Complex interactomes and post-translational modifications of the regulatory proteins HABP4 and SERBP1 suggest pleiotropic cellular functions

Table 1 Table summarizing the interactions of hyaluronic acid binding protein 4 and serpin mRNA binding protein 1 with proteins related to the hormones progesterone and estradiol

Gene	Protein	Biological process reference	Interaction reference
UBR5	E3 ubiquitin-protein ligase UBR5	Progesterone receptor signaling pathway[158]	SERBP1[22]
EIF2B2	Translation initiation factor eIF-2B subunit beta	Ovarian follicle development[159]	SERBP1[22]
FOS	Proto-oncogene c-Fos	Response to progesterone stimulus[160]	SERBP1[22]
PGRMC1	Membrane-associated progesterone receptor component 1	Progesterone receptor signaling pathway[161,162]	SERBP1[149]
ESR2	Estrogen receptor beta	Cellular response to estradiol stimulus[163]	SERBP1, HABP4[22]
MDM2	E3 ubiquitin-protein ligase Mdm2	Cellular response to progesterone stimulus[164]	SERBP1, HABP4[165]
NEDD4	E3 ubiquitin-protein ligase NEDD4	Progesterone receptor signaling pathway[166]	SERBP1, HABP4[22]
ESR1	Estrogen receptor	Cellular response to estradiol stimulus[163]	SERBP1, HABP4 [22]
PKC	Protein Kinase C	Cellular response to estradiol stimulus[167]	HABP4[20]
p53	Cellular tumor antigen p53	Cellular response to estradiol stimulus[168]	HABP4[21]

Table 2 Hyaluronic acid binding protein 4 and serpin mRNA binding protein 1 expression in different types of cancer

Protein	Expression/overexpression	Cancer types	Ref.
HABP4	Expression	Hodgkin’s lymphoma	Kobarg et al[112]
HABP4	Expression	B-cell lymphatic leukemia	Kobarg et al[112]
HABP4	Expression	non-Hodgkin-T-cell lymphoma	Kobarg et al[112]
HABP4	Expression	Bladder	Kobarg et al[112]
SERBP1	Overexpression	Ovarian	Koensgen et al[51]
SERBP1	Overexpression	Breast	Serce et al[144]
SERBP1	Overexpression	Colon	Wang et al[81]
SERBP1	Overexpression	Prostate	Guo et al[145]
SERBP1	Overexpression	Lung	Sun et al[147]
SERBP1	Overexpression	Glioblastoma	Hlavaty et al[146]