive wire insertion angles generated a higher moment under a counter-clockwise rotational force, it is recommended to place the head hole considering the implanting direction of the miniscrew. Clinically, multidirectional and higher forces can be applied to the miniscrew with an eccentric head hole position.
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Affiliation(s)
- Jin-Young Choi
- Department of Orthodontics, Kyung Hee University Dental Hospital, Seoul 02447, Korea;
| | - Min-Jung Kim
- Department of Convergence Medicine, Asan Medical Center, Asan Medical Institute of Convergence Science and 8 Technology, Seoul 02447, Korea;
| | - Seong-Hun Kim
- Department of Orthodontics, Graduate School of Dentistry, Kyung Hee University, Seoul 02447, Korea;
- Correspondence:
| | - Kyu-Rhim Chung
- Department of Orthodontics, Graduate School of Dentistry, Kyung Hee University, Seoul 02447, Korea;
| | - Gerald Nelson
- Division of Orthodontics, Department of Orofacial Science, University of California, San Francisco, CA 94143, USA;
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Gasik M, Lambert F, Bacevic M. Biomechanical Properties of Bone and Mucosa for Design and Application of Dental Implants. MATERIALS 2021; 14:ma14112845. [PMID: 34073388 PMCID: PMC8199480 DOI: 10.3390/ma14112845] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 05/05/2021] [Revised: 05/22/2021] [Accepted: 05/24/2021] [Indexed: 12/20/2022]
Abstract
Dental implants’ success comprises their proper stability and adherence to different oral tissues (integration). The implant is exposed to different mechanical stresses from swallowing, mastication and parafunctions for a normal tooth, leading to the simultaneous mechanical movement and deformation of the whole structure. The knowledge of the mechanical properties of the bone and gingival tissues in normal and pathological conditions is very important for the successful conception of dental implants and for clinical practice to access and prevent potential failures and complications originating from incorrect mechanical factors’ combinations. The challenge is that many reported biomechanical properties of these tissues are substantially scattered. This study carries out a critical analysis of known data on mechanical properties of bone and oral soft tissues, suggests more convenient computation methods incorporating invariant parameters and non-linearity with tissues anisotropy, and applies a consistent use of these properties for in silico design and the application of dental implants. Results show the advantages of this approach in analysis and visualization of stress and strain components with potential translation to dental implantology.
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Affiliation(s)
- Michael Gasik
- School of Chemical Engineering, Aalto University Foundation, 02150 Espoo, Finland
- Correspondence:
| | - France Lambert
- Dental Biomaterials Research Unit, University of Liege, 4000 Liège, Belgium; (F.L.); (M.B.)
| | - Miljana Bacevic
- Dental Biomaterials Research Unit, University of Liege, 4000 Liège, Belgium; (F.L.); (M.B.)
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Alexopoulou M, Lambert F, Knafo B, Popelut A, Vandenberghe B, Finelle G. Immediate implant in the posterior region combined with alveolar ridge preservation and sealing socket abutment: A retrospective 3D radiographic analysis. Clin Implant Dent Relat Res 2021; 23:61-72. [PMID: 33438320 DOI: 10.1111/cid.12974] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/17/2020] [Revised: 12/02/2020] [Accepted: 12/17/2020] [Indexed: 02/02/2023]
Abstract
BACKGROUND Customized sealing socket abutment (SSA) has been claimed to optimize the peri-implant hard and soft tissues in type 1 implant placement. However, the evidence to claim the benefits of this technique over the use a conventional healing abutment remains weak. PURPOSE The aim of this retrospective study was to provide a 3D-radiographic evaluation of hard tissues changes following immediate implant placement in molar sites combined to ARP technique and installation of SSA. MATERIALS AND METHODS Baseline and follow-up (FU) CBCTs (from 1 to 5 years) of 26 patients were collected and included in the study. Baseline and FU CBCTs were superimposed and horizontal and vertical bone changes were assessed. RESULTS A total of 26 patients and 27 implants were included. Horizontal bone remodeling was not significant in any of the measured areas except in the most cervical level, where a mean bone remodeling of 0.73 mm was found. Proximal and buccal vertical bone changes were not significant. CONCLUSIONS Within the limits of a retrospective study, dimensional alveolar ridge changes 1 to 5 years after immediate implant placement in molar sites with simultaneous ARP technique and installation of SSA seem to be very limited.
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Affiliation(s)
- Marianzela Alexopoulou
- Department of Periodontology and Oral and implant Surgery, Faculty of Medicine, University of Liege, Liege, Belgium
| | - France Lambert
- Dental Biomaterial Research Unit, University of Liege, Liege, Belgium.,Department of Periodontology and Oral and Implant Surgery, CHU of Liege, Liege, Belgium
| | | | - Antoine Popelut
- Department of Periodontology, Pellegrin Hospital, Bordeaux Private Practice, Odontia, Bordeaux, France
| | | | - Gary Finelle
- Harvard School, Boston, MA, USA, of Dental Medicine, Private Practice Paris & Marseille, Marseille, France
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Chuang YH, Chen JH, Ho KH, Wang KL, Hsieh SC, Chang HM. The role of micro-implant-assisted rapid palatal expansion (MARPE) in clinical orthodontics — a literature review. AUSTRALASIAN ORTHODONTIC JOURNAL 2021. [DOI: 10.21307/aoj-2021.018] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/11/2022]
Abstract
Abstract
A maxillary transverse deficiency is a common craniofacial problem. Rapid palatal expansion (RPE) has been traditionally considered for the treatment of children and young adolescents, but this is not applicable in late adolescents or adults due to the ossification of facial sutures. A surgically assisted rapid palatal expansion (SARPE) was initially advocated for this group of patients, but the surgical procedure is associated with morbidity. As temporary anchorage devices (TADs) have been recently and popularly applied in clinical orthodontics, micro-implant-assisted rapid palatal expansion (MARPE) has been employed to facilitate maxillary expansion in skeletally mature patients. There have been various proposed MARPE designs and the outcomes appear promising. The aim of the present article is to discuss the role of MARPE in clinical orthodontics by reviewing its background, design, indications, treatment effects, stability, and limitations in the current literature. The treatment effects of two types of MARPE, bone-borne and tooth-bone-borne (hybrid), will be individually assessed.
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Affiliation(s)
- Yun-Hsuan Chuang
- DDS, Orthodontic Department, Chang Bing Show Chwan Memorial Hospital , Changhua , Taiwan
| | - Jen-Hsuan Chen
- DDS, Oromaxillofacial Department, Show Chwan Memorial Hospital , Changhua , Taiwan
| | - Kwok-Hing Ho
- DDS, Orthodontic Department, Chang Bing Show Chwan Memorial Hospital , Changhua , Taiwan
| | - Kai-Long Wang
- DDS, Orthodontic Department, Chang Bing Show Chwan Memorial Hospital , Changhua , Taiwan
| | - Shun-Chu Hsieh
- DDS, Orthodontic Department, Chang Bing Show Chwan Memorial Hospital , Changhua , Taiwan
| | - Heng-Ming Chang
- Chang Bing Show Chwan Memorial Hospital Changhua County , Changhua , Taiwan
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Ahad A, Haque E, Naaz S, Bey A, Rahman SA. Pattern of buccal and palatal bone density in the maxillary premolar region: an anatomical basis of anterior-middle superior alveolar (AMSA) anesthetic technique. J Dent Anesth Pain Med 2020; 20:387-395. [PMID: 33409367 PMCID: PMC7783380 DOI: 10.17245/jdapm.2020.20.6.387] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/09/2020] [Revised: 10/15/2020] [Accepted: 11/05/2020] [Indexed: 11/15/2022] Open
Abstract
Background The anterior-middle superior alveolar (AMSA) anesthetic technique has been reported to be a less traumatic alternative to several conventional nerve blocks and local infiltration for anesthesia of the maxillary teeth, their periodontium, and the palate. However, its anatomic basis remains controversial. The present study aimed to determine if the pattern of cortical and cancellous bone density in the maxillary premolar region can provide a rationale for the success of the AMSA anesthetic technique. Methods Cone-beam computed tomography scans of 66 maxillary quadrants from 34 patients (16 men and 18 women) were evaluated using a volumetric imaging software for cortical and cancellous bone densities in three interdental regions between the canine and first molar. Bone density was measured in Hounsfield units (HU) separately for the buccal cortical, palatal cortical, buccal cancellous, and palatal cancellous bones. Mean HU values were compared using the Mann-Whitney U test and one-way ANOVA with post-hoc analysis. Results Cancellous bone density was significantly lower (P ≤ 0.001) in the palatal half than in the buccal half across all three interdental regions. However, there was no significant difference (P = 0.106) between the buccal and palatal cortical bone densities at the site of AMSA injection. No significant difference was observed between the two genders for any of the evaluated parameters. Conclusions The palatal half of the cancellous bone had a significantly lower density than the buccal half, which could be a reason for the effective diffusion of the anesthetic solution following a palatal injection during the AMSA anesthetic technique.
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Affiliation(s)
- Abdul Ahad
- Department of Dentistry, Medini Rai Medical College, Palamu, Jharkhand, India
| | - Ekramul Haque
- Department of Periodontics, Dr. Ziauddin Ahmad Dental College, Faculty of Medicine, Aligarh Muslim University, Aligarh, UP, India
| | - Sabiha Naaz
- Department of Periodontics, Dr. Ziauddin Ahmad Dental College, Faculty of Medicine, Aligarh Muslim University, Aligarh, UP, India
| | - Afshan Bey
- Department of Periodontics, Dr. Ziauddin Ahmad Dental College, Faculty of Medicine, Aligarh Muslim University, Aligarh, UP, India
| | - Sajjad Abdur Rahman
- Department of Oral and Maxillofacial Surgery, Dr. Ziauddin Ahmad Dental College, Faculty of Medicine, Aligarh Muslim University, Aligarh, UP, India
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ElNaghy R, Bous R, Chinoy A, Kumar A, Valiathan M. A Qualitative Assessment of Bone Mineral Density in Individuals With Hemifacial Microsomia: A Cone-Beam Computed Tomography Study. Cleft Palate Craniofac J 2020; 58:1086-1093. [PMID: 33251829 DOI: 10.1177/1055665620975638] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022] Open
Abstract
OBJECTIVE The purpose of this study is to utilize cone-beam computed tomography (CBCT) to compare the bone mineral density (BMD) on the affected versus nonaffected side, among individuals with hemifacial microsomia (HFM). METHODS This retrospective study included 9 patients with HFM. Pretreatment CBCT volumes were imported into Invivo5 software, which was used to measure BMD through Hounsfield units (HU) in 3 regions of the mandible; inferior to the lower lateral incisors, inferior to the first molar and at the ramus inferior to the sigmoid notch. Each region was measured at the buccal cortical bone, lingual cortical bone, and cancellous bone. The densities on the right and left sides were compared by Wilcoxon signed-rank test. RESULTS Overall, the BMD on the affected side tended to show slightly lower values when compared with the nonaffected side. Differences ranged from 14 HU at the lingual cortical plate of the first molar region to 234 HU at the buccal cortical plate of the ramus region. Differences were only statistically significant at the ramus region for the buccal (P = .002) and lingual (P < .001) cortical plates and at the lower incisor region at the buccal cortical plate (P = .016) and cancellous bone (P = .044). The differences, however, did not seem to be clinically significant. CONCLUSIONS The current study shows that the quality of bone on the affected side may be slightly reduced but did not seem to be clinically significant. This should be accounted for during surgical and orthodontic planning for patients with HFM.
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Affiliation(s)
- Rahma ElNaghy
- Craniofacial, Surgical and Special Care Orthodontics, Case Western Reserve University, School of Dental Medicine, Cleveland, OH, USA
| | - Rany Bous
- Craniofacial, Surgical and Special Care Orthodontics, Case Western Reserve University, School of Dental Medicine, Cleveland, OH, USA
| | | | - Anand Kumar
- Case Western Reserve University, School of Medicine, Cleveland, OH, USA.,Pediatric Plastic Surgery, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH, USA
| | - Manish Valiathan
- Case Western Reserve University, School of Dental Medicine, Cleveland, OH, USA
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Abdel Hamid MA, Zaied AA, Zayet MK, Abdelmageed H, Hassan EA, Amaroli A. Efficacy of Flat-Top Hand-Piece Using 980 nm Diode Laser Photobiomodulation on Socket Healing after Extraction: Split-Mouth Experimental Model in Dogs. Photochem Photobiol 2020; 97:627-633. [PMID: 33190304 DOI: 10.1111/php.13356] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/24/2020] [Accepted: 11/09/2020] [Indexed: 12/22/2022]
Abstract
The objective was to evaluate the effect of photobiomodulation (PBM) using 980 nm diode laser therapy (0.60 W, 0.77 W cm-2 , 36 J, 46 J cm-2 , 60 s) irradiated in continuous wave mode by flat-top hand-piece on socket healing in the maxilla and mandible. A split-mouth experimental design was performed on 6 dogs. The 3rd premolar tooth was extracted from the maxilla and mandibles for both sides. The right-sided sockets were irradiated (PBM group), and the left-sided sockets were kept as control. Irradiation was done after extraction and at 48-h interval for 14 days. Both the buccal and lingual sides were irradiated to reach a total irradiation time of 120 s. Bone density was evaluated at 3, 4 and 5 weeks using cone beam computed tomography. We showed that maxillary sockets in the PBM group had higher bone density compared to control one at 3, 4, 5 weeks (P = 0.029, <0.001, <0.001), respectively. Mandibular sockets revealed no significant difference between PBM and control at 3 weeks (P = 0.347), while at 4 and 5 weeks PBM group showed higher bone density (P = 0.004, <0.001). In both groups, there was a significant increase (P < 0.001) in bone density by time which was higher in the PBM group. We concluded that PBM using a flat-top hand-piece of 980-nm improved the bone density of extraction sockets.
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Affiliation(s)
- Mohamed A Abdel Hamid
- Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt
| | - Amira A Zaied
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Fayoum University, Fayoum, Egypt
| | - Mohamed Khalifa Zayet
- Oral and Maxillofacial Radiology, Faculty of Dentistry, Cairo University, New Giza University, Giza, Egypt
| | - Hany Abdelmageed
- Laser Therapy Centre, Department of Surgical and Diagnostic Sciences (DISC), University of Genoa, Genoa, Italy
| | - Elham A Hassan
- Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt
| | - Andrea Amaroli
- Faculty of Dentistry, Department of Orthopaedic Dentistry, First Moscow State Medical University (Sechenov University), Moscow, Russia
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Möhlhenrich SC, Kniha K, Magnuska Z, Gremse F, Peters F, Danesh G, Hölzle F, Modabber A. Ischial tuberosity: new donor site for bone grafts in animal cleft research. Sci Rep 2020; 10:20699. [PMID: 33244089 PMCID: PMC7691372 DOI: 10.1038/s41598-020-77862-w] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/16/2020] [Accepted: 11/17/2020] [Indexed: 12/30/2022] Open
Abstract
In the context of cleft repair in animal research in rat models, different areas can be used for bone grafting. The aim of the present study was to present the tuberosity of the ischium as a new donor site and to evaluate its quality in relation to an artificial alveolar cleft. Four weeks after creating experimental alveolar clefts in seven Wistar rats, the repair was performed in the now twelve-week-old male animals using bone blocks grafted from the ischial tuberosity. Two days before surgery and two as well as twenty-eight days after surgery, microCT scans were performed, and the grafted bone blocks were analyzed regarding height, width, thickness, and volume. Additionally, bone mineral density (BMD) and bone volume fraction (BV/TV) were measured in the repaired cleft. The mean bone volume of the graft was about 19.77 ± 7.77mm3. Immediately after jaw reconstruction the BMD and BV/TV were about 0.54 ± 0.05 g/cm3 and 54.9 ± 5.07% for the transplant and about 1.13 ± 0.08 g/cm3 and 94.5 ± 3.70%, respectively, for the surrounding bone. Four weeks later the BMD and BV/TV were about 0.57 ± 0.13 g/cm3 and 56.60 ± 13.70% for the transplant and about 11.17 ± 0.07 g/cm3 and 97.50 ± 2.15%, respectively, for the surrounding bone. A hip fracture was found in four of the animals after surgery. The ischial tuberosity offers large bone blocks, which are sufficient for cleft repair in the rat model. However, the bone quality regarding BMD and BV/TV is less compared with the surrounding bone of the alveolar cleft, even after a period of 4 weeks, despite recognizable renovation processes.
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Affiliation(s)
- Stephan Christian Möhlhenrich
- Department of Orthodontics, University of Witten/Herdecke, Alfred-Herrhausen Str. 45, 58455, Witten, Germany. .,Department of Oral and Maxillofacial Surgery, University Hospital of Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
| | - Kristian Kniha
- Department of Oral and Maxillofacial Surgery, University Hospital of Aachen, Pauwelsstraße 30, 52074, Aachen, Germany
| | - Zuzanna Magnuska
- Institute for Experimental Molecular Imaging, RWTH Aachen University, Forckenbeckstrasse 55, 52074, Aachen, Germany
| | - Felix Gremse
- Institute for Experimental Molecular Imaging, RWTH Aachen University, Forckenbeckstrasse 55, 52074, Aachen, Germany
| | - Florian Peters
- Department of Oral and Maxillofacial Surgery, University Hospital of Aachen, Pauwelsstraße 30, 52074, Aachen, Germany
| | - Gholamreza Danesh
- Department of Orthodontics, University of Witten/Herdecke, Alfred-Herrhausen Str. 45, 58455, Witten, Germany
| | - Frank Hölzle
- Department of Oral and Maxillofacial Surgery, University Hospital of Aachen, Pauwelsstraße 30, 52074, Aachen, Germany
| | - Ali Modabber
- Department of Oral and Maxillofacial Surgery, University Hospital of Aachen, Pauwelsstraße 30, 52074, Aachen, Germany
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Groeneveldt LC, Herpelinck T, Maréchal M, Politis C, van IJcken WFJ, Huylebroeck D, Geris L, Mulugeta E, Luyten FP. The Bone-Forming Properties of Periosteum-Derived Cells Differ Between Harvest Sites. Front Cell Dev Biol 2020; 8:554984. [PMID: 33324630 PMCID: PMC7723972 DOI: 10.3389/fcell.2020.554984] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/23/2020] [Accepted: 10/22/2020] [Indexed: 12/16/2022] Open
Abstract
The development of alternatives for autologous bone grafts is a major focus of bone tissue engineering. To produce living bone-forming implants, skeletal stem and progenitor cells (SSPCs) are envisioned as key ingredients. SSPCs can be obtained from different tissues including bone marrow, adipose tissue, dental pulp, and periosteum. Human periosteum-derived cells (hPDCs) exhibit progenitor cell characteristics and have well-documented in vivo bone formation potency. Here, we have characterized and compared hPDCs derived from tibia with craniofacial hPDCs, from maxilla and mandible, respectively, each representing a potential source for cell-based tissue engineered implants for craniofacial applications. Maxilla and mandible-derived hPDCs display similar growth curves as tibial hPDCs, with equal trilineage differentiation potential toward chondrogenic, osteogenic, and adipogenic cells. These craniofacial hPDCs are positive for SSPC-markers CD73, CD164, and Podoplanin (PDPN), and negative for CD146, hematopoietic and endothelial lineage markers. Bulk RNA-sequencing identified genes that are differentially expressed between the three sources of hPDC. In particular, differential expression was found for genes of the HOX and DLX family, for SOX9 and genes involved in skeletal system development. The in vivo bone formation, 8 weeks after ectopic implantation in nude mice, was observed in constructs seeded with tibial and mandibular hPDCs. Taken together, we provide evidence that hPDCs show different profiles and properties according to their anatomical origin, and that craniofacial hPDCs are potential sources for cell-based bone tissue engineering strategies. The mandible-derived hPDCs display - both in vitro and in vivo - chondrogenic and osteogenic differentiation potential, which supports their future testing for use in craniofacial bone regeneration applications.
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Affiliation(s)
- Lisanne C Groeneveldt
- Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.,Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.,OMFS IMPATH Research Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.,Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.,Department of Cell Biology, Erasmus University Medical Center, Rotterdam, Netherlands
| | - Tim Herpelinck
- Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.,Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium
| | - Marina Maréchal
- Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.,Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium
| | - Constantinus Politis
- OMFS IMPATH Research Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.,Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium
| | - Wilfred F J van IJcken
- Department of Cell Biology, Erasmus University Medical Center, Rotterdam, Netherlands.,Center for Biomics, Erasmus University Medical Center, Rotterdam, Netherlands
| | - Danny Huylebroeck
- Department of Cell Biology, Erasmus University Medical Center, Rotterdam, Netherlands.,Department of Development and Regeneration, KU Leuven, Leuven, Belgium
| | - Liesbet Geris
- Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.,Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.,Biomechanics Research Unit, GIGA-R In Silico Medicine, Université de Liége, Liège, Belgium.,Biomechanics Section, KU Leuven, Leuven, Belgium
| | - Eskeatnaf Mulugeta
- Department of Cell Biology, Erasmus University Medical Center, Rotterdam, Netherlands
| | - Frank P Luyten
- Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.,Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.,Department of Development and Regeneration, KU Leuven, Leuven, Belgium
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48
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Short versus standard implants for single-crown restorations in the posterior region: A systematic review and meta-analysis. J Prosthet Dent 2020; 124:530-538. [DOI: 10.1016/j.prosdent.2019.09.030] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/27/2019] [Revised: 09/27/2019] [Accepted: 09/30/2019] [Indexed: 01/10/2023]
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Teh NHK, Sivarajan S, Asif MK, Ibrahim N, Wey MC. Distribution of mandibular trabeculae bone volume fraction in relation to different MOP intervals for accelerating orthodontic tooth movement. Angle Orthod 2020; 90:774-782. [PMID: 33378515 DOI: 10.2319/032820-227.1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/01/2020] [Accepted: 06/01/2020] [Indexed: 11/23/2022] Open
Abstract
OBJECTIVES To investigate the effect of micro-osteoperforation (MOP) on the horizontal and vertical distribution of mandibular trabeculae bone volume fraction in relation to different MOP intervals during canine retraction. MATERIALS AND METHODS This single-center, single-blinded, prospective randomized split-mouth clinical trial included 30 healthy participants aged 18 years and older, randomized into three groups of different MOP intervals (4, 8, and 12-weekly). Cone beam computed tomography images were taken to assess the bone volume fraction (bone volume over total volume or BV/TV). RESULTS BV/TV was significantly reduced (mean difference: 9.79%, standard deviation [SD]: 11.89%; 95% confidence interval [CI]: 4.77, 14.81%; P < .01) and canine retraction increased (mean difference: -1.25 mm/4 mo, SD: 0.79 mm; 95% CI: -1.59, -0.92 mm; P < .01) with MOP, compared to control sites. MOP significantly changed the vertical and horizontal patterns of trabeculae bone with lower values nearer to intervention sites. Only the 4-weekly MOP interval group showed significant decrease in BV/TV (mean difference: 14.73%, SD: 12.88%; 95% CI: 3.96, 25.50%; P = .01) despite significant increase in canine retraction rate for all interval groups. With the use of MOP, BV/TV was found to be inversely correlated to the rate of canine retraction (r = -0.425; P = .04). CONCLUSIONS Mandibular trabecular alveolar bone volume fraction was reduced and rate of orthodontic tooth movement increased with MOP, especially in the 4-weekly interval. However, this effect was limited to the immediate interdental region of MOP.
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50
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Popa A, Dehelean C, Calniceanu H, Watz C, Brad S, Sinescu C, Marcu OA, Popa CS, Avram S, Nicolov M, Szuhanek CA. A Custom-Made Orthodontic Mini-Implant-Effect of Insertion Angle and Cortical Bone Thickness on Stress Distribution with a Complex In Vitro and In Vivo Biosafety Profile. MATERIALS 2020; 13:ma13214789. [PMID: 33120951 PMCID: PMC7663474 DOI: 10.3390/ma13214789] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 10/09/2020] [Revised: 10/19/2020] [Accepted: 10/23/2020] [Indexed: 12/12/2022]
Abstract
BACKGROUND Orthodontic mini-implant failure is a debatable subject in clinical practice. However, the most important parameter to evaluate the success rate of mini-implant is the primary stability, which is mainly influenced by cortical bone thickness (CBT) and insertion angle. MATERIALS AND METHODS Three-dimensional finite element models of the maxilla were created and a custom-made, self-drilling, tapered mini-implant was designed. For the pull-out test, 12 simulations were performed, sequentially increasing the thickness of the cortical bone (1, 1.5 and 2 mm) and the insertion angle (30°, 60°, 90°, 120°). For the force analysis, 24 simulations were performed using an experimental orthodontic traction force of 2 N both in the horizontal and vertical axis. RESULTS Insertion angle and CBT have significant impact on force reaction values (p < 0.05). Cortical bone stress had the lowest value when the mini-implant had a 30° insertion angle and the highest value when the implant had a 120° insertion angle, while the CBT was 1 mm. Cortical bone stress had the lowest value with an insertion angle of 90° and the highest value when the implant was inserted at an angle of 30°, while the CBT was 2 mm independent of the force direction. Regarding the biosafety profile of the mini-implant alloy, the present results reveal that the custom-made mini-implant presents good biocompatibility. CONCLUSIONS When the CBT is reduced, we recommend inclined insertion while, when the CBT is appropriate, perpendicular insertion is advised.
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Affiliation(s)
- Adelina Popa
- 2nd Department of Orthodontics, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania; (A.P.); (C.A.S.)
| | - Cristina Dehelean
- 2nd Department of Toxicology and Drug Industry, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania;
| | - Horia Calniceanu
- 1st Department/Periodontology, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
- Correspondence: (H.C.); (C.W.); Tel.: +40-745-322-649 (H.C.); +40-746-227-217 (C.W.)
| | - Claudia Watz
- 1st Department of Pharmaceutical Physics and Biophysics, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania;
- Correspondence: (H.C.); (C.W.); Tel.: +40-745-322-649 (H.C.); +40-746-227-217 (C.W.)
| | - Silviu Brad
- 2nd Department of Radiology, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania;
| | - Cosmin Sinescu
- 2nd Department of Prostheses Technology and Dental Material, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania;
| | - Olivia A. Marcu
- Dental Medicine Department, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania;
| | | | - Stefana Avram
- 2nd Department of Pharmacognosy, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania;
| | - Mirela Nicolov
- 1st Department of Pharmaceutical Physics and Biophysics, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania;
| | - Camelia A. Szuhanek
- 2nd Department of Orthodontics, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania; (A.P.); (C.A.S.)
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