Copyright ©The Author(s) 2021.
World J Biol Chem. Mar 27, 2021; 12(2): 15-37
Published online Mar 27, 2021. doi: 10.4331/wjbc.v12.i2.15
Table 3 Marine compounds with potential anticancer activity from marine fishes and invertebrates against breast cancer
Marine compound
Chemical nature
Mechanism of action
n-3 PUFA, α-linolenic acidFatty acidsDecreased the risk of BCMoghtaderi et al[74]
EPA, DHA, n-3 fatty acidsFatty acids(1) Decreased the risk of BC; and (2) Inhibited growth BC cellsResmi et al[104] and Mohamed et al[105]
K092A and K092BPeptidesInduced apoptosis by altering the cytoskeleton via targeting actin and tubulin and halting cell cycle at the G2M and decreasing mitochondrial activityResmi et al[104] and Mohamed et al[105]
Tetrahydro-isoquinolineAlkaloid(1) Induced death receptor-mediated apoptosis by increasing the expression of TRAIL-R1, -R2, Fas, TNF RI, and FADD; and (2) Induced mitochondrial-mediated apoptosis by decreasing the of Bcl2 and Bcl-XL expression and increasing the Bax, Bad, cytochrome C and caspase 3 expression via increasing the ROS generationChen et al[75]