Morphomics in esophageal cancer: Validation and association with muscular and cardiorespiratory fitness

Figure 1 Heatmap of correlation matrix between morphomics. A: Bioelectrical impedance analysis related body composition; B: Cardiopulmonary exercise testing and hand grip strength. DMG: Dorsal muscle group; BMD: Bone mineral density; SF: Subcutaneous fat; VF: Visceral fat; BCM: Body cell mass; SM: Skeletal muscle; LBM: Lean body mass; FFM: Fat free mass; ASM: Appendicular skeletal muscle; ASMI: Appendicular skeletal muscle index; LA: Left arm; LL: Left leg; MM: Muscle mass; RA: Right arm; RL: Right leg; TR: Trunk; HGS: Hand grip strength; OUES: Oxygen uptake efficiency slope; WR: Work rate; VAT: Ventilatory anaerobic threshold; BW: Body weight; EqO₂: Ventilatory equivalent for O₂; VO₂: Oxygen consumption; EqCO₂: Ventilatory equivalent for CO₂.

Figure 2 Scatterplots of selected parameters between morphomics and bioelectrical impedance analysis/ hand grip strength/ cardiopulmonary exercise testing (orange line: Linear regression; grey line: Locally estimated scatterplot smoothing curve; blue shading = 95%CI; n = 50). DMG: Dorsal muscle group; BMD: Bone mineral density; SF: Subcutaneous fat; VF: Visceral fat; BW: Body weight; LBM: Lean body mass; FFM: Fat free mass; ASM: Appendicular skeletal muscle; VAT: Ventilatory anaerobic threshold; HGS: Hand grip strength; SM: Skeletal muscle; VO₂: Oxygen consumption.

Figure 3 Receiver operator curve analysis for predicting patients with low cardiorespiratory fitness from the morphomics. The area under the receiver operator curve curves (AUC) was 0.840, and optimism-corrected AUC was 0.778 under the setting of 1000 bootstrap resamples internal validation (95% confidence interval 0.628-0.0.882, P < 0.001). AUC: Area under the receiver operator curve; ROC: Receiver operator curve.