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Yilmaz S, Ugurlu ET, Gumusoglu AY, Degerli MS, Dolay K, Balli E, Kara Y, Kocataş A, Çakar E, Gürbulak B, Yüksel S, Arikan S, Bektaş H, Aytin YE, Albayrak D, Gok AFK, Ertekin C, Çalta AF, Oğuz S, Örmeci M, Özcan AH, Sevinç B, Karahan Ö, Tümkaya İ, Kones O, Bilgi Kirmaci M, Yavuz M, Akın E, Yeşilsancak M. Results of endoscopic retrograde cholangiopancreatography procedures at surgical clinics: A multicenter observational study in Türkiye. World J Gastrointest Surg 2025; 17:104618. [DOI: 10.4240/wjgs.v17.i5.104618] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/31/2024] [Revised: 02/24/2025] [Accepted: 03/18/2025] [Indexed: 05/23/2025] Open
Abstract
BACKGROUND Endoscopic retrograde cholangiopancreatography (ERCP) is an invasive endoscopic procedure used mainly to treat hepato-pancreato-biliary (HPB) diseases. The need for ERCP has increased with the rising number of HPB diseases over the past decade. Thus, due to increased demand, ERCP is performed at more centers. Currently, it is performed by general surgeons, gastroenterology and invasive radiology specialists in the United States and Europe as recommended by the British Society of Gastroenterology (BSG).
AIM To present the results of ERCP procedures from fourteen surgical centers in Türkiye.
METHODS Fourteen surgical centers performing ERCP were included in the present study. The age, gender, ERCP indication, success status, post-ERCP complications, ERCP reports and the files of 66993 patients who underwent ERCP were collected from the participating centers. The results are discussed according to the targets declared by the BSG, which are volume load per annum, proportion of successful cannulation (> 85%), bile duct clearance rate (> 75%), stenting rate for strictures (> 80%) and complications (< 6%).
RESULTS A total of 66993 ERCP procedures were performed in the centers included in the study up to August 2024. 29250 (43.6%) of the procedures were performed urgently, especially for suppurative cholangitis, biliary tract injuries, etc. The remaining 37743 (56.4%) cases were performed electively. 50.2% of the patients were female and 49.8% were male. The average ages were 56.5 years for women and 55.9 years for men. General anesthesia was used in 84.1% of the patients while sedation was used in 15.9%. The indications were bile duct stone (78.7%), pancreatic tumor (3.9%), papillary tumor (3.3%), cholangiocarcinoma (2.6%), Oddi sphincter dysfunction (2.4%), bile leakage after cholecystectomy (2%), bile leakage after hydatid cyst surgery (1.9%), biliary stricture (1.7%), and other diseases (3.1%). Hyperamylasemia and post-ERCP pancreatitis were the most common complications as observed in 8.1% of the patients. They were usually self-limited and responded to supportive measures. The frequency of the other complications was also consistent with the literature.
CONCLUSION There is a huge shortage of ERCP endoscopists worldwide due to insufficient ERCP training and centers especially in developing and underdeveloped countries. As patients requiring ERCP usually present to surgical practitioners, the incorporation of surgeons into this training program is an effective and reliable solution. The BSG recommends the incorporation of surgeons and radiologists in addition to gastroenterology specialists. This study is the first to present the results of ERCP procedures from fourteen surgical centers throughout Türkiye. The results suggest that the surgical centers included were able to achieve the targets set by the BSG. This study demonstrated that the surgical ERCP units in the present work have reached satisfactory results and provided a reliable and successful ERCP service. There are currently no issues regarding the validity and appropriateness of the surgeons performing ERCP. Therefore, ERCP training should be encouraged in surgeons and more surgical ERCP centers should be provided.
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Affiliation(s)
- Sezgin Yilmaz
- Health, Education and Research Center, Afyonkarahisar Health Sciences University, Afyonkarahisar 03100, Türkiye
| | - Esat Taylan Ugurlu
- Health Sciences University, Mehmet Akif Inan Training and Research Hospital, Sanlıurfa 63040, Türkiye
| | | | - Mahmut Said Degerli
- Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul 34147, Türkiye
| | - Kemal Dolay
- Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul 34147, Türkiye
| | - Emre Balli
- Health, Education and Research Center, Afyonkarahisar Health Sciences University, Afyonkarahisar 03100, Türkiye
| | - Yasin Kara
- Health Sciences University, Kanunı Sultan Suleyman Traınıng & Research Hospıtal, Istanbul 34303, Türkiye
| | - Ali Kocataş
- Health Sciences University, Kanunı Sultan Suleyman Traınıng & Research Hospıtal, Istanbul 34303, Türkiye
| | - Ekrem Çakar
- Istanbul Training and Research Hospital, Istanbul 34098, Türkiye
| | | | - Sercan Yüksel
- Başakşehir Çam and Sakura City Hospital, Istanbul 34480, Türkiye
| | - Soykan Arikan
- Başakşehir Çam and Sakura City Hospital, Istanbul 34480, Türkiye
| | - Hasan Bektaş
- Medicana Zincirlikuyu Hospital, Istanbul 34098, Türkiye
| | | | - Doğan Albayrak
- Faculty of Medicine, Trakya University, Edirne 22030, Türkiye
| | - Ali Fuat Kaan Gok
- Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Türkiye
| | - Cemalettin Ertekin
- Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Türkiye
| | | | - Serhat Oğuz
- Faculty of Medicine, Bandırma 17 Eylül University, Balıkesir 100200, Türkiye
| | - Mustafa Örmeci
- Bandırma Training and Research Hospital, Bandırma 100200, Türkiye
| | - Ali Haldun Özcan
- Bandırma Training and Research Hospital, Bandırma 100200, Türkiye
| | - Barış Sevinç
- Faculty of Medicine, Uşak University, Uşak 64100, Türkiye
| | - Ömer Karahan
- Faculty of Medicine, Uşak University, Uşak 64100, Türkiye
| | - İhsan Tümkaya
- Prof. Dr. Alaeddin Yavaşça State Hospital, Kilis 79000, Türkiye
| | - Osman Kones
- Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul 34147, Türkiye
| | - Mehlika Bilgi Kirmaci
- Health, Education and Research Center, Afyonkarahisar Health Sciences University, Afyonkarahisar 03100, Türkiye
| | - Mustafa Yavuz
- Tarsus MMT American Hospital, Istanbul 33400, Türkiye
| | - Emrah Akın
- Faculty of Medicine, Sakarya University, Sakarya 54050, Türkiye
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Abstract
PURPOSE The prevalence of gallstones in children has increased over the last years. Choledocholithiasis (CD) is present in up to 30% of the cases. There is a scarcity of studies on the management of choledocholithiasis in children. The aim of this study was to develop a score that would allow predicting accurately the risk of CD in children with gallstones and reduce the number of non-therapeutic ERCP. MATERIALS AND METHODS We conducted a retrospective study in children with gallstones and suspected CD seen between January 2010 and December 2019. The main outcome was the presence of CD confirmed by at least one of the following diagnostic tests: magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), and/or intraoperative cholangiography (IOC). We developed a risk score based on the presence or absence of the following risk factors: acute biliary pancreatitis, ascending cholangitis, elevated liver function tests (AST, ALT, total bilirubin [TB, ≥ 2 mg/dl], conjugated bilirubin, gamma-glutamyl transpeptidase, and alkaline phosphatase), CD on ultrasound (US; this was considered predictive but not confirmatory of CD), and dilation of the common bile duct (> 6 mm) by US. The score was divided into three different categories: low risk (no risk factors), intermediate risk (one risk factor present), high risk (≥ 2 risk factors present or ascending cholangitis). Given the main goal of reducing the number of diagnostic ERCPs, a very-high-risk subgroup (3 risk factors present or ascending cholangitis) was identified. RESULTS We reviewed 133 patients with gallstones and suspected CD. In 56 (42.1%) patients, the presence of CD was confirmed by one or more of the definitive diagnostic tests (MRCP, ERCP, and IOC). The following variables were found to be the strongest predictors of CD: ascending cholangitis, TB ≥ 2 mg/dl, common bile duct > 6 mm, and the presence of CD by US. The positive predictive value for CD was 7.5% in the low-risk group (OR 0.06, P = < 0.001); 22.9% in the intermediate-risk group (OR 0.31, P = 0.007); 77.6% in the high-risk group (OR 20.14, P = < 0.001); and 95.7% in very-high-risk subgroup (OR 49.18, P = < 0.001). CONCLUSION The risk score proposed in this study predicts accurately the presence of CD in children with gallstones. It can serve as a helpful tool to triage the need for costly and complex studies in the workup of CD, particularly in centers with limited resources. Finally, due to its high specificity and positive predictive value (PPV), the use of the very-high-risk criteria would allow for an important decrease in the number of non-therapeutic ERCP.
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