Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Figure 3 Roles of the myomiRs during cancer progression. Altered expression of myomiRs is associated with cancer progression and metastasis. Note that the changed level of myomiR typically contributes to cancer progression. Reduced levels of a single myomiR are associated with PDAC[103], NSCLC[105] and HCC[98], whilst an elevated single miR is associated with cervical carcinoma[121] and bladder cancer (TCC)[122]. Increased expression of miR-1/-133a is associated with t(14;16) translocation multiple myeloma[152], whilst reduced expression is associated with prostate cancer[102] and RCC[138], respectively. Reduced expression of other myomiR combinations is also associated with TSCC[111], ESCC[132], HNSCC[114,143], GIST[281], bladder cancer (TCC)[93], lung cancer[85,99], colorectal cancer[86,87] and rhabdomyosarcoma[88].