Copyright ©2010 Baishideng Publishing Group Co.
World J Biol Chem. Mar 26, 2010; 1(3): 31-40
Published online Mar 26, 2010. doi: 10.4331/wjbc.v1.i3.31
Table 2 PPARγ-independent signals triggered by PPARγ ligands in lung cancer cells
↑Tumor suppressors (e.g. LKB1, AMPK, TSC2)
↑ROS production and ERK, SAPK/JNK, p38 MAPK activation (note
that this also occurs in PPARγ-dependent pathways)
↓Effects on transcription factors (e.g. AP-1, NF-κB, Smads, Sp1, CRE)
↓Nicotine receptor signaling (e.g. α4 and α7 nAChRs)
↓Apoptosis-related signals (e.g. Bcl-2, cyclin D1, c-FLIP, DR-5)
↑Apoptosis-related signals (e.g. casease 3/7, cyclin D1, p53)