Is Entresto good for the brain?

Table 1 Overview of drugs targeting the neprilysin pathways and its pathways

Drug	Mechanism	Clinical trials and year	Results on HF symptoms
Nestiride	Increasing natriuretic peptide activity	VMAC, 2000[20] PRECEDENT, 2002[21] ASCENT-HF, 2009[22]	Improved BP and dyspnea Less cardiac arrhythmias More hypotension
Candoxatril	NPi	Single-centered investigation with only a limited number of patients[23-25]	More exercise tolerance Increase in vascular resistance
Omapatrilat	NPi	IMPRESS, 2000[26] OVERTURE, 2002[27] OCTAVE, 2004[28]	More exercise tolerance Increase in angioedema Reduction in BP Lower mortality
LCZ696	NPi	PARAMOUNT, 2012[29] PARADIGM, 2014[30,31] PARAGON, ongoing[32]	Reduction in BP Improved ejection fraction Lower mortality No change in angioedema

BP: Blood pressure; HF: Heart failure; NPi: Neprilysin inhibitors.