Role of platelet-rich plasma in ischemic heart disease: An update on the latest evidence

Table 1 Summary of the effects of platelet-rich plasma in ischemic heart disease

Ref.	Type of study	Animal model	Delivery method	Effect
Gallo et al[37]	Experimental	Sheep	Implantation	Increased formation of new vessels
Hargrave et al[38]	Experimental	Rabbit	Intramyocardial injection	Reduced reactive oxygen species generation
				Stabilized the mitochondria of the ischemic/reperfused heart
Mishra et al[39]	Experimental	Murine (Mouse)	Intramyocardial injection	Higher left ventricular ejection fraction after ischemia
Vu et al[40]	Experimental	Porcine	Intramyocardial injection	Attenuated adverse cardiac remodeling
Yu et al[41]	Experimental	Murine (Rat)	Intramyocardial injection	Decreased infarct size
				Increased ventricular wall thickness
				Improved cardiac function and reperfusion
Li et al[42]	Experimental	Murine (Rat)	Intramyocardial injection	Limitation of ventricular expansion,
				Attenuated myocardial hypertrophy in the noninfarct region
				Facilitated angiogenesis and arteriogenesis in the infarct.
Sun et al[43]	Experimental	Murine (Rat)	Intramyocardial injection	Improved LV performance
Wehberg et al[10]	Clinical	-	Intramyocardial injection	More efficacious at relieving angina
				Improved myocardial function