Copyright ©The Author(s) 2021.
World J Biol Chem. Mar 27, 2021; 12(2): 15-37
Published online Mar 27, 2021. doi: 10.4331/wjbc.v12.i2.15
Table 2 Marine compounds with potential anticancer activity against breast cancer from crustaceans
Marine compound
Chemical nature
Mechanism of action
Hydro-alcoholic extract of crabChitosan and AstaxanthinReduced proliferation by inducing apoptosis and decreasing nitric oxide productionMoghtaderi et al[74]
ChitosanPolysaccharide (1) Reduced proliferation without affecting normal fibroblasts by inducing arrest at the G2M phase; and (2) Induced apoptosis by decreasing the expression of Bcl2 via elevation of p53 levelResmi et al[104] and Mohamed et al[105]
AstaxanthinOligosaccharide Induced PCD in BC cells via alteration in the cyclin D1, p53, Bax, and Bcl2 expression through inducing arrest at G0/G1 stageResmi et al[104] and Mohamed et al[105]
Chondroitin sulfateMuco-polysaccharideInhibited angiogenesis by reducing tube formation via inhibiting the expression of VEGFChen et al[75]
β-caroteneTerpenoidsStimulated apoptosis in BC cells by inducing the release of cytochrome C, increasing PPAR-γ, and p21 (WAF1/CIP1) expression and decreasing cyclooxygenase-2 expression through ROS generationMoon et al[102]