Copyright ©The Author(s) 2015.
World J Biol Chem. Aug 26, 2015; 6(3): 162-208
Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.162
Table 5 Targets and pathways influenced by the upregulated myomiRs in different cancers
Upregulated miR-133b
Activated p-ERK, pAKT1 cause in vitro proliferation of cervical cancer cell lines, and promote in vivo tumorigenesis and metastasisDownregulation of MST2, CDC42, RHOAUpregulated miR-133bHuman cervical carcinoma tissue compared to surrounding normal cervical tissue[121]
Decreased patient survivalUpregulated miR-133bProgression bladder cancer[122]
Androgen receptormiR-133b directly represses CDC2L5, PTPRK, RB1CC1, CPNE3miR-133b directly upregulated by ARHormone-sensitive human prostate cancer (LNCaP) cells stimulated by androgen[123]
Activativated neuroendocrine neoplasia proliferationMutation in von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase gene (VHL)Upregulated miR-133b expression in VHL- deficient pheochromocytomaHuman pheochromocytoma (PCCs) and paraganglioma (PGLs) neuroendocrine neoplasias[318]
Upregulated miR-206
Cell reprogramming factor KLF4KLF4 downregulated in colon cancer tissue, associated with increased miR-206miR-206 strongly upregulated in colon cancer tissuesHuman colon cancer tissue[116]
Upregulated miR-1 and miR-133
Decreased survival of R172 IDH2-mutated subset of CN-AML patients, increases resistance to chemotherapyDistinctive gene and microRNA expression profiles accurately predicted R172 IDH2 mutationsUpregulated expression of miR-1 and miR-133De novo CN-AML patient bone marrow and blood samples[151]
EVI1 increases aggressive cancer growthEVI1 expression upregulated in established patient samplesUpregulated expression of miR-1-2 and miR-133-a-1EVI1 expressing AML subset of patients[120]
ChIP assays show EVI1 binds to miR-1-2 gene promoter directly
CCND2miR-1 and miR-133a were specifically overexpressed in the cases with t(14;16) translocation, correlates with down-regulated CCND2 expressionUpregulated miR-1 and miR-133-aMultiple myeloma[152]
Secreted myomiRs
miRs selectively released into serum (within exosome microparticles)miR-1, miR-133a, and miR-133b selectively releasedHuman breast cancer[319]
Circulating microRNATumor-derived exosomesHuman non-small-cell lung cancer[320]