Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host

Table 1 Estimated number of Disability-Adjusted Life Year (× 1000) by cause and by region (excluding the Europe)¹ 2004

Neglected disease	World2	Region (OMS criteria)
		Africa	Americas	East of Mediterran	Southeast Asia	Pacific West
Sleeping sickness	1673	1609	0	62	0	0
Chagas disease	430	0	426	0	0	0
Schistosomiasis	1707	1502	46	145	0	13
Leishmaniasis	1974	328	45	281	1264	51
Filariasis	5941	2263	10	75	3525	65
Onchocerciasis	389	375	1	11	0	0
Leprosy	194	25	16	22	118	13
Dengue	670	9	73	28	391	169
Trichomoniasis	1334	601	15	208	88	419
Ascaridiasis3	1851	915	60	162	404	308
Trichiuriasis3	1012	236	73	61	372	269
Ancylostomiasis3	1092	377	20	43	286	364

¹Source: The global burden of disease: 2004 update. Geneva, World Health Organization[18];

²Europe was ommited, so the sum of the regions will not be equal to the total value;

³Soil-transmitted helminthiasis.