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Feng M, Gu L, Zeng Y, Gao W, Cai C, Chen Y, Guo X. The efficacy of resistance exercise training on metabolic health, body composition, and muscle strength in older adults with type 2 diabetes: A systematic review and Meta-Analysis. Diabetes Res Clin Pract 2025; 222:112079. [PMID: 40090422 DOI: 10.1016/j.diabres.2025.112079] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/28/2024] [Revised: 12/25/2024] [Accepted: 03/03/2025] [Indexed: 03/18/2025]
Abstract
This systematic review and meta-analysis evaluated the efficacy of Resistance Exercise Training (RET) on metabolic health, body composition, and muscle strength in older adults with type 2 diabetes (T2DM). Electronic databases were systematically searched and meta-analyses were conducted using random-effects models. Meta-regression analyses were also performed to explore potential sources of heterogeneity. Nineteen randomized controlled trials (RCTs) met the inclusion criteria. RET significantly improved hemoglobin A1c (MD: -0.51, P < 0.0001) and fasting blood glucose (mean differences: MD: -1.43 mg/dl, P = 0.04), though insulin levels remained unchanged. Lipid profile analysis revealed significant reductions in triglycerides (MD: -0.32, P = 0.03), total cholesterol (MD: -7.08, P = 0.005), and low-density lipoprotein (MD: -1.91, P = 0.05), without significant changes in high-density lipoprotein. RET increased lean mass and reduced waist circumference but had no effect on body weight and fat mass. Muscle strength improved significantly, but there was no impact on blood pressure or heart rate. These findings suggest that RET is beneficial for enhancing glycemic control, lipid profiles, lean mass, and muscle strength in older adults with T2DM, while its effects on body weight, fat mass, and cardiovascular health remain inconclusive. Further studies are needed to explore long-term effects.
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Affiliation(s)
- Mingxing Feng
- Hainan Vocational University of Science and Technology, Haikou, Hainan 571137, China
| | - Luyan Gu
- Hainan Vocational University of Science and Technology, Haikou, Hainan 571137, China
| | - Yan Zeng
- Hainan Vocational University of Science and Technology, Haikou, Hainan 571137, China
| | - Wenjing Gao
- Hainan General Hospital, Haikou, Hainan, 570311, China
| | - Chongyu Cai
- Hainan Chengmei Hospital, Haikou, Hainan 570311, China
| | - Yingqiu Chen
- Baoting County Traditional Chinese Medicine Hospital, Baoting, Hainan 572399, China
| | - Xiuying Guo
- Hainan Vocational University of Science and Technology, Haikou, Hainan 571137, China.
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Lu Y, Chen J, Zhang XL. Low-Intensity Resistance Exercise Based on Myofascial Chains Alters the Lower-Limb Tension and Improves Health Status in Female Individuals With Knee Osteoarthritis. J Sport Rehabil 2023; 32:818-826. [PMID: 37527818 DOI: 10.1123/jsr.2022-0367] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/16/2022] [Revised: 04/25/2023] [Accepted: 05/19/2023] [Indexed: 08/03/2023]
Abstract
BACKGROUND Low-intensity resistance exercise therapy (LIRET) based on myofascial chains, applied to both affected and nonlocal joints, is an effective method for knee osteoarthritis (OA) rehabilitation. This study applied LIRET in a comparison of prevalues and postvalues of lower-limb tension in female patients with knee OA and asymptomatic participants. METHODS Twenty-four female participants with knee OA and 20 asymptomatic women took part in a 3-month long application of LIRET. Participants' ankle passive torque and ankle range of motion in the sagittal plane were assessed with an isokinetic dynamometer. The collected values were used to estimate the sagittal-plane lower-limb tension. RESULTS Compared with the asymptomatic group, participants with knee OA presented decreased maximum ankle dorsiflexion (P < .001), decreased ankle plantar flexion range (P = .023), ankle resting position more inclined to dorsiflexion (P = .017), increased ankle dorsiflexion stiffness (P = .005), and lower ankle plantar flexion stiffness (P = .034). After exercise intervention, the knee OA group self-reported less knee pain (P < .001), improved physical function (P < .001), increased maximum dorsiflexion (P = .021), and increased plantar flexion range (P < .001). While plantar flexion stiffness increased (P = .037), dorsiflexion stiffness decreased (P = .015) and ankle resting position moved toward dorsiflexion (P = .002). Results suggest possible decreased anterior leg tension and possible increased posterior leg tension in patients with knee OA. CONCLUSIONS The results supported that knee OA patients present imbalanced myofascial tension of lower limbs. LIRET based on myofascial chains appears to decrease pain, and stiffness, and improve physical function of patients with knee OA and change their lower-limb tension.
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Affiliation(s)
- Yao Lu
- Qilu Institute of Technology, Qufu, SD,China
| | - Jie Chen
- Qingdao Hengxing University of Science and Technology, Qingdao, SD,China
- Auckland Bioengineering Institute, The University of Auckland, Auckland,New Zealand
| | - Xue-Lin Zhang
- Department of Physical Science, Qufu Normal University, Qufu, SD,China
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Lim ST, Kang S. Exercise therapy for sarcopenia and diabetes. World J Diabetes 2023; 14:565-572. [PMID: 37273255 PMCID: PMC10237001 DOI: 10.4239/wjd.v14.i5.565] [Citation(s) in RCA: 9] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/19/2022] [Revised: 02/13/2023] [Accepted: 04/10/2023] [Indexed: 05/15/2023] Open
Abstract
Aging is characterized by the gradual deterioration of function at the molecular, cellular, tissue, and organism levels in humans. The typical diseases caused by changes in body composition, as well as functional decline in the human body’s organs due to aging include sarcopenia and metabolic disorders. The accumulation of dysfunctional aging β cells with age can cause decreased glucose tolerance and diabetes. Muscle decline has a multifactorial origin, involving lifestyle habits, disease triggers, and age-dependent biological changes. The reduced function of β cells in elderly people lowers insulin sensitivity, which affects protein synthesis and interferes with muscle synthesis. The functional decrease and aggravation of disease in elderly people with less regular exercise or physical activity causes imbalances in food intake and a continuous, vicious cycle. In contrast, resistance exercise increases the function of β cells and protein synthesis in elderly people. In this review, we discuss regular physical activities or exercises to prevent and improve health, which is sarcopenia as decreased muscle mass and metabolic disorders as diabetes in the elderly.
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Affiliation(s)
- Seung-Taek Lim
- Institute of Sports and Arts Convergence (ISAC), Inha University, Incheon 22212, South Korea
- Waseda Institute for Sport Sciences, Waseda University, Saitama 341-0018, Japan
| | - Sunghwun Kang
- Laboratory of Exercise Physiology, College of Art, Culture and Engineering, Kangwon National University, Chuncheon-si 24341, South Korea
- Interdisciplinary Program in Biohealth-machinery convergence engineering, Kangwon National University, Chuncheon-si 24341, South Korea
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Kim H, Jung J, Park S, Joo Y, Lee S, Sim J, Choi J, Lee H, Hwang G, Lee S. Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis. Int J Mol Sci 2023; 24:ijms24087284. [PMID: 37108444 PMCID: PMC10139099 DOI: 10.3390/ijms24087284] [Citation(s) in RCA: 8] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/22/2023] [Revised: 04/13/2023] [Accepted: 04/13/2023] [Indexed: 04/29/2023] Open
Abstract
This systematic review aimed to synthesize and quantify the results of the studies investigating the changes in fibroblast growth factor-21 (FGF-21) induced by exercise. We searched for studies that did not differentiate between patients and healthy adults but compared them before and after exercise and with and without exercise. For quality assessment, the risk-of-bias assessment tool for nonrandomized studies and the Cochrane risk-of-bias tool were used. A quantitative analysis was performed using the standardized mean difference (SMD) and random-effects model in RevMan 5.4. A total of 94 studies were searched in international electronic databases, and after screening, 10 studies with 376 participants were analyzed. Compared with no exercise, there was a significant increase in the FGF-21 levels from before to after exercise (SMD = 1.05, 95% confidence interval (CI), 0.21 to 1.89). The changes in FGF-21 levels in the exercise group showed a significant difference from the levels in the controls. The results of the random-effects model were as follows: SMD = 1.12; 95% CI, -0.13 to 2.37. While the data on acute exercise were not synthesized in this study, FGF-21 levels generally increased after chronic exercise compared with no exercise.
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Affiliation(s)
- Hyunjoong Kim
- Seogwangju Chung Yeon Rehabilitation Hospital, 61, Gaegeum-gil, Gwangju 72070, Republic of Korea
- Department of Physical Therapy, Gwangju Health University, 73, Bungmun-daero 419, Gwangju 62287, Republic of Korea
| | - Jihye Jung
- Institute of SMART Rehabilitation, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
| | - Sungeon Park
- Department of Physical Therapy, Graduate School, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
| | - Younglan Joo
- Department of Physical Therapy, Graduate School, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
| | - Sangbong Lee
- Department of Physical Therapy, Graduate School, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
| | - Jeongu Sim
- Department of Physical Therapy, Graduate School, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
| | - Jinhyeong Choi
- Department of Physical Therapy, Graduate School, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
| | - Hyun Lee
- Department of Physical Therapy, Graduate School, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
| | - Gyujeong Hwang
- Department of Physical Therapy, Graduate School, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
| | - Seungwon Lee
- Department of Physical Therapy, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
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Park S, Park SK, Jee YS. Effects of walking training at different speeds on body composition, muscle contractility, and immunocytes in the elderly: A single-blinded randomized controlled trial. Arch Gerontol Geriatr 2023; 106:104871. [PMID: 36450211 DOI: 10.1016/j.archger.2022.104871] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/28/2022] [Revised: 11/11/2022] [Accepted: 11/16/2022] [Indexed: 11/19/2022]
Abstract
BACKGROUND This study investigated the changes in body composition, muscle contractility and immunocytes of the elderly using three types of walking. MATERIAL AND METHODS Seventy-six participants were randomly assigned to control group (CON), slow walking group (SWG), moderate walking group (MWG), or fast walking group (FWG). RESULTS Muscle mass in CON decreased (-2.55 ± 3.63%; P < 0.05), while it increased in FWG (1.92 ± 4.46%; P < 0.05). Fat mass in CON increased, whereas it decreased in MWG and FWG (-18.71 ± 14.22%; P < 0.001). Tc (contraction time) of biceps femoris (BF) decreased in CON, while a decreasing tendency was seen in SWG. Although Tc of BF increased in MWG, it showed a marked increase in FWG (21.19 ± 24.53%; P < 0.05). A similar tendency was observed in the rectus femoris. Leukocytes did not change in CON, but they showed an increasing tendency in MWG and FWG. Neutrophils decreased in CON, whereas the other groups showed an increasing tendency. Lymphocytes (10.25 ± 19.48%; P < 0.01) and helper T cells (14.32 ± 17.99%; P < 0.05) showed an increase in FWG, and NK cell was improved in SWG, but showed a clear increase in MWG (38.45 ± 96.96%; P < 0.05) and FWG (52.69 ± 58.37%; P < 0.05). CONCLUSIONS This study concludes that fast walking by the elderly improves the muscle contractility, which can also be expected to improve the function of immunocytes by increased or maintained muscle mass and decreased fat mass after 12 weeks.
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Affiliation(s)
- Sihwa Park
- Research Institute of Sports and Industry Science, Hanseo University, #1 Hanseo-ro, Haemi-myeon, Seosan 31962, Korea
| | - Sang-Kyun Park
- Department of Physical Education, Chungnam National University, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
| | - Yong-Seok Jee
- Research Institute of Sports and Industry Science, Hanseo University, #1 Hanseo-ro, Haemi-myeon, Seosan 31962, Korea.
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Chien YH, Tsai CJ, Wang DC, Chuang PH, Lin HT. Effects of 12-Week Progressive Sandbag Exercise Training on Glycemic Control and Muscle Strength in Patients with Type 2 Diabetes Mellitus Combined with Possible Sarcopenia. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:15009. [PMID: 36429728 PMCID: PMC9690442 DOI: 10.3390/ijerph192215009] [Citation(s) in RCA: 16] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 10/20/2022] [Revised: 11/11/2022] [Accepted: 11/11/2022] [Indexed: 06/16/2023]
Abstract
Patients with type 2 diabetes mellitus (T2DM) are at a three-fold increased risk of developing sarcopenia compared to those without diabetes. The objective of this study was to investigate whether an intervention involving progressive sandbag exercises is beneficial to patients with T2DM and possible sarcopenia in terms of enhancing muscle strength and controlling blood sugar levels. Forty patients with T2DM and possible sarcopenia (age > 50 years) were recruited and randomly divided into resistance training and control groups. Resistance exercises for the upper and lower extremities were performed using sandbags (0.5 kg at the beginning to 1 kg after 1 month). Patients in the control group were asked to maintain their usual daily lifestyle. After 12 weeks, the training group were significant better than the control group in terms of glycosylated hemoglobin, the five times sit-to-stand test, skeletal muscle mass and calf circumference, and the physiological domain of the World Health Organization Quality of Life Questionnaire. In conclusion, these simple home exercises are beneficial to patients with T2DM combined with possible sarcopenia. This approach can assist patients in controlling their levels of glycosylated hemoglobin as well as improve physical fitness and quality of life.
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Affiliation(s)
- Yu-Hsuan Chien
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 833, Taiwan
- Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
| | - Chia-Jen Tsai
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 833, Taiwan
| | - Dean-Chuan Wang
- Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
- Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
| | - Pin-Hung Chuang
- Department of Leisure and Sports Management, Cheng Shiu University, Kaohsiung 833, Taiwan
| | - Hwai-Ting Lin
- Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
- Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
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Selected Methods of Resistance Training for Prevention and Treatment of Sarcopenia. Cells 2022; 11:cells11091389. [PMID: 35563694 PMCID: PMC9102413 DOI: 10.3390/cells11091389] [Citation(s) in RCA: 9] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/17/2022] [Revised: 04/15/2022] [Accepted: 04/18/2022] [Indexed: 11/16/2022] Open
Abstract
Resistance training is an extremely beneficial intervention to prevent and treat sarcopenia. In general, traditional high-load resistance training improves skeletal muscle morphology and strength, but this method is impractical and may even reduce arterial compliance by about 20% in aged adults. Thus, the progression of resistance training methods for improving the strength and morphology of muscles without applying a high load is essential. Over the past two decades, various resistance training methods that can improve skeletal muscle mass and muscle function without using high loads have attracted attention, and their training effects, molecular mechanisms, and safety have been reported. The present study focuses on the relationship between exercise load/intensity, training effects, and physiological mechanisms as well as the safety of various types of resistance training that have attracted attention as a measure against sarcopenia. At present, there is much research evidence that blood-flow-restricted low-load resistance training (20–30% of one repetition maximum (1RM)) has been reported as a sarcopenia countermeasure in older adults. Therefore, this training method may be particularly effective in preventing sarcopenia.
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Terauchi Y, Takada T, Yoshida S. A randomized controlled trial of a structured program combining aerobic and resistance exercise for adults with type 2 diabetes in Japan. Diabetol Int 2022; 13:75-84. [PMID: 35059244 PMCID: PMC8733075 DOI: 10.1007/s13340-021-00506-5] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/19/2021] [Accepted: 04/05/2021] [Indexed: 11/26/2022]
Abstract
BACKGROUND We assessed the effect of supervised, combined aerobic and resistance exercise on diabetic parameters in Japanese patients with type 2 diabetes mellitus (T2DM). METHODS This 12-week, multicenter (17 medical institutions), open-label, parallel-group study (clinicaltrials.jp; JapicCTI-184002), randomized (1:1) Japanese patients aged 20-75 years with T2DM and hemoglobin A1c (HbA1c) of 7.0-10.0% to supervised exercise (n = 113) or standard therapy (n = 115). The supervised exercise group undertook supervised aerobic (30 min) and resistance exercise 3 times/week (20 designated gyms). Primary endpoint was change in HbA1c from baseline at week 13. Secondary endpoints were change in fasting blood glucose (FBG), glycoalbumin, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and HOMA-β at week 13. RESULTS Of 228 randomized patients, 97 (85.8%) in the supervised exercise group and 108 (93.9%) in the standard therapy group completed the study. Supervised exercise significantly lowered HbA1c at week 13 versus standard therapy (estimated difference in change from baseline [95% confidence interval]: - 0.44% [- 0.61, - 0.28], p < 0.001). Supervised exercise also significantly decreased FBG (estimated difference: - 13.0 [- 19.2, - 6.7] mg/dL) and glycoalbumin (estimated difference: - 1.52% [- 2.10, - 0.93]) compared with standard therapy. Fasting insulin (- 0.5 µIU/mL) and HOMA-IR (- 0.3) decreased with supervised exercise, but group differences were not significant. Treatment-emergent adverse events were more frequent in the supervised exercise group (42.5%) than in the standard therapy group (29.6%); however, no major safety concerns were identified. CONCLUSIONS A structured, supervised, aerobic and resistance exercise program improved HbA1c and was well accepted among patients with T2DM. SUPPLEMENTARY INFORMATION The online version contains supplementary material available at 10.1007/s13340-021-00506-5.
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Affiliation(s)
- Yasuo Terauchi
- Department of Endocrinology and Metabolism, Yokohama City University, Yokohama, Japan
| | - Tetsushi Takada
- Clinical Operation and Innovation Group–Japan/Asia Clinical Development Department 2, Astellas Pharma Inc, 2-5-1, Nihonbashi-Honcho, Chuo-Ku, Tokyo, 103-8411 Japan
| | - Satoshi Yoshida
- Data Science Department, Development Division, Astellas Pharma Inc, Tokyo, Japan
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Lee M. Blood glucose control: Where are we? J Diabetes Investig 2021; 12:1762-1764. [PMID: 34288537 PMCID: PMC8504917 DOI: 10.1111/jdi.13632] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/03/2021] [Revised: 07/13/2021] [Accepted: 07/19/2021] [Indexed: 11/30/2022] Open
Abstract
Optimal blood glucose control warrants both early intensive therapy and individualization strategies in patients with diabetes mellitus.
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Affiliation(s)
- Moon‐Kyu Lee
- Division of Endocrinology & MetabolismDepartment of Internal MedicineUijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbuKorea
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Dora K, Suga T, Tomoo K, Sugimoto T, Mok E, Tsukamoto H, Takada S, Hashimoto T, Isaka T. Similar improvements in cognitive inhibitory control following low-intensity resistance exercise with slow movement and tonic force generation and high-intensity resistance exercise in healthy young adults: a preliminary study. J Physiol Sci 2021; 71:22. [PMID: 34273958 PMCID: PMC10717914 DOI: 10.1186/s12576-021-00806-0] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/08/2021] [Accepted: 06/26/2021] [Indexed: 01/02/2023]
Abstract
This study compared the effects of low-intensity resistance exercise with slow movement and tonic force generation (ST-LRE) and high-intensity resistance exercise (HRE) on post-exercise improvements in cognitive inhibitory control (IC). Sixteen young males completed ST-LRE and HRE sessions in a crossover design. Bilateral knee extensor ST-LRE and HRE (8 repetitions/set, 6 sets) were performed with 50% of one-repetition maximum with slow contractile speed and 80% of one-repetition maximum with normal contractile speed, respectively. The IC was assessed using the color-word Stroop task at six time points: baseline, pre-exercise, immediate post-exercise, and every 10 min during the 30-min post-exercise recovery period. The blood lactate response throughout the experimental session did not differ between ST-LRE and HRE (condition × time interaction P = 0.396: e.g., mean ± standard error of the mean; 8.1 ± 0.5 vs. 8.1 ± 0.5 mM, respectively, immediately after exercise, P = 0.983, d = 0.00). Large-sized decreases in the reverse-Stroop interference scores, which represent improved IC, compared to those before exercise (i.e., baseline and pre-exercise) were observed throughout the 30 min post-exercise recovery period for both ST-LRE and HRE (decreasing rate ≥ 38.8 and 41.4%, respectively, all ds ≥ 0.95). The degree of post-exercise IC improvements was similar between the two protocols (condition × time interaction P = 0.998). These findings suggest that despite the application of a lower exercise load, ST-LRE improves post-exercise IC similarly to HRE, which may be due to the equivalent blood lactate response between the two protocols, in healthy young adults.
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Affiliation(s)
- Kento Dora
- Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan
| | - Tadashi Suga
- Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan.
| | - Keigo Tomoo
- Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan
| | - Takeshi Sugimoto
- Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan
| | - Ernest Mok
- Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan
| | - Hayato Tsukamoto
- Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan
| | - Shingo Takada
- Faculty of Lifelong Sport, Department of Sports Education, Hokusho University, Ebetsu, Hokkaido, Japan
| | - Takeshi Hashimoto
- Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan
| | - Tadao Isaka
- Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan
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Dora K, Suga T, Tomoo K, Sugimoto T, Mok E, Tsukamoto H, Takada S, Hashimoto T, Isaka T. Effect of very low-intensity resistance exercise with slow movement and tonic force generation on post-exercise inhibitory control. Heliyon 2021; 7:e06261. [PMID: 33665431 PMCID: PMC7903307 DOI: 10.1016/j.heliyon.2021.e06261] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/08/2020] [Revised: 01/05/2021] [Accepted: 02/08/2021] [Indexed: 11/30/2022] Open
Abstract
Background The extremely low loads (e.g., <30% of one-repetition maximum) involved in performing resistance exercise are effective in preventing musculoskeletal injury and enhancing exercise adherence in various populations, especially older individuals and patients with chronic diseases. Nevertheless, long-term intervention using this type of protocol is known to have little effects on muscle size and strength adaptations. Despite this knowledge, very low-intensity resistance exercise (VLRE) with slow movement and tonic force generation (ST) significantly increases muscle size and strength. To further explore efficacy of ST-VLRE in the clinical setting, this study examined the effect of ST-VLRE on post-exercise inhibitory control (IC). Methods Twenty healthy, young males (age: 21 ± 0 years, body height: 173.4 ± 1.2 cm, body weight: 67.4 ± 2.2 kg) performed both ST-VLRE and normal VLRE in a crossover design. The load for both protocols was set at 30% of one-repetition maximum. Both protocols were programmed with bilateral knee extension for six sets with ten repetitions per set. The ST-VLRE and VLRE were performed with slow (3-sec concentric, 3-sec eccentric, and 1-sec isometric actions with no rest between each repetition) and normal contractile speeds (1-sec concentric and 1-sec eccentric actions and 1-sec rests between each repetition), respectively. IC was assessed using the color-word Stroop task at six time points: baseline, pre-exercise, immediate post-exercise, and every 10 min during the 30-min post-exercise recovery period. Results The reverse-Stroop interference score, a parameter of IC, significantly decreased immediately after both ST-VLRE and VLRE compared to that before each exercise (decreasing rate >32 and 25%, respectively, vs. baseline and/or pre-exercise for both protocols; all Ps < 0.05). The improved IC following ST-VLRE, but not following VLRE, remained significant until the 20-min post-exercise recovery period (decreasing rate >48% vs. baseline and pre-exercise; both Ps < 0.001). The degree of post-exercise IC improvements was significantly higher for ST-VLRE than for VLRE (P = 0.010 for condition × time interaction effect). Conclusions These findings suggest that ST-VLRE can improve post-exercise IC effectively. Therefore, ST-VLRE may be an effective resistance exercise protocol for improving cognitive function.
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Affiliation(s)
- Kento Dora
- Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan
| | - Tadashi Suga
- Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan
| | - Keigo Tomoo
- Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan
| | - Takeshi Sugimoto
- Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan
| | - Ernest Mok
- Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan
| | - Hayato Tsukamoto
- Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan
| | - Shingo Takada
- Faculty of Lifelong Sport, Department of Sports Education, Hokusho University, Ebetsu, Hokkaido, Japan
| | - Takeshi Hashimoto
- Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan
| | - Tadao Isaka
- Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan
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Nakamura M, Kiyono R, Sato S, Yahata K, Morishita S. One-repetition maximum can be estimated with a handheld dynamometer and circumference in community-dwelling older adults. J Phys Ther Sci 2020; 32:669-673. [PMID: 33132528 PMCID: PMC7590855 DOI: 10.1589/jpts.32.669] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/19/2020] [Accepted: 07/17/2020] [Indexed: 11/24/2022] Open
Abstract
[Purpose] One-repetition maximum is an essential statistic for physical therapists and coaches in rehabilitation and athletic settings. In a previous study, we showed that one-repetition maximum of the knee extensor could be predicted more accurately with the combination of maximal voluntary isometric contraction strength, as measured by a handheld dynamometer, muscle thickness, and thigh circumference, in young adults. However, there has been no study in older adults investigating the relationship between one-repetition maximum and maximal voluntary isometric contraction strength, or muscle thickness, and thigh circumference. Therefore, the aim of this study was to investigate the relationship between one-repetition maximum and maximal voluntary isometric contraction strength, or muscle thickness, and thigh circumference in older adults. [Participants and Methods] Twenty-eight older community-dwelling adults (18 males and 10 females) participated in this study. Muscle strength of the knee extensor was measured using one-repetition maximum and maximal voluntary isometric contraction strength. In addition, muscle thicknesses of the refutes femoris and the vastus intermedius, and thigh circumference were measured using ultrasonography and measuring tape, respectively. [Results] Stepwise regression analysis revealed that body mass, gender, thigh circumference at 15 cm above the patella, and maximal voluntary isometric contraction strength were significant and independent determinants (R2=0.868). [Conclusion] One-repetition maximum could be predicted more accurately using a combination of maximal voluntary isometric contraction strength, as measured with a handheld dynamometer, and thigh circumference in older adults.
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Affiliation(s)
- Masatoshi Nakamura
- Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare: 1398 Shimami-cho, Kita-ku, Niigata City, Niigata 950-3198, Japan
| | - Ryosuke Kiyono
- Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare: 1398 Shimami-cho, Kita-ku, Niigata City, Niigata 950-3198, Japan
| | - Shigeru Sato
- Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare: 1398 Shimami-cho, Kita-ku, Niigata City, Niigata 950-3198, Japan
| | - Kaoru Yahata
- Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare: 1398 Shimami-cho, Kita-ku, Niigata City, Niigata 950-3198, Japan
| | - Shinichiro Morishita
- Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare: 1398 Shimami-cho, Kita-ku, Niigata City, Niigata 950-3198, Japan
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Wake AD. Antidiabetic Effects of Physical Activity: How It Helps to Control Type 2 Diabetes. Diabetes Metab Syndr Obes 2020; 13:2909-2923. [PMID: 32884317 PMCID: PMC7443456 DOI: 10.2147/dmso.s262289] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/11/2020] [Accepted: 07/01/2020] [Indexed: 12/15/2022] Open
Abstract
Despite the improvements in clinical care of the patients, research updates, and public health interventions, there is still an increase in the prevalence, incidence, and mortality because of diabetes mellitus (DM). DM is a public health problem in both developed and developing countries. It has increased alarmingly, putting this disease in the dimension of an epidemic. Diabetes is associated with several complications which increase the risk of many serious health problems on the other side. Therefore, this review was aimed to discuss the antidiabetic effects of physical activity (PA) on type 2 DM (T2DM) by summarizing the significant studies on this topic. This review found that several studies have recommended the utilization of PA for the effective management of T2DM. PA is a non-pharmacologic therapy which is a significant strategy for the management of T2DM and is an appropriate lifestyle modification approach to be practiced by these patients. The studies showed that PA has antidiabetic effects which are evidenced by its substantial role in improving the blood glucose (BG) levels of the individuals with T2DM where it helps them to control their levels of glucose in the blood. It plays a significant role in glycemic control of this disease by lowering the BG levels through possible mechanisms such as decreasing insulin resistance, increasing production of glucose transporter type 4 (GLUT-4), lowering visceral adipose tissue (VAT), increasing pancreatic β-cell functions, using glucose for energy, and so on. In turn, the controlled glycemia helps to prevent the complications associated with uncontrolled T2DM and this would further improve the overall health of the patients and the burden on the health professionals as well. Finally, this review concludes that PA is the cornerstone in the management of T2DM. It also suggests that more attention is needed to its significance in the prevention, glycemic control, and its role in the management of the morbidity and mortality associated with T2DM. Practical PA recommendations and suggestions for the future direction of research in this area are also provided.
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Affiliation(s)
- Addisu Dabi Wake
- Nursing Department, College of Health Sciences, Arsi University, Assela, Oromia, Ethiopia
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Shabkhiz F, Khalafi M, Rosenkranz S, Karimi P, Moghadami K. Resistance training attenuates circulating FGF-21 and myostatin and improves insulin resistance in elderly men with and without type 2 diabetes mellitus: A randomised controlled clinical trial. Eur J Sport Sci 2020; 21:636-645. [PMID: 32345132 DOI: 10.1080/17461391.2020.1762755] [Citation(s) in RCA: 38] [Impact Index Per Article: 7.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/25/2022]
Abstract
Fibroblast growth factor 21 (FGF-21) and myostatin have been proposed to be potential therapeutic target for insulin resistance in age-related metabolic disorders including type 2 diabetes (T2D). Moreover, despite the potential metabolic effect of resistance training on insulin resistance, aging, and T2D; the effect of this type of exercise training on FGF-21 and myostatin in elderly men with and without T2D are unknown. Forty-four elderly men were assigned to either the RT training (RT; without T2D: 12, with TD2 = 10) or the control group (C; without T2D: 12, with TD2 = 10). The RT group performed 12-wk resistance training intervention, 3 days/wk, 10 repetitions with 70% 1RM. At the baseline, the elderly men with T2D had a higher FGF-21 (p = 0.002) and myostatin (p = 0.02) concentrations and lower muscle strength (p = 0.01) than the elderly men without T2D. RT resulted in significant decrease in FGF-21 and myostatin concentration and increase in muscle strength in both elderly men with and without T2D (P = 0.001, for all) as well as decrease in HOMA-IR in only elderly men without T2D (P = 0.001). There was no significant difference in the RT-induced FGF-21 reduction between elderly men with and without T2D (p = 0.77, p = 0.28, respectively), but, RT caused a larger reduction in circulating myostatin in elderly men without T2D than with T2D (P = 0.007). Taken together, our results demonstrated that 12 weeks of RT induced an overall significant reduction of FGF-21 and myostatin in elderly men with and without T2D; with higher reduction of myostatin in elderly men without T2D.
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Affiliation(s)
- Fatemeh Shabkhiz
- Faculty of Physical Education and Sport Sciences, Department of Exercise Physiology, Tehran University, Tehran, Iran
| | - Mousa Khalafi
- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran
| | - Sara Rosenkranz
- Department of Food, Nutrition, Dietetics and Health, College of Health and Human Sciences, Kansas State University, Manhattan, KS, USA
| | - Pouran Karimi
- Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
| | - Kamilia Moghadami
- Department of pure and basic science, Hashtgerd Branch, Islamic Azad University, Karaj, Iran
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Amanat S, Ghahri S, Dianatinasab A, Fararouei M, Dianatinasab M. Exercise and Type 2 Diabetes. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 2020; 1228:91-105. [PMID: 32342452 DOI: 10.1007/978-981-15-1792-1_6] [Citation(s) in RCA: 74] [Impact Index Per Article: 14.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/22/2022]
Abstract
The epidemic of diabetes mellitus has already become a serious global health threat. In the past three decades, the number of people with diabetes mellitus has quadrupled globally, and diabetes mellitus is known as the ninth major cause of death in the world nowadays. The increasing prevalence of type 2 diabetes mellitus is in coincidence with the augmentation of obesity in most developed countries as well as in developing countries. A sedentary lifestyle is well-known as one of the major reasons for the rising epidemic of type 2 diabetes mellitus besides the other reasons such as adopting energy-dense diets relative to the actual need for energy and population aging. Exercise as a regular physical activity at a medium to vigorous intensity is found to be an efficient influencer that would switch back most of the known type 2 diabetes mellitus factors toward healthier positions. Exercise is proven to have clinical benefits, such as improved insulin sensitivity, reductions in glycosylated hemoglobin (A1C) and increased peak oxygen consumption (VO2peak) which are definitely preventive toward diabetes. Exercise training can favorably affect glycemic parameters, the lipid profile, blood pressure, and high-sensitivity C-reactive protein. Exercise improves blood glucose control in type 2 diabetes, reduces cardiovascular risk factors, and regulates body weight by reducing body fat percentage and enhancing lean mass. In this chapter, the effect of regular exercise on the prevention of diabetes and short-term glucose and energy metabolism will be discussed. In addition, the effect of exercise on most common complications of type 2 diabetes including cardiovascular diseases, dyslipidemia, nephropathy, neuropathy, and retinopathy will be reviewed.
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Affiliation(s)
- Sasan Amanat
- Department of Nutrition, School of Health, Larestan University of Medical Sciences, Larestan, Iran
| | - Simin Ghahri
- Department of Sport Physiology, Shahrood University of Technology, Shahrood, Iran
| | - Aria Dianatinasab
- Department of Biochemistry, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Mohammad Fararouei
- Faculty of Public Health, Department of Epidemiology, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Mostafa Dianatinasab
- Department of Epidemiology, Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran.
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Hart PD, Buck DJ. The effect of resistance training on health-related quality of life in older adults: Systematic review and meta-analysis. Health Promot Perspect 2019; 9:1-12. [PMID: 30788262 PMCID: PMC6377696 DOI: 10.15171/hpp.2019.01] [Citation(s) in RCA: 58] [Impact Index Per Article: 9.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/07/2018] [Accepted: 11/24/2018] [Indexed: 12/13/2022] Open
Abstract
Background: Resistance training (RT) is recommended as part of our national physical activity guidelines which includes working all major muscle groups on two or more days a week.Older adults can gain many health benefits from RT, such as increased muscle strength,increased muscle mass, and maintenance of bone density. Additionally, certain dimensions of health-related quality of life (HRQOL) have been shown to improve in older adults due to RT intervention. The purpose of this study was to use systematic review and meta-analytic techniques to examine the effect of RT on HRQOL in older adults. Methods: A systematic review of current studies (2008 thru 2017) was conducted using PubMed. Studies were included if they used a randomized controlled design, had RT as an intervention, measured HRQOL using the SF-36/12 assessment, and included adults 50+ years of age. Eight dimension scores (physical functioning, bodily pain, physical role function, general health, mental health, emotional role function, social function, and vitality) and two summary scores (physical component and mental component) were extracted. Ten meta-analyses were performed using standardized mean effect sizes and random effects models. Study quality,moderator and sensitivity analyses were conducted. Results: A total of 16 studies were included in the analyses with a mean Physiotherapy Evidence Database (PEDro) score of 4.9 (SD=1.0). Among the mental health measures, RT had the greatest effect on mental health (Effect size [ES]=0.64, 95% CI: 0.30-0.99, I2=79.7). Among the physical health measures, RT had the largest effect on body pain (ES=0.81, 95% CI: 0.26-1.35, I2=85.9).Initially, RT did not significantly affect measures of emotional role function, social function or physical role function. However, after removing a single study, RT significantly increased all HRQOL measures. Conclusion: The meta-analytic evidence presented in this research clearly supports the promotion of RT in improving HRQOL in older adults.
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Affiliation(s)
- Peter D Hart
- Health Promotion Program, Montana State University - Northern, Havre, MT 59501, USA.,Kinesmetrics Lab, Montana State University - Northern, Havre, MT 59501, USA
| | - Diona J Buck
- Health Promotion Program, Montana State University - Northern, Havre, MT 59501, USA
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Silva CRDS, Costa ADS, Rocha T, de Lima DAM, do Nascimento T, de Moraes SRA. Quadriceps muscle architecture ultrasonography of individuals with type 2 diabetes: Reliability and applicability. PLoS One 2018; 13:e0205724. [PMID: 30335818 PMCID: PMC6193658 DOI: 10.1371/journal.pone.0205724] [Citation(s) in RCA: 17] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/23/2018] [Accepted: 10/01/2018] [Indexed: 12/25/2022] Open
Abstract
Muscle architecture parameters performed using ultrasound serve as an aid to monitor muscle changes derived from diseases, however there are no studies that determine the reliability and applicability of this evaluation in individuals with type 2 diabetes (DM2). Three raters captured three images of measurements of thickness of the rectus femoris (RF), vastus intermedius and anterior quadriceps, RF muscle cross-sectional area, RF pennation angle in 17 individuals with DM2 above 50 and sedentary. Intra and inter-raters analysis showed reliability from high to very high for the three raters (ICC> 0.87), except for the RF pennation angle with moderate to low intra-raters (ICC = 0.58, 0.48, 0.51), and high inter-rater reliability (ICC = 0.70). Ultrasound measurements of quadriceps muscles showed high to very high intra and inter-raters reliability, thus allowing its use to monitor muscle changes provoked by diabetes or interventions in individuals with DM2.
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Affiliation(s)
- Camilla Rodrigues de Souza Silva
- Programa de Pós-Graduação em Neuropsiquiatria e Ciências do Comportamento, Universidade Federal de Pernambuco, Recife, Brasil
- * E-mail:
| | | | - Taciano Rocha
- Programa de Pós-Graduação em Fisioterapia, Universidade Federal do Rio Grande do Norte, Natal, Brasil
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