Cost-effectiveness modelling of percutaneous coronary interventions in stable coronary artery disease

Table 1 Charge table (i€)

Resource utilization	Mini	Mean	Max	Tariff
GP visit				22
Specialist visit (cardiologist)				23
Lab tests without markers of myocardial damage				21
Lab tests with markers of myocardial damage				39
ECG at rest				14
Stress test ECG				77
Stress test echocardiography				165
Myocardial scintigraphy				409
Coronary angiography				1954
Standard combination therapy (1 yr): aspirin + statin + ACE inhibitors	364		743
GTN (1 yr)	39.4		73.2
β-Blocker (1 yr)	52.9		210.9
Calcium Inhibitors (1 yr)	87.5		311
Hospitalization stay for PCI with BMS (1.6 stent)	4074		4573
Hospitalization stay for PCI with DES (1.6 stent)	5284		5704
Hospitalization stay for CABG surgery		14065
Hospitalization stay for a clinical failure		2096

DES: Drug eluting stents; BMS: Bare metal stent; PCI: Percutaneous coronary interventions; CABG: Coronary artery bypass graft; ACE: Angiotensin-converting-enzyme; ECG: Electrocardiogram.

Table 2 Effectiveness data of drug eluting stents model

	Minimum	Maximum	Ref.
Probability of success of a CABG surgery following a coronary angiography after a failure of a DES	90%	-	Sheiban et al[18]
Probability of success of pharmaceutical treatment after a failure of a DES	85%	90%	Sheiban et al[18]
Probability of success after a first DES	82.2%	97.5%	Simsek et al[19] Bakhai et al[20] Meredith et al[21] Morice et al[22] Toutouzas et al[23] Weisz et al[24] Serruys et al[25] Yan et al[26]
Probability of success after 1 yr of surveillance following a first DES	86.3%	98.7%	Simsek et al[19] Meredith et al[21] Park et al[27]
Probability of undergoing a second PCI following a coronary angiography after a failure of a DES	50%	60%	Malenka et al[28]
Probability of undergoing a surgery following a coronary angiography after a failure of a bare metal stent	30%	40%	Malenka et al[28]
Probability of undergoing a DES after a failure of a first DES	60%	70%	Sheiban et al[18]
Probability of success of a DES after a failure of a first DES	74.8%	90%	Steinberg et al[29] Ge et al[30] Lee et al[31]
Probability of success of a CBA after a failure of a first DES	60%	77%	Park et al[32]

DES: Drug eluting stents; PCI: Percutaneous coronary interventions; CABG: Coronary artery bypass graft; CBA: Coronary balloon angioplasty.

Table 3 Effectiveness data of bare metal stent model

	Minimum	Maximum	Ref.
Probability of success after a first bare metal stent	70.9%	86.4%	Simsek et al[19] Daemen et al[33] Bakhai et al[20] Morice et al[22] Weisz et al[24]
Probability of success after 1 yr of surveillance following a first bare metal stent	85%	96%	Simsek et al[19]
Probability of undergoing a second PCI following a coronary angiography after a failure of a bare metal stent	80%	-	Malenka et al[28]
Probability of undergoing a surgery following a coronary angiography after a failure of a bare metal stent	10%	15%	Malenka et al[28]
Probability of undergoing a DES after a failure of a bare metal stent	50%	-	Konstance et al[34]
Probability of success of a DES after a failure of a bare metal stent	78%	89%	Steinberg et al[29]
Probability of success of a second bare metal stent after a failure of a first bare metal stent	58%	67.3%	Singh et al[35]
Probability of success of a CABG surgery following a coronary angiography after a failure of a bare metal stent	90%	-	Malenka et al[28] Konstance et al[34]
Probability of success of pharmaceutical treatment after a failure of a bare metal stent	85%	90%	Sheiban et al[18]

DES: Drug eluting stents; PCI: Percutaneous coronary interventions; CABG: Coronary artery bypass graft.