Copyright ©2010 Baishideng Publishing Group Co.
World J Biol Chem. Jan 26, 2010; 1(1): 3-12
Published online Jan 26, 2010. doi: 10.4331/wjbc.v1.i1.3
Figure 2
Figure 2 Autophagy regulates protein homeostasis through interaction with p62 and NBR1. A: A schematic diagram showing the domain organization of p62 and NBR1 proteins. PB1: Phox and Bem1p domain; ZZ: Zinc finger domain; TB: TRAF6-binding domain; CC: Coiled-coil domain; LIR: LC3-interacting region; UBA: Ub-associated domain; B: p62 and NBR1 are autophagy receptors that interact with both ubiquitin-positive protein aggregates through their UBA domains and target them to autophagosomes through their LIR regions with LC3 on the autophagosomal membranes, thereby promoting autophagy of ubiquitinated targets.