Systematic review and meta-analysis of outcomes of anatomic repair in congenitally corrected transposition of great arteries

Table 1 Baseline characteristics of included studies

Ref.	Country	Total patients	Double (arterial/atrial) switch	Atrial switch-Rastelli or hemi-Mustard Glenn-Rastelli	Age at operation (yr)	Mean/median follow up (yr)
Ilbawi et al[11], 2002	United States	12	2	10	0.75	7.6
Duncan et al[12], 2003	United States	46	26	20	2.3	2
Hörer et al[13], 2008	Germany	6	0	6	3.5	7
Gaies et al[14], 2009	United States	65	35	30	2.2	4.6
Ly et al[15], 2009	France	20	20	0	2.2	5
Sharma et al[16], 2009	India	68	31	37	5.2	4.9
Lim et al[17], 2010	South Korea	44	10	34	-	5.4
Malhotra et al[4], 2011	United States	48	23	25	3	4.9
Murtuza et al[18], 2011	United Kingdom	113	68	45	3.2	6.9
Hiramatsu et al[19], 2012	Japan	90	18	72	6.8	12.5
Sojak et al[20], 2012	Netherlands	8	2	6	2.9	4.5
Hoashi et al[21], 2013	Japan	47	0	47	5.5	11.6
Bautista-Hernandez et al[22], 2014	United States/Spain	106	64	42	1.2	5.2
Hsu et al[23], 2015	Taiwan	18	13	5	8.4	5.0
Tocharoenchok et al[24], 2016	Thailand	22	0	22	10.9	5.3
Brizard et al[25], 2017	Australia	32	27	5	1.9	5.4
De León et al[26], 2017	United States	26	16	10	3	10
Hraska et al[27], 2017	United States/Germany	63	38	25	1.6	5
Ibrahimiye et al[28], 2017	United States	18	14	4	3	5
Marathe et al[29], 2017	Australia	12	6	6	2.3	7.2
Zhang et al[30], 2017	China	31	0	31	5.4	3.3
		895	413	482	Median age – 3 yr	Median f/u 5.2 yr

Table 2 Outcomes of anatomic repair in long term follow up

Variable	No. of studies	Pooled estimate	95%CI
Mortality after initial operation survival (n/100 PY)	21	0.6	0.4-0.8
Transplant free survival (%/100 PY)	20	92.5	89.5-95.4
NYHA I/II symptoms (%/100 PY)	13	84.7	79.6-89.9
Left ventricular systolic dysfunction (n/100 PY)	19	1.7	1.0-2.4
Left ventricular outflow tract obstruction (n/100 PY)	16	0.2	0.1-0.3
Permanent pacemaker	19	0.3	0.1-0.4
Total Reinterventions (n/100 PY)	20	5.3	3.8-6.8
Conduit interventions/operations	20	1.5	0.9-2.1
Baffle stenosis/leak	19	1.1	0.8-1.5
Tricuspid valve operations	21	0.2	0.1-0.3

CI: Confidence intervals; PY: Patient years; NYHA: New York Heart Association.