Copyright ©The Author(s) 2021.
World J Biol Chem. Mar 27, 2021; 12(2): 15-37
Published online Mar 27, 2021. doi: 10.4331/wjbc.v12.i2.15
Table 4 Marine compounds with potential anticancer activity and chemotherapeutics against breast cancer
Marine compound
Chemical nature
Mechanism of action
ElisidepsinCyclic peptideWith combination of cisplatin or paclitaxel showed synergistic toxicity on BC cells by reducing the phosphorylation of Akt and inhibiting the MAPK pathway via targeting ErbB expressionMoghtaderi et al[74]
Sipholenol ATriterpeneIncreased the sensitivity of paclitaxel in BC cells by inhibiting P-gp and MRP1Resmi et al[104] and Mohamed et al[105]
Permethyl ningalin BPyrrole-containingcompoundSensitized BC cells to paclitaxel by inhibiting drug efflux activity of P-gp and increasing drug accumulationResmi et al[104] and Mohamed et al[105]
TrabectedinAlkaloidCombination with cisplatin or paclitaxel or doxorubicin showed an additive effect in the preclinical systemChen et al[75]
Marine polysaccharidePolysaccharide In combination with cisplatin, synergistically inhibited the proliferation and migration by blocking the MMP-2 and MMP-9 expressionChen et al[75]
Iturin ACyclo-lipopeptideIn combination with docetaxel, substantially sensitized docetaxel-resistant TNBC cells by reducing proliferation via massive arresting at the G1 stage and activating caspase 3 as well as inhibiting Akt and its downstream signaling pathwaysDey et al[119]
Renieramycin MTetrahydro-isoquinolineSensitized MCF-7 cells synergistically to doxorubicin by promoting doxorubicin-induced DNA damage, cell cycle arrest, and apoptosis via downregulating ErbB/PI3K-Akt, integrin, and focal adhesion signalingTun et al[120]
Sulfated polysaccharide-In combination with pH-sensitive DOX releasing nanosystem inhibited growth and metastasis of BC cells in tumor-bearing miceZhang et al[121]
PapuaminePentacyclic alkaloidInhibited colony formation of BC cells by targeting activation of JNKKanno et al[122]