Retrospective Cohort Study
Copyright ©The Author(s) 2016.
World J Gastrointest Surg. Jul 27, 2016; 8(7): 492-500
Published online Jul 27, 2016. doi: 10.4240/wjgs.v8.i7.492
Table 1 Demographic and clinical data n (%)
Initial medical therapy (n = 115)
Clinical detailsEarly surgery (n = 42)IMT (n =115)P valueDS (n = 62)1P value
Gender M:F22:2050:650.53124:38:000.227
Age at diagnosis (yr), median (IQR)34.5 (24-46)24 (19-33)0.000123.5 (18.25-31.75)0.006
Smoking15 (35.7)43 (37.4)0.85225 (40.3)0.685
Phenotype
B1 (non-stricturing)3 (7.1)38 (36.2)0.0014 (6.5)0.968
B2 (stricturing)17 (40.5)26 (24.8)24 (38.7)
B3 (penetrating)22 (52.4)41 (39.0)34 (54.8)
Location
L1 (ileal)28 (66.7)25 (24.5)0.000117 (26.3)0.0001
Perianal disease06 (5.2)3 (4.8)
L3 (ileocolonic)
Perianal disease14 (33.3)74 (69.4)45 (70.2)
5 (11.9)40 (34.8)16 (25.8)
Table 2 Indications for early surgery n (%)
Clinical detailsEarly surgery (n = 42)Deferred surgery (n = 62)
Indication for surgery
Acute obstruction – emergency resection9 (21.4)4 (23.0)
Subacute obstruction – elective resection-20 (32.3)
Perforation15 (35.7)7 (11.3)
Fistula/phlegmon5 (11.9)15 (24.2)
Abdominal pain5 (11.9)2 (3.2)
Haemorrhage3 (7.1)-
Not specified5 (11.9)14 (23.0)
Table 3 Comparison of early vs initial medical therapy in Crohn’s disease n (%)
Initial medical therapy (n = 115)
Clinical detailsEarly surgery (n = 42)Initial medical therapy (n = 115)P valueDeferred surgery (n = 62)1P value
Number requiring surgery
3 yr5 (11.9)24 (20.7)0.2505 (8.1)0.521
5 yr6 (14.2)36 (31.3)0.04110 (16.1)NS
Completion of study period7 (16.7)62 (53.9)< 0.000120 (32.3)0.110
Number of admission to hospital per patient, median (IQR)1 (1-2)3 (1-5)0.0122 (1-4.5)0.002
Days in hospital (d), median (IQR)12.5 (9-22.5)11 (3-28)0.23017 (8-28)0.347
Medical therapy
Immune modulator32 (76.2)101 (87.8)0.08354 (87.1)0.189
Steroids12 (28.6)34 (29.6)NS23 (37.1)0.404
Anti-TNF14 (33.3)69 (60.0)0.00442 (67.7)0.001
No requirement for medical therapy10 (23.8)5 (4.3)0.0080 (0)< 0.0001
Follow-up months (mo), median (IQR)67 (31-114)97 (58-150)64 (19-121)
Table 4 Comparison of extent of resection performed in early surgery vs deferred surgery cohorts n (%)
Clinical detailsEarly surgery (n = 42)Deferred surgery (n = 62)P value
Operation
Small bowel resection5 (11.9)7 (11.3)NS
Ileocolic resection31 (73.8)30 (48.4)0.015
Small bowel and segmental colonic resection3 (7.1)9 (14.5)0.352
Small bowel and total colectomy2 (4.8)9 (14.5)0.193
Data unavailable1 (2.9)7 (11.3)0.139
Stoma formation3 (7.1)5 (8.1)NS