Mental health disorders are a growing public health challenge globally. This study aimed to utilize the Stress Susceptibility-Recovery Model to identify the relationship between sleep duration, daytime outdoor activities, and major mental health outcomes among adolescents.

Data from the Yunnan Students' Common Disease Survey was analyzed. Multi-factorial logistic regression assessed the impact of each variable on mental health, while subgroup analyses and interaction tests examined the stability of the association between sleep duration, daytime outdoor activity, and mental health. Mendelian Randomization analysis assessed causal effects.

The analysis included 204,158 participants aged 12-18 from 953 surveillance schools. After adjusting for covariates, the prevalence of depressive mood increased from 18.81 % (12-13 years) to 24.89 % (16-18 years); Females had a higher prevalence than males (1:1.36). Senior high school students (26.04 %) had a significantly higher rate than junior high school (21.41 %), and vocational high school students (18.42 %). Students with <2 h of daytime outdoor activity had a higher prevalence of depressive mood (24.40 %) compared to those with 2 or more hours of daytime outdoor activity (19.96 % for 2 h and 19.70 % for 3 or more hours). Short sleep duration mediated the association between reduced daytime outdoor activity and increased depressive mood or affective disorders risk, supporting the Stress Susceptibility-recovery Model.

Sleep duration and daytime outdoor activity were key determinants of emotional well-being, considering aging and gender disparities.

Potential sampling bias due to differences in baseline characteristics between participants with and without missing data.

Emerging evidence indicates that autistic adults without intellectual disabilities (ID) are at elevated risk of developing cardiovascular disease (CVD).

This cross-sectional survey study aimed to assess the prevalence of physiological and mental health risk factors for CVD and examine how physical activity (PA) and sedentary time (ST) relate to CVD risk in autistic adults without ID.

An online self-report survey addressing PA, ST, and CVD risk factors was delivered to 229 autistic adults without ID aged 18-55 years. Participants were recruited via direct contact with autism advocacy organizations in the U.S. and autism support groups on social media. Binary logistic regression analyses were used to explain the impact of PA and ST on CVD risk factors.

Higher ST was significantly associated with increased odds for high blood pressure, stroke, and mental health risk factors (depression, anxiety, bipolar, and obsessive-compulsive disorder; all p < 0.05). No significant associations were found between PA and CVD risk factors.

Excessive ST in autistic adults without ID is associated with an increased risk for certain CVD factors, particularly those related to poor mental health. Health interventions should focus on breaking up prolonged sitting as a CVD prevention strategy in this population.

The interrelation of physical activity, sedentarism, and sleep concerning the onset and persistence of depression is underexplored. This study examines the joint effect of time spent in these activities on clinically relevant depressive symptoms (CRDS). It also examines the influence of history of depressive disorder and whether results extend to serious psychological distress (SPD).

Longitudinal data from the Canadian Longitudinal Study on Aging, including 25,665 middle-aged and older (45-85 years) people, were used. Self-reported questionnaires were used for time spent walking, moderate physical activity (MPA), vigorous physical activity (VPA), sitting, and sleep. CRDS and SPD were assessed with the 10-item Center for Epidemiologic Studies Depression scale and the Kessler Psychological Distress scale, respectively. Logistic regression models, adjusted for covariates, estimated the association between activities and mental health outcomes.

At baseline, 15 % experienced CRDS, and 11 % SPD. Those with low activity patterns (high sitting levels, low levels of walking, MPA, VPA, and short sleep) were more likely to develop CRDS and to retain it than those with medium-high activity patterns. These patterns mostly also applied to SPD. Among those with history of depression, sedentary behavior and sleep were less strongly related to CRDS, but walking, MPA and VPA were equally strongly related.

Those with low activity patterns (high levels of sitting, little time spent in physical activities) had the worst mental health outcomes, while participants with higher activity level are less likely to continue or develop CRDS and SPD. Short sleep should be targeted for both mental conditions.

Mental health issues in preschool children are a significant public health concern with long-term developmental implications. Understanding how reallocations of time among different 24-hour movement behaviors-moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), sedentary behavior (SED), and sleep (SLP)-affect various dimensions of mental health is essential for designing effective interventions.

In this cross-sectional study, 828 Chinese preschool children aged 3 to 6 years were assessed. Physical activity and sleep were objectively measured using accelerometers to capture MVPA, LPA, SED, and SLP. Mental health was evaluated using the Strengths and Difficulties Questionnaire (SDQ), assessing Total Difficulties, Internalizing Problems, Externalizing Problems, and Prosocial Behavior. Compositional data analysis was conducted using isometric log-ratio (ilr) transformation, followed by multivariate linear regression to assess associations. Additionally, isotemporal substitution modeling and dose-response analysis were applied to examine the effects of reallocating time between behaviors on mental health outcomes, adjusting for age, gender, BMI, parental education, and parental attitudes toward physical activity.

Increased MVPA was significantly associated with lower Total Difficulties (ßMVPA= - 1.587; P < 0.001) and Internalizing Problems (ßMVPA= - 0.663; P = 0.017). Increased SED was associated with higher Total Difficulties (ßSED= 1.512; P < 0.05), while increased SLP was linked to improved Externalizing Problems (ßLPA= - 1.792; P = 0.008). Reallocating as little as 1 min from LPA or SED to MVPA or SLP significantly reduced Total Difficulties and Internalizing Problems (P < 0.05). Conversely, replacing SED or SLP with LPA increased Externalizing Problems, particularly Conduct Problems and Hyperactivity/Inattention (P < 0.05). A critical threshold at 30 min was identified, beyond which the effects on mental health outcomes became more pronounced.

Reallocating time from LPA or SED to MVPA or SLP significantly improves Total Difficulties and Internalizing Problems in preschool children, even with brief substitutions. However, increasing LPA at the expense of SED or SLP exacerbates Externalizing Problems, especially Conduct Problems and Hyperactivity/Inattention. Interventions should promote MVPA and adequate sleep while considering the critical 30-minute threshold where effects become more pronounced to enhance emotional and behavioral well-being.

To investigate the associations between accelerometer-measured physical activity and sedentary behavior with depression and anxiety.

We used accelerometer data from the UK biobank. Time spent in moderate-to-vigorous physical activity (MVPA) was classified into four categories: very-low (0-74.9 min/week), low (75-149.9 min/week), moderate (150-299.9 min/week), and high (≥300 min/week). Associations were examined using Cox proportional hazard regression models. Restricted cubic splines were used to evaluate dose-response associations.

A total of 71556 adults (mean [SD] age, 62.11 [7.83] years; 54.5% were female) were included. When stratified by MVPA, 10562 participants were in the very-low group (14.8%), 11578 were in the low group (16.2%), 20700 were in the moderate group (28.9%), and 28716 were in the high group (40.1%). Both MVPA and total physical activity showed nonlinear associations with the risk of depression and anxiety. Compared with very-low level MVPA, moderate MVPA might reduce the risk of depression (HR, 0.71; 95% CI, 0.63-0.79) and anxiety (HR, 0.80; 95% CI, 0.71-0.90). High MVPA was associated with a 30% lower risk of depression (HR, 0.70; 95% CI, 0.62-0.78) and anxiety (HR, 0.70; 95% CI, 0.62-0.79). For sedentary behavior, quartile 4 (≥10.60 h/d) was associated with a 19% higher risk of depression (HR, 1.19; 95% CI, 1.05-1.35) compared to quartile 1 (<8.21 h/d).

The WHO guideline of 150-300 min/week of MVPA may reduce the risk of depression by 29% and anxiety by 20% compared to less than 75 min/week. Prolonged sedentary behavior was associated with a higher risk of depression.

Despite growing evidence linking 24-h movement behaviors to health outcomes, there is limited research examining these relationships among university students in Southeast Asia. Therefore, the purpose of this study was to examine the prevalence and associations of adherence to 24-h movement guidelines (HMG) with dietary behaviour and mental health among university students in ASEAN.

A multi-center cross-sectional survey was conducted in 2015 included 3223 university students from five ASEAN nations-Indonesia, Malaysia, Myanmar, Thailand, and Vietnam-aged 18 to 30 years, selected by stratified random sampling. Established measures included demographics, social support, perceived stress, self-rated health status, body mass index, six dietary behaviours, eight mental health outcomes, and adherence to 24-h movement guidelines (24-HMG) was assessed based on self-reported physical activity (≥ 150 min/week), sedentary time (≤ 480 min/day), screen time (≤ 180 min/day), and sleep duration (7-9 h). The relationship between dietary behaviours, mental health indicators and meeting the 24-HMG number was investigated using logistic regression models, adjusted for relevant confounders.

Among 3,223 participants, 11.7% met all three 24-h movement guidelines, while 13.1% met none, and 37.6% met either one or two guidelines. Adherence to all guidelines was higher among males, participants aged 22-30 years, and those from lower-income countries (Indonesia, Myanmar, and Vietnam). Multiple logistic regression analyses, adjusted for relevant confounders, revealed that meeting more movement guidelines was associated with: Increased odds of healthy dietary behaviors (fruit and vegetable intake: Adjusted Odds Ratio-AOR: 1.96, 95% Confidence intervals-CI: 1.35-2.83; breakfast intake: AOR: 2.48, 95% CI: 1.84-3.34; meal frequency: AOR: 1.83, 95% CI: 1.36-2.45; low soft drink intake: AOR: 2.20, 95% CI: 1.54-3.14; high sugared coffee or tea intake: AOR: 0.39, 95% CI: 0.24-0.61; low fast food intake: AOR: 1.46, 95% CI: 1.08-1.96; and low snacking: AOR: 2.71, 95% CI: 2.00-3.66), and Decreased odds of mental health issues (depressive symptoms: AOR: 0.43, 95% CI: 0.26-0.70; suicidal behaviour: AOR: 0.66, 95% CI: 0.47-0.93; pathological internet use: AOR: 0.60, 95% CI: 0.45-0.81; hazardous or harmful alcohol use: AOR: 0.44, 95% CI: 0.29-0.66; illicit drug use: AOR: 0.38, 95% CI: 0.20-0.73; and had poorer sleep quality: AOR: 0.33, 95% CI: 0.16-0.68). No significant associations were found between guideline adherence and PTSD symptoms or tobacco use (p > 0.05).

This is the first study to look at the prevalence, correlates, and relationships between 24-HMG adherence and dietary behaviour and mental health outcomes among university students in ASEAN. This pioneering study among ASEAN university students demonstrates that adherence to 24-h movement guidelines is associated with better dietary behaviours and mental health outcomes in a dose-response manner. Future university health policies should incorporate 24-h movement guidelines into existing health promotion strategies, particularly in resource-limited settings.

Healthy lifestyles may have the potential to be protective factors for mental health problems. The aim was to classify drinkers and former drinkers in depression sufferers or non-sufferers according to demographic data and lifestyle habits, using a classification and regression tree (CRT). This cross-sectional study is based on the NHANES 2011-20. 3175 participants (2342 males and 833 females) drinkers and former drinkers formed the final sample. CRT analysis was used to classify them in depression sufferers and non-sufferers. Odds ratio (OR) and relative risks (RR) of suffering depression for each branch of the tree were calculated. The model was found to have an 82.0% accuracy. Independent variables were classified by their importance in the model, in this order: diet (0.007; 100.0%), gender (0.004; 60.4%), PA group (0.003; 45.4%), sedentary time (0.002; 32.6%), education level (0.001; 29.1%) and age (<0.001; 7.1%). Elevated OR and RR of suffering depression were found for participants with: fair and poor diet compared to good, very good or excellent diet (OR = 2.02, CI95%: 1.69-2.43, RR = 1.77, CI95%: 1.52-2.10), for inactive, walkers and low PA, compared to moderate PA and high PA (OR = 1.99,CI95% = 1.53-2.60, RR = 1.68, CI95%:1.37-2.07), for females compared to males (OR = 2.00, CI95%:1.54-2.66, RR = 1.81, CI95%:1.45-2.26), for people with a '9-11th grade' or below education level compared to those with a higher level of education (OR = 1.50, CI95%:1.05-2.15, RR = 1.32, CI95%:1.04-1.67) in branch beneath node 3; and for people with a high school/GED or below education level, compared to those with higher education (OR = 1.99, CI95%:1.27-3.13, RR = 1.71, CI95%:1.21-2.43), in branch beneath node 6. Diet, PA group, sedentary time, gender, education level and age allow us to classify drinkers and former drinkers in sufferers or non-sufferers of depression. The CRT model combined with OR and RR allow us to identify which participants have greater odds of suffering depression based on lifestyle and demographic data.

Sedentary behaviour (SB) is related to lower worker health-related quality of life (HRQOL), mental health and productivity. However, it is unknown whether reducing SB improves these outcomes. This study assessed whether a 3-month SB reduction intervention improved or was associated with dose-response changes in workplace satisfaction, productivity, mood and HRQOL.

Inactive desk workers with elevated blood pressure were randomised to a 3-month SB reduction intervention (n=135) or control (n=136). The intervention used a sit-stand desk, wrist-worn activity prompter and bi-monthly individual coaching to primarily replace work SB with standing and stepping. SB measured via a thigh-mounted activPAL3 micro, workplace satisfaction, productivity, mood and HRQOL were assessed at baseline and 3 months. Analyses of covariance compared changes in outcomes between groups with adjustment for baseline values. In both groups, associations between changes in work and non-work SB and outcomes were examined using linear regression.

Compared with control, reducing SB did not significantly change workplace satisfaction, productivity or HRQOL. Among mood measures, only vigour improved (1.01 vs 0.1 points, p=0.0302). Among all participants, reductions in non-work SB were associated with improvements in workplace satisfaction (+0.15 and +0.27 points/hour of non-work standing and stepping, respectively) and productivity (+0.47 points/hour of non-work stepping), while changes in SB during work were not related.

Interventions reducing non-work rather than work SB may be more impactful for improving workplace satisfaction and HRQOL outcomes. Future studies should explore workplace-based SB reduction interventions that are longer and target non-work time to improve similar outcomes.

NCT03307343.

Studies investigating the associations of 24-h movement behaviours (including moderate-to-vigorous-intensity physical activity (MVPA), light-intensity PA (LPA), sedentary time (ST) and sleep) with depressive symptoms are scarce. It is also unclear whether possible associations differ between urban and rural residents. Hence, we aimed to investigate these associations in a population-based sample of middle-aged Finnish adults.

The study population consisted of 4295 adults, aged 46 years, from the Northern Finland Birth Cohort 1966. The participants wore a hip-worn accelerometer for 14 days. Time spent in sedentary, LPA and MVPA was obtained from accelerometer data and then combined with self-reported sleep duration to obtain the 24-h composition. The residential environment was classified as urban or rural based on the participants' home addresses. Depressive symptoms were assessed using the Beck Depression Inventory-II (BDI-II). Multivariable adjusted regression analysis using a compositional data analysis approach based on isometric log-ratio transformation was used to determine the associations between movement behaviours and depressive symptoms in urban and rural residential environments.

The 24-h movement behaviour composition was significantly associated with the BDI-II score both in urban and rural residential environment. More time spent in sleep relative to other behaviours was associated with lower BDI-II score in rural residential environments. More time spent in ST among urban residents and in LPA among rural residents was associated with higher BDI-II scores. When modelling pairwise reallocations of time, more MVPA or more sleep at the expense of LPA or ST was associated with lower BDI-II score among rural residents. For urban residents, reallocating time from ST to any other behaviour was associated with lower BDI-II score.

Our findings showed that more relative time spent in MVPA and sleep was associated with lower levels of depressive symptoms among rural residents, and more relative time spent in any other behaviour at the expense of ST was associated with lower levels of depressive symptoms among urban residents. These differences should be considered in the prevention and treatment of depressive symptoms. Due to the cross-sectional design of this study, causality cannot be inferred, and further research exploring the mechanisms underlying these associations in diverse populations and longitudinal study settings are needed.

Background/Objectives: This study examined the relationship between grit-a measure of perseverance and diligence-and depressive symptoms in the context of the COVID-19 pandemic. While low levels of grit have typically been associated with increased vulnerability to mental health challenges, the pandemic introduced elements that may have altered this relationship. Methods: Using data from 5039 participants in the National Longitudinal Survey of Youth 97, one-way MANCOVAs were conducted to compare depressive symptoms across low-, moderate-, and high-grit individuals before and during the pandemic. Results: The findings show that in pre-pandemic periods, low-grit individuals displayed a significantly higher risk of depressive symptoms than their moderate- and high-grit counterparts. However, during the pandemic, this differential risk diminished, with higher-grit groups showing depressive symptoms comparable to those of lower-grit groups. Conclusions: These results suggest that public health crises entailing limited public mobility and social distancing may alter the traditional protective role of grit, prompting further investigation into how resilience factors interact with external stressors during times of widespread adversity.

Psychological symptoms and sleep disturbance are common during pregnancy. Observational data suggest that being physically active during pregnancy is related to better mood and sleep, but whether sedentary behavior reduction interventions provide similar benefits is untested. We aimed to determine whether reducing sedentary behavior across pregnancy improved psychological and sleep parameters.

Pregnant participants (n = 51) were allocated 2:1 to a sedentary behavior reduction intervention or control in their first trimester. Depressive symptoms, perceived stress, mood disturbance, nausea/vomiting quality of life, and sleep parameters were assessed with validated questionnaires in each trimester. Linear mixed effects regression examined differences between groups across pregnancy. Spearman correlations tested whether changes in sedentary time and physical activity were associated with changes in psychological and sleep outcomes without regard to group.

Despite significant reductions in sedentary behavior (-0.84 hour/day), the intervention had no effect on psychological health outcomes. Further, intervention participants demonstrated significant worsening of sleep efficiency factor scores compared with control (p = 0.038). Small but significant correlations were found between changes in sedentary time and nausea/vomiting quality of life, and between changes in physical activity and nausea/vomiting quality of life, sleep duration, and sleep efficiency.

Reducing sedentary behavior during pregnancy did not improve psychological symptoms and may worsen sleep efficiency. Recommendations for future sedentary behavior reduction research in pregnancy include a larger sample with poorer psychological health and sleep at baseline, targeting reductions in mentally passive sedentary behavior, and including device-based sleep assessments.

University students incur significantly elevated levels of stress compared to the general population and their non-student counterparts. Health risk behaviours are important modifiable determinants for the onset and aggravation of various mental health disorders, in which, university students generally exhibit poor engagement. Thus, this study aims to determine the efficacy of health behaviour interventions in relation to change in health behaviour and mental health outcomes, the impact of interventions (i.e., penetration, fidelity, and implementation), intervention characteristics associated with improved outcomes (efficacy) and the economic evaluation of interventions.

Six electronic databases were searched for randomised controlled trials (RCT) published from the 1st January 2012 to 11th July 2023. Eligible RCTs included university students, evaluated behavioural interventions targeting health behaviours (i.e. dietary intake, physical activity, sedentary behaviour, alcohol use, substance use, smoking, and sleep) and reported a change in both health behaviour and mental health outcomes.

Twenty-two RCTs met the study inclusion criteria. Overall, only seven studies were effective in improving both health behaviour and mental health outcomes, with most (n = 4) focused on improving sleep behaviours. Insufficient evidence was found regarding intervention impact, intervention characteristics associated with improved outcomes and the economic evaluation of interventions to guide future implementation of health behaviour interventions in universities due to inadequate reporting of outcomes.

There is limited evidence regarding the efficacy of health behaviour interventions in improving both health behaviour and mental health outcomes. There is also insufficient evidence regarding intervention impact, intervention characteristics associated with improved outcomes and economic evaluation to guide the implementation of these interventions in the university setting.

Nurses belong to a professional cohort that frequently experiences depression and stress. The objective of this research was to examine the correlation between objective physical activity (PA) with depression and stress among nurses, with a specific focus on the mediating role of resilience.

This study employed the descriptive-correlation method. One-hundred twenty-seven nurses (76 women) working in hospitals in Bitlis province, Türkiye in 2023 were selected using a convenience sampling. To measure PA, depression, stress, and resilience, ActiGraph GT3X-BT accelerometer, Beck Depression Inventory, Perceived Stress Scale, and Connor-Davidson Resilience Scale were utilized, respectively. Data analysis was conducted using Pearson correlation test and structural equation modeling.

Nurses, particularly women, experienced a moderate level of depression and stress. Moreover, the number of step counts was significantly higher in day vs. night shift. Overall, the nurses in this study, especially women, engaged in PA levels that were significantly below the international guidelines for adults (p<0.001). Additionally, higher intensity levels of PA (i.e., moderate PA [MPA] and vigorous PA [VPA]) were found to be linked with reduced levels of depression (β=-0.528, β=-0.410, respectively) and stress (β=-0.605, β=-0.531, respectively). Lastly, resilience was identified as a significant mediator in the correlation between MPA and VPA with depression and stress (p<0.05).

These findings hold great significance as they demonstrate the positive impact of both resilience and PA on the mental well-being of nurses. It is advisable for healthcare authorities to formulate policies and strategies aimed at enhancing the overall stability and performance of the healthcare sector.

To (1) examine how physical activity and sedentary behavior are related to mental distress and (2) identify and compare how various levels of sedentary behaviors may differentially predict mental distress after accounting for physical activity, among caregivers vs non-caregivers.

Cross-sectional secondary data.

National Cancer Institute's Health Information National Trends Survey Cycle 6 fielded online from March-November 2022.

U.S. adults aged 18 and older.

The Patient Health Questionnaire-4 was administered along with caregiving status, moderate weekly physical activity, sedentary behavior, and sociodemographic characteristics.

After applying population weights, we conducted multiple adjusted logistic regression models and estimated predictive margins to understand whether a specific dose of sedentary behavior (hours/day) is associated with risk of mental distress, at different levels of physical activity.

Caregivers (15.41% of sample) reporting 10-hour of daily sedentary behavior were significantly more likely to experience mental distress, than those reporting lower amounts of sedentary behavior (OR = 3.372, 95%CI = 1.968, 5.776, P < 0.001). Regardless of physical activity amount, 10 hours of sedentary behavior may be a risk factor for mental distress among non-caregivers. Just 6 hours of sedentary behavior may be related to mental distress among caregivers.

Physical activity interventions tailored to caregivers' needs, responsibilities, and circumstances are required. Innovative methodologies are needed to understand caregivers' daily behaviors and the intensity of their caregiving activities.

The relationship between leisure sedentary behaviors and mental health remains inconclusive. This study aims to provide evidence on leisure sedentary behaviors on mental health using longitudinal data, along with its moderating and mediating roles.

We utilized data from four waves (2006-2015) of the China Health and Nutrition Survey (CHNS), focusing on adults who completed their education, with a total sample of 23,693 observations. Leisure sedentary time, the independent variable, was measured based on self-reported data, while mental health issues were the dependent variables based on the Simplified Symptom Self-Rating Scale (SCL) and the Perceived Stress Scale (PSS-14). The primary analysis employed ordinary least squares (OLS) regression. Potential endogeneity was addressed by instrumental variable (IV) method via two-stage least squares (2SLS) regression and a continuous difference-in-differences (DID) design.

Our findings indicate that high levels of sedentary time are associated adversely with mental health issues. Moderating roles show that improving health literacy and reducing sedentary time were effective in alleviating this adverse impact. Among older adults, social engagement and support from female caregivers showed greater potential to reduce the detrimental mental health impact of leisure sedentary time. Furthermore, obesity serve as its mediating role.

This study highlights the potential adverse impact of increased leisure sedentary time on mental health among Chinese population. These results provide a foundation for public health initiatives aimed at addressing the rising prevalence of sedentary behavior and its association with mental health issues.

Evidence strongly suggests that moderate-to-vigorous physical activity (MVPA) can help reduce symptoms of depression. However, the relationship between 24-h movement behaviors and depressive symptoms, as well as the potential substitution effects between different behaviors, remains unclear. Therefore, this study seeks to investigate how the time spent in one behavior relative to others is associated with depressive symptoms.

The study recruited 366 participants, who had their levels of MVPA, light PA (LPA), and sedentary behavior (SB) recorded using tri-axial accelerometers over 7 consecutive days. Participants also self-reported their sleep duration (SLP). Depression scores were measured using the Center for Epidemiological Studies Depression Scale (CESD). Using compositional linear regression, the study explored the connections between different compositions of time spent in movement behaviors and depression symptom scores.

Spending more time on LPA and MVPA relative to other behaviors were associated with lower depression scores, whereas a higher proportion of SB relative to other activities was linked to increased depression scores. Reallocating time spent on SB to LPA and MVPA was associated with decreased depression scores.

This study is a cross-sectional research design, and causality cannot be inferred. In addition, the sampling method of this study may have imposed some limitations on the representativeness of the sample. Further longitudinal studies could be conducted by selecting a large, representative sample.

Within the spectrum of 24-h movement behaviors, increasing the duration of LPA and MVPA emerges as advantageous for reducing depression scores, suggesting a potential benefit in reallocating SB to PA, especially MVPA.

This paper describes the data collection and management methods for the Cancer Prevention Study-3 (CPS-3) Accelerometry Substudy, a nested cohort of device-based physical activity and sedentary time data.

US-based CPS-3 participants (initially enrolled 2006-2013) who completed the 2018 follow-up survey and had a valid email address were invited to the Accelerometry Substudy (n=109 780). Among the 23 111 participants who registered and were shipped an ActiGraph GT3X+ accelerometer, 21 219 participants returned the device with a complete wear log (91.8%) and 20 950 (90.6%) provided at least three adherent days of data (eg, days with at least 10 hours of wear).

Participants with ≥3 adherent days were predominantly female (n=16 187, 77.3%), non-Latino white (n=17 977, 85.8%) and had an average age of 58 years (SD=9.8). The median daily wear time was 15.3 hours, which did not vary considerably by wear day. The median time spent in moderate-intensity aerobic physical activity was 29 min/day (IQR=36), and the median time in vigorous physical activity was 3 min/day (IQR=13). Participants were sedentary for 9.4 hours (564 min, IQR=171 min) and accumulated a median of 6474 steps per day (IQR=5348).

The full CPS-3 cohort will be linked with the National Death Index and state cancer registries biennially. Participants will be sent triennial surveys for the next two decades. Future analyses within the CPS-3 Accelerometry Substudy more specifically aim to identify relationships between physical activity, sedentary time and health outcomes, primarily cancer incidence, survival and survivorship.

Sedentary behavior and depression have been linked to inflammation. However, the specific role of inflammation in the relationship between sedentary behavior and depression remains unclear.

We examined associations among the inflammatory marker (neutrophil-to-lymphocyte ratio [NLR]), sedentary behavior, and depression in a robust, ethnically diverse sample (n = 29,769) from the National Health and Nutrition Examination Survey (NHANES).

Our findings indicate that individuals experiencing depression and/or engaging in sedentary behavior show elevated levels of the NLR. Even after adjusting for confounding variables such as age, sex, and body mass index, sedentary behavior remains significantly associated with both depression and NLR levels. Additionally, our analysis reveals a non-linear relationship between NLR levels and depression, suggesting a complex interaction. Importantly, NLR partially mediates a modest yet statistically significant portion (1.920 %, p = 0.014) of the association between sedentary behavior and depression.

This study highlights the intricate interplay among sedentary behavior, inflammation, and depression, providing insights into potential avenues for intervention and management.

More screen time (ST) is associated with dysregulation of the individual biological systems (cardiovascular, immune, metabolic, and neuroendocrine) involved in the stress response in youth. However, its relationship with allostatic load (AL), a measure of the cumulative physiological stress response, is unclear in youth.

To investigate the associations between ST types and AL outcomes in youth and to explore sociodemographic and behavioral moderators of these relationships.

Cross-sectional data were from 1053 US youth aged 12-17 years (Mage = 14.20; 54% male; 21% Hispanic) in the 2015-2018 National Health and Nutrition Examination Survey (NHANES). ST was assessed as watching TV/videos and computer use/playing computer games. AL was measured using 7 biomarkers across 3 systems: cardiovascular (systolic and diastolic blood pressure, heart rate), immune (C-reactive protein), and metabolic (body mass index, glycohemoglobin, and high-density lipoprotein). Weighted multivariable regression models assessed whether ST predicted AL composite and subsystem (cardiovascular, immune, and metabolic) scores. Moderation by age, sex, income, race/ethnicity, and physical activity was explored.

A 1-hour/day increase in watching TV/videos was associated with a 4% increase in mean AL composite score (incident rate ratio = 1.040; 95% CI = 1.008, 1.073; P = .015), while computer use/gaming showed no significant associations (P's > .05). Age moderated the TV/videos-AL cardiovascular association (P = .009), with older youth having higher AL cardiovascular scores.

More time spent watching TV/videos was associated with higher cumulative physiological stress in youth. Prospective studies are needed to determine causal pathways and potential intervention targets in youth.

This study aimed to assess the psychological health status of children aged 3-7 years in Wuxi and analyze the correlation between dietary behaviors, lifestyle, and psychological problems.

Using a stratified cluster random sampling method, 3-7-year-old children from 18 kindergartens across Wuxi were selected as the survey subjects. An online survey was conducted to collect demographic information about children and their parents, dietary information, lifestyle data, and family backgrounds. Psychological assessments were conducted using the Strengths and Difficulties Questionnaire (SDQ).

A total of 3727 preschool children were included. The average SDQ score was 16.12 ± 4.00, with an abnormal rate of 40.81% (1521/3727). After adjusting for various confounding factors, logistic regression analysis indicated that low dietary diversity (OR = 1.299, 95% CI: 1.131-1.492), daily consumption of ultra-processed foods (OR = 1.202, 95% CI: 1.051-1.376), picky eating behavior or ideas occurring more than twice per week (OR = 1.405, 95% CI: 1.227-1.608), engaging in other activities while eating (such as watching TV or playing with toys) more than twice per week (OR = 1.742, 95% CI: 1.510-2.011), lack of a fixed dining position (OR = 1.222, 95% CI: 1.012-1.476), daily screen time exceeding 1 h (OR = 1.353, 95% CI: 1.152-1.590), and daily sleep duration of less than 9 h or more than 13 h (OR = 1.535, 95% CI: 1.262-1.866) were risk factors for psychological problems.

The findings highlight the urgent need for targeted interventions addressing insufficient dietary diversity, distracted eating, excessive screen time, and unhealthy sleep habits to improve the psychological well-being of preschool children. Future studies should explore the effectiveness of tailored health and lifestyle interventions for children and their families to mitigate these risks.

Knowledge about transdiagnostic factors associated with global symptom severity among patients diagnosed with various mental disorders remains limited. This study examined the cross-sectional associations between transdiagnostic processes including global emotion regulation and specific emotion regulation strategies (i.e., amount of physical activity and sedentary behaviour, repetitive negative thinking and sleep routines) with global symptom severity, while controlling for sociodemographic data (age, gender, employment status, relationship status, and educational level) and fear of the coronavirus.

Data from 401 outpatients, aged 42.08 years on average (SD = 13.26; 71.3% female), diagnosed with depressive disorders, non-organic primary insomnia, agoraphobia, panic disorder and/or post-traumatic stress disorder were examined. This study is a secondary analysis of a randomized controlled trial. Data were collected from 10 different study sites between March 2021 and May 2022 for cross-sectional analysis. The influence of predictors of global symptom severity was determined using three-step hierarchical multiple regression: (1) control variables, (2) global emotion regulation and (3) specific emotion regulation strategies. Global symptom severity was measured using the Global Severity Index, derived from the Brief Symptom Inventory-18. Predictors were measured using validated scales, and physical activity was additionally assessed via accelerometer-based sensors.

In the first step, control variables accounted for 4% of variance in global symptom severity. The inclusion of global emotion regulation in the second step explained 26% of the outcome variance, and the incorporation of specific emotion regulation strategies in the third step increased the explained variance to 37%. Significant predictors included global emotion regulation (β = 0.28), repetitive negative thinking (β = 0.26) and sleep routines (β = 0.25).

Global emotion regulation along with repetitive negative thinking and sleep routines as specific emotion regulation strategies are identified as transdiagnostic psychological processes that may serve as treatment targets for evidence-based interventions designed to enhance emotion regulation, particularly in transdiagnostic samples of stress-related disorders. Additional prospective longitudinal studies with transdiagnostic samples are necessary to explore possible causal relationships.

Understanding the complex relationship between sedentary breaks, affective well-being and cognition in daily life is critical as modern lifestyles are increasingly characterized by sedentary behavior. Consequently, the World Health Organization, with its slogan "every move counts", emphasizes a central public health goal: reducing daily time spent in sedentary behavior. Previous studies have provided evidence that short sedentary breaks are feasible to integrate into daily life and can improve affective and cognitive parameters. However, observational studies do not allow for causal interpretation. To overcome this limitation, we conducted the first empirical study that integrated the within-person encouragement approach to test the causal effects of short 3-min sedentary breaks on affective and cognitive parameters in daily life. The results suggest that brief sedentary breaks may have a beneficial impact on valence and energetic arousal. Moreover, our methodological approach powerfully demonstrated the possibility of moving towards causal effects in everyday life.

There is growing evidence on the association between meeting the recommendations of isolated movement behaviors (physical activity, sedentary time, and sleep) with anxiety and depressive symptoms. However, the joint association of meeting the 24 h movement guidelines with anxiety and depressive symptoms is still unknown. The aim of this study was to analyze the association of meeting 24-hour movement guidelines with symptoms of anxiety and of depression in adults. The sample included 212 participants. Anxiety and depressive symptoms were evaluated using the Hospital Anxiety and Depression Scale (HADS), while physical activity and sedentary time were evaluated by accelerometry, and daily slept hours were self-reported. Age, sex, socioeconomic status, accelerometer wear time, and waist circumference were covariates. Poisson regression models (crude and adjusted by covariates) were used to analyze association between variables. Meeting isolate recommendations of 24-hour movement guidelines were not associated with symptoms of anxiety or depression. However, meeting two or three recommendations was inversely associated with symptoms of anxiety (β= -0.235; 95%CI= -0.447; -0.024); (β= -0.569; 95%CI= -0.853; -0.285) and of depression (β= -0.275; 95%CI= -0.509; -0.040); (β= -0.551; 95%CI= -0.877; -0.224), respectively. Intervention strategies for reducing anxiety and depressive symptoms should target the meeting of more than one movement guidelines, such as increasing physical activity, reducing sedentary time, and promoting adequate sleep time for adults.

This study aims to examine the independent and joint associations of physical activity (PA) and sedentary behaviour with depressive symptoms. A population-based cross-sectional study conducted in China included 17,861 adults. PA and sedentary behaviour were assessed using the International Physical Activity Questionnaire. Depressive symptoms were determined by the 9-item Patient Health Questionnaire score ≥10. Logistic regression models were used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). The prevalence of depressive symptoms among all participants was 20.6% (3679/17861). Higher levels of PA were inversely associated with depressive symptoms, whereas prolonged sedentary behaviour was associated with increased odds of depressive symptoms. The positive associations between sedentary behaviour and depressive symptoms remained significant, regardless of PA levels. In joint analyses, the depressive symptoms OR comparing adults who reported low level of PA with the highest tertile of sedentary behaviour to those reporting high level of PA with the lowest tertile of sedentary behaviour was 1.99 (95% CI 1.64 to 2.40). This study indicated that high level of PA may not offset the increased risk of depressive symptoms associated with high amounts of sedentary behaviour, and therefore these behaviours should be considered jointly to obtain optimal prevention effects.

Antenatal mental disorders are associated with maternal and fetal adverse events. Previous studies have been focused on the postpartum period, rather than pregnancy, yet the association of risk factors with prenatal depression and anxiety through pregnancy has been rarely reported. This study aimed to identify the risk factors of prenatal depression and anxiety, and access their potential roles in developing mental disorders during pregnancy.

This is a prospective study in 6470 participants from the Tianjin Birth Cohort in China (TJBC). The degree of prenatal depression and anxiety was evaluated using a questionnaire of Self-Rating Depression scale (SDS) and Self-Rating Anxiety Scale (SAS), which was given to pregnant women at 15-27 (Stage-2), and 28-41 (Stage-3) gestational weeks. The questionnaire also collected demographic, personal, and lifestyle information. The association of different factors with SDS/SAS score was examined by logistic regression analysis.

We observed an overall depression rate of 12.4 % and an overall anxiety rate of 7.7 % during pregnancy in the TJBC. In the Stage-2, the depression rate was 14.5 % and the anxiety rate was 9.5 %. In the Stage-3, the depression rate dropped to 9.7 % while the anxiety rate dropped to 5.3 %. With univariate analysis, we found that age, education, social support, marriage satisfaction, secondhand smoke (SHS), sleeping time and stress were common factors of prenatal mental health. Working status, family income, gravidity, smoking, electronic using, recreational activities were associated with depression risk, whereas BMI, disease history, changing eating habits, and feeding animal were associated with anxiety risk. Using logistic regression, we found that low education level, low social support, low marriage satisfaction, thyroid disfunction, Stage-2(second trimester), and stress were related to prenatal mental health.

The prevalence anxiety and depression in Tianjin is normal as national level. Age appropriateness, a good education level, sufficient social support, marital satisfaction, normal thyroid function, and absence of stress are associated with relieving depression and anxiety during gestation. However, due to individual difference, expectant mothers should seek professional support and guidance to address their mental health needs during gestation.

Prevalence of chronic musculoskeletal pain and depressive symptoms in adults is high; however, whether there is an association between these conditions in older adults is unknown.

The aim of this study was to investigate the association of depressive symptoms with chronic musculoskeletal pain, and specifically with chronic LBP and knee osteoarthritis (OA), in community-dwelling older adults. In addition, we explored whether physical activity can mitigate these associations.

A cross-sectional study design. A cross-sectional study design. Participants recruited were older adults (age ≥60 years) living in the community. Chronic musculoskeletal pain was assessed by specific questions regarding the presence of chronic LBP and knee OA. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale. Multivariable regression model adjusted for potential confounders (i.e., age, sex, economic status, body composition, and physical activity) was used to investigate the association between chronic musculoskeletal pain and depressive symptoms. Separate analyses were also conducted for older adults with LBP and with knee OA.

A total of 509 (69% women) older adults were recruited. The regression analysis showed that musculoskeletal pain was associated with higher depressive symptoms (β  = 2.52, 95% CI: 0.50 to 4.54; p-value < .05) compared with older adults without chronic musculoskeletal pain. Similarly, in the fully adjusted model, which included physical activity, LBP was associated with higher depressive symptoms (β  = 2.80, 95% CI: 0.82 to 4.79; p-value < .01). The association between knee OA and depressive symptoms was not statistically significant after adjusting for physical activity (β  = 2.00, 95% CI: -0.13 to 4.13; p-value = .06).

Older adults with chronic musculoskeletal pain have higher depressive symptoms scores, when compared to those without musculoskeletal pain. Physical activity does not seem to influence this association.

To examine the dose‒response relationships of sedentary behavior (SB) and physical activities (PAs) with depression, and to explore the effects of replacing SB with PAs on depression risk.

The study used data from UK Biobank aged 37 to 73 years. Light physical activity (LPA), moderate-to-vigorous activity (MVPA), sleep duration, and total sedentary behavior (TSB) were measured by accelerometers. Self-reported SB was also adopted when daily screen-sedentary behavior time (SSB) and leisure-sedentary behavior time (LSB) were the focus. Incident depression was obtained from the part of mental and behavioral disorders in the "first occurrence fields" of UK Biobank. A Cox proportional hazard model and isotemporal substitution model were performed to explore the associations of LPA, MVPA, TSB, LSB, SSB, and sleep on depression and the effects of replacing SB time with equal PA time.

Highest levels of MVPA (HR = 0.58, 95%CI: 0.50-0.68) were associated with decreased depression risk compared with the lowest level (Q1). Longer SSB time (HR = 1.18, 95%CI: 1.06-1.32), LSB time (HR = 1.19, 95%CI: 1.07-1.32), and TSB time (HR = 1.17, 95%CI: 1.00-1.38) could increase depression risk significantly. Replacing 1h/day TSB, SSB, and LSB with MVPA brought the greatest risk reductions [31% (HR = 0.69, 95%CI: 0.62-0.77), 30% (HR = 0.70, 95%CI: 0.65-0.77), and 29% (HR = 0.71, 95%CI: 0.65-0.77)]. Under the same conditions, the effects of LPA replacement were also significant, but weaker than those of MVPA. Subgroup analyses showed that replacing 1h/d TSB with LPA could significantly decrease the depression risk for the females, but not for the males.

Large benefits for reducing the risk of incident depression could be attained by replacing a period of TSB, SSB, or LSB with equal PA time, especially for MVPA. Regular PA and less SB were recommended for improving mental health.

Depression is one of the most prevalent diseases worldwide, with almost half of the adolescent population affected according to latest research. Given this serious burden of disease, research points toward interventions that could effectively fight this disease in this population subset. One of these pivotal interventions is physical activity, although the effects of different sport types and sport performance level on depression have not yet been studied in adolescent populations. Accordingly, the objective of the current study was to assess the relationship between depressive symptoms, sport type and performance level in a large adolescent population.

Cross-sectional study assessing a large cohort of adolescents through self-reported data.

10,248 participants aged 11-19 years old answered questionnaires regarding depressive symptoms and sporting habits and were classified according to their sport performance level: from physically inactive to internationally competitive.

Girls reported higher incidence of depressive symptoms than boys, difference that further increased during late adolescence. Performance level was related to depressive symptoms: inactive participants reported the highest depressive scores while internationally competitive athletes reported the lowest. However, there were no differences between competitive athletes of different performance levels. Further, sport type had a small influence on depressive symptoms.

All these findings result in a potential guideline for future research and community health recommendations: as long as sufficient physical activity levels are met and the adolescent engages in sporting activities, the protection against depressive symptoms remains largely unrelated to the sport type and the level at which he or she performs.

Although the increased prevalence of sedentary behavior and insufficient physical activity constitutes a global public health concern, there is limited research on their effects on mental health. We investigated the combined association of sedentary behavior (daily sitting or reclining ≥10 h/day) and physical activity domains (evaluated using the Global Physical Activity Questionnaire, including occupational physical activity, leisure-time physical activity, and transportation-related physical activity) with depression (Patient Health Questionnaire-9, cutoff score: 10). This cross-sectional study utilized biennial data of 21,416 adults (age >20 years) from the Korea National Health and Nutrition Examination Survey waves 7-9 (2016-2022). Joint associations were explored by combining sedentary behavior and each physical activity domain into four levels. Sedentary behavior and occupational physical activity increased the risk of depression, leisure-time physical activity decreased the risk only in men, and transportation-related physical activity showed no significant association. Logistic regression each physical activity domain revealed, for men and women, a significantly higher risk of depression in the sedentary behavior (+)/occupational physical activity (+) group than in the sedentary behavior (-)/occupational physical activity (-) group (odds ratio: 3.05 and 2.66, respectively). The sedentary-behavior (+)/leisure-time physical-activity (-) group showed a significantly higher risk of depression than the sedentary behavior (-)/leisure-time physical activity (+) group (odds ratio: 2.50 and 2.14), and sedentary behavior (+)/transportation-related physical activity (-) group also showed a significantly higher risk of depression compared to the sedentary behavior (-)/transportation-related physical activity (+) group (odds ratio: 1.83 and 1.61). With concurrent exposure to sedentary behavior, the occupational physical activity and lack of leisure time and transportation-related physical activity synergistically increased the risk of depression. Encouraging leisure-time physical activity, minimizing rigorous occupational physical activity, and reducing sedentary behavior may reduce depressive symptoms, and research into specific domains of sedentary behavior and the quantity and quality of transportation-related physical activity is needed.

The study aimed to validate the Cravings for Rest and Volitional Energy Expenditure (CRAVE) scale among Chinese adults with different health conditions (healthy control, chronic illnesses, and psychiatric disorders) and skill levels (athletes vs. non-athletes).

In Study 1, a confirmatory factor analysis (CFA) using the Maximum Likelihood Method (MLM) was performed on a Chinese sample of emerging adults (N = 481) to evaluate the structural validity of the Cravings for Rest and Volitional Energy Expenditure-Chinese version (CRAVE-C). In Study 2, differences in "Move" and "Rest" desires were examined among patients with psychiatric disorders, patients with chronic illnesses, and healthy controls. In study 3, investigated the relationship between cardiorespiratory fitness and exercise motivation using the CRAVE-C (N = 83). In Study 4, the changes in "Move" desire from baseline to post-training were compared between athletes and non-athletes.

Results from Study 1 indicated that the 10-item CRAVE-C showed good fit indices ( Chi2 (34) = 118.769, CFI  = 0.95, TLI = 0.934, SRMR = 0.053, RMSEA = 0.072). "Move" positively correlated with various factors of the Affective Exercise Experiences Questionnaire-Chinese and the Physical Effort Scale-Chinese, while "Rest" correlated negatively. In Study 2, Patients with psychiatric disorders had a significantly higher "Move" desire than healthy controls. Patients with chronic illnesses had a significantly higher "Rest" desire than healthy controls. In Study 3, higher cardiorespiratory fitness was associated with a slight increase in "Move" desire (3.26% ± 37.35%) and a decrease in "Rest" desire (18.94% ± 66.99%). Lower fitness was linked to a significant decline in "Move" desire (-54.61% ± 111.33%) and an increase in "Rest" desire (43.62% ± 63.64%). In Study 4, the athlete group demonstrated a significant increase in "Move" desire from baseline to post-training, whereas the non-athlete group reported a significant decrease in "Move" desire from baseline to post-training.

The 10-item CRAVE-C has good reliability and validity in the Chinese cultural context and can be used among Chinese adults with different health conditions and skill levels.

Sedentary behaviour is a public health problem. We mainly have sedentary behaviour at work, transforming them into occupational risk. To our knowledge, there is no intervention study on the reduction of occupational sedentary behaviour in a real work situation and its impact on health and biomarkers of stress. The main objective is to study changes in sedentary behaviour following a behavioural intervention (sit-and-stand desk and cycle ergometer).

This is a randomised controlled trial in cross-over design conducted in a single centre. The study will be proposed to emergency medical dispatchers of Clermont-Ferrand. Each volunteer will be followed during three cycles of 1 week (3 weeks in total). Each 1-week cycle is made up of 12 hours of work (three conditions: a control and two interventions), 12 hours of successive rest and 6 days of follow-up. For each condition, the measurements will be identical: questionnaire, measure of heart rate variability, electrodermal activity and level of physical activity, saliva and blood sampling. The primary outcome is sedentary behaviour at work (ie, number of minutes per day standing/active). Data will be analysed with both intention-to-treat and per protocol analysis. A p<0.05 will be considered as indicating statistical significance.

The study protocol has been approved by the Ethics Committee Ouest IV, FRANCE. The study is registered in ClinicalTrials.gov. All patients will be informed about the details of the study and sign written informed consent before enrolment in the study. Results from this study will be published in a peer-reviewed journal. This study involves human participants and was approved by Comité de protection des personnes Ouest IVCPP reference: 23/132-2National number: 2022-A02730-43.

NCT05931406.

The COVID-19 pandemic resulted in a shift to working and learning from home and a concomitant rise in the use of virtual communication technology, such as videoconferencing. The current study prospectively examined the association between videoconferencing and sleep in a sample of young adults attending a university during the pandemic. The effects of videoconferencing on health and wellness outcomes and academic performance were also evaluated.

Participants completed the core Consensus Sleep Diary and reported engagement in videoconferencing, the use of electronic devices, and physical activity daily for 8 consecutive days. They also completed baseline measures of sleep, communication technology use, physical activity, and mental distress, as well as released their end-of-term GPA. Results were evaluated via multilevel modeling and path analysis.

Participants with a heavier videocall volume lost 17 m of sleep and suffered nearly a 1% reduction in sleep efficiency for each additional hour of videoconferencing compared to those with a lower call volume. They also tended to spend more time awake during the night, have earlier sleep midpoints, and report worse sleep, although those trends did not reach statistical significance. For everyone, including individuals with lower videocall volume, earlier sleep midpoints, lower sleep quality, somewhat shorter sleep, and higher fatigue were reported on days with a relatively high videocall load compared to days with a low videocall load. Increased academic engagement with videoconferencing predicted lower academic performance and higher psychological distress: Both relationships were mediated by sleep. Use of videoconferencing for personal reasons, however, was directly associated with a reduction in distress.

Videoconferencing is an important determinant of sleep and may impact health and wellness as well as academic outcomes in young adults. The effects of virtual communication on sleep and human behavior warrant further study in this and other populations.

The association between sedentary behavior and depression in older adults has been reported in several studies; however, study results on the relationship between the different types of sedentary behavior and depression are not uniform. The purpose of this study was to quantitatively review the association between depression and total sedentary behavior, mentally active sedentary behavior, and passive sedentary behavior.

We systematically searched for observational studies on the association between sedentary behavior and depression in older adults using PubMed, Embase, and Web of Science databases. A random effects model was used to combine odds ratios (ORs) and 95 % confidence intervals (CIs). In addition, we performed subgroup and sensitivity analyses to explore potential sources of heterogeneity.

Five longitudinal and 10 cross-sectional studies with a total of 144,161 participants were included in the meta-analysis. The OR of total sedentary behavior associated with depression was 1.49 (95 % CI 1.24-1.79). The combined OR value of mentally active sedentary behavior and depression was 0.82 (95 % CI 0.69-0.97), and no association was found between passive sedentary behavior and the risk of depression.

We were unable to find dose-response relationships between the different types of sedentary behavior and depression because there were too few studies with raw data to analyze.

Total sedentary behavior may increase the risk of depression in older adults, whereas mentally active sedentary behavior is associated with a lower risk of depression. Differentiating between the types of sedentary behavior can inform interventions to prevent or ameliorate depression in older adults.

Huntington's disease (HD) is a neurodegenerative disorder for which effective therapies are currently lacking. Studies suggest that increasing physical activity (PA) and reducing leisure sedentary behavior (LSB) mitigate the progression of HD, but their causal relationship with the age at onset (AAO) of HD remains uncertain. To investigate this, we conducted the Two-sample Mendelian Randomization (MR).

Exposure were retrieved from the UK BioBank's (UKB) Genome-Wide Association Study (GWAS). PA included accelerometer-based average PA, vigorous PA, self-reported moderate-to-vigorous PA (MVPA), and light do-it-yourself activity. LSB included television (TV) time, computer time, and driving time. Outcome came from the GWAS of the GEM-HD Consortium. We applied several MR methods such as inverse variance weighted (IVW), MR-Egger regression, weighted median (WM) for sensitivity analysis.

Increases in light PA (β = 8.53 years, 95 % CI = 10.64 to 44.09, P = 0.001) and accelerometer-based vigorous PA (β = 5.18, 95 % CI = 0.92 to 9.43, P = 0.017) delayed AAO of HD, while longer TV time was associated with earlier AAO of HD (β = -2.88 years, 95 % CI = -4.99 to -0.77, P = 0.007). However, other PA and LSB phenotypes did not significantly affect AAO of HD.

The study revealed a unidirectional causality between PA, LSB and the AAO of HD. Increasing PA and reducing TV time delay HD onset. Therefore, we recommend increasing physical activity and reducing sedentary behavior to delay the occurrence of motor symptoms for premanifest HD individuals.

We present the findings from a pilot study to evaluate the effects of a six-week adapted folk-dance intervention on physical and mental health for at-risk adolescents conducted in schools. At-risk adolescents are at particular risk for sedentary behavior, poor mental health, and lower quality of life, and are likely to benefit from motivating and health-promoting activities such as dance. However, it can be challenging to conduct and evaluate evidence-based interventions with this population. We conducted a convergent parallel mixed-method design using pre-post measures of mental well-being, as well as pre-post measures using inertial measurement units to assess physical activity during a 6-week adapted folk-dance intervention. At the completion of the study, we conducted semi-structured interviews with all stakeholder groups. We observed significant improvements in mental well-being, as indicated by increased WEMWBS and MHC-SF scores, while the UCLA score showed no significant change, with these outcomes independent of age and gender. Furthermore, at-risk adolescents reduced the time spent in stationary/resting position, while their heart rates were also reduced by ∼15% in such conditions. Our results suggest that at-risk youth who participated in adapted folk-dance became more enthusiastic and showed more willingness to move over the course of the intervention. Quantitative results were supported by interviews, which found that participants responded positively to the adapted folk-dance classes, and reported both elevated physical exertion and high levels of enjoyment. The mixed-method research design also provided insights into the suitability of data collection methods for this hard-to-reach population. We report on these outcomes, including best practices for working within schools on health-promoting physical activities.

Major Depressive Disorder (MDD) is characterized by persistent symptoms such as fatigue, loss of interest in activities, feelings of sadness and worthlessness. MDD often coexist with cardiovascular disease (CVD), yet the precise link between these conditions remains unclear. This review explores factors underlying the development of MDD and CVD, including genetic, epigenetic, platelet activation, inflammation, hypothalamic-pituitary-adrenal (HPA) axis activation, endothelial cell (EC) dysfunction, and blood-brain barrier (BBB) disruption.

Single nucleotide polymorphisms (SNPs) in the membrane-associated guanylate kinase WW and PDZ domain-containing protein 1 (MAGI-1) are associated with neuroticism and psychiatric disorders including MDD. SNPs in MAGI-1 are also linked to chronic inflammatory disorders such as spontaneous glomerulosclerosis, celiac disease, ulcerative colitis, and Crohn's disease. Increased MAGI-1 expression has been observed in colonic epithelial samples from Crohn's disease and ulcerative colitis patients. MAGI-1 also plays a role in regulating EC activation and atherogenesis in mice and is essential for Influenza A virus (IAV) infection, endoplasmic reticulum stress-induced EC apoptosis, and thrombin-induced EC permeability. Despite being understudied in human disease; evidence suggests that MAGI-1 may play a role in linking CVD and MDD. Therefore, further investigation of MAG-1 could be warranted to elucidate its potential involvement in these conditions.

Increased mechanization and technological advances have simplified our lives on the one hand and increased sedentary behaviors on the other hand, paving the way for emerging global health concerns, i.e., sedentarism, which could be the leading cause of all major chronic health problems worldwide. Sedentarism is a habitual behavior of choosing and indulging in low-energy expenditure activities (≤1.5 metabolic equivalents), such as chairtype (sitting, studying, traveling) or screen-type activities (TV, computers, mobile). With technological advancements, there is a significant transition in the lifestyles of people from being active (walking) to being more deskbound (sitting). Prolonged sitting can have unintended consequences for health with sitting time >7 h/d, leading to a 5% increase in all-cause mortality with each additional hour spent sitting (i.e., +7 h/d), while considering physical activity levels. This review will highlight how sedentarism is emerging as a major risk factor for the rising incidence of non-communicable diseases, especially among young adults and adults. Chronic diseases, such as obesity, diabetes, coronary heart disease, and cancer, are the leading causes of death worldwide. Hence, there is an urgent need for collective action to mitigate the burgeoning public health crisis posed by sedentarism in the 21st century. This paper intends to set in motion a call for all policymakers and public health professionals placed nationally or internationally to reach a consensus on ending sedentarism and provide viable resolutions for effective management of excessive sedentary behaviors and healthy adoption and maintenance of active lifestyles among individuals of all age groups.

A low handgrip strength (HGS) is a significant risk factor for multiple diseases. However, most relevant studies investigate the complications of a low HGS, while the risk potential of causative factors of low HGS remain poorly characterized.

We investigated the potentials of quality of life, depression, dyslipidaemia, diabetes mellitus, cancer, Alzheimer's disease, stroke, frailty, and difficulties performing daily activities in predicting low HGS (≤ 27 kg for men, ≤ 16 kg for women) in European older adults aged 50 or above from 15 countries (n = 42,183). All data was collected from four successive waves of survey of health, ageing, and retirement in Europe (SHARE) conducted between 2013 and 2020. Logistic models are applied, and estimated effects are presented as odds ratios and probabilities.

Collectively, 3016 participants (men; n = 1395; 7.38%, women; n = 1621, 6.97%) developed low HGS during the 6.5 years study period. After adjusting for covariables, we identified an advancing age (1.6-48.1% points higher risk of low HGS), male gender (1.0%-point higher risk of low HGS), lower quality of life (1.6%-point higher), and stroke (1.5%-points) as significant risk factors for low HGS. We also found a dose-dependent association of Euro-D depression scores with the risk of low HGS, as the higher scores were associated with between 0.6- and 2.3%-points higher risk of developing low HGS than participants without depression. Among physical performance indicators, difficulty climbing stairs (2.0%-points higher low HGS risk) or rising from a chair (0.7%-points) were significantly associated with developing low HGS. Lastly, frailty (0.9%-points higher risk of low HGS) and the fear of falling down (1.6%-points higher risk) also increased the risk of developing low HGS.

Altogether, we report several risk factors for developing low HGS. Our observations may help evaluating and monitoring high-risk population for developing low HGS in pre-clinical settings.

White collar workers spend an increasing amount of time in occupational sedentary behavior (OSB) and are thereby at risk for adverse health outcomes. Nevertheless, the association between OSB and the need for recovery (NFR), an important indicator of wellbeing, is unknown and therefore examined.

Baseline data from a cluster randomized controlled trial was used. A subgroup of 89 white collar workers wore a triaxial accelerometer for 7 days. NFR was measured using the Questionnaire on the Experience and Evaluation of Work. Compositional data analysis was applied to determine the composition of different OSB bouts (short, medium and long) and occupational physical activity (OPA) (light, moderate and vigorous and standing). Linear regression analyses were performed to explore the associations between occupational compositions and NFR.

Relatively more time spent in long OSB bouts was associated with a lower NFR (β: -11.30, 95% CI: -20.2 to -2.4). Short and medium OSB bouts and OPA were not associated with NFR.

Associations between OSB bouts, OPA and NFR hinted at contrasting trends, suggesting the need to consider different bout lengths of OSB in future studies.