Novel approaches for the treatment of ventricular tachycardia

Table 1 Summary of studies investigating novel approaches for the treatment of ventricular tachycardia

Ref.	Type of study	No. of subjects	Focus of study	Complications
Della Bella et al[14]	Clinical	528	Endo-epicardial Ablation	Pericardial effusion, tamponade
Kim et al[15]	Clinical	1	Cardioplegia/Transcoronary alcohol ablation	Atrioventricular block, extensive myocardial damage, perforation
Sapp et al[17]	Clinical	8	Intramyocardial infusion-needle catheter ablation	Atrioventricular block, perforation, tamponade
Tholakanahalli et al[18]	Clinical	2	Intracoronary wire mapping and coil embolization	Atrioventricular block, coronary injury, embolization of unintended branches
Vaseghi et al[21]	Clinical	121	Cardiac sympathetic denervation	Hemothorax, pneumothorax, ptosis or Horner syndrome
Cuculich et al[29]	Clinical	5	Stereotactic radioablation therapy	Fatigue
Rivera et al[31]	Clinical	21	Cryoablation	-
Li et al[34]	Clinical	38	Surgical epicardial ablation	Ventricle laceration
Berte et al[35]	Experimental	5 (sheep)	Surgical cryoablation	-
Liang et al[36]	Clinical	20	Surgical cryoablation	-
Denegri et al[42]	Experimental	25 (mice)	Viral gene transfer of wild-type CASQ2	-
Li et al[44]	Experimental	9 (mice)	Tetracaine derivatives (RyR2 inhibitors)	-
Arenal et al[45]	Experimental	31 (pigs)	MRI-based signal intensity mapping for epicardial substrate	Coronary occlusion
Klein et al[46]	Clinical	15	3D meta-iodobenzyl-guanidine innervation maps to assess substrate and successful ablation sites	-
Zhang et al[47]	Clinical	32	Non-invasive high-resolution endocardial and epicardial mapping and electro-cardiographic imaging	-
Luther et al[48]	Clinical	15	Cardiac ripple mapping for slow conducting channels	-
Jamil-Copley et al[49]	Clinical	21	Cardiac ripple mapping for slow conducting channels	-