Hepatic histopathology and postoperative outcome after preoperative chemotherapy for Chinese patients with colorectal liver metastases

doi:10.4240/wjgs.v5.i3.30

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Mar 27, 2013 (publication date) through Jul 26, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Mar 27, 2013; 5(3): 30-36
Published online Mar 27, 2013. doi: 10.4240/wjgs.v5.i3.30

Table 3 Liver injury characteristics stratified by preoperative therapy n (%)

Regimen	Liver toxicity (n = 51)			Steatosis > 30% (n = 16)			Sinusoidal dilation (n =31)			Steatohepatitis (n = 20)
	Yes	No	¹P value	Yes	No	¹P value	Yes	No	¹P value	Yes	No	¹P value
No CTx	19 (35.8)	34 (64.2)		5 (9.4)	48 (90.6)		11 (20.8)	42 (79.2)		6 (11.3)	47 (88.7)
Oxaliplatin	19 (57.6)	14 (42.4)	0.04	5 (15.2)	28 (84.8)	NS	14 (42.4)	19 (57.6)	0.03	7 (21.2)	26 (78.8)	NS
Irinotecan	5 (55.6)	4 (44.4)	NS	2 (22.2)	7 (77.8)	NS	1 (11.1)	8 (88.9)	NS	3 (33.3)	6 (66.7)	0.08
HAI	8 (72.7)	3 (27.3)	0.02	4 (36.4)	7 (63.6)	0.02	5 (45.5)	6 (54.5)	0.08	4 (36.4)	7 (63.6)	0.03

¹Presence of liver injury characteristic; each chemotherapy group vs no chemotherapy. CTx: Chemotherapy; NS: Not significant; HAI: Hepatic artery infusion.

Citation: Lu QY, Zhao AL, Deng W, Li ZW, Shen L. Hepatic histopathology and postoperative outcome after preoperative chemotherapy for Chinese patients with colorectal liver metastases. World J Gastrointest Surg 2013; 5(3): 30-36
URL: https://www.wjgnet.com/1948-9366/full/v5/i3/30.htm
DOI: https://dx.doi.org/10.4240/wjgs.v5.i3.30