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Sert H, Gulbahar Eren M, Gurcay B, Koc F. The effectiveness of a high-intensity interval exercise on cardiometabolic health and quality of life in older adults: a systematic review and meta-analysis. BMC Sports Sci Med Rehabil 2025; 17:128. [PMID: 40413509 PMCID: PMC12102952 DOI: 10.1186/s13102-025-01176-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/07/2025] [Accepted: 05/08/2025] [Indexed: 05/27/2025]
Abstract
BACKGROUND High-intensity interval training (HIIT) is an effective exercise for improving physical and psychological function. However, there is an ongoing debate about the effects of HIIT on older adults. This study aimed to examine the effects of HIIT on cardiometabolic health and quality of life in older adults and to provide evidence-based information on the effectiveness of this type of exercise by performing a meta-analysis of randomized controlled trials. METHODS The ScienceDirect, PubMed, Web of Science, Scopus, Cochrane CENTRAL, CINAHL, and Pedro databases were used to search for all studies conducted up to December 1, 2024. Data were analyzed using Cochrane Review Manager (RevMan) [version 5.4.1] software. Quality of life data was analyzed using standardized mean difference (SMD), while mean difference (MD) was calculated for continuous variables such as heart (bpm), V̇O₂peak (mL·kg⁻1·min⁻1), 6MWT (m), and gait speed (m/s). In cases where high heterogeneity was observed, the random-effects model was preferred, and in cases where low heterogeneity was observed, the fixed-effects model was preferred. RESULTS This meta-analysis was performed using data from 11 studies. HIIT intervention groups had statistically significant increases in 6MWT (z = 3.24; 95% CI = [24.56, 78.67]; p = 0.0002), V̇O₂peak (z = 3.74; 95% CI = [1.38, 4.42]; p = 0.0002), and quality of life (z = 2.66; 95% CI = [0.40, 2.63]; p = 0.008) compared to the control groups. However, the meta-analysis indicated that HIIT resulted in non-significant changes in gait speed (z = 1.43; 95% Cl = [-0.04, 0.28]; p = 0.15). CONCLUSIONS This meta-analysis revealed that HIIT interventions in older adults positively affect cardiometabolic health parameters (6MWT, V̇O₂peak) and quality of life. Conducting HIIT as a supportive treatment component with health professionals such as physicians, physiotherapists, and nurses within the framework of a multidisciplinary team approach may contribute to improving the health of older adults. TRIAL REGISTRATION The study was registered on the International Prospective Registry of Systematic Reviews-PROSPERO database (CRD42023481425) on November 20, 2023.
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Affiliation(s)
- Havva Sert
- Deparment of Internal Medicine Nursing, Faculty of Health Science, Sakarya University, Sakarya, Turkey.
| | - Merve Gulbahar Eren
- Deparment of Internal Medicine Nursing, Faculty of Health Science, Sakarya University, Sakarya, Turkey
| | - Busra Gurcay
- Internal Medicine Nursing Department, Sakarya University, Institute of Health Science, Sakarya, Turkey
| | - Ferhat Koc
- Internal Medicine Nursing Department, Sakarya University, Institute of Health Science, Sakarya, Turkey
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Xing S, Zhang Y, Chen Y, Feng S, Zhang Y, Moreira P. Comparing the impacts of different exercise interventions on patients with type 2 diabetes mellitus: a literature review and meta-analysis. Front Endocrinol (Lausanne) 2025; 16:1495131. [PMID: 40391012 PMCID: PMC12086073 DOI: 10.3389/fendo.2025.1495131] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/14/2024] [Accepted: 03/20/2025] [Indexed: 05/29/2025] Open
Abstract
Objective Exercise interventions are a recommended method of diabetes management through which patients can achieve blood glucose control, increase muscle volume, and improve insulin sensitivity, while also improving blood lipids, blood pressure, and cardiovascular health. A few studies on the effects of physical exercise on diabetic patients have been published in recent years. This article focuses on exploring evidence on which exercise interventions generate which effects in diabetic patients, namely, high-intensity interval training (HIIT), method training (MT), aerobic exercise training (AET), resistance training (RT), and combined training (CBT). Methods Randomized controlled trials (RCTs) that focused on the effects of exercise interventions on blood glucose and blood lipids of patients with type 2 diabetes mellitus were reviewed. A network meta-analysis was performed to compare the effects of the five exercise interventions in diabetic patients, namely the impacts on glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL). The study was strictly conducted following the PRISMA Protocol, and the Cochrane Risk of Bias Assessment Tool 2.0 was used to objectively evaluate the risk of bias in the implementation of the study. Results This review included 25 RCTs in total, with 1,711 subjects. Meta-analysis suggests that, compared with conventional therapeutic treatment, exercise interventions can reduce blood glucose indexes, namely HbA1c, FBG, TC, TG, HDL, and LDL. RT and AET have been shown to reduce TC; HIIT, MT, AET, and CBT have been shown to improve HDL; and HIIT, MT, AET, and CBT have been shown to improve HDL. The MT and RT exercise types can reduce LDL. Evidence also suggests that MT can lower HbA1c, TG, and LDL levels, and RT lowers cholesterol levels. HIIT exercise appears to improve FBG and HDL levels. Conclusion The five types of exercise generate different effects on the key clinical dimensions of diabetes. MT seems to be the optimal choice to improve HbA1c, TG levels, and LDL, while HIIT improves FBG and HDL levels, whereas RT exercise appears to be the optimal exercise to lower cholesterol levels.
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Affiliation(s)
- Shuangtao Xing
- Physical Education Institute of Henan Normal University, Henan, Xinxiang, China
| | - Yifan Zhang
- Department of Public Basic Education of Henan Vocational University of Science and Technology, Henan, Zhoukou, China
| | - Yanjiao Chen
- Research Center for Social Work and Governance, College of Social Affairs, Henan Normal University, Henan, Xinxiang, China
| | - Shijie Feng
- Physical Education Institute of Henan Normal University, Henan, Xinxiang, China
| | - Yiqing Zhang
- Research Center for Social Work and Governance, College of Social Affairs, Henan Normal University, Henan, Xinxiang, China
| | - Paulo Moreira
- International Healthcare Management Research & Development Center (IHM-RDC), First Affiliated Hospital of the Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China
- Atlantica Instituto Universitario, Gestao em Saude, Oeiras, Portugal
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Tremblay R, Marcotte-Chénard A, Deslauriers L, Boulay P, Boisvert FM, Geraldes P, Gayda M, Christou DD, Little JP, Mampuya W, Riesco E. Acute Effect of High-Intensity Interval Exercise on Blood Pressure in Females Living with Type 2 Diabetes and Hypertension. Med Sci Sports Exerc 2025; 57:951-961. [PMID: 39787496 DOI: 10.1249/mss.0000000000003639] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/12/2025]
Abstract
BACKGROUND The acute effects of high-intensity interval training (HIIT) on blood pressure (BP) may depend on the exercise protocol performed. PURPOSE To compare the acute effect of high- and low-volume HIIT on post-exercise and ambulatory BP in untrained older females diagnosed with both type 2 diabetes and hypertension. METHODS Fifteen females (69 (65-74) yr) completed a crossover study with three experimental conditions: 1) REST (35 min in sitting position); 2) HIIT10 (10 × 1 min at 90% heart rate max (HRmax)), and 3) HIIT4 (4 × 4 min at 90% HRmax). After each experimental condition, BP was measured under controlled (4 h) and in subsequent free-living conditions (20 h). RESULTS In the controlled post-condition 4-h period, no significant interaction (time-condition) was observed for all BP parameters ( P ≥ 0.082). Similarly, during the subsequent 20-h free-living ambulatory monitoring (diurnal and nocturnal), no differences between conditions were detected ( P ≥ 0.094). A significant reduction in nighttime pulse pressure was observed in both HIIT4 and HIIT10 compared with REST (46 (44-50), 45 (42-53) vs 50 (45-57) mm Hg, respectively; P ≤ 0.018) with no differences between HIIT conditions ( P = 0.316). Changes in nocturnal systolic BP approached but did not reach statistical significance ( P = 0.068). CONCLUSIONS This study suggests that in untrained older females living with type 2 diabetes and hypertension, the HIIT10 and HIIT4 protocols have very limited to no acute effect on post-exercise and ambulatory BP. The fact that the vast majority of participants had well-controlled office and ambulatory BP values as well as low cardiorespiratory fitness could explain these findings.
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Affiliation(s)
| | | | | | - Pierre Boulay
- Faculty of Physical Activity Sciences, Université de Sherbrooke, Sherbrooke, QC, CANADA
| | | | | | | | - Demetra D Christou
- Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL
| | - Jonathan P Little
- Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, CANADA
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Li Y, Zhao W, Yang Q. Effects of high-intensity interval training and moderate-intensity continuous training on mitochondrial dynamics in human skeletal muscle. Front Physiol 2025; 16:1554222. [PMID: 40313872 PMCID: PMC12043657 DOI: 10.3389/fphys.2025.1554222] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/01/2025] [Accepted: 04/08/2025] [Indexed: 05/03/2025] Open
Abstract
Exercise and physical activity confer health advantages, in part, by enhancing skeletal muscle mitochondrial respiratory function. The objective of this study is to analyze the impacts of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the dynamics and functionality of the mitochondrial network within skeletal muscle. 20 young male participants were assigned to either HIIT or MICT group. Initial assessments of exercise-related indicators were conducted, followed by skeletal muscle biopsies from the vastus lateralis before, 1 day after, and 6 weeks post-experiment. We utilized multi-dimensional myofiber imaging to analyze mitochondrial morphology and arrangement, and assessed citrate synthase activity, complex I activity, and dynamics-related mRNA. Both training modalities increased VO2max, Wmax, citrate synthase and complex I activities, mitochondrial content, and volume density, though the changes differed between the two groups. 6 weeks training induced remodeling of the mitochondrial network within skeletal muscle. Before training, the network appeared sparse and punctate. After MICT, it adopted a grid-like structure with partially robust longitudinal connections. In contrast, HIIT resulted in a less obvious grid structure but showed a stronger longitudinally oriented network. Training also increased mRNA expression of mitochondrial fusion proteins and decreased fission protein expression, with these effects being more pronounced in HIIT. Similarly, peroxisome proliferator-activated receptor γ coactivator 1-alpha mRNA expression showed a comparable trend, though the changes differed between 1 day and 6 weeks of training. In conclusion, HIIT and MICT induce distinct mitochondrial adaptation in skeletal muscle, reflected in different network remodeling and molecular pathways. These findings may be due to HIIT's more pronounced effect on mitochondrial dynamics or respiratory function, but the study has only conducted preliminary observational experiments and further evidence is required for confirmation.
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Affiliation(s)
- Yuqing Li
- Orthopedic Department, Hunan Children’s Hospital (The Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University), Changsha, Hunan, China
- Hunan Provincial Key Laboratory of Pediatric Orthopedics, Changsha, Hunan, China
- The School of Pediatrics, University of South China, Changsha, Hunan, China
| | - Wanjun Zhao
- Otolaryngology-Head and Neck Surgery Department, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
| | - Qi Yang
- Physical Education and Sports Training School, Hunan Provincial Sports Vocational College, Changsha, Hunan, China
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Ko JM, So WY, Park SE. Narrative Review of High-Intensity Interval Training: Positive Impacts on Cardiovascular Health and Disease Prevention. J Cardiovasc Dev Dis 2025; 12:158. [PMID: 40278218 PMCID: PMC12027975 DOI: 10.3390/jcdd12040158] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/12/2025] [Revised: 04/11/2025] [Accepted: 04/15/2025] [Indexed: 04/26/2025] Open
Abstract
BACKGROUND High-intensity interval training (HIIT) has gained recognition for its positive impacts on cardiovascular (CV) health, metabolic outcomes, mental health, and quality of life (QoL). This narrative review aims to comprehensively evaluate the efficacy of HIIT in enhancing CV health and preventing CV disease (CVD). METHODS A comprehensive search of PubMed identified 257 articles, of which 39 studies met predefined inclusion and exclusion criteria for quality assessment. Key metrics evaluated included blood pressure, vascular function, lipid profiles, body composition, and CRF. RESULTS HIIT significantly improved vascular function, evidenced by reductions in systolic and diastolic blood pressure and enhanced flow-mediated dilation. Improvements in cardiac function were observed through increased cardiac output and heart rate variability. Additionally, HIIT positively influenced lipid profiles, decreasing low-density lipoprotein and triglycerides while increasing high-density lipoprotein. Significant reductions in body fat and improvements in VO2peak were noted, contributing to enhanced CRF. HIIT also positively impacted mental health and QoL, reducing anxiety and depressive symptoms. Importantly, HIIT was safely and effectively applied to high-risk populations-individuals with obesity, metabolic syndrome, CVD, and cancer survivors-with a low incidence of adverse effects. CONCLUSIONS This review highlights HIIT as an effective and safe exercise modality for improving CV health, metabolic indicators, mental health, and QoL. Future research should focus on developing tailored HIIT protocols to optimize adherence and efficacy across diverse populations, considering variations in age, sex, health status, and underlying medical conditions.
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Affiliation(s)
- Jae-Myun Ko
- Department of Physical Education, Yonsei University, Seoul 03722, Republic of Korea;
| | - Wi-Young So
- Department of Sports Medicine, College of Humanities, Korea National University of Transportation, Chungju-si 27469, Republic of Korea
| | - Sung-Eun Park
- Department of Sport Science, University of Seoul, Seoul 02504, Republic of Korea
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Chang KY, Haun T, Liu Z, Gil A, Taherzadeh Z, Fadel PJ, Phillips SA, Piano MR, Hwang CL. Effects of at-risk alcohol use on nighttime blood pressure, urinary catecholamines, and sleep quality in midlife adults. ALCOHOL, CLINICAL & EXPERIMENTAL RESEARCH 2025; 49:843-853. [PMID: 40059037 DOI: 10.1111/acer.70021] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/15/2024] [Accepted: 02/15/2025] [Indexed: 04/23/2025]
Abstract
BACKGROUND The association between alcohol and hypertension has been predominantly based on office blood pressure (BP) measurements. However, little is known about the effect of alcohol use on nighttime BP and the underlying mechanisms. The purpose of this study was to investigate the effects of at-risk alcohol use on nighttime BP, urinary catecholamines, and sleep quality in midlife adults. METHODS A total of 32 midlife men and 30 postmenopausal women, free of major clinical diseases and nonsmokers (age: 58 ± 4; mean ± SD), were included. Among all participants, 22 were currently taking antihypertensive medications. At-risk drinkers were defined as those who had a dried blood spot phosphatidylethanol level ≥20 ng/mL. All participants completed 24-h ambulatory BP monitoring and urine collection to determine nighttime (or asleep) BP and nighttime urinary catecholamine levels. Sleep quality was determined by using the Pittsburgh Sleep Quality Index. RESULTS In midlife adults free of antihypertensive medications, at-risk drinkers had a higher nighttime systolic (118 ± 14 vs. 107 ± 14 mmHg, p = 0.02) and diastolic BP (70 ± 9 vs. 62 ± 9 mmHg, p = 0.003) than low-risk drinkers with no between-group differences in sleep quality component scores (p ≥ 0.14). In midlife adults taking antihypertensive medications, no difference in nighttime BP was found between at-risk drinkers and low-risk drinkers (p ≥ 0.68), with a higher score for the "use of sleeping medication" component in high-risk drinkers (p = 0.02). Regardless of antihypertensive medication use, no difference between at-risk drinkers and low-risk drinkers was found in nighttime urinary catecholamine levels (p ≥ 0.19). CONCLUSIONS Our findings suggest that in midlife adults free of antihypertensive medication use, at-risk alcohol use is associated with an increase in nighttime BP, and the increase in nighttime BP may be mediated by mechanisms other than increased catecholamines and poor sleep quality.
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Affiliation(s)
- Keng-Yu Chang
- Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA
| | - Tabitha Haun
- Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA
| | - Zhaoli Liu
- College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas, USA
| | - Alfredo Gil
- Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA
| | - Ziba Taherzadeh
- Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA
| | - Paul J Fadel
- Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA
| | - Shane A Phillips
- Department of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois, USA
| | - Mariann R Piano
- School of Nursing, Vanderbilt University, Nashville, Tennessee, USA
| | - Chueh-Lung Hwang
- Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA
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Scoubeau C, Carpentier J, Baudry S, Faoro V, Klass M. Comparison of body composition, cardiorespiratory, and neuromuscular adaptations induced by three different high intensity training protocols. Physiol Rep 2025; 13:e70306. [PMID: 40170529 PMCID: PMC11962203 DOI: 10.14814/phy2.70306] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/18/2024] [Revised: 03/08/2025] [Accepted: 03/24/2025] [Indexed: 04/03/2025] Open
Abstract
This study investigated body composition, cardiorespiratory, and neuromuscular adaptations induced by three high intensity trainings easy to fit into daily routine. Thirty-seven adults participated in one of the following 8-week interventions: vigorous intensity continuous training (VICT; 28 min at 70% of peak oxygen uptake [VO2peak]), long interval high intensity interval training (LI-HIIT; 6 × 2 min at 85% VO2peak), or short interval HIIT (SI-HIIT; 12 × 30 s at 125% maximal power output). Heart rate (HR) and rating of perceived exertion (RPE) were measured during sessions. Pre- and post-intervention assessments included fat and lean mass, cardiopulmonary exercise testing, knee extensors maximal isometric torque, voluntary activation, and endurance during a submaximal contraction. Compared to SI-HIIT and VICT, LI-HIIT sessions were characterized by a shorter duration, a similar time spent above 90% HRmax, but a higher RPE (p < 0.05). VO2peak and muscle endurance increased respectively by 14% and 12%, while knee extensors torque, voluntary activation, and lean mass increased to a lesser extent (1%-3%) after the interventions (ANOVA time-effect, all p < 0.05). There was no significant difference between the modalities (intervention × time interaction, all p > 0.05). In conclusion, comparable body composition, cardiorespiratory, and neuromuscular adaptations were induced by the three high intensity training protocols, while RPE was higher during LI-HIIT sessions.
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Affiliation(s)
- Corentin Scoubeau
- Cardio‐Pulmonary Exercise LaboratoryFaculty of Human Motor Sciences, Université Libre de BruxellesBrusselsBelgium
| | - Julie Carpentier
- Research Unit in Biometry and Exercise NutritionFaculty of Human Motor Sciences, Université Libre de BruxellesBrusselsBelgium
| | - Stéphane Baudry
- Laboratory of Applied Biology and Research Unit in Applied NeurophysiologyFaculty of Human Motor Sciences, ULB Neuroscience Institute, Université Libre de BruxellesBrusselsBelgium
| | - Vitalie Faoro
- Cardio‐Pulmonary Exercise LaboratoryFaculty of Human Motor Sciences, Université Libre de BruxellesBrusselsBelgium
| | - Malgorzata Klass
- Research Unit in Biometry and Exercise NutritionFaculty of Human Motor Sciences, Université Libre de BruxellesBrusselsBelgium
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Men J, Zhao C, Xiang C, Zhu G, Yu Z, Wang P, Wu S, Zhang Y, Li Y, Wang L, Gong X, Yang X, Zou S, Ma J, Cui C, Li H, Ma X, Wu W, Wang Y. Effects of high-intensity interval training on physical morphology, cardiopulmonary function, and metabolic indicators in older adults: a systematic review and meta-analysis. Front Endocrinol (Lausanne) 2025; 16:1526991. [PMID: 40201761 PMCID: PMC11975580 DOI: 10.3389/fendo.2025.1526991] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/20/2024] [Accepted: 02/19/2025] [Indexed: 04/10/2025] Open
Abstract
Background Despite the growing attention towards the efficacy of high-intensity interval training (HIIT) on older adult health, a consensus regarding the pleiotropic effects of HIIT in this population is yet to be reached. Previous studies have predominantly focused on specific outcomes or particular groups, lacking comprehensive analysis. Objective We aimed to conduct a systematic evaluation of the impact of HIIT on body composition, cardiopulmonary function, and metabolic parameters in older adults. Methods The databases searched included PubMed, Web of Science, Cochrane Library, Scopus, WanFang, and other relevant sources from the inception of the database until July 2023. Randomized controlled trials (RCTs) on the effects of HIIT on body shape, cardiopulmonary function, and metabolic parameters in the older adult were searched. Results A total of 87 RCTs meeting the criteria were included, involving 4,213 older adult people. Meta-analysis results showed that HIIT significantly improved body fat percentage (BF%) [MD: -1.63%, p = 0.005], maximal oxygen uptake (VO2max) [MD: 2.46 mL min-1 kg-1, p < 0.00001], maximal heart rate (HRmax) [MD: 2.83 beats min-1, p = 0.02], and high-density lipoprotein (HDL) levels [MD: 0.04 mmol L-1, p = 0.002]. However, for systolic blood pressure (SBP) [MD: 0.49 mmHg, p = 0.60], resting heart rate (HRrest) [MD: -0.95 BPM -1, p = 0.24], triglycerides (TG) [tendency for MD: -0.02 mmol L-1, p = 0.61], low-density lipoprotein (LDL) [MD: -0.04 mmol L-1, p = 0.27] had no significant effect. Sensitivity analysis found that HIIT significantly improved waist circumference (WC) [MD: -1.89 cm, p = 0.17], diastolic blood pressure (DBP) [MD: -0.63 mmHg, p = 0.23], respiratory exchange rate (RER) [MD: 0.01, p = 0.20], total cholesterol (TC) [MD: 0.10 mmol L-1, p = 0.14], and fasting plasma glucose (FPG) [MD:-0.20 mmol L-1, p = 0.08], but the results lacked robustness. There was no significant improvement in DBP [MD: -0.63 mmHg, p = 0.23] and body mass index (BMI) [MD: -0.36 kg m-2, p = 0.06]. Conclusions HIIT has shown certain potential and advantages in improving the physical health of the older adult, especially in cardiopulmonary function. However, more high-quality studies are needed to confirm the effects of HIIT on the physical health of the older adult in the future. It also provides a reference for the clinical practice and family health management of HIIT in the older adult and the development of HIIT guidelines. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/myprospero, identifier CRD42023460252.
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Affiliation(s)
- Jie Men
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Chengrui Zhao
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Chenmin Xiang
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Guoyu Zhu
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Zhengyang Yu
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Pengbo Wang
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Simin Wu
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Yuxi Zhang
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Yishan Li
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Liuliu Wang
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Xueyan Gong
- Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital Department of Immunology & Rheumatology, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, China
| | - Xiang Yang
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Shuangling Zou
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Jia Ma
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Chenglong Cui
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Hao Li
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Xuedi Ma
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Wenjie Wu
- Fenyang College, Shanxi Medical University, Fenyang, China
| | - Yaoming Wang
- Fenyang College, Shanxi Medical University, Fenyang, China
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Zhu Q, Xiong X, Zheng Q, Deng Q, Hao Y, Liu D, Zheng J, Zhang G, Li J, Yang L. High-intensity interval training versus moderate-intensity continuous training for localized prostate cancer under active surveillance: a systematic review and network meta-analysis. Prostate Cancer Prostatic Dis 2025; 28:11-22. [PMID: 38378977 DOI: 10.1038/s41391-024-00801-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/08/2023] [Revised: 01/21/2024] [Accepted: 01/25/2024] [Indexed: 02/22/2024]
Abstract
BACKGROUND High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) have been increasingly adopted for localized prostate cancer (PCa) under active surveillance (AS). However, it is unclear which training modality is the most favorable in terms of cardiorespiratory fitness and biochemical progression. METHODS We searched PubMed, Cochrane and Embase for relevant RCTs. PRISMA guideline was adopted to ensure optimal conduct of this study. Serum prostate specific antigen (PSA) and peak VO2 were selected as primary outcomes and PSA doubling time (PSADT) and testosterone were selected as secondary outcomes. Only articles written in English were included. Cochrane risk-of-bias tool was used for risk of bias evaluation. RESULTS A total of 501 studies were selected. Six RCTs with 222 patients were included for data extraction and analysis. High-intensity interval training (HIIT) group demonstrated significantly lower PSA compared with usual care (UC) (MD = -1.4; 95%CI = -2.77 to -0.03) and moderate-intensity continuous training (MICT) group (MD = -1.67; 95%CI = -3.30 to -0.05). Both HIIT and MICT showed significantly improved peak VO2 compared with UC. No significant difference was observed in PSADT and testosterone among different training modalities and UC. Regarding peak VO2, MICT had the highest surface under cumulative ranking curve (SUCRA) scores (98.1%). For serum PSA, HIIT had the highest probability (97.8%) to be the training with the highest efficacy. The potential source of bias mainly came from poorly performed allocation concealment and blinding strategies. CONCLUSIONS The present study indicated that HIIT and MICT showed considerable cardiorespiratory benefits for localized PCa. HIIT was preferred over MICT in biochemical progression control in terms of decreasing serum PSA levels. However, MICT was favored over HIIT regarding cardiorespiratory benefits. The findings of this study may facilitate future lifestyle intervention, particularly in the form of physical training, for individuals diagnosed with localized PCa under AS.
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Affiliation(s)
- Qiyu Zhu
- Department of Urology, Institute of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, PR China
| | - Xingyu Xiong
- Department of Urology, Institute of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, PR China
| | - Qian Zheng
- West China School of Medicine, Sichuan University, Chengdu, Sichuan, PR China
| | - Qi Deng
- West China School of Medicine, Sichuan University, Chengdu, Sichuan, PR China
| | - Yun Hao
- West China School of Medicine, Sichuan University, Chengdu, Sichuan, PR China
| | - Dingbang Liu
- West China School of Medicine, Sichuan University, Chengdu, Sichuan, PR China
| | - Jiaming Zheng
- West China School of Medicine, Sichuan University, Chengdu, Sichuan, PR China
| | - Guangyue Zhang
- West China School of Medicine, Sichuan University, Chengdu, Sichuan, PR China
| | - Jiakun Li
- Department of Urology, Institute of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, PR China.
| | - Lu Yang
- Department of Urology, Institute of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, PR China.
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Sugimoto T, Hashida R, Iwanaga S, Baba E, Omoto M, Nakano D, Yoshio S, Kawaguchi T, Matsuse H. Increase in Brain-Derived Neurotrophic Factor After Cycling Exercise Resisting Electrically Stimulated Antagonist Muscle Contractions in Overweight Japanese People: A Randomized, Controlled, Single-Blind, Crossover Trial. Cureus 2025; 17:e80694. [PMID: 40242707 PMCID: PMC12000850 DOI: 10.7759/cureus.80694] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 03/16/2025] [Indexed: 04/18/2025] Open
Abstract
BACKGROUND A hybrid training system (HTS) combining antagonist muscle electrical stimulation and voluntary muscle contraction has been developed using electrically stimulated eccentric antagonist muscle contractions. The exercise method that combines a conventional cycle ergometer with HTS (HERG) adds additional exercise intensity to the conventional cycle ergometer through electrical stimulation. Exercise-induced brain-derived neurotrophic factor (BDNF) production appears to have neuroprotective effects and contributes to improved metabolic regulation. Changes in BDNF after exercise are related to exercise intensity. Therefore, combining a cycle ergometer with electrical stimulation may be an effective approach. PURPOSE The purpose of this study was to evaluate the effect of the HERG on BDNF secretion. PARTICIPANTS AND METHODS Fourteen healthy adults participated in the study. The participants performed two types of exercise at the anaerobic threshold: HERG and a cycling ergometer alone (CERG). A comparative study using a 2×2 crossover method was conducted to examine the differences in BDNF and lactate levels after HERG and CERG. A linear mixed model was used to compare changes in BDNF between HERG and CERG. RESULTS Both HERG and CERG significantly increased BDNF and lactate levels after exercise. In overweight individuals with a BMI of 25 or higher, the change in BDNF levels after HERG was significantly greater than after CERG [ΔBDNF: 5500.96±7965.83 ng/ml, 1921.29±5308.22 ng/ml, respectively; p=0.0339]. There was no significant difference in the change in lactate levels after exercise between HERG and CERG (p=0.8632). CONCLUSION In overweight individuals, HERG increased post-exercise serum BDNF levels more than ergometer exercise alone, despite the exercise intensity remaining the same at the anaerobic threshold. The exercise method that combines the HERG may be a useful form of exercise for overweight individuals.
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Affiliation(s)
| | - Ryuki Hashida
- Division of Rehabilitation, Kurume University Hospital, Kurume, JPN
| | - Sohei Iwanaga
- Division of Rehabilitation, Kurume University Hospital, Kurume, JPN
| | - Eriko Baba
- Division of Rehabilitation, Kurume University Hospital, Kurume, JPN
| | - Masayuki Omoto
- Division of Rehabilitation, Kurume University Hospital, Kurume, JPN
| | - Dan Nakano
- Division of Gastroenterology, Kurume University Hospital, Kurume, JPN
| | - Sachiyo Yoshio
- Department of Human Immunology and Translational Research, National Center for Global Health and Medicine, Tokyo, JPN
| | - Takumi Kawaguchi
- Division of Gastroenterology, Kurume University School of Medicine, Kurume, JPN
| | - Hiroo Matsuse
- Division of Rehabilitation, Kurume University Hospital, Kurume, JPN
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11
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Li J, Liu G, Zhang D, Zhang K, Cao C. Physiological Mechanisms Driving Microcirculatory Enhancement: the Impact of Physical Activity. Rev Cardiovasc Med 2025; 26:25302. [PMID: 40026510 PMCID: PMC11868893 DOI: 10.31083/rcm25302] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2024] [Revised: 09/03/2024] [Accepted: 09/20/2024] [Indexed: 03/05/2025] Open
Abstract
Background Physical activity induces many beneficial adaptive changes to blood vessel microcirculation, ultimately improving both health and exercise performance. This positions it an effective non-pharmacological therapeutic approach for the rehabilitation of patients with various chronic diseases. Understanding the impact of different types of physical activities on microcirculation and elucidating their physiological mechanisms is crucial for optimizing clinical practice. Methods A comprehensive literature search was performed across multiple databases including PubMed, EBSCO, ProQuest, and Web of Science. Following a rigorous screening process, 48 studies were selected for inclusion into the study. Results Existing studies demonstrate that various forms of physical activity facilitate multiple positive adaptive changes at the microcirculation level. These include enhanced microvascular dilation-driven by endothelial cell factors and mechanical stress on blood vessels-as well as increased capillary density. The physiological mechanisms behind these improvements involve the neurohumoral regulation of endothelial cell factors and hormones, which are crucial for these positive effects. Physical activity also ameliorates inflammation markers and oxidative stress levels, upregulates the expression of silent information regulator 2 homolog 3, genes for hypoxia-inducible factors under hypoxic conditions, and induces favorable changes in multiple hemodynamic and hemorheological parameters. These structural and functional adaptations optimize myocardial blood flow regulation during exercise and improve both oxygen transport and utilization capacity, which are beneficial for the rehabilitation of chronic disease patients. Conclusions Our provides a reference for using physical activity as a non-pharmacological intervention for patients with chronic conditions. This framework includes recommendations on exercise types, intensity, frequency, and duration. Additionally, we summarize the physiological mechanisms through which physical activity improves microcirculation, which can inform clinical decision-making.
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Affiliation(s)
- Jianyu Li
- Division of Sports Science and Physical Education Tsinghua University, Tsinghua University, 100084 Beijing, China
| | - Guochun Liu
- Division of Sports Science and Physical Education Tsinghua University, Tsinghua University, 100084 Beijing, China
- College of Exercise Medicine, Chongqing Medical University, 400331 Chongqing, China
| | - Dong Zhang
- Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, 100091 Beijing, China
| | - Keying Zhang
- Department of Physical Education, Southeast University, 210012 Nanjing, Jiangsu, China
| | - Chunmei Cao
- Division of Sports Science and Physical Education Tsinghua University, Tsinghua University, 100084 Beijing, China
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12
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Yan X, Lu Y, Zhang H, Zhu C, Tian L, Chen J, He E, Li Y. Optimal strategies for exercise intervention in older people diabetic patients: The impacts of intensity, form, and frequency on glycemic control: An exercise prescription for older people with diabetes. Arch Gerontol Geriatr 2025; 128:105621. [PMID: 39326291 DOI: 10.1016/j.archger.2024.105621] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/14/2024] [Revised: 08/26/2024] [Accepted: 09/03/2024] [Indexed: 09/28/2024]
Abstract
OBJECTIVE This study aims to investigate the optimal exercise intensity, type, and weekly duration for improving glycated haemoglobin (HbA1c) and fasting blood glucose (FBG) levels in older people individuals with diabetes. MATERIALS AND METHODS PubMed, EMBASE, Web of Science and other databases were searched to identify randomised controlled trials (RCTs) starting from January 2000 to February 2024 that reported improved effects on fasting glucose and glycated haemoglobin after different exercises in middle-aged and elderly diabetic patients. Meta-analyses Review Manager V.5.3 was used. RESULTS Meta-analysis showed that moderate- and high-intensity exercise had a significant effect on HbA1c levels, with a mean difference (MD) of -0.34 (95 % CI: -0.44 ∼ -0.24, p < 0.01) for moderate-intensity exercise and -0.54 (95 % CI: -0.78 ∼ -0.3, p < 0.001) for high-intensity exercise.. Both moderate-intensity and high-intensity exercise demonstrated statistical significance in lowering fasting blood glucose levels (p < 0.001). Additionally, there was no significant difference between aerobic and resistance exercise forms (p= 0.72). Furthermore, for reducing HbA1c levels, engageing in weekly exercise for at least 2.5 hours showed a MD of-0.44(95 % CI:-0.63∼0.25;p<0.001). CONCLUSIONS In summary, in terms of exercise intensity, medium and high-intensity exercise can significantly reduce HbA1c and FBG levels in middle-aged and older people diabetic patients; in terms of exercise form, the effects of different exercise forms within medium and high-intensity on HbA1c and FBG are not statistically significant; and in terms of exercise time, in moderate-intensity aerobic exercise, older people exercising for more than 2.5 h per week are more beneficial.
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Affiliation(s)
- Xueru Yan
- Sports Human Science Laboratory, Xinjiang Normal University, China
| | - Yujuan Lu
- Beijing Sports University,Beijing, China
| | - Haoda Zhang
- Sports Human Science Laboratory, Xinjiang Normal University, China
| | - Chen Zhu
- Sports Human Science Laboratory, Xinjiang Normal University, China
| | - Lan Tian
- Sports Human Science Laboratory, Xinjiang Normal University, China
| | - Jishuai Chen
- Sports Human Science Laboratory, Xinjiang Normal University, China
| | - Enpeng He
- Sports Human Science Laboratory, Xinjiang Normal University, China.
| | - Yingying Li
- Sports Human Science Laboratory, Xinjiang Normal University, China
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13
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Opazo-Díaz E, Montes-de-Oca-García A, Galán-Mercant A, Marín-Galindo A, Corral-Pérez J, Ponce-González JG. Characteristics of High-Intensity Interval Training Influence Anthropometrics, Glycemic Control, and Cardiorespiratory Fitness in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Sports Med 2024; 54:3127-3149. [PMID: 39358495 DOI: 10.1007/s40279-024-02114-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 08/29/2024] [Indexed: 10/04/2024]
Abstract
BACKGROUND Exercise is a non-pharmacological intervention for type 2 diabetes mellitus (T2DM), including moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT). Despite diverse exercise protocol variations, the impact of these variations in HIIT on T2DM anthropometrics, glycemic control, and cardiorespiratory fitness (CRF) remains unclear. OBJECTIVE The aim was to examine the influence of HIIT protocol characteristics on anthropometrics, glycemic control, and CRF in T2DM patients and compare it to control (without exercise) and MICT. METHODS This review is registered in PROSPERO (CRD42021281398) and follows Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search, employing "high-intensity interval training" and "diabetes mellitus" in PubMed and Web of Science databases, with a "randomized controlled trial" filter, spanned articles up to January 2023. RESULTS Of 190 records, 29 trials were included, categorized by HIIT interval duration, training volume, and intervention period. Long-duration, high-volume, and long-term HIIT yields superior outcomes compared to control conditions for body mass, waist circumference, fasting plasma glucose, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), glycosylated hemoglobin (%HbA1c), and CRF. The findings favored HIIT over MICT for body mass in long-duration, high-volume, and short-term intervals (mean difference [MD] - 3.45, - 3.13, and - 5.42, respectively, all p < 0.05) and for CRF in long and medium work intervals and high volume (MD 1.91, 2.55, and 2.43, respectively, all p < 0.05), as well as in medium and long-term intervention (MD 2.66 and 2.21, respectively, all p < 0.05). Regardless of specific HIIT characteristics, no differences were found in the HIIT versus MICT comparison for glycemic control. CONCLUSIONS Specific HIIT protocol characteristics influence changes in anthropometrics, glycemic control, and CRF compared to control groups. However, compared to MICT, only longer duration, higher volume, and short-term HIIT improved body mass, waist circumference, and CRF in individuals with T2DM.
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Affiliation(s)
- Edgardo Opazo-Díaz
- ExPhy Research Group, Department of Physical Education, University of Cadiz, Puerto Real, Cádiz, Spain
- Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain
- Exercise Physiology Lab, Physical Therapy Department, University of Chile, Santiago, Chile
| | - Adrián Montes-de-Oca-García
- ExPhy Research Group, Department of Physical Education, University of Cadiz, Puerto Real, Cádiz, Spain.
- Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain.
| | - Alejandro Galán-Mercant
- Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain
- MOVE-IT Research Group, Department of Nursing and Physiotherapy, Faculty of Health Sciences, University of Cádiz, Cádiz, Spain
| | - Alberto Marín-Galindo
- ExPhy Research Group, Department of Physical Education, University of Cadiz, Puerto Real, Cádiz, Spain
- Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain
| | - Juan Corral-Pérez
- ExPhy Research Group, Department of Physical Education, University of Cadiz, Puerto Real, Cádiz, Spain
- Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain
| | - Jesús Gustavo Ponce-González
- ExPhy Research Group, Department of Physical Education, University of Cadiz, Puerto Real, Cádiz, Spain.
- Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain.
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14
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Zhang Y, Wang R, Liu T, Wang R. Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms. Metabolites 2024; 14:589. [PMID: 39590824 PMCID: PMC11596326 DOI: 10.3390/metabo14110589] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/29/2024] [Revised: 10/25/2024] [Accepted: 10/28/2024] [Indexed: 11/28/2024] Open
Abstract
Obesity is a complex, multifactorial condition involving excessive fat accumulation due to an imbalance between energy intake and expenditure, with its global prevalence steadily rising. This condition significantly increases the risk of chronic diseases, including sarcopenia, type 2 diabetes, and cardiovascular diseases, highlighting the need for effective interventions. Exercise has emerged as a potent non-pharmacological approach to combat obesity, targeting both central and peripheral mechanisms that regulate metabolism, energy expenditure, and neurological functions. In the central nervous system, exercise influences appetite, mood, and cognitive functions by modulating the reward system and regulating appetite-controlling hormones to manage energy intake. Concurrently, exercise promotes thermogenesis in adipose tissue and regulates endocrine path-ways and key metabolic organs, such as skeletal muscle and the liver, to enhance fat oxidation and support energy balance. Despite advances in understanding exercise's role in obesity, the precise interaction between the neurobiological and peripheral metabolic pathways remains underexplored, particularly in public health strategies. A better understanding of these interactions could inform more comprehensive obesity management approaches by addressing both central nervous system influences on behavior and peripheral metabolic regulation. This review synthesizes recent insights into these roles, highlighting potential therapeutic strategies targeting both systems for more effective obesity interventions.
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Affiliation(s)
- Yiyin Zhang
- School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China; (Y.Z.); (R.W.)
| | - Ruwen Wang
- School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China; (Y.Z.); (R.W.)
| | - Tiemin Liu
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China
| | - Ru Wang
- School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China; (Y.Z.); (R.W.)
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15
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Brummett M, Oglesby C, Barkus S, Wheelock NM, Tate A. The importance of education combined with tailored exercise in the health and wellness of older adults: a community case study. Front Psychol 2024; 15:1488903. [PMID: 39450129 PMCID: PMC11499106 DOI: 10.3389/fpsyg.2024.1488903] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/30/2024] [Accepted: 09/30/2024] [Indexed: 10/26/2024] Open
Abstract
Current literature states the importance of mental and physical health in combating the effects of metabolic syndrome; however, there is limited information on whether providing education on the syndrome along with mental and individualized physical exercises improves perceived confidence in the older adult population. A solution to this problem would be to provide a course to this population with a primary goal of education and exercise prescription. A community case study was implemented in the spring of 2024 with the purpose of measuring perceived confidence in metabolic syndrome, management of stress and anxiety, and how to move safely with exercise. Twenty-nine older adults with an average age of 76.1 years were recruited from a local senior citizen center. A course was given to the participants that included education and prescription of exercises tailored to the needs of the individual. Before and after the course, participants completed a confidence survey investigating their confidence in lowering the risk for metabolic syndrome, managing stress/anxiety, and understanding how to move safely with exercise. Regarding the post surveys, knowing how to lower the risk of metabolic syndrome increased by 46%, learning how to manage stress and anxiety increased by 50%, and understanding how to exercise safely increased by 41%. The data from this study suggests that providing education along with specific exercise prescription improved the participant's confidence in lowering their risk for metabolic syndrome, management of stress and anxiety, and how to move safely with exercise.
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16
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Liao T, Zheng C, Xue J, Wang Y“T. Effects of aquatic and land high-intensity interval trainings on selected bio- and physiological variables among obese adolescents. Front Endocrinol (Lausanne) 2024; 15:1381925. [PMID: 39398340 PMCID: PMC11466748 DOI: 10.3389/fendo.2024.1381925] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/04/2024] [Accepted: 09/06/2024] [Indexed: 10/15/2024] Open
Abstract
Background Obesity among adolescents have become a global public health problem. Exercises can effectively improve the bio-physiological factors of obese adolescents. High-intensive interval training (HIIT) has been applied to obese adolescents. Studies have reported that the Aquatic environment may bring the same or more positive exercise effects as the land environment. Therefore, the purpose of this study was to examine the effects of aquatic and land interventions on selected bio-and physiological variables among obese adolescences. Methods Twenty-eight obese adolescents who met the requirements participated in and completed this study. The participants were randomly assigned to Aquatic HIIT group (n=17) or Land HIIT group (n=11) for a four-week exercise intervention, 3 time/week. Each Intervention program was one-hour long, including 20 minutes of warm-up, 30 minutes of HIIT and 10 minutes of stretching and relaxation. Bio- and physiological variables including Anthropometry and body composition, Physical Function and blood pressure, and Lipid metabolism indexes were collected before and after the Aquatic and Land interventions. Results After four weeks of exercise interventions, the body mass, BMI, body fat rate, waist circumference, hip circumference and body water content were significantly reduced (p<0.05), and the lean body mass were significantly increased (p<0.05) in both groups. Both group exhibited significant effects in decreasing, systolic blood pressure (p<0.05), diastolic blood pressure (p<0.01), and increasing vital capacity and total energy consumption (p<0.05). The Aquatic HIIT group showed significant effects on reducing Rest heart rate (p<0.05), but no significant changes in Rest heart rate in Land HIIT group (p=0.364). The low-density lipoprotein cholesterol in both groups was significantly decreased (p<0.05). Moreover, the Aquatic HIIT group had significant better improvements (p<0.05) in lean body mass, waist circumference, waist-to-hip ratio, vital capacity and total energy consumption than Land HIIT group did. Conclusions The results of the present study demonstrated that in a short-term (4 weeks) both Aquatic and Land HIIT interventions may improve the body composition, physical function, blood pressure and low-density lipoprotein cholesterol (LDL-C) of overweight and obese adolescents. Furthermore, the Aquatic HIIT may be superior than the Land HIIT in weight control among the obese adolescents.
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Affiliation(s)
- Ting Liao
- Aquatic Therapy and Fitness Research Centre, Wuhan Sports University, Wuhan, China
| | - Chuanbo Zheng
- Aquatic Therapy and Fitness Research Centre, Wuhan Sports University, Wuhan, China
| | - Jungang Xue
- Aquatic Therapy and Fitness Research Centre, Wuhan Sports University, Wuhan, China
| | - Yong “Tai” Wang
- Aquatic Therapy and Fitness Research Centre, Wuhan Sports University, Wuhan, China
- College of Health Sciences and Technology, Rochester Institute of Technology, Rochester, NY, United States
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17
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Liang W, Wang X, Cheng S, Jiao J, Zhu X, Duan Y. Effects of High-Intensity Interval Training on the Parameters Related to Physical Fitness and Health of Older Adults: A Systematic Review and Meta-Analysis. SPORTS MEDICINE - OPEN 2024; 10:98. [PMID: 39266933 PMCID: PMC11393274 DOI: 10.1186/s40798-024-00767-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/17/2023] [Accepted: 08/27/2024] [Indexed: 09/14/2024]
Abstract
BACKGROUND As a novel and time-efficient exercise form, high-intensity interval training (HIIT) has shown great potential in improving health-related physical fitness among diverse populations. However, empirical evidence on its efficacy among the elderly has not been well summarized. This systematic review and meta-analysis aimed to determine the effect of HIIT interventions on the parameters related to physical fitness and health of older adults, including resting heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), cardiorespiratory fitness (CRF), body mass index (BMI), body fat percent (BF%), waist circumference (WC), muscular endurance (ME), muscular strength (MS), muscular power (MP), balance and flexibility, compared to non-exercise and other-exercise (e.g., moderate-intensity continuous training, resistance training) conditions. METHODS Literature published from January 2000 to May 2023 was collected through extensive searches across eight databases and relevant review papers. Randomized controlled trials (RCTs) featuring a minimum 2-week exercise intervention for older adults (≥ 60 years) were included. The pooled effect size of Hedges'g was estimated using random-effects models in R. Meta-regression was performed for both categorical (health status, duration of training programme, and frequency) and continuous moderators (mean age, male rate, and attrition rate). RESULTS Forty-four eligible RCTs with 1863 participants (52.1% female; 60.5-81.2 years) were included in the quantitative analysis. Compared to non-exercise condition, HIIT significantly improved resting HR (g = -0.36, 95%CI = [-0.67, -0.05], P = 0.032), SBP (g = -0.29, 95%CI = [-0.54, -0.03], P = 0.008), CRF (g = 0.77, 95%CI = [0.51, 1.04], P < 0.001), BF% (g = -0.26, 95%CI = [-0.41, -0.11], P = 0.006), MS (g = 0.47, 95%CI = [0.23, 0.71], P = 0.004), ME (g = 0.65, 95%CI = [0.10, 1.19], P = 0.036), and balance (e.g., timed-up-and-go) (g = -0.79, 95%CI = [-1.19, -0.40], P = 0.035). Compared to other-exercise condition, HIIT significantly improved resting HR (g = -0.11, 95%CI = [-0.21, -0.01], P = 0.029), SBP (g = -0.14, 95%CI = [-0.28, -0.01], P = 0.038), and CRF (g = 0.23, 95%CI = [0.07, 0.38], P = 0.008). No significant difference was found between HIIT and non-exercise condition for DBP, BMI and WC, as well as between HIIT and other-exercise condition for DBP, BMI, BF%, WC, ME, and balance (all P > 0.05). Meta-regression indicated that mean age moderated the HIIT effect on resting HR (b = -0.02, P = 0.014; HIIT vs. other-exercise condition) and SBP (b = 0.03, P = 0.048; HIIT vs. non-exercise), and attrition rate moderated the effect on CRF (b = 0.03, P = 0.007; HIIT vs. non-exercise). CONCLUSION This study supports the efficacy of HIIT in improving resting HR, SBP, CRF, BF%, MS, ME and balance among older adults. More empirical evidence is needed to determine the efficacy of HIIT for MP and flexibility in this population. TRIAL REGISTRATION PROSPERO CRD42022316246.
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Affiliation(s)
- Wei Liang
- School of Physical Education, Shenzhen University, Shenzhen, China
| | - Xiang Wang
- Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, China.
| | - Shishi Cheng
- Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, China
| | - Jiao Jiao
- Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, China
| | - Xiangui Zhu
- School of Physical Education, Hebei Normal University, Shijiazhuang, China
| | - Yanping Duan
- Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, China.
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18
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Xie H, Mao X, Wang Z. Effect of high-intensity interval training and moderate-intensity continuous training on blood lactate clearance after high-intensity test in adult men. Front Physiol 2024; 15:1451464. [PMID: 39308979 PMCID: PMC11413624 DOI: 10.3389/fphys.2024.1451464] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2024] [Accepted: 08/19/2024] [Indexed: 09/25/2024] Open
Abstract
This study compared the effects of High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on blood lactate clearance. 21 adult males were equally and randomly assigned to the HIIT and MICT groups, and completed 8 weeks of training. Before the training intervention, after 4 weeks and 8 weeks of training, all subjects were tested for blood lactate levels between 0 and 55 min after the same high-intensity test. The results show that after 8 weeks, blood lactate levels were significantly lower than pre-tests in both the HIIT and MICT groups at "0-55 min" after high-intensity test (p < 0.05), and the blood lactate clearance percentage at15-min and 30-min in both groups were significantly higher than the pre-tests (P < 0.01). The blood lactate levels in the HIIT group were significantly lower than those in the MICT group at 15 min and 30 min after test (P < 0.05), and the blood lactate clearance percentage at 30 min in the HIIT group was significantly higher than those in the MICT group (P < 0.05). In conclusion, both HIIT and MICT enhance blood lactate clearance in adult males post high-intensity test, with HIIT demonstrating superior effectiveness, making it a viable alternative to MICT.
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Affiliation(s)
- Han Xie
- College of Physical Education and Sports, Beijing Normal University, Beijing, China
| | - Xiaojin Mao
- College of Physical Education, Shandong Normal University, Jinan, China
| | - Zhaohong Wang
- College of Physical Education and Sports, Beijing Normal University, Beijing, China
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19
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Miranda-Tueros M, Ramirez-Peña J, Cabanillas-Lazo M, Paz-Ibarra JL, Pinedo-Torres I. Effects of aerobic exercise on components of the metabolic syndrome in older adults with type 2 diabetes mellitus: systematic review and meta-analysis. Rev Peru Med Exp Salud Publica 2024; 41:146-155. [PMID: 39166637 PMCID: PMC11300696 DOI: 10.17843/rpmesp.2024.412.12751] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/30/2023] [Accepted: 03/27/2024] [Indexed: 08/23/2024] Open
Abstract
OBJECTIVE. To determine the effects of aerobic exercise on the components of the metabolic syndrome in older adult diabetic patients by means of a systematic review with meta-analysis. MATERIALS AND METHODS. We used the PubMed/Medline, Scopus, Cochrane library, Web of Science databases and the Google Scholar search engine. Randomized controlled trials (RCTs) were selected according to the inclusion criteria. Two reviewers independently determined whether studies met the inclusion criteria, extracted data, and used the Cochrane risk of bias tool (RoB 2). Quantitative analyses were performed in R v 4.0.5, using random effects. RESULTS. We identified 8697 studies, of which 7 RCTs were included in the qualitative synthesis. Most studies were assessed as having a high or low RoB in at least three domains. Meta-analysis showed that aerobic exercise was effective in improving glucose levels (standardized mean difference [SMD]: -1.04; 95% confidence interval [95% CI] -1.27, -0.81), systolic blood pressure (SMD: -0.79; 95% CI: -1.02, -0.56), diastolic blood pressure (SMD: -0.75; 95% CI: -0.98, -0.52), glycosylated hemoglobin (SMD: -0.57, 95% CI: -0.77, -0.37), HDL (SMD: 0.35, 95% CI: 0.15, 0.55), triglycerides (SMD: -0.26, 95% CI: -0.47, -0.06). No significant adverse effects were reported. The level of certainty of the results was low for fasting glucose, moderate for systolic and diastolic blood pressure, and very low for the other outcomes, in addition to few adverse effects. However, these results should be interpreted with caution due to the use of surrogate markers. CONCLUSIONS. Aerobic exercise was shown to have a significant improvement in the components of the metabolic syndrome in older diabetic adults, and no major adverse effects were reported. However, we recommend more RCTs with longer intervention time to establish the impact on symptoms and complications. Motivation for the study. The motivation for this research arises from the high prevalence of metabolic syndrome and diabetes mellitus around the world. Despite their impact, there is a gap in knowledge regarding non-pharmacological interventions in older adults aimed at improving the metabolic profile of these patients. Main findings. Our results show a significant improvement in glucose, blood pressure, glycosylated hemoglobin, HDL, and triglyceride levels after the aerobic exercise intervention. In addition, no significant adverse effects were observed. Public health implications. Physical exercise is an affordable and globally available strategy. It improves the metabolic profile of older adult patients with metabolic syndrome.
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Affiliation(s)
- Mercedes Miranda-Tueros
- Universidad Científica del Sur, Faculty of Health Sciences, Lima, Peru.Universidad Científica del SurUniversidad Científica del SurFaculty of Health SciencesLimaPeru
| | - Joshua Ramirez-Peña
- Universidad Científica del Sur, Faculty of Health Sciences, Lima, Peru.Universidad Científica del SurUniversidad Científica del SurFaculty of Health SciencesLimaPeru
| | - Miguel Cabanillas-Lazo
- Clinical and Health Effectiveness Network, REDECS, Lima, Peru.Clinical and Health Effectiveness NetworkREDECSLimaPeru
- University of Huanuco, Huanuco, Peru.University of HuanucoUUniversity of HuanucoHuánucoPeru
| | - José Luis Paz-Ibarra
- School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.Universidad Nacional Mayor de San MarcosSchool of MedicineUniversidad Nacional Mayor de San MarcosLimaPeru
- Edgardo Rebagliati Martins National Hospital, Lima, Peru.Edgardo Rebagliati Martins National HospitalLimaPerú
| | - Isabel Pinedo-Torres
- NEURONECS Research Group: Neuroscience, clinical effectiveness and public health, Universidad Científica del Sur, Lima, Peru.Universidad Científica del SurNEURONECS Research Group: Neuroscience, clinical effectiveness and public healthUniversidad Científica del SurLimaPeru
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20
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Karstoft K, Thorsen IK, Nielsen JS, Solomon TPJ, Masuki S, Nose H, Ried-Larsen M. Health benefits of interval walking training. Appl Physiol Nutr Metab 2024; 49:1002-1007. [PMID: 38507778 DOI: 10.1139/apnm-2023-0595] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/22/2024]
Abstract
Interval walking training (IWT) is a free-living training intervention involving alternating fast and slow walking cycles. IWT is efficacious in improving physical fitness and muscle strength, and reducing factors associated with lifestyle-related diseases. In individuals with type 2 diabetes, IWT improves glycemic control directly through enhanced glucose effectiveness, challenging conventional views on mechanisms behind training-induced improvements in glycemic control. Whereas adherence to IWT in short-term studies is high, ensuring long-term adherence remains a challenge, particularly in populations with chronic diseases and/or overweight/obesity. Long-term studies in real-world settings are imperative to ascertain the widespread effectiveness of IWT and elucidate its impact on hard endpoints.
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Affiliation(s)
- Kristian Karstoft
- Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
- Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
- Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
| | - Ida Kær Thorsen
- Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
| | - Jens Steen Nielsen
- Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark
- Department of Clinical Research, University of Southern Denmark, Odense, Denmark
| | | | - Shizue Masuki
- Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, Japan
| | - Hiroshi Nose
- Department of e-Health Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, Japan
| | - Mathias Ried-Larsen
- Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
- The University of Southern Denmark, Institute of Sports and Clinical Biomechanics, Odense, Denmark
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21
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Marcotte-Chénard A, Tremblay R, Deslauriers L, Geraldes P, Gayda M, Christou D, Mampuya W, Little JP, Riesco E. Comparison of 10 × 1-minute high-intensity interval training (HIIT) versus 4 × 4-minute HIIT on glucose control and variability in females with type 2 diabetes. Appl Physiol Nutr Metab 2024; 49:487-500. [PMID: 38052023 DOI: 10.1139/apnm-2023-0326] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/07/2023]
Abstract
Two high-intensity interval training (HIIT) regimens are often used in research and clinical settings. Yet, there has been no direct comparison to determine if one can improve glucose control and variability to a greater extent in individuals living with type 2 diabetes (T2D). Fourteen older females with T2D participated in a semi-randomized control trial where HIIT10 (10 × 1-min intervals at 90% heart rate max; HRmax) and HIIT4 (4 × 4-min intervals at 90% of HRmax) were compared to a control condition (CON; no exercise). Continuous glucose monitoring was used to assess glucose control and variability over 24 h after each condition. Both HIIT10 (-2.1 ± 1.1 mmol/L) and HIIT4 (-2.1 ± 1.3 mmol/L) acutely lowered glucose compared to CON (-0.7 ± 0.8 mmol/L; p = 0.001), with no difference between exercise conditions. This glucose-lowering effect did not persist over the 24-h post-exercise period, as both mean glucose (p = 0.751) and glucose variability (p = 0.168) were not significantly different among conditions. However, exploratory analyses focusing on individuals with less optimal glucose control (above median 24-h mean glucose in the CON condition; n = 7) revealed that 24-h mean glucose (7.4 [7.14-8.92] vs. 8.4 [7.5-9.9] mmol/L; p = 0.048), glucose variability (p = 0.010), and peak glucose (p = 0.048) were lower following HIIT10 compared to CON, while HIIT4 reduced time spent in moderate hyperglycemia compared to CON (p = 0.023). Both HIIT10 and HIIT4 acutely lower glycemia, but the effect does not persist over 24 h. However, in individuals with worse glucose control, HIIT10 may improve mean 24-h glucose and glycemic variability, while HIIT4 may reduce time spent in moderate hyperglycemia.
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Affiliation(s)
- A Marcotte-Chénard
- Research Centre on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, QC J1H 4C4, Canada
- Faculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke QC, J1K 2R1, Canada
| | - R Tremblay
- Research Centre on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, QC J1H 4C4, Canada
- Faculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke QC, J1K 2R1, Canada
| | - L Deslauriers
- Research Centre on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, QC J1H 4C4, Canada
- Faculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke QC, J1K 2R1, Canada
| | - P Geraldes
- CHUS Research Centre, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
| | - M Gayda
- ÉPIC Center of the Montreal Heart Institute, University of Montreal, Montreal, QC H1T 1N6, Canada
| | - D Christou
- Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL 32611-8205, USA
| | - W Mampuya
- Research Centre on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, QC J1H 4C4, Canada
- CHUS Research Centre, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
| | - J P Little
- School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC V1V 1V7, Canada
| | - E Riesco
- Research Centre on Aging, CIUSSS de l'Estrie - CHUS, Sherbrooke, QC J1H 4C4, Canada
- Faculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke QC, J1K 2R1, Canada
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22
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Cavalli NP, de Mello MB, Righi NC, Schuch FB, Signori LU, da Silva AMV. Effects of high-intensity interval training and its different protocols on lipid profile and glycaemic control in type 2 diabetes: A meta-analysis. J Sports Sci 2024; 42:333-349. [PMID: 38531052 DOI: 10.1080/02640414.2024.2330232] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/20/2023] [Accepted: 03/07/2024] [Indexed: 03/28/2024]
Abstract
This meta-analysis of randomised clinical trials aimed to compare the effects of high-intensity interval training (HIIT) and its different protocols versus moderate-intensity continuous training (MICT) and/or control on total cholesterol, HDL, LDL, triglycerides, HbA1c levels, and fasting glucose in individuals with type 2 diabetes mellitus (T2DM). The search strategy was performed in PubMed/MEDLINE, Cochrane CENTRAL, EMBASE, Web of Science, Sport DISCUS, and PEDro, until January 2023. A total of 31 studies (1092 individuals) were included. When compared to control, HIIT decreased total cholesterol by -0.31 mmol/L (95% CI -0.49; -0.12), LDL by -0.31 mmol/L (95% CI -0.49; -0.12), triglycerides by -0.27 mmol/L (95% CI -0.33; -0.2), HbA1c by -0.75% (95% CI -0.97; -0.53), fasting glucose by -1.15 mmol/L (95% CI -1.44; -0.86), and increased HDL by 0.24 mmol/L (95% CI 0.06; 0.42). No difference was found in the comparison between HIIT versus MICT for any of the outcomes analysed, however subgroup analysis showed that a moderate-interval (>30s to < 2 min) and moderate-term (>4 to < 12 weeks) HIIT protocol reduced total cholesterol, when compared to MICT. HIIT is able to improve lipid profile and glycaemic control in T2DM individuals, and specific protocols can be recommended for improving total cholesterol levels.
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Affiliation(s)
- Nandiny Paula Cavalli
- Postgraduate Program in Movement Sciences and Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil
| | - Mariana Brondani de Mello
- Postgraduate Program in Functional Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil
| | - Natiele Camponogara Righi
- Postgraduate Program in Rehabilitation Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil
| | - Felipe Barreto Schuch
- Department of Sport Methods and Techniques, Postgraduate Program in Movement Sciences and Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil
| | - Luis Ulisses Signori
- Department of Physiotherapy and Rehabilitation, Postgraduate Program in Movement Sciences and Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil
| | - Antônio Marcos Vargas da Silva
- Department of Physiotherapy and Rehabilitation, Postgraduate Program in Movement Sciences and Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil
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23
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Arrieta-Leandro MC, Moncada-Jiménez J, Morales-Scholz MG, Hernández-Elizondo J. The effect of chronic high-intensity interval training programs on glycaemic control, aerobic resistance, and body composition in type 2 diabetic patients: a meta-analysis. J Endocrinol Invest 2023; 46:2423-2443. [PMID: 37454031 DOI: 10.1007/s40618-023-02144-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/15/2022] [Accepted: 06/18/2023] [Indexed: 07/18/2023]
Abstract
BACKGROUND Type 2 diabetes is an increasing health problem worldwide. HIIT has been proposed as an exercise alternative to be part of integral type 2 diabetes treatment. OBJECTIVE The aim of this meta-analysis was to determine the effect of different types of chronic HIIT on glycaemic control, aerobic resistance, and body composition in individuals above 18 years with T2D. DESIGN This meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and was registered with PROSPERO on November 21st, 2021. DATA SOURCES A systematic literature search of the following databases: EbscoHost (Academic Search Ultimate, Fuente Académica Plus, MEDline and SportDiscus), Web of Science, PubMed, and EMBASE between April of 2021 and April of 2023 was conducted. ELIGIBILITY CRITERIA FOR SELECTING STUDIES Eligibility criteria included (1) participants aged ≥ 18 years with a diagnosis of type 2 diabetes, (2) an HIIT protocol with detailed description, (3) control group and/or continuous aerobic training comparison group, (4) report of pre-test and post-test values for at least one of the studied variables (from glycaemic control, aerobic resistance, and/or body composition), and (5) experimental or quasi-experimental intervention design. ANALYSES Meta-analysis was made by a pre-post-test between-group analysis following the inverse variance heterogeneity model for each variable, and then, a subgroup analysis by type of HIIT was conducted. RESULTS Of the 2817 records obtained, 180 records were included for meta-analysis. Significant improvements were found in the most part of the variables when HIIT was compared to control group, while fat-free mass kept without changes. HIIT vs. continuous aerobic training results showed and advantage in favor of HIIT for fasting blood glycemia. Subgroup analysis refers a possible advantage of SI-HIIT and SIT-HIIT in the improvement of fasting glycemia and SIT-HIIT advantage in HOMA 1-IR decrease. CONCLUSIONS HIIT improves glycaemic control, aerobic resistance, and % fat and waist circumference, and kept fat-free mass unchanged in individuals with T2D. SI-HIIT and SIT-HIIT could be better than the other types of HIIT. HIIT benefit is similar to continuous aerobic training except for fasting blood glycemia.
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Affiliation(s)
- M C Arrieta-Leandro
- School of Physical Education and Sports, University of Costa Rica, San Jose, Costa Rica.
| | - J Moncada-Jiménez
- School of Physical Education and Sports, University of Costa Rica, San Jose, Costa Rica
- Human Movement Sciences Research Center (CIMOHU), University of Costa Rica, San Jose, Costa Rica
| | - M G Morales-Scholz
- School of Physical Education and Sports, University of Costa Rica, San Jose, Costa Rica
- Human Movement Sciences Research Center (CIMOHU), University of Costa Rica, San Jose, Costa Rica
| | - J Hernández-Elizondo
- School of Physical Education and Sports, University of Costa Rica, San Jose, Costa Rica
- Human Movement Sciences Research Center (CIMOHU), University of Costa Rica, San Jose, Costa Rica
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24
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Ruegsegger GN, Ekholm ER, Monroe CE, Rappaport CI, Huppert RD, Anton CR, Ferguson MJ. Glucose tolerance status associates with improvements in cognitive function following high-intensity exercise in adults with obesity. Physiol Behav 2023; 272:114389. [PMID: 37890604 DOI: 10.1016/j.physbeh.2023.114389] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2023] [Revised: 09/28/2023] [Accepted: 10/24/2023] [Indexed: 10/29/2023]
Abstract
PURPOSE Obesity, insulin resistance (IR), and proinflammatory cytokines associate with cognitive decline. Numerous studies document cognitive benefits of acute exercise bouts in lean individuals. However, how co-morbidities such as obesity and IR influence cognitive changes induced by acute exercise is unclear. We examined the effects of acute high-intensity aerobic exercise on cognitive function in age-matched and BMI-matched obese adults with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT) and in lean, NGT adults. METHODS 49 adults (15 Lean, 18 Obese-NGT, 16 Obese-IGT) performed one session of high-intensity interval exercise (four cycles of 4-min at 75% Wmax with 3-min rest). Cognitive function testing and blood sampling were performed pre- and post-exercise. RESULTS Following exercise, measurements of executive function and working memory were improved in Lean and Obese-NGT (p < 0.05), but not Obese-IGT. Changes in cognitive function following exercise negatively correlated with 2-hr glucose during an OGTT after controlling for body weight and body composition (rp = -0.40, p = 0.007). Serum levels of inflammatory cytokines IL-6 and CRP remained increased 60-minutes post-exercise in Obese-IGT, but not in Lean or Obese-NGT, which positively associated with 2-hr glucose during an OGTT (p < 0.01) and negatively with changes in cognitive function following exercise (p < 0.01). Greater insulin levels in Obese-IGT post-exercise also negatively correlated with changes in cognitive function following exercise (p < 0.01). CONCLUSION Improvements in cognition following acute high-intensity exercise positively associate with glucose tolerance, independent of body weight and body composition. Further, poorer changes in cognitive performance following exercise associate with persistent peripheral inflammation.
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Affiliation(s)
- Gregory N Ruegsegger
- Department of Health and Human Performance, University of Wisconsin-River Falls, A173 Falcon Center, 410 S. 3rd St., River Falls, WI, 54022, United States.
| | - Emily R Ekholm
- Department of Health and Human Performance, University of Wisconsin-River Falls, A173 Falcon Center, 410 S. 3rd St., River Falls, WI, 54022, United States
| | - Chandler E Monroe
- Department of Health and Human Performance, University of Wisconsin-River Falls, A173 Falcon Center, 410 S. 3rd St., River Falls, WI, 54022, United States
| | - Chapin I Rappaport
- Department of Health and Human Performance, University of Wisconsin-River Falls, A173 Falcon Center, 410 S. 3rd St., River Falls, WI, 54022, United States
| | - Rocco D Huppert
- Department of Health and Human Performance, University of Wisconsin-River Falls, A173 Falcon Center, 410 S. 3rd St., River Falls, WI, 54022, United States
| | - Caleb R Anton
- Department of Health and Human Performance, University of Wisconsin-River Falls, A173 Falcon Center, 410 S. 3rd St., River Falls, WI, 54022, United States
| | - Mia J Ferguson
- Department of Health and Human Performance, University of Wisconsin-River Falls, A173 Falcon Center, 410 S. 3rd St., River Falls, WI, 54022, United States
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25
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CHANG YH, SHUN SC, CHEN MH, CHANG YF. Feasibility of Different Exercise Modalities for Community-Dwelling Residents With Physical Inactivity: A Randomized Controlled Trial. J Nurs Res 2023; 31:e301. [PMID: 37883059 PMCID: PMC11812666 DOI: 10.1097/jnr.0000000000000578] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/02/2022] [Accepted: 04/14/2023] [Indexed: 10/27/2023] Open
Abstract
BACKGROUND Exercise interventions can promote health, but they can be difficult to implement. Moreover, no consensus has been reached regarding which exercise modality promotes the most significant improvement in metabolic health. PURPOSE This feasibility study was conducted to (a) determine the implementation efficacy of supervised and home-based exercise interventions by investigating their respective rates of intervention adherence, adherence to targeted intensity, attrition, and adverse events and (b) explore the preliminary efficacy of 12-week exercise programs among aerobic exercise, aerobic exercise combined with resistance exercise, and high-intensity interval training on body composition, anthropometric parameters, and lipid profiles for community-dwelling residents with physical inactivity. METHODS This randomized controlled trial was conducted from April to October 2020. Seventy-two sedentary participants aged 40-70 years were enrolled and randomized into one of four groups: 12-week aerobic exercise, aerobic exercise combined with resistance exercise, high-intensity interval training, and control. The three exercise groups performed at least moderate-intensity supervised exercise twice a week and home-based exercise once a week, whereas the control group maintained their usual daily activities. The target variables, including body composition, anthropometric parameters, and lipid profiles, were measured before and after the 12-week intervention. RESULTS The intervention adherence rates were 74.01%-87.54% for the supervised exercise group, 64.98%-83.90% for the home-based exercise group, and 82.65%-92.65% for the target exercise intensity group. The attrition rate ranged from 12.50% to 17.65%, and no adverse events were reported in any of the exercise groups. Preliminary efficacy data show the reductions in body weight (95% CI [0.01, 1.20], p = .048) and low-density lipoprotein (95% CI [2.76, 30.32], p = .02) were greater in the exercise groups than the control group, although the intergroup differences were not significant. CONCLUSIONS/IMPLICATIONS FOR PRACTICE Body weight and low-density lipoprotein may be efficiently reduced in a 12-week period using any of the three exercise modalities with at least 82.65% adherence to moderate-intensity exercise and 70.84% adherence to exercising 3 times a week.
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Affiliation(s)
- Yu-Hsuan CHANG
- PhD, RN, Assistant Professor, Department of Nursing, National Tainan Junior College of Nursing, Tainan, Taiwan
| | - Shiow-Ching SHUN
- PhD, RN, Professor, Institute of Clinical Nursing, College of Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan
| | - Min-Hsin CHEN
- MS, Assistant Professor, General Education Center, National Tainan Junior College of Nursing, Tainan, Taiwan; and Doctoral Student, National Taiwan Sport University, Taoyuan, Taiwan
| | - Yin-Fan CHANG
- MD, Assistant Professor, Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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26
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Drewniok N, Kiselev J, Daum N, Mörgeli R, Spies C, Schaller SJ. Concepts for exercise therapy in prehabilitation for elderly people with frailty or pre-frailty prior to elective surgery. A scoping review. J Bodyw Mov Ther 2023; 36:74-82. [PMID: 37949603 DOI: 10.1016/j.jbmt.2023.05.004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/10/2022] [Revised: 03/19/2023] [Accepted: 05/01/2023] [Indexed: 11/12/2023]
Abstract
BACKGROUND Frailty is a state of reduced functional capacities in older people that can be reversed through multimodal therapy concepts. The effect of preoperative prehabilitation on frailty has been examined, but the heterogeneity of exercise regimens has prevented conclusive evidence. This scoping review analyses prehabilitation interventions, particularly exercise methods, published in trials for prefrail and frail elderly patients. METHOD We identified studies evaluating prehabilitation for frail elderly using the framework of Arksey and O'Malley. Five scientific databases were searched until March 2022. Articles were screened by two independent reviewers. Data extraction included, but was not limited to, study design, intervention protocol of the prehabilitation including exercise therapy and additional interventions, and safety of the reported exercise concepts. RESULTS Nineteen studies were included, offering an insight into the utilized prehabilitation concepts for exercise. All study interventions were based around exercise programs, potentially with complementary interventions. Twelve studies based their exercise programs on a combination of endurance and strength training. Breathing exercises were prescribed in five studies, flexibility routines in five, and one study included balance training. Further interventions included nutritional counselling/supplementation in nine studies, smoking/alcohol cessation in five, in addition to two physiological and three medical/pharmaceutical interventions. DISCUSSION Prehabilitation for the frail elderly is safe and feasible. The general concept of prehabiliation for frail patients is promising. An exercise program should focus on improving the patient's endurance and strength, considering the positive effects that can be provided by breathing exercises and other additional interventions, such as nutritional support or lifestyle counselling.
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Affiliation(s)
- Nils Drewniok
- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Berlin, Germany
| | - Jörn Kiselev
- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Berlin, Germany
| | - Nils Daum
- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Berlin, Germany
| | - Rudolf Mörgeli
- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Berlin, Germany
| | - Claudia Spies
- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Berlin, Germany
| | - Stefan J Schaller
- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Berlin, Germany.
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27
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D’Haese S, Verboven M, Evens L, Deluyker D, Lambrichts I, Eijnde BO, Hansen D, Bito V. Moderate- and High-Intensity Endurance Training Alleviate Diabetes-Induced Cardiac Dysfunction in Rats. Nutrients 2023; 15:3950. [PMID: 37764732 PMCID: PMC10535416 DOI: 10.3390/nu15183950] [Citation(s) in RCA: 6] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/16/2023] [Revised: 09/06/2023] [Accepted: 09/08/2023] [Indexed: 09/29/2023] Open
Abstract
Exercise training is an encouraging approach to treat cardiac dysfunction in type 2 diabetes (T2DM), but the impact of its intensity is not understood. We aim to investigate whether and, if so, how moderate-intensity training (MIT) and high-intensity interval training (HIIT) alleviate adverse cardiac remodeling and dysfunction in rats with T2DM. Male rats received standard chow (n = 10) or Western diet (WD) to induce T2DM. Hereafter, WD rats were subjected to a 12-week sedentary lifestyle (n = 8), running MIT (n = 7) or HIIT (n = 7). Insulin resistance and glucose tolerance were assessed during the oral glucose tolerance test. Plasma advanced glycation end-products (AGEs) were evaluated. Echocardiography and hemodynamic measurements evaluated cardiac function. Underlying cardiac mechanisms were investigated by histology, western blot and colorimetry. We found that MIT and HIIT lowered insulin resistance and blood glucose levels compared to sedentary WD rats. MIT decreased harmful plasma AGE levels. In the heart, MIT and HIIT lowered end-diastolic pressure, left ventricular wall thickness and interstitial collagen deposition. Cardiac citrate synthase activity, mitochondrial oxidative capacity marker, raised after both exercise training modalities. We conclude that MIT and HIIT are effective in alleviating diastolic dysfunction and pathological cardiac remodeling in T2DM, by lowering fibrosis and optimizing mitochondrial capacity.
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Affiliation(s)
- Sarah D’Haese
- UHasselt, Cardio & Organ Systems (COST), Biomedical Research Institute, Agoralaan, 3590 Diepenbeek, Belgium; (S.D.)
- Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
| | - Maxim Verboven
- UHasselt, Cardio & Organ Systems (COST), Biomedical Research Institute, Agoralaan, 3590 Diepenbeek, Belgium; (S.D.)
| | - Lize Evens
- UHasselt, Cardio & Organ Systems (COST), Biomedical Research Institute, Agoralaan, 3590 Diepenbeek, Belgium; (S.D.)
| | - Dorien Deluyker
- UHasselt, Cardio & Organ Systems (COST), Biomedical Research Institute, Agoralaan, 3590 Diepenbeek, Belgium; (S.D.)
| | - Ivo Lambrichts
- UHasselt, Cardio & Organ Systems (COST), Biomedical Research Institute, Agoralaan, 3590 Diepenbeek, Belgium; (S.D.)
| | - BO Eijnde
- UHasselt, Cardio & Organ Systems (COST), Biomedical Research Institute, Agoralaan, 3590 Diepenbeek, Belgium; (S.D.)
- UHasselt, SMRC Sports Medical Research Center, Agoralaan, 3590 Diepenbeek, Belgium
- Division of Sport Science, Faculty of Medicine & Health Sciences, Stellenbosch University, Stellenbosch 7602, South Africa
| | - Dominique Hansen
- UHasselt, REVAL Rehabilitation Research Centre, Faculty of Rehabilitation Sciences, Agoralaan, 3590 Diepenbeek, Belgium
- Department of Cardiology, Heart Centre Hasselt, Jessa Hospital, Stadsomvaart 11, 3500 Hasselt, Belgium
| | - Virginie Bito
- UHasselt, Cardio & Organ Systems (COST), Biomedical Research Institute, Agoralaan, 3590 Diepenbeek, Belgium; (S.D.)
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28
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Tao D, Awan-Scully R, Cole A, Gao Y, Ash GI, Gu Y, Dutheil F, Sun Y, Baker JS. Integration of exercise prescription into medical provision as a treatment for non-communicable diseases: A scoping review. Front Public Health 2023; 11:1126244. [PMID: 37501942 PMCID: PMC10369190 DOI: 10.3389/fpubh.2023.1126244] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/17/2022] [Accepted: 03/22/2023] [Indexed: 07/29/2023] Open
Abstract
Background The purpose of this scoping review is to stimulate interest and to raise awareness, among researchers, healthcare practitioners, and policymakers regarding the current scientific literature related to exercise prescription for non-communicable diseases (NCDs). Exercise prescription is a safe and cost-effective method that enables physicians to use exercise as a complementary addition to NCDs management and treatment. Methods This scoping review followed the PRISMA Extension Guidelines for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Using this framework, we considered information from qualitative and quantitative studies to identify research gaps. We provide feasible suggestions to guide future research for the implementation of exercise prescription in the healthcare environment. The literature search was conducted using SPIDER and PICO tools for qualitative, quantitative, and mixed-study designs. Inclusion criteria included articles that investigated patients with NCDs and considered exercise interventions. Systematic searches of PubMed, Web of Science, MEDLINE, EMBASE, and ScienceDirect were undertaken on 26 July 2022 and all reference lists were manually searched. Data processing was performed using EndNote 2.0 software and data charts were used for numerical summary and thematic analysis. Results There were 10,951 articles retrieved, of which 28 met the inclusion criteria. Based on the evidence, exercise was a feasible, safe, and acceptable method to prevent and manage non-communicable diseases in inpatient and outpatient settings. Six research directions were identified and discussed. In addition, implementation evidence and suggestions for policy-reconfiguration are also provided. Conclusion This scoping review summarizes the current evidence for the effectiveness of exercise in the treatment of non-communicable diseases. The review provides key findings supporting exercise prescription for the inpatient and outpatient healthcare service. We suggest that governments and healthcare policymakers globally advocate the inclusion of structured exercise prescription within the NCDs treatment setting.
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Affiliation(s)
- Dan Tao
- Research Academy of Medicine Combining Sports, Ningbo No. 2 Hospital, Ningbo, China
- Department of Government and International Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
| | - Roger Awan-Scully
- Department of Government and International Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
| | - Alistair Cole
- Department of Government and International Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
| | - Yang Gao
- Centre for Health and Exercise Science Research, Population Health and Medical Informatics, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
| | - Garrett I. Ash
- Center for Medical Informatics, Yale School of Medicine, Yale University, New Haven, CT, United States
| | - Yaodong Gu
- Research Academy of Medicine Combining Sports, Ningbo No. 2 Hospital, Ningbo, China
| | - Frederic Dutheil
- CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Preventive and Occupational Medicine, University Clermont Auvergne, Clermont-Ferrand, France
| | - Yan Sun
- Centre for Health and Exercise Science Research, Population Health and Medical Informatics, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
| | - Julien S. Baker
- Centre for Health and Exercise Science Research, Population Health and Medical Informatics, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
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Clemente-Suárez VJ, Martín-Rodríguez A, Redondo-Flórez L, López-Mora C, Yáñez-Sepúlveda R, Tornero-Aguilera JF. New Insights and Potential Therapeutic Interventions in Metabolic Diseases. Int J Mol Sci 2023; 24:10672. [PMID: 37445852 DOI: 10.3390/ijms241310672] [Citation(s) in RCA: 14] [Impact Index Per Article: 7.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/18/2023] [Revised: 06/13/2023] [Accepted: 06/21/2023] [Indexed: 07/15/2023] Open
Abstract
Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this review, we discussed the rise of metabolic diseases, especially in Western countries, the genetical, psychological, and behavioral basis of metabolic diseases, the role of nutrition and physical activity in the development of metabolic diseases, the role of single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, and cell-based therapies in metabolic diseases. Finally, practical applications derived from this information are made.
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Affiliation(s)
- Vicente Javier Clemente-Suárez
- Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain
- Grupo de Investigación en Cultura, Educación y Sociedad, Universidad de la Costa, Barranquilla 080002, Colombia
| | | | - Laura Redondo-Flórez
- Department of Health Sciences, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Tajo Street s/n, 28670 Villaviciosa de Odon, Spain
| | - Clara López-Mora
- Facultad de Ciencias Biomédicas y de la Salud, Universidad Europea de Valencia, Pg. de l'Albereda, 7, 46010 València, Spain
| | - Rodrigo Yáñez-Sepúlveda
- Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar 2520000, Chile
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Kourek C, Karatzanos E, Raidou V, Papazachou O, Philippou A, Nanas S, Dimopoulos S. Effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in type 2 diabetes: A systematic review. World J Cardiol 2023; 15:184-199. [PMID: 37124974 PMCID: PMC10130888 DOI: 10.4330/wjc.v15.i4.184] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/29/2023] [Revised: 02/22/2023] [Accepted: 03/29/2023] [Indexed: 04/20/2023] Open
Abstract
BACKGROUND Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome characterized by insulin resistance and hyperglycemia that may lead to endothelial dysfunction, reduced functional capacity and exercise intolerance. Regular aerobic exercise has been promoted as the most beneficial non-pharmacological treatment of cardiovascular diseases. High intensity interval training (HIIT) seems to be superior than moderate-intensity continuous training (MICT) in cardiovascular diseases by improving brachial artery flow-mediated dilation (FMD) and cardiorespiratory fitness to a greater extent. However, the beneficial effects of HIIT in patients with T2DM still remain under investigation and number of studies is limited. AIM To evaluate the effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in patients with T2DM. METHODS We performed a search on PubMed, PEDro and CINAHL databases, selecting papers published between December 2012 and December 2022 and identified published randomized controlled trials (RCTs) in the English language that included community or outpatient exercise training programs in patients with T2DM. RCTs were assessed for methodological rigor and risk of bias via the Physiotherapy Evidence Database (PEDro). The primary outcome was peak VO2 and the secondary outcome was endothelial function assessed either by FMD or other indices of microcirculation. RESULTS Twelve studies were included in our systematic review. The 12 RCTs resulted in 661 participants in total. HIIT was performed in 310 patients (46.8%), MICT to 271 and the rest 80 belonged to the control group. Peak VO2 increased in 10 out of 12 studies after HIIT. Ten studies compared HIIT with other exercise regimens (MICT or strength endurance) and 4 of them demonstrated additional beneficial effects of HIIT over MICT or other exercise regimens. Moreover, 4 studies explored the effects of HIIT on endothelial function and FMD in T2DM patients. In 2 of them, HIIT further improved endothelial function compared to MICT and/or the control group while in the rest 2 studies no differences between HIIT and MICT were observed. CONCLUSION Regular aerobic exercise training has beneficial effects on cardiorespiratory fitness and endothelial function in T2DM patients. HIIT may be superior by improving these parameters to a greater extent than MICT.
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Affiliation(s)
- Christos Kourek
- Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, 1 Critical Care Medicine Department, Evangelismos Hospital, Athens 10676, Greece
- Department of Cardiology, 417 Army Share Fund Hospital of Athens, Athens 11521, Greece
| | - Eleftherios Karatzanos
- Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, 1 Critical Care Medicine Department, Evangelismos Hospital, Athens 10676, Greece
| | - Vasiliki Raidou
- Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, National and Kapodistrian University of Athens, Athens 10676, Greece
| | - Ourania Papazachou
- Department of Cardiology, "Helena Venizelou" Hospital, Athens 10676, Greece
| | - Anastassios Philippou
- Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, 1 Critical Care Medicine Department, Evangelismos Hospital, Athens 10676, Greece
- Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece
| | - Serafim Nanas
- Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, 1 Critical Care Medicine Department, Evangelismos Hospital, Athens 10676, Greece
| | - Stavros Dimopoulos
- Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, 1 Critical Care Medicine Department, Evangelismos Hospital, Athens 10676, Greece
- Cardiac Surgery Intensive Care Unit, Onassis Cardiac Surgery Center, Athens 17674, Greece.
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Fazeli PL, Willig AL, Oliveira V, Buford TW, Vance DE, Burkholder G, Crane HM, Horvat Davey C, Fleming J, Webel AR. The Association Between Objectively-Measured Physical Activity and Cognitive Functioning in Middle-Aged and Older People Living with HIV. AIDS Behav 2023; 27:1199-1210. [PMID: 36163604 PMCID: PMC10129017 DOI: 10.1007/s10461-022-03857-5] [Citation(s) in RCA: 7] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 09/04/2022] [Indexed: 02/08/2023]
Abstract
Middle-aged and older people living with HIV (PWH) are at higher risk for cognitive impairment and engage in lower levels of physical activity (PA) than seronegative counterparts. Research examining the association between objectively-measured PA and cognitive function in this population is scarce. This cross-sectional study examined the association between accelerometry-measured PA and cognitive functioning among 75 PWH (mean age 55.63). Light PA was the PA variable with the most consistent associations with cognition, with more minutes per week of light PA (performed in bouts of ≥ 10 min) being associated with better executive function, working memory/attention, and speed of processing performance, adjusted for age and current CD4 count. Findings suggest that although middle-aged and older PWH engage in more light than moderate-to-vigorous PA, light PA may be beneficial to cognition. Longitudinal studies are needed to understand PA dose-response associations with cognitive trajectories, cognitive domain specificity of PA effects, and underlying neural mechanisms of PA.
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Affiliation(s)
- Pariya L Fazeli
- School of Nursing, University of Alabama at Birmingham, Birmingham, USA.
- Department of Family, Community, and Health Systems, UAB School of Nursing, NB 470C, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA.
| | - Amanda L Willig
- School of Medicine, University of Alabama at Birmingham, Birmingham, USA
| | - Vitor Oliveira
- School of Nursing, University of Washington, Seattle, USA
| | - Thomas W Buford
- School of Medicine, University of Alabama at Birmingham, Birmingham, USA
| | - David E Vance
- School of Nursing, University of Alabama at Birmingham, Birmingham, USA
| | - Greer Burkholder
- School of Medicine, University of Alabama at Birmingham, Birmingham, USA
| | - Heidi M Crane
- Department of Medicine, University of Washington, Seattle, USA
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Shima T, Kawabata-Iwakawa R, Onishi H, Jesmin S, Yoshikawa T. Light-intensity exercise improves memory dysfunction with the restoration of hippocampal MCT2 and miRNAs in type 2 diabetic mice. Metab Brain Dis 2023; 38:245-254. [PMID: 36370225 DOI: 10.1007/s11011-022-01117-y] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/15/2022] [Accepted: 10/28/2022] [Indexed: 11/15/2022]
Abstract
Cognitive decline associated with type 2 diabetes mellitus (T2DM) is a risk factor to impair human health. Although light-intensity exercise prevents hippocampal memory dysfunction in pre-symptomatic T2DM animals by altering hippocampal lactate transport and neurotrophic factors, the effects of light-intensity exercise in an advanced stage of T2DM animals remain unclear. Here, ob/ob mice, an animal model of T2DM, were subjected to light-intensity exercise (5.0 m/min) for 30 min/day, five days/week for four weeks. The effects of light-intensity exercise on hippocampal complications, mRNA expressions of monocarboxylate transporter (MCT), and miRNA levels were assessed. The light-intensity exercise improved hippocampal memory retention in ob/ob mice. Downregulated hippocampal Mct2 mRNA levels in T2DM were improved with light-intensity exercise. Hippocampal mRNA levels of Mct1 and Mct4 were unchanged within groups. Based on miRNA sequencing, sedentary ob/ob mice exhibited that 71 miRNAs were upregulated, and 77 miRNAs were downregulated in the hippocampus. In addition, the exercise significantly increased 24 miRNAs and decreased 4 miRNAs in the T2DM hippocampus. The exercise reversed T2DM-induced alterations of hippocampal 9 miRNAs, including miR-200a-3p. Our findings imply that miR-200a-3p/Mct2 in the hippocampus would be a possible clinical target for treating T2DM-induced memory dysfunction.
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Affiliation(s)
- Takeru Shima
- Department of Health and Physical Education, Cooperative Faculty of Education, Gunma University, 4-2 Aramaki-machi, Gunma, 371-8510, Maebashi, Japan.
| | - Reika Kawabata-Iwakawa
- Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan
| | - Hayate Onishi
- Department of Health and Physical Education, Cooperative Faculty of Education, Gunma University, 4-2 Aramaki-machi, Gunma, 371-8510, Maebashi, Japan
| | - Subrina Jesmin
- Faculty of Medicine, Toho University Graduate School of Medicine, 5-21-16 Omorinishi, Ota-ku, 143-0015, Tokyo, Japan
| | - Tomonori Yoshikawa
- Department of Health and Physical Education, Cooperative Faculty of Education, Gunma University, 4-2 Aramaki-machi, Gunma, 371-8510, Maebashi, Japan
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Hamasaki H. High-intensity Interval Training in Patients with Type 2 Diabetes: A Perspective from Previous Systematic Reviews. Endocr Metab Immune Disord Drug Targets 2023; 23:1248-1253. [PMID: 37005528 DOI: 10.2174/1871530323666230330124105] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/15/2022] [Revised: 02/11/2023] [Accepted: 02/16/2023] [Indexed: 04/04/2023]
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Pfeifer LO, De Nardi AT, da Silva LXN, Botton CE, do Nascimento DM, Teodoro JL, Schaan BD, Umpierre D. Association Between Physical Exercise Interventions Participation and Functional Capacity in Individuals with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Controlled Trials. SPORTS MEDICINE - OPEN 2022; 8:34. [PMID: 35244804 PMCID: PMC8897547 DOI: 10.1186/s40798-022-00422-1] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 09/23/2021] [Accepted: 02/13/2022] [Indexed: 11/25/2022]
Abstract
Background The prevalence of type 2 diabetes mellitus increases with age, and people with type 2 diabetes are more affected by reductions in functional performance. Although exercise interventions are recommended for people with diabetes, it is relevant to assess the effects of different training modes on the available functional outcomes. Therefore, our purpose was to systematically assess the effect of different physical exercise modalities in patients with type 2 diabetes with an average age of 45 years or older on outcomes used to measure functional capacity.
Methods A systematic review and meta-analysis of controlled trials was conducted. Seven databases were searched from January 1987 to December 2021 (PubMed, Physiotherapy Evidence Database, Cochrane Library, SPORTDiscus, and in grey literature: Open Grey and Google Scholar). Eligible studies should last 8 weeks or longer, comparing structured exercise training and non-exercise control for one out of six pre-specified functional capacity outcomes (Timed Up and Go test, chair stands, walking performance, upper-limb muscle strength, lower-limb muscle strength, physical fitness parameter), in patients with type 2 diabetes, aged ≥ 45 years. The risk of bias was assessed with the Downs & Black checklist. Pooled mean differences were calculated using a random-effects model, followed by sensitivity and meta-regression analyses. Results Of 18,112 references retrieved, 29 trials (1557 patients) were included. Among these, 13 studies used aerobic training, 6 studies used combined training, 4 studies used resistance training, 3 studies had multiple intervention arms and 3 studies used other types of training. Exercise training was associated with an increase in functional capacity outcomes, as reflected by changes in 6-min walk test (n = 8) [51.6 m; 95% CI 7.6% to 95.6%; I2 92%], one-repetition maximum leg-press (n = 3) [18.0 kg; 95% CI 4.0% to 31.9%; I2 0%], and maximum oxygen consumption (VO2max) (n = 20) [2.41 mL/kg·min; 95% CI 1.89% to 2.92%; I2 100%] compared with control groups. In sensitivity and subgroup analyses using VO2max as outcome and stratified by type of study (randomized and non-randomized controlled clinical trials), duration of diabetes diagnosis, and sex, we observed overlapping confidence intervals. Meta-regression showed no association between glycated hemoglobin (HbA1C) levels and VO2max [p = 0.34; I2 99.6%; R2 = 2.6%]. In addition, the quality of the included studies was mostly low. Conclusion The results indicate that structured physical exercise programs might improve functional capacity in patients with type 2 diabetes, except for the upper-limb muscle strength. However, we could not identify potential effect predictors associated with directional summary estimates. Trial registration This systematic review was registered in the PROSPERO international prospective register of systematic reviews (CRD42020162467); date of registration: 12/15/2019. The review protocol is hosted at the Open Science Framework (OSF) (Preprint https://doi.org/10.31219/osf.io/kpg2m). Supplementary Information The online version contains supplementary material available at 10.1186/s40798-022-00422-1.
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Youssef L, Granet J, Marcangeli V, Dulac M, Hajj-Boutros G, Reynaud O, Buckinx F, Gaudreau P, Morais JA, Mauriège P, Gouspillou G, Noirez P, Aubertin-Leheudre M. Clinical and Biological Adaptations in Obese Older Adults Following 12-Weeks of High-Intensity Interval Training or Moderate-Intensity Continuous Training. Healthcare (Basel) 2022; 10:healthcare10071346. [PMID: 35885872 PMCID: PMC9315493 DOI: 10.3390/healthcare10071346] [Citation(s) in RCA: 12] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/27/2022] [Revised: 07/16/2022] [Accepted: 07/18/2022] [Indexed: 12/30/2022] Open
Abstract
Sarcopenia and obesity are considered a double health burden. Therefore, the implementation of effective strategies is needed to improve the quality of life of older obese individuals. The aim of this study was to compare the impact of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on functional capacities, muscle function, body composition and blood biomarkers in obese older adults. Adipose tissue gene expression and markers of muscle mitochondrial content and quality control involved in exercise adaptations were also investigated. Sixty-eight participants performed either HIIT (n = 34) on an elliptical trainer or MICT (n = 34) on a treadmill, three times per week for 12 weeks. HIIT produced significantly higher benefits on some physical parameters (six-minute walking test (HIIT: +12.4% vs. MICT: +5.2%); step test (HIIT: +17.02% vs. MICT: +5.9%); ten-repetition chair test (HIIT: −17.04% vs. MICT: −4.7%)). Although both HIIT and MICT led to an improvement in lower limb power (HIIT: +25.2% vs. MICT: +20.4%), only MICT led to higher improvement in lower limb muscle strength (HIIT: +4.3% vs. MICT: +23.2%). HIIT was more beneficial for increasing total lean body mass (HIIT: +1.58% vs. MICT: −0.81%), while MICT was more effective for decreasing relative gynoid fat mass (HIIT: −1.09% vs. MICT: −4.20%). Regarding adipose tissue gene expression, a significant change was observed for cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in the HIIT group (A.U; HIIT at T0: 32.10 ± 39.37 vs. HIIT at T12: 48.2 ± 59.2). Mitochondrial transcription factor A (TFAM) content, a marker of mitochondrial biogenesis, increased significantly following HIIT (+36.2%) and MICT (+57.2%). A significant increase was observed in the HIIT group for Translocase of Outer Membrane 20 (TOM20; +54.1%; marker of mitochondrial content), Mitofusin-2 (MFN2; +71.6%; marker of mitochondrial fusion) and Parkin RBR E3 Ubiquitin Protein Ligase (PARKIN; +42.3%; marker of mitophagy). Overall, our results indicate that even though MICT (walking on treadmill) and HIIT (on an elliptical) are effective intervention strategies in obese older adults, HIIT appears to have slightly more beneficial effects. More specifically, HIIT led to higher improvements than MICT on functional capacities, lean mass and skeletal muscle markers of mitochondrial content, fusion, and mitophagy. Thus, MICT but also HIIT (time-efficient training) could be recommended as exercise modalities for obese older adults to maintain or improve mobility, health and quality of life.
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Affiliation(s)
- Layale Youssef
- École de Kinésiologie et des Sciences de l’Activité Physique, Université de Montréal, Montreal, QC H3T 1J4, Canada;
- Centre de Recherche de l’Institut, Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada; (J.G.); (F.B.); (G.G.)
| | - Jordan Granet
- Centre de Recherche de l’Institut, Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada; (J.G.); (F.B.); (G.G.)
- Département des Sciences Biologiques, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada; (V.M.); (M.D.); (O.R.)
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada
| | - Vincent Marcangeli
- Département des Sciences Biologiques, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada; (V.M.); (M.D.); (O.R.)
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada
| | - Maude Dulac
- Département des Sciences Biologiques, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada; (V.M.); (M.D.); (O.R.)
- Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada; (G.H.-B.); (J.A.M.)
| | - Guy Hajj-Boutros
- Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada; (G.H.-B.); (J.A.M.)
| | - Olivier Reynaud
- Département des Sciences Biologiques, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada; (V.M.); (M.D.); (O.R.)
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada
| | - Fanny Buckinx
- Centre de Recherche de l’Institut, Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada; (J.G.); (F.B.); (G.G.)
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada
| | - Pierrette Gaudreau
- Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, QC H2X 3E4, Canada;
| | - José A. Morais
- Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada; (G.H.-B.); (J.A.M.)
| | - Pascale Mauriège
- Centre de Recherche de l’Institut Universitaire de Cardiologie et Pneumologie de Québec, Université Laval, Quebec City, QC G1V 4G5, Canada;
- Département de Kinésiologie, Université Laval, Quebec City, QC G1V 0A6, Canada
| | - Gilles Gouspillou
- Centre de Recherche de l’Institut, Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada; (J.G.); (F.B.); (G.G.)
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada
- Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada; (G.H.-B.); (J.A.M.)
- Groupe de Recherche en Activité Physique Adaptée, Montreal, QC H2X 1Y4, Canada
| | - Philippe Noirez
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada
- PSMS, UFR STAPS, Université de Reims Champagne Ardenne, 51100 Reims, France
- T3S, Inserm, Université Paris Cité, 75006 Paris, France
- Institut de Recherche Médicale et d’Épidémiologie du Sport (IRMES), INSEP, Université Paris Cité, 75012 Paris, France
- Correspondence: (P.N.); (M.A.-L.)
| | - Mylène Aubertin-Leheudre
- École de Kinésiologie et des Sciences de l’Activité Physique, Université de Montréal, Montreal, QC H3T 1J4, Canada;
- Centre de Recherche de l’Institut, Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada; (J.G.); (F.B.); (G.G.)
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada
- Groupe de Recherche en Activité Physique Adaptée, Montreal, QC H2X 1Y4, Canada
- Correspondence: (P.N.); (M.A.-L.)
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Hovsepian V, Marandi SM, Esfarjani F, Zavar R, Sadeghi M. The Effect of All Extremity High Intensity Interval Training on Athero-Protective Factors and Endothelial Function in Overweight and Obese Women. Int J Prev Med 2021; 12:141. [PMID: 34912517 PMCID: PMC8631139 DOI: 10.4103/ijpvm.ijpvm_248_19] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/10/2019] [Accepted: 01/23/2020] [Indexed: 12/29/2022] Open
Abstract
Context: Obesity is associated with endothelial dysfunction and cardiovascular diseases. Adiponectin and fibroblast growth factor 21 (FGF21) as hormones are highly contributive in cardiovascular system, while they are disrupted through obesity. Weight-bearing high intensity interval training (HIIT) as an effective procedure in preventing obesity-related complications in adults with obesity may be limited due to the subjects' muscular weakness and complications interfering walking. Aims: The purpose of this study was to assess the effectiveness of non-weight bearing all extremity HIIT (all ex. HIIT) on FGF21, adiponectin, nitric oxide (NO), and flow mediated dilation (FMD) in overweight and obese women. Methods: Thirty healthy overweight and obese sedentary university female students within 20.53 ± 1.50 age range and BMI ≥27 kg.m-2 were assigned in two experimental and control groups. All ex. HIIT consisted of 4 × 4 min at 85–90% max HR with an interspersed with 3 × 3 min recovery per round at 70% max HR by upper and lower ergometers in a simultaneous manner on 10 weeks of four sessions of 40 min each. FGF21, adiponectin, NO, FMD, weight, waist and maximal oxygen uptake (VO2max) were measured in pre and post-tests. Paired sample t-test and analysis of covariance are applied for statistical analysis. Results: Results indicated a significant increase in adiponectin (P ≤ 0.01) and FMD (P ≤ 0.001), while there existed no changes in FGF21 at (P ≥ 0.10) and NO (P ≥ 0.84). The weight and waist decreased at (P ≤ 0.001), and the VO2max increased at (P ≤ 0.001). Conclusions: All ex. HIIT may be a safe alternative for overweigh and obese women who have complications with weight-bearing exercises, and may increase adiponectin, and improve the FMD, aerobic fitness, and body composition.
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Affiliation(s)
- Volga Hovsepian
- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran
| | - Sayad M Marandi
- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran
| | - Fahimeh Esfarjani
- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran
| | - Reihaneh Zavar
- Heart Failure Research Centre, Cardiovascular Research Institute Isfahan University of Medical Sciences, Isfahan, Iran
| | - Masoumeh Sadeghi
- Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan Iran, University of Medical Sciences, Isfahan, Iran
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de Mello MB, Righi NC, Schuch FB, Signori LU, da Silva AMV. Effect of high-intensity interval training protocols on VO 2max and HbA1c level in people with type 2 diabetes: A systematic review and meta-analysis. Ann Phys Rehabil Med 2021; 65:101586. [PMID: 34648979 DOI: 10.1016/j.rehab.2021.101586] [Citation(s) in RCA: 25] [Impact Index Per Article: 6.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/02/2021] [Revised: 07/19/2021] [Accepted: 08/10/2021] [Indexed: 12/16/2022]
Abstract
BACKGROUND The effect of high-intensity interval training (HIIT) protocols according to different work intervals, session volumes and training periods has not been evaluated in patients with type 2 diabetes mellitus (T2DM). OBJECTIVE This was a systematic review and meta-analysis of the effect of HIIT and its different protocols compared to moderate-intensity continuous training (MICT) and the control group on VO2max and glycated hemoglobin (HbA1c) level in patients with T2DM. METHODS The search strategy considered studies published up to September 2020 in the databases MEDLINE (PubMed), EMBASE, Cochrane CENTRAL, Web of Science and SPORTDiscus. Two authors independently searched the selected databases for randomized clinical trials that compared HIIT to MICT or the control in adults with T2DM. A random-effects meta-analysis was performed and the data are presented as the mean difference (95% confidence intervals [95% CIs]) between HIIT, MICT and control groups. RESULTS A total of 20 studies (738 participants) were included. Overall, HIIT increased VO2max by 5.09 mL/kg/min (95% CI 2.99; 7.19, I² = 80.89) versus the control and by 1.9 mL/kg/min (95% CI 0.81; 2.98, I² = 25.62) versus MICT. HIIT promoted a significant reduction in HbA1c level of -0.8% (95% CI -1.06; -0.49, I² = 77.31) versus the control but with no difference versus MICT. Moderate-interval, high-volume and long-term training promoted a greater increase in VO2max. A long interval and moderate volume and period conferred a greater increase in VO2max versus MICT. A short interval and moderate volume and period conferred a greater reduction in HbA1c level versus the control. No publication bias was detected, as evaluated by a funnel chart and Egger's test (p > 0.05). CONCLUSIONS As compared with MICT, HIIT had better effect on VO2max and a similar effect on HbA1C level. Interval protocols, moderate to long training period and moderate to high volume may maximize the HIIT effect in patients with T2DM.
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Affiliation(s)
- Mariana Brondani de Mello
- Postgraduate Program in Functional Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil
| | - Natiele Camponogara Righi
- Postgraduate Program in Rehabilitation Sciences at the Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil
| | - Felipe Barreto Schuch
- Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, Brazil; Department of Physiotherapy and Rehabilitation, Post-Graduate Programme in Functional Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil
| | - Luis Ulisses Signori
- Department of Physiotherapy and Rehabilitation, Post-Graduate Programme in Functional Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil
| | - Antônio Marcos Vargas da Silva
- Department of Physiotherapy and Rehabilitation, Post-Graduate Programme in Functional Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil.
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Chang SH, Wang LT, Chueh TY, Hsueh MC, Hung TM, Wang YW. Effectiveness of Facebook Remote Live-Streaming-Guided Exercise for Improving the Functional Fitness of Community-Dwelling Older Adults. Front Med (Lausanne) 2021; 8:734812. [PMID: 34631751 PMCID: PMC8495005 DOI: 10.3389/fmed.2021.734812] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/01/2021] [Accepted: 08/23/2021] [Indexed: 01/02/2023] Open
Abstract
Background: The aim of this study was to determine the effect of Facebook remote live-streaming-guided exercise on the functional fitness of community-dwelling older adults. Method: This study used a non-randomized controlled design with single-blinding (outcome assessors). Older adults (mean age = 70.36 ± 4.51 years) were assigned to either the experimental group (n = 39) or the control group (n = 34). The experimental group participated in a 75-min Facebook remote live-streaming-guided exercise routine twice a week for 8 weeks at home, whereas the control group maintained their original lifestyle without any intervention. Functional fitness was assessed using the Senior Fitness Test, which assessed upper and lower limb flexibility and muscle strength, cardiorespiratory fitness, and balance. The test was administered before and after the intervention. Results: The results revealed that an 8-week Facebook remote live-streaming-guided exercise intervention increased lower limb flexibility and muscle strength and cardiorespiratory fitness in community-dwelling older adults. Conclusion: The current findings suggest that a home-based exercise program using the Facebook platform may be a feasible method to broadly improve the functional fitness of community-dwelling older adults.
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Affiliation(s)
- Shao-Hsi Chang
- Department of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan
| | - Li-Ting Wang
- Department of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan
| | - Ting-Yu Chueh
- Department of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan
| | - Ming-Chun Hsueh
- Graduate Institute of Sport Pedagogy, University of Taipei, Taipei, Taiwan
| | - Tsung-Min Hung
- Department of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan.,Institute for Research Excellence in Learning Sciences, National Taiwan Normal University, Taipei, Taiwan
| | - Yu-Wen Wang
- Office of Physical Education, Chang Gung University, Taoyuan, Taiwan
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You Y, Li W, Liu J, Li X, Fu Y, Ma X. Bibliometric Review to Explore Emerging High-Intensity Interval Training in Health Promotion: A New Century Picture. Front Public Health 2021; 9:697633. [PMID: 34368063 PMCID: PMC8342813 DOI: 10.3389/fpubh.2021.697633] [Citation(s) in RCA: 77] [Impact Index Per Article: 19.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/20/2021] [Accepted: 05/27/2021] [Indexed: 12/12/2022] Open
Abstract
Background: High-intensity interval training (HIIT) is an emerging exercise strategy and is considered to be a recipe for health promotion. This study aimed to systematically identify collaboration networks, track research trends, highlight current hotspots, and predict future frontiers in HIIT and its applications in health promotion since the start of the new century. Methods: Relevant original publications were obtained from the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) database between 2001 and 2020. CiteSpace and VOSviewer software were used to perform bibliometric visualization and comparative analysis of involved indexes that included countries, institutions, journals, authors, references, and keywords. Results: A total of 572 papers were included, and the trend of annual publications showed a remarkable growth. The United States and the University of Exeter were the most productive country and institutions, respectively, with 107 and 18 publications, respectively. European Journal of Applied Physiology took the lead in the number of published articles, and Medicine and Science in Sports and Exercise ranked first in the cocitation counts. Barker AR and Gibala MJ were considered as the most productive and the most highly-cited authors. Conclusions: "Health risks," "adolescent," and "aging" are the three noteworthy topics during the evolution of HIIT-health promotion (HIIT-HP) research. The current research hotspots of HIIT and its practices in the health promotion domain lies in "metabolic diseases," "cardiovascular diseases," "neurological diseases," and "musculoskeletal diseases." The authors summarize that "prevention and rehabilitation," "micro and molecular level," and "cognition and mental health" are becoming frontiers and focus on the health topics related to HIIT in the upcoming years, which are worthy of further exploration.
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Affiliation(s)
- Yanwei You
- Division of Sport Science & Physical Education, Tsinghua University, Beijing, China
| | - Wenkai Li
- China Table Tennis College, Shanghai University of Sport, Shanghai, China
| | - Jianxiu Liu
- Division of Sport Science & Physical Education, Tsinghua University, Beijing, China
| | - Xingtian Li
- Division of Sport Science & Physical Education, Tsinghua University, Beijing, China
| | - Yingyao Fu
- Division of Sport Science & Physical Education, Tsinghua University, Beijing, China
| | - Xindong Ma
- Division of Sport Science & Physical Education, Tsinghua University, Beijing, China
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Marriott CFS, Petrella AFM, Marriott ECS, Boa Sorte Silva NC, Petrella RJ. High-Intensity Interval Training in Older Adults: a Scoping Review. SPORTS MEDICINE - OPEN 2021; 7:49. [PMID: 34279765 PMCID: PMC8289951 DOI: 10.1186/s40798-021-00344-4] [Citation(s) in RCA: 40] [Impact Index Per Article: 10.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 11/01/2020] [Accepted: 07/04/2021] [Indexed: 12/12/2022]
Abstract
High-intensity interval training (HIIT) is an increasingly popular form of aerobic exercise which includes bouts of high-intensity exercise interspersed with periods of rest. The health benefits, risks, and optimal design of HIIT are still unclear. Further, most research on HIIT has been done in young and middle-aged adults, and as such, the tolerability and effects in senior populations are less well-known. The purpose of this scoping review was to characterize HIIT research that has been done in older adults including protocols, feasibility, and safety and to identify gaps in the current knowledge. Five databases were searched with variations of the terms, "high-intensity interval training" and "older adults" for experimental or quasi-experimental studies published in or after 2009. Studies were included if they had a treatment group with a mean age of 65 years or older who did HIIT, exclusively. Of 4644 papers identified, 69 met the inclusion criteria. The average duration of training was 7.9 (7.0) weeks (mean [SD]) and protocols ranged widely. The average sample size was 47.0 (65.2) subjects (mean [SD]). Healthy populations were the most studied group (n = 30), followed by subjects with cardiovascular (n = 12) or cardiac disease (n = 9), metabolic dysfunction (n = 8), and others (n = 10). The most common primary outcomes included changes in cardiorespiratory fitness (such as VO2peak) as well as feasibility and safety of the protocols as measured by the number of participant dropouts, adverse events, and compliance rate. HIIT protocols were diverse but were generally well-tolerated and may confer many health advantages to older adults. Larger studies and more research in clinical populations most representative of older adults are needed to further evaluate the clinical effects of HIIT in these groups.
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Affiliation(s)
- Catherine F. S. Marriott
- Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON Canada
| | - Andrea F. M. Petrella
- Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON Canada
| | - Emily C. S. Marriott
- Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON Canada
| | - Narlon C. Boa Sorte Silva
- Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON Canada
- Aging, Mobility, and Cognitive Neuroscience Lab, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC Canada
- Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada
| | - Robert J. Petrella
- Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON Canada
- School of Kinesiology, Western University, London, ON Canada
- School of Kinesiology, Faculty of Education, University of British Columbia, Vancouver, BC Canada
- Department of Family Practice, Faculty of Medicine, University of British Columbia, 320 - 5950 University Boulevard, Vancouver, BC V6T 1Z3 Canada
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Wu ZJ, Wang ZY, Gao HE, Zhou XF, Li FH. Impact of high-intensity interval training on cardiorespiratory fitness, body composition, physical fitness, and metabolic parameters in older adults: A meta-analysis of randomized controlled trials. Exp Gerontol 2021; 150:111345. [PMID: 33836261 DOI: 10.1016/j.exger.2021.111345] [Citation(s) in RCA: 53] [Impact Index Per Article: 13.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2020] [Revised: 03/30/2021] [Accepted: 03/31/2021] [Indexed: 01/03/2023]
Abstract
High-intensity interval training (HIIT) can effectively increase peak oxygen consumption, body composition, physical fitness, and health-related characteristics of adults; however, its impact in the older population remains highly debated. This review and meta-analysis aimed to evaluate the effects of high-intensity interval training on cardiorespiratory fitness, body composition, physical fitness, and health-related outcomes in older adults. Four electronic databases (PubMed, Scopus, Medline, and Web of Science) were searched (until July 2020) for randomized trials comparing the effect of HIIT on physical fitness, metabolic parameters, and cardiorespiratory fitness in older adults. The Cochrane risk of bias assessment tool was used to evaluate the methodological quality of the included studies; Stata 14.0 software was used for statistical analysis. HIIT significantly improved the maximum rate of oxygen consumption (VO2peak) as compared to a moderate-intensity continuous training (MICT) protocol (HIIT vs. MICT: weighted mean difference = 1.74, 95% confidence interval: 0.80-2.69, p < 0.001). Additional subgroup analyses determined that training periods >12 weeks, training frequencies of 2 sessions/week, session lengths of 40 min, 6 sets and repetitions, training times per repetition of >60 s, and rest times of <90 s were more effective for VO2peak. This systematic review and meta-analysis showed that HIIT induces favorable adaptions in cardiorespiratory fitness, physical fitness, muscle power, cardiac contractile function, mitochondrial citrate synthase activity, and reduced blood triglyceride and glucose levels in older individuals, which may help to maintain aerobic fitness and slow down the process of sarcopenia.
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Affiliation(s)
- Zhi-Jian Wu
- School of Sport Sciences, Nanjing Normal University, Nanjing, China
| | - Zhu-Ying Wang
- School of Sport Sciences, Nanjing Normal University, Nanjing, China
| | - Hao-En Gao
- School of Sport Sciences, Nanjing Normal University, Nanjing, China
| | - Xian-Feng Zhou
- School of Sport Sciences, Nanjing Normal University, Nanjing, China
| | - Fang-Hui Li
- School of Sport Sciences, Nanjing Normal University, Nanjing, China.
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