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Artigas C, Morales-Torres R, Rojas-Thomas F, Villena-González M, Rubio I, Ramírez-Benavides D, Bekinschtein T, Campos-Arteaga G, Rodríguez E. When alertness fades: Drowsiness-induced visual dominance and oscillatory recalibration in audiovisual integration. Int J Psychophysiol 2025; 212:112562. [PMID: 40187499 DOI: 10.1016/j.ijpsycho.2025.112562] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/22/2025] [Revised: 04/01/2025] [Accepted: 04/02/2025] [Indexed: 04/07/2025]
Abstract
Multisensory integration allows the brain to align inputs from different sensory modalities, enhancing perception and behavior. However, transitioning into drowsiness, a state marked by decreased attentional control and altered cortical dynamics, offers a unique opportunity to examine adaptations in these multisensory processes. In this study, we investigated how drowsiness influences reaction times (RTs) and neural oscillations during audiovisual multisensory integration. Participants performed a task where auditory and visual stimuli were presented either in a coordinated manner or with temporal misalignment (visual-first or auditory-first uncoordinated conditions). Behavioral results showed that drowsiness slowed RTs overall but revealed a clear sensory dominance effect: visual-first uncoordination facilitated RTs compared to auditory-first uncoordination, reflecting vision's dominant role in recalibrating sensory conflicts. In contrast, RTs in coordinated conditions remained stable across alert and drowsy states, suggesting that multisensory redundancy compensates for reduced cortical integration during drowsiness. At the neural level, distinct patterns of oscillatory activity emerged. Alpha oscillations supported attentional realignment and temporal alignment in visual-first conditions, while Gamma oscillations were recruited during auditory-first uncoordination, reflecting heightened sensory-specific processing demands. These effects were state-dependent, becoming more pronounced during drowsiness. Our findings demonstrate that drowsiness fundamentally reshapes multisensory integration by amplifying sensory dominance mechanisms, particularly vision. Compensatory neural mechanisms involving Alpha and Gamma oscillations maintain perceptual coherence under conditions of reduced cortical interaction. These results provide critical insights into how the brain adapts to sensory conflicts during states of diminished awareness, with broader implications for performance and decision-making in real-world drowsy states.
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Affiliation(s)
- Claudio Artigas
- Departamento de Ciencias Biológicas, Universidad Autónoma de Chile, Santiago, RM, Chile.
| | | | - Felipe Rojas-Thomas
- Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile
| | | | - Iván Rubio
- Psychology Department, Pontificia Universidad Católica de Chile, Santiago, RM, Chile
| | | | - Tristán Bekinschtein
- Consciousness and Cognition Laboratory, Department of Psychology, University of Cambridge, Cambridge, UK
| | | | - Eugenio Rodríguez
- Psychology Department, Pontificia Universidad Católica de Chile, Santiago, RM, Chile
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2
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Palacino F, Manganotti P, Benussi A. Targeting Neural Oscillations for Cognitive Enhancement in Alzheimer's Disease. MEDICINA (KAUNAS, LITHUANIA) 2025; 61:547. [PMID: 40142358 PMCID: PMC11943909 DOI: 10.3390/medicina61030547] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 01/19/2025] [Revised: 03/13/2025] [Accepted: 03/18/2025] [Indexed: 03/28/2025]
Abstract
Alzheimer's disease (AD), the most prevalent form of dementia, is marked by progressive cognitive decline, affecting memory, language, orientation, and behavior. Pathological hallmarks include extracellular amyloid plaques and intracellular tau tangles, which disrupt synaptic function and connectivity. Neural oscillations, the rhythmic synchronization of neuronal activity across frequency bands, are integral to cognitive processes but become dysregulated in AD, contributing to network dysfunction and memory impairments. Targeting these oscillations has emerged as a promising therapeutic strategy. Preclinical studies have demonstrated that specific frequency modulations can restore oscillatory balance, improve synaptic plasticity, and reduce amyloid and tau pathology. In animal models, interventions, such as gamma entrainment using sensory stimulation and transcranial alternating current stimulation (tACS), have shown efficacy in enhancing memory function and modulating neuroinflammatory responses. Clinical trials have reported promising cognitive improvements with repetitive transcranial magnetic stimulation (rTMS) and deep brain stimulation (DBS), particularly when targeting key hubs in memory-related networks, such as the default mode network (DMN) and frontal-parietal network. Moreover, gamma-tACS has been linked to increased cholinergic activity and enhanced network connectivity, which are correlated with improved cognitive outcomes in AD patients. Despite these advancements, challenges remain in optimizing stimulation parameters, individualizing treatment protocols, and understanding long-term effects. Emerging approaches, including transcranial pulse stimulation (TPS) and closed-loop adaptive neuromodulation, hold promise for refining therapeutic strategies. Integrating neuromodulation with pharmacological and lifestyle interventions may maximize cognitive benefits. Continued interdisciplinary efforts are essential to refine these approaches and translate them into clinical practice, advancing the potential for neural oscillation-based therapies in AD.
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Affiliation(s)
| | | | - Alberto Benussi
- Neurology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy; (F.P.); (P.M.)
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Erboz A, Kesekler E, Gentili PL, Uversky VN, Coskuner-Weber O. Electromagnetic radiation and biophoton emission in neuronal communication and neurodegenerative diseases. PROGRESS IN BIOPHYSICS AND MOLECULAR BIOLOGY 2025; 195:87-99. [PMID: 39732343 DOI: 10.1016/j.pbiomolbio.2024.12.004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/15/2024] [Revised: 12/08/2024] [Accepted: 12/24/2024] [Indexed: 12/30/2024]
Abstract
The intersection of electromagnetic radiation and neuronal communication, focusing on the potential role of biophoton emission in brain function and neurodegenerative diseases is an emerging research area. Traditionally, it is believed that neurons encode and communicate information via electrochemical impulses, generating electromagnetic fields detectable by EEG and MEG. Recent discoveries indicate that neurons may also emit biophotons, suggesting an additional communication channel alongside the regular synaptic interactions. This dual signaling system is analyzed for its potential in synchronizing neuronal activity and improving information transfer, with implications for brain-like computing systems. The clinical relevance is explored through the lens of neurodegenerative diseases and intrinsically disordered proteins, where oxidative stress may alter biophoton emission, offering clues for pathological conditions, such as Alzheimer's and Parkinson's diseases. The potential therapeutic use of Low-Level Laser Therapy (LLLT) is also examined for its ability to modulate biophoton activity and mitigate oxidative stress, presenting new opportunities for treatment. Here, we invite further exploration into the intricate roles the electromagnetic phenomena play in brain function, potentially leading to breakthroughs in computational neuroscience and medical therapies for neurodegenerative diseases.
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Affiliation(s)
- Aysin Erboz
- Molecular Biotechnology, Turkish-German University, Sahinkaya Caddesi No. 106, Beykoz, Istanbul, 34820, Turkey
| | - Elif Kesekler
- Molecular Biotechnology, Turkish-German University, Sahinkaya Caddesi No. 106, Beykoz, Istanbul, 34820, Turkey
| | - Pier Luigi Gentili
- Department of Chemistry, Biology, and Biotechnology, Università degli Studi di Perugia, 06123, Perugia, Italy.
| | - Vladimir N Uversky
- Department of Molecular Medicine and USF Health Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC07, Tampa, FL 33612, USA.
| | - Orkid Coskuner-Weber
- Molecular Biotechnology, Turkish-German University, Sahinkaya Caddesi No. 106, Beykoz, Istanbul, 34820, Turkey.
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Jin Z, Xing Y, Duan P, Bi Y, Li X, Feng W, Zhang B. Revealing the molecular links between coronary heart disease and cognitive impairment: the role of aging-related genes and therapeutic potential of stellate ganglion block. Biogerontology 2024; 26:16. [PMID: 39609308 PMCID: PMC11604741 DOI: 10.1007/s10522-024-10159-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/29/2024] [Accepted: 11/19/2024] [Indexed: 11/30/2024]
Abstract
Coronary heart disease (CHD) and cognitive impairment frequently co-occur in aging populations, yet the molecular mechanisms linking these conditions remain unclear. This study aims to elucidate the roles of key aging-related genes (ARGs), specifically FKBP5 and DDIT3, in the pathophysiology of CHD and cognitive impairment, and to evaluate the therapeutic potential of stellate ganglion block (SGB). Using single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (bulk RNA-seq) data, we identified FKBP5 and DDIT3 as pivotal genes upregulated in both conditions. Experimental findings show that SGB effectively modulates these ARG-related pathways through autonomic regulation, specifically suppressing estrogen and NF-κB signaling pathways, thereby reducing the expression of pro-inflammatory cytokines such as SRC, MMP2, FKBP5, IRAK1, and MYD88, while upregulating the vasodilation-related gene NOS3. This modulation improved endothelial and cardiac function and enhanced cerebral blood flow (CBF), leading to cognitive improvement. Behavioral assessments, including novel object recognition (NOR) and Morris water maze (MWM) tests, demonstrated that SGB-treated rats outperformed untreated MI rats, with significant cognitive recovery over time. Further support from laser Doppler flowmetry (LDF) and electroencephalogram (EEG) analyses revealed increased left frontal blood flow and stabilized neural activity, indicating a favorable neurophysiological environment for cognitive rehabilitation. Our findings suggest that left stellate ganglion block (LSGB) provides both cardiac and cognitive benefits through targeted gene modulation, establishing its therapeutic potential for addressing the intersecting pathologies of CHD and cognitive impairment.
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Affiliation(s)
- Zhehao Jin
- Heilongjiang Province Key Laboratory of Research on Anesthesiology and Critical Care Medicine, Harbin, China
- Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang Province, China
| | - Yuling Xing
- Heilongjiang Province Key Laboratory of Research on Anesthesiology and Critical Care Medicine, Harbin, China
| | - Pengyu Duan
- Heilongjiang Province Key Laboratory of Research on Anesthesiology and Critical Care Medicine, Harbin, China
- The Key Laboratory of Myocardial Ischemia Organization, Chinese Ministry of Education, Harbin, China
| | - Yonghong Bi
- Heilongjiang Province Key Laboratory of Research on Anesthesiology and Critical Care Medicine, Harbin, China
- Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang Province, China
| | - Xiaoyan Li
- Heilongjiang Province Key Laboratory of Research on Anesthesiology and Critical Care Medicine, Harbin, China
| | - Weiyu Feng
- Heilongjiang Province Key Laboratory of Research on Anesthesiology and Critical Care Medicine, Harbin, China
| | - Bing Zhang
- Heilongjiang Province Key Laboratory of Research on Anesthesiology and Critical Care Medicine, Harbin, China.
- Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang Province, China.
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Siebenhühner F, Palva JM, Palva S. Linking the microarchitecture of neurotransmitter systems to large-scale MEG resting state networks. iScience 2024; 27:111111. [PMID: 39524335 PMCID: PMC11544385 DOI: 10.1016/j.isci.2024.111111] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/22/2024] [Revised: 07/06/2024] [Accepted: 10/02/2024] [Indexed: 11/16/2024] Open
Abstract
Neuronal oscillations are ubiquitous in brain activity at all scales and their synchronization dynamics are essential for information processing in neuronal systems. The underlying synaptic mechanisms, while mainly based on GABA- and glutamatergic neurotransmission, are influenced by neuromodulatory systems that have highly variable densities of neurotransmitter receptors and transporters across the cortical mantle. How they constrain the network structures of interacting oscillations has remained a central unaddressed question. We asked here whether the receptor and transporter densities covary with the frequency-specific neuroanatomical patterns of inter-areal phase synchrony (PS) and amplitude correlation (AC) networks in resting-state magnetoencephalography (MEG) data. Network centrality in delta and gamma frequencies covaried positively with GABA-, NMDA-, dopaminergic-, and most serotonergic receptor and transporter densities while covariance was negative in alpha and beta bands. These results show that local receptor microarchitecture shapes macro-scale oscillation networks in spectrally specific patterns.
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Affiliation(s)
- Felix Siebenhühner
- Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
- BioMag Laboratory, HUS Medical Imaging Centre, Helsinki University, Helsinki, Finland
- Department of Neuroscience and Bioengineering (NBE), Aalto University, Espoo, Finland
- Department of Electrical Engineering and Information Technology, Technical University Darmstadt, Darmstadt, Germany
| | - J. Matias Palva
- Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
- Department of Neuroscience and Bioengineering (NBE), Aalto University, Espoo, Finland
- Centre for Cognitive Neuroimaging (CCNi), School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK
| | - Satu Palva
- Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
- Centre for Cognitive Neuroimaging (CCNi), School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK
- Division of Psychology, VISE, Faculty of Education and Psychology, University of Oulu, Oulu, Finland
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Javanshir R, Sedghi M, Esmaeili M, Charsouei S, Anvar LH, Ahmadalipour A. Automatic classification of fatty acid amide hydrolase polymorphism genotype based on EEG signal. Soft comput 2024; 28:12575-12585. [DOI: 10.1007/s00500-024-10306-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 07/31/2024] [Indexed: 02/18/2025]
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Ji C, Yang X, Eleish M, Jiang Y, Tetlow AM, Song SC, Martín‐Ávila A, Wu Q, Zhou Y, Gan W, Lin Y, Sigurdsson EM. Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy. Alzheimers Dement 2024; 20:7954-7970. [PMID: 39368113 PMCID: PMC11567809 DOI: 10.1002/alz.14273] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/03/2024] [Revised: 08/27/2024] [Accepted: 08/28/2024] [Indexed: 10/07/2024]
Abstract
INTRODUCTION It is unclear how early neuronal deficits occur in tauopathies, if these are associated with changes in neuronal network activity, and if they can be alleviated with therapies. METHODS To address this, we performed in vivo two-photon Ca2+ imaging in tauopathy mice at 6 versus 12 months, compared to controls, and treated the younger animals with a tau antibody. RESULTS Neuronal function was impaired at 6 months but did not deteriorate further at 12 months, presumably because cortical tau burden was comparable at these ages. At 6 months, neurons were mostly hypoactive, with enhanced neuronal synchrony, and had dysregulated responses to stimulus. Ex vivo, electrophysiology revealed altered synaptic transmission and enhanced excitability of motor cortical neurons, which likely explains the altered network activity. Acute tau antibody treatment reduced pathological tau and gliosis and partially restored neuronal function. DISCUSSION Tauopathies are associated with early neuronal deficits that can be attenuated with tau antibody therapy. HIGHLIGHTS Neuronal hypofunction in awake and behaving mice in early stages of tauopathy. Altered network activity disrupted local circuitry engagement in tauopathy mice. Enhanced neuronal excitability and altered synaptic transmission in tauopathy mice. Tau antibody acutely reduced soluble phospho-tau and improved neuronal function.
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Affiliation(s)
- Changyi Ji
- Department of Neuroscience and PhysiologyNeuroscience Institute, New York University Grossman School of MedicineNew YorkUSA
| | - Xiaofeng Yang
- Department of Neuroscience and PhysiologyNeuroscience Institute, New York University Grossman School of MedicineNew YorkUSA
| | - Mohamed Eleish
- Department of Neuroscience and PhysiologyNeuroscience Institute, New York University Grossman School of MedicineNew YorkUSA
| | - Yixiang Jiang
- Department of Neuroscience and PhysiologyNeuroscience Institute, New York University Grossman School of MedicineNew YorkUSA
| | - Amber M. Tetlow
- Department of Neuroscience and PhysiologyNeuroscience Institute, New York University Grossman School of MedicineNew YorkUSA
| | - Soomin C. Song
- Department of PathologyNew York University Grossman School of MedicineNew YorkUSA
- IonLabNew York University Grossman School of MedicineNew YorkUSA
| | - Alejandro Martín‐Ávila
- Department of Neuroscience and PhysiologyNeuroscience Institute, New York University Grossman School of MedicineNew YorkUSA
| | - Qian Wu
- Department of Neuroscience and PhysiologyNeuroscience Institute, New York University Grossman School of MedicineNew YorkUSA
| | - Yanmei Zhou
- Skirball InstituteNew York University Grossman School of MedicineNew YorkUSA
| | - Wenbiao Gan
- Skirball InstituteNew York University Grossman School of MedicineNew YorkUSA
| | - Yan Lin
- Department of Neuroscience and PhysiologyNeuroscience Institute, New York University Grossman School of MedicineNew YorkUSA
| | - Einar M. Sigurdsson
- Department of Neuroscience and PhysiologyNeuroscience Institute, New York University Grossman School of MedicineNew YorkUSA
- Department of PsychiatryNew York University Grossman School of MedicineNew YorkUSA
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Annadurai H, Vengudusamy R, Chen SM, Kao CR. Facile stoichiometric interfacial surface bonded cerium oxide and graphene oxide heterostructure for efficient electrochemical non-enzymatic detection of dopamine. J Mater Chem B 2024; 12:9979-9990. [PMID: 39229782 DOI: 10.1039/d4tb01729c] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/05/2024]
Abstract
Emerging technology in the new era of sensors to detect and quantify neurological reaction-based research has demanded the development of sensors for the neurotransmitter dopamine (DA). In recent decades, electrochemical sensors have offered rapid and sensitive detection of DA, but the presence of interfering compounds, such as uric acid (UA) and ascorbic acid (AA), poses a great threat to the development of DA sensors. Additionally, reusing traditional methods leads to challenges like prolonged preparation and expensive instruments. This research work offers a nanohybrid two-dimensional (2D) paper-like graphene oxide (GO) and three-dimensional (3D) cerium oxide nanosphere (CeONS) heterostructure composite (G-CeONS) created via stoichiometric synthesis for the non-enzymatic detection of DA oxidation in the presence of other complex biological compounds. The constructed G-CeONS nanohybrid composite enables enhanced selectivity and sensitivity towards DA detection through its interfacial engineering. The heterostructure formation of a 2D nanosheet draped over 3D nanospheres exhibits a wide linear concentration range of 100-30 800 nM with a low detection limit of 20.98 nM. Further investigation of the real-time performance on human saliva and DA injections afforded prominent results. In addition, the synergetic effect of G-CeONS improves DA detection accuracy and reliability towards enabling transformational neurochemical and medicinal applications.
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Affiliation(s)
- Hemarani Annadurai
- Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan.
| | - Renganathan Vengudusamy
- Department of Materials Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
| | - Shen-Ming Chen
- Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan.
| | - C R Kao
- Department of Materials Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
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Su Z, Zhang H, Wang Y, Chen B, Zhang Z, Wang B, Liu J, Shi Y, Zhao X. Neural oscillation in bipolar disorder: a systematic review of resting-state electroencephalography studies. Front Neurosci 2024; 18:1424666. [PMID: 39238928 PMCID: PMC11375681 DOI: 10.3389/fnins.2024.1424666] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/28/2024] [Accepted: 07/30/2024] [Indexed: 09/07/2024] Open
Abstract
Bipolar disorder (BD) is a severe psychiatric disease with high rates of misdiagnosis and underdiagnosis, resulting in a significant disease burden on both individuals and society. Abnormal neural oscillations have garnered significant attention as potential neurobiological markers of BD. However, untangling the mechanisms that subserve these baseline alternations requires measurement of their electrophysiological underpinnings. This systematic review investigates consistent abnormal resting-state EEG power of BD and conducted an initial exploration into how methodological approaches might impact the study outcomes. This review was conducted in Pubmed-Medline and Web-of-Science in March 2024 to summarize the oscillation changes in resting-state EEG (rsEEG) of BD. We focusing on rsEEG to report spectral power in different frequency bands. We identified 10 studies, in which neural oscillations was compared with healthy individuals (HCs). We found that BD patients had abnormal oscillations in delta, theta, beta, and gamma bands, predominantly characterized by increased power, indicating potential widespread neural dysfunction, involving multiple neural networks and cognitive processes. However, the outcomes regarding alpha oscillation in BD were more heterogeneous, which is thought to be potentially influenced by the disease severity and the diversity of samples. Furthermore, we conducted an initial exploration into how demographic and methodological elements might impact the study outcomes, underlining the importance of implementing standardized data collection methods. Key aspects we took into account included gender, age, medication usage, medical history, the method of frequency band segmentation, and situation of eye open/eye close during the recordings. Therefore, in the face of abnormal multiple oscillations in BD, we need to adopt a comprehensive research approach, consider the multidimensional attributes of the disease and the heterogeneity of samples, and pay attention to the standardized experimental design to improve the reliability and reproducibility of the research results.
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Affiliation(s)
- Ziyao Su
- National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
- Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
- The second Affiliated Hospital of Xinjiang Medical University, Urumqi, China
| | - Haoran Zhang
- National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
- Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Yingtan Wang
- National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
- Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Bingxu Chen
- Faculty of Information Technology, Beijing University of Technology, Beijing, China
| | - Zhizhen Zhang
- School of Mathematical Sciences, East China Normal University, Shanghai, China
| | - Bin Wang
- National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
- Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Jun Liu
- National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
- Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Yuwei Shi
- The second Affiliated Hospital of Xinjiang Medical University, Urumqi, China
| | - Xixi Zhao
- National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
- Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
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Gao XY, Zhou CX, Li HM, Cheng M, Chen D, Li ZY, Feng B, Song J. Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes. World J Diabetes 2024; 15:1263-1271. [PMID: 38983812 PMCID: PMC11229970 DOI: 10.4239/wjd.v15.i6.1263] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/22/2023] [Revised: 03/28/2024] [Accepted: 04/24/2024] [Indexed: 06/11/2024] Open
Abstract
BACKGROUND Cognitive dysfunction is the main manifestation of central neuropathy. Although cognitive impairments tend to be overlooked in patients with diabetes mellitus (DM), there is a growing body of evidence linking DM to cognitive dysfunction. Hyperglycemia is closely related to neurological abnormalities, while often disregarded in clinical practice. Changes in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM (T2DM). AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c (HbA1c) levels. METHODS A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East Hospital. The participants were divided into four groups according to their HbA1c levels using the interquartile method, namely Q1 (< 7.875%), Q2 (7.875%-9.050%), Q3 (9.050%-11.200%) and Q4 (≥ 11.200%). Clinical data were collected and measured, including age, height, weight, neck/waist/hip circumferences, blood pressure, comorbidities, duration of DM, and biochemical indicators. Meanwhile, neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance spectroscopy. RESULTS The HbA1c level was significantly associated with urinary microalbumin (mALB), triglyceride, low-density lipoprotein cholesterol (LDL-C), homeostasis model assessment of insulin resistance (HOMA-IR), and beta cell function (HOMA-β), N-acetylaspartate/creatine (NAA/Cr), and NAA/choline (NAA/Cho). Spearman correlation analysis showed that mALB, LDL-C, HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c (P < 0.05), whereas HOMA-β was negatively correlated with the HbA1c level (P < 0.05). Ordered multiple logistic regression analysis showed that NAA/Cho [Odds ratio (OR): 1.608, 95% confidence interval (95%CI): 1.004-2.578, P < 0.05], LDL-C (OR: 1.627, 95%CI: 1.119-2.370, P < 0.05), and HOMA-IR (OR: 1.107, 95%CI: 1.031-1.188, P < 0.01) were independent predictors of poor glycemic control. CONCLUSION The cerebral neurotransmitter concentrations in the left brainstem area in patients with T2DM are closely related to glycemic control, which may be the basis for the changes in cognitive function in diabetic patients.
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Affiliation(s)
- Xiang-Yu Gao
- Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
- Department of Endocrinology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266000, Shandong Province, China
| | - Chen-Xia Zhou
- Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
| | - Hong-Mei Li
- Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
| | - Min Cheng
- Department of Immunization Program, Huangdao District Center for Disease Prevention and Control, Qingdao 266400, Shandong Province, China
| | - Da Chen
- Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
| | - Zi-Yi Li
- Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
| | - Bo Feng
- Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
| | - Jun Song
- Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
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Shigapova RR, Mukhamedshina YO. Electrophysiology Methods for Assessing of Neurodegenerative and Post-Traumatic Processes as Applied to Translational Research. Life (Basel) 2024; 14:737. [PMID: 38929721 PMCID: PMC11205106 DOI: 10.3390/life14060737] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/27/2024] [Revised: 05/30/2024] [Accepted: 05/31/2024] [Indexed: 06/28/2024] Open
Abstract
Electrophysiological studies have long established themselves as reliable methods for assessing the functional state of the brain and spinal cord, the degree of neurodegeneration, and evaluating the effectiveness of therapy. In addition, they can be used to diagnose, predict functional outcomes, and test the effectiveness of therapeutic and rehabilitation programs not only in clinical settings, but also at the preclinical level. Considering the urgent need to develop potential stimulators of neuroregeneration, it seems relevant to obtain objective data when modeling neurological diseases in animals. Thus, in the context of the application of electrophysiological methods, not only the comparison of the basic characteristics of bioelectrical activity of the brain and spinal cord in humans and animals, but also their changes against the background of neurodegenerative and post-traumatic processes are of particular importance. In light of the above, this review will contribute to a better understanding of the results of electrophysiological assessment in neurodegenerative and post-traumatic processes as well as the possibility of translating these methods from model animals to humans.
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Affiliation(s)
- Rezeda Ramilovna Shigapova
- Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan 420008, Russia;
| | - Yana Olegovna Mukhamedshina
- Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan 420008, Russia;
- Department of Histology, Cytology and Embryology, Kazan State Medical University, Kazan 420012, Russia
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Li H, Wang X, Hamalainen T, Meng Z. Effects of different speed-accuracy instructions on perception in psychology experiments: evidence from event-related potential and oscillation. Front Neurosci 2024; 18:1354051. [PMID: 38881749 PMCID: PMC11177619 DOI: 10.3389/fnins.2024.1354051] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/12/2023] [Accepted: 05/16/2024] [Indexed: 06/18/2024] Open
Abstract
Introduction In cognitive behavioral experiments, we often asked participants to make judgments within a deadline. However, the most common instruction of "do the task quickly and accurately" does not highlight the importance of the balance between being fast and accurate. Methods Our research aimed to explore how instructions about speed or accuracy affect perceptual process, focus on event-related potentials (ERPs) and event-related oscillations (EROs) of two brain responses for visual stimuli, known as P1 and N1. Additionally, we compared the conventional analysis approach with principal component analysis (PCA) based methods to analyze P1 and N1 ERP amplitude and ERO power. Results The results showed that individuals instructed to respond quickly had lower P1 amplitude and alpha ERO than those who prioritized accuracy, using the PCA-based approach. However, these two groups had no differences between groups in the N1 theta band using both methods. The traditional time-frequency analysis method could not detect any ERP or ERO distinctions between groups due to limitations in detecting specific components in time or frequency domains. That means PCA is effective in separating these components. Discussion Our findings indicate that the instructions given regarding speed and accuracy impact perceptual process of subjects during cognitive behavioral experiments. We suggest that future researchers should choose their instructions carefully, considering the purpose of study.
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Affiliation(s)
- Haijian Li
- School of Sport and Health Sciences, Dalian University of Technology, Dalian, China
- Faculty of Information Technology, University of Jyväskylä, Jyväskylä, Finland
| | - Xiaoshuang Wang
- School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, China
| | - Timo Hamalainen
- Faculty of Information Technology, University of Jyväskylä, Jyväskylä, Finland
| | - Zhaoli Meng
- School of Sport and Health Sciences, Dalian University of Technology, Dalian, China
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13
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Ji C, Yang X, Eleish M, Jiang Y, Tetlow A, Song S, Martín-Ávila A, Wu Q, Zhou Y, Gan W, Lin Y, Sigurdsson EM. Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2024:2024.04.29.591735. [PMID: 38746288 PMCID: PMC11092661 DOI: 10.1101/2024.04.29.591735] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/16/2024]
Abstract
We previously reported altered neuronal Ca 2+ dynamics in the motor cortex of 12-month-old JNPL3 tauopathy mice during quiet wakefulness or forced running, with a tau antibody treatment significantly restoring the neuronal Ca 2+ activity profile and decreasing pathological tau in these mice 1 . Whether neuronal functional deficits occur at an early stage of tauopathy and if tau antibody treatment is effective in younger tauopathy mice needed further investigation. In addition, neuronal network activity and neuronal firing patterns have not been well studied in behaving tauopathy models. In this study, we first performed in vivo two-photon Ca 2+ imaging in JNPL3 mice in their early stage of tauopathy at 6 months of age, compared to 12 month old mice and age-matched wild-type controls to evaluate neuronal functional deficits. At the animal level, frequency of neuronal Ca 2+ transients decreased only in 6 month old tauopathy mice compared to controls, and only when animals were running on a treadmill. The amplitude of neuronal transients decreased in tauopathy mice compared to controls under resting and running conditions in both age groups. Total neuronal activity decreased only in 6 month old tauopathy mice compared to controls under resting and running conditions. Within either tauopathy or wild-type group, only total activity decreased in older wild-type animals. The tauopathy mice at different ages did not differ in neuronal Ca 2+ transient frequency, amplitude or total activity. In summary, neuronal function did significantly attenuate at an early age in tauopathy mice compared to controls but interestingly did not deteriorate between 6 and 12 months of age. A more detailed populational analysis of the pattern of Ca 2+ activity at the neuronal level in the 6 month old cohort confirmed neuronal hypoactivity in layer 2/3 of primary motor cortex, compared to wild-type controls, when animals were either resting or running on a treadmill. Despite reduced activity, neuronal Ca 2+ profiles exhibited enhanced synchrony and dysregulated responses to running stimulus. Further ex vivo electrophysiological recordings revealed reduction of spontaneous excitatory synaptic transmission onto and in pyramidal neurons and enhanced excitability of inhibitory neurons in motor cortex, which were likely responsible for altered neuronal network activity in this region. Lastly, tau antibody treatment reduced pathological tau and gliosis partially restored the neuronal Ca 2+ activity deficits but failed to rescue altered network changes. Taken together, substantial neuronal and network dysfunction occurred in the early stage of tauopathy that was partially alleviated with acute tau antibody treatment, which highlights the importance of functional assessment when evaluating the therapeutic potential of tau antibodies. Highlights Layer 2/3 motor cortical neurons exhibited hypofunction in awake and behaving mice at the early stage of tauopathy.Altered neuronal network activity disrupted local circuitry engagement in tauopathy mice during treadmill running.Layer 2/3 motor cortical neurons in tauopathy mice exhibited enhanced neuronal excitability and altered excitatory synaptic transmissions.Acute tau antibody treatment reduced pathological tau and gliosis, and partially restored neuronal hypofunction profiles but not network dysfunction.
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Khanjanianpak M, Azimi-Tafreshi N, Valizadeh A. Emergence of complex oscillatory dynamics in the neuronal networks with long activity time of inhibitory synapses. iScience 2024; 27:109401. [PMID: 38532887 PMCID: PMC10963234 DOI: 10.1016/j.isci.2024.109401] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/12/2023] [Revised: 12/30/2023] [Accepted: 02/28/2024] [Indexed: 03/28/2024] Open
Abstract
The brain displays complex dynamics, including collective oscillations, and extensive research has been conducted to understand their generation. However, our understanding of how biological constraints influence these oscillations is incomplete. This study investigates the essential properties of neuronal networks needed to generate oscillations resembling those in the brain. A simple discrete-time model of interconnected excitable elements is developed, capable of closely resembling the complex oscillations observed in biological neural networks. In the model, synaptic connections remain active for a duration exceeding individual neuron activity. We show that the inhibitory synapses must exhibit longer activity than excitatory synapses to produce a diverse range of the dynamical states, including biologically plausible oscillations. Upon meeting this condition, the transition between different dynamical states can be controlled by external stochastic input to the neurons. The study provides a comprehensive explanation for the emergence of distinct dynamical states in neural networks based on specific parameters.
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Affiliation(s)
- Mozhgan Khanjanianpak
- Physics Department, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran
- Pasargad Institute for Advanced Innovative Solutions (PIAIS), Tehran 1991633357, Iran
| | - Nahid Azimi-Tafreshi
- Physics Department, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran
| | - Alireza Valizadeh
- Physics Department, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran
- Pasargad Institute for Advanced Innovative Solutions (PIAIS), Tehran 1991633357, Iran
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15
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Lee KKY, Chattopadhyaya B, do Nascimento ASF, Moquin L, Rosa-Neto P, Amilhon B, Di Cristo G. Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice. Neurobiol Dis 2024; 193:106465. [PMID: 38460800 DOI: 10.1016/j.nbd.2024.106465] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/04/2023] [Revised: 03/03/2024] [Accepted: 03/04/2024] [Indexed: 03/11/2024] Open
Abstract
Children who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin (5-HT) project to the PFC, and compounds modulating 5-HT activity influence emotion and cognition. Whether 5-HT dysregulations contribute to MPA-induced cognitive problems is unknown. We established a MPA mouse model, which displays recognition and spatial memory impairments and dysfunctional cognitive flexibility. We found that 5-HT expression levels, quantified by immunohistochemistry, and 5-HT release, quantified by in vivo microdialysis in awake mice, are reduced in PFC of adult MPA mice. MPA mice also show impaired body temperature regulation following injection of the 5-HT1A receptor agonist 8-OH-DPAT, suggesting the presence of deficits in 5-HT auto-receptor function on raphe neurons. Finally, chronic treatment of adult MPA mice with fluoxetine, an inhibitor of 5-HT reuptake transporter, or the 5-HT1A receptor agonist tandospirone rescues cognitive flexibility and memory impairments. All together, these data demonstrate that the development of 5-HT system function is vulnerable to moderate perinatal asphyxia. 5-HT hypofunction might in turn contribute to long-term cognitive impairment in adulthood, indicating a potential target for pharmacological therapies.
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Affiliation(s)
- Karen Ka Yan Lee
- Neurosciences Department, Université de Montréal, Montréal, Canada; CHU Sainte-Justine Azrieli Research Center, Montréal, Canada
| | | | | | - Luc Moquin
- Department of Psychiatry, McGill University, Douglas Hospital Research Center, Canada
| | - Pedro Rosa-Neto
- Department of Psychiatry, McGill University, Douglas Hospital Research Center, Canada
| | - Bénédicte Amilhon
- Neurosciences Department, Université de Montréal, Montréal, Canada; CHU Sainte-Justine Azrieli Research Center, Montréal, Canada.
| | - Graziella Di Cristo
- Neurosciences Department, Université de Montréal, Montréal, Canada; CHU Sainte-Justine Azrieli Research Center, Montréal, Canada.
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Bai Y, Gong A, Wang Q, Guo Y, Zhang Y, Feng Z. Breakdown of oscillatory effective networks in disorders of consciousness. CNS Neurosci Ther 2024; 30:e14469. [PMID: 37718541 PMCID: PMC10916448 DOI: 10.1111/cns.14469] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/05/2023] [Revised: 08/24/2023] [Accepted: 09/04/2023] [Indexed: 09/19/2023] Open
Abstract
INTRODUCTION Combining transcranial magnetic stimulation with electroencephalography (TMS-EEG), oscillatory reactivity can be measured, allowing us to investigate the interaction between local and distant cortical oscillations. However, the extent to which human consciousness is related to these oscillatory effective networks has yet to be explored. AIMS We tend to investigate the link between oscillatory effective networks and brain consciousness, by monitoring the global transmission of TMS-induced oscillations in disorders of consciousness (DOC). RESULTS A cohort of DOC patients was included in this study, which included 28 patients with a minimally conscious state (MCS) and 20 patients with vegetative state/unresponsive wakefulness syndrome (VS/UWS). Additionally, 25 healthy controls were enrolled. The oscillatory reactivity to single-pulse TMS of the frontal, sensorimotor and parietal cortex was measured using event-related spectral perturbation of TMS-EEG. The temporal-spatial properties of the oscillatory reactivity were illustrated through life time, decay gradients and accumulative power. In DOC patients, an oscillatory reactivity was observed to be temporally and spatially suppressed. TMS-EEG of DOC patients showed that the oscillations did not travel as far in healthy controls, in terms of both temporal and spatial dimensions. Moreover, cortical theta reactivity was found to be a reliable indicator in distinguishing DOC versus healthy controls when TMS of the parietal region and in distinguishing MCS versus VS/UWS when TMS of the frontal region. Additionally, a positive correlation was observed between the Coma Recovery Scale-Revised scores of the DOC patients and the cortical theta reactivity. CONCLUSIONS The findings revealed a breakdown of oscillatory effective networks in DOC patients, which has implications for the use of TMS-EEG in DOC evaluation and offers a neural oscillation viewpoint on the neurological basis of human consciousness.
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Affiliation(s)
- Yang Bai
- Department of Rehabilitation MedicineThe First Affiliated Hospital of Nanchang UniversityNanchangChina
- Rehabilitation Medicine Clinical Research Center of Jiangxi ProvinceNanchangChina
| | - Anjuan Gong
- Center for Cognition and Brain DisordersThe Affiliated Hospital of Hangzhou Normal UniversityHangzhouChina
| | - Qijun Wang
- Center for Cognition and Brain DisordersThe Affiliated Hospital of Hangzhou Normal UniversityHangzhouChina
| | - Yongkun Guo
- The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
| | - Yin Zhang
- Center for Cognition and Brain DisordersThe Affiliated Hospital of Hangzhou Normal UniversityHangzhouChina
| | - Zhen Feng
- Department of Rehabilitation MedicineThe First Affiliated Hospital of Nanchang UniversityNanchangChina
- Rehabilitation Medicine Clinical Research Center of Jiangxi ProvinceNanchangChina
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17
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Gohil C, Huang R, Roberts E, van Es MWJ, Quinn AJ, Vidaurre D, Woolrich MW. osl-dynamics, a toolbox for modeling fast dynamic brain activity. eLife 2024; 12:RP91949. [PMID: 38285016 PMCID: PMC10945565 DOI: 10.7554/elife.91949] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/30/2024] Open
Abstract
Neural activity contains rich spatiotemporal structure that corresponds to cognition. This includes oscillatory bursting and dynamic activity that span across networks of brain regions, all of which can occur on timescales of tens of milliseconds. While these processes can be accessed through brain recordings and imaging, modeling them presents methodological challenges due to their fast and transient nature. Furthermore, the exact timing and duration of interesting cognitive events are often a priori unknown. Here, we present the OHBA Software Library Dynamics Toolbox (osl-dynamics), a Python-based package that can identify and describe recurrent dynamics in functional neuroimaging data on timescales as fast as tens of milliseconds. At its core are machine learning generative models that are able to adapt to the data and learn the timing, as well as the spatial and spectral characteristics, of brain activity with few assumptions. osl-dynamics incorporates state-of-the-art approaches that can be, and have been, used to elucidate brain dynamics in a wide range of data types, including magneto/electroencephalography, functional magnetic resonance imaging, invasive local field potential recordings, and electrocorticography. It also provides novel summary measures of brain dynamics that can be used to inform our understanding of cognition, behavior, and disease. We hope osl-dynamics will further our understanding of brain function, through its ability to enhance the modeling of fast dynamic processes.
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Affiliation(s)
- Chetan Gohil
- Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of OxfordOxfordUnited Kingdom
| | - Rukuang Huang
- Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of OxfordOxfordUnited Kingdom
| | - Evan Roberts
- Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of OxfordOxfordUnited Kingdom
| | - Mats WJ van Es
- Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of OxfordOxfordUnited Kingdom
| | - Andrew J Quinn
- Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of OxfordOxfordUnited Kingdom
- Centre for Human Brain Health, School of Psychology, University of BirminghamBirminghamUnited Kingdom
| | - Diego Vidaurre
- Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of OxfordOxfordUnited Kingdom
- Center for Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus UniversityAarhusDenmark
| | - Mark W Woolrich
- Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of OxfordOxfordUnited Kingdom
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Boetzel C, Stecher HI, Herrmann CS. ERP-aligned delta transcranial alternating current stimulation modulates the P3 amplitude. Int J Psychophysiol 2023; 193:112247. [PMID: 37769997 DOI: 10.1016/j.ijpsycho.2023.112247] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/12/2023] [Revised: 08/31/2023] [Accepted: 09/23/2023] [Indexed: 10/02/2023]
Abstract
The underlying mechanisms of the event-related potential (ERP) generation are still under debate. One popular model considers the ERP as a superposition of phase-resets of ongoing endogenous oscillations of different frequencies. Brain oscillations have been shown to be modulated by transcranial alternating current stimulation (tACS). Thus, it seems feasible, that an ERP could be altered by modulating the contributing oscillations using tACS. One possible approach would be to target a frequency-matched stimulation signal to a specific ERP-component. One possible target for such an approach is the P3, which appears as delta/theta oscillations in the frequency-domain. Thus, an ERP-aligned stimulation in the delta/theta-range might be suitable to force synchronization in the stimulated frequency band and thus increase the amplitude of the P3 component. Building on an existing paradigm, in the present study 21 healthy participants received individualized ERP-aligned delta tACS and control stimulation while performing a visual task. The visual stimulation was matched to the continuous tACS in order to align the tACS peak with the P3 peak. Both the P3 amplitude and the evoked delta power were significantly increased after ERP-aligned tACS but not after control stimulation. The investigated behavioral parameter showed no stimulation dependent effect. Our results may provide new insights into the debate on the contribution of phase-reset mechanisms to the generation of ERPs and offer new opportunities for clinical trials.
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Affiliation(s)
- Cindy Boetzel
- Experimental Psychology Lab, Department of Psychology, European Medical School, Cluster for Excellence "Hearing for All", Carl von Ossietzky University, Oldenburg, Germany
| | - Heiko I Stecher
- Experimental Psychology Lab, Department of Psychology, European Medical School, Cluster for Excellence "Hearing for All", Carl von Ossietzky University, Oldenburg, Germany
| | - Christoph S Herrmann
- Experimental Psychology Lab, Department of Psychology, European Medical School, Cluster for Excellence "Hearing for All", Carl von Ossietzky University, Oldenburg, Germany; Neuroimaging Unit, European Medical School, Carl von Ossietzky University, Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky University, Oldenburg, Germany.
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19
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Lee I, Kim KM, Lim MH. Theta and Gamma Activity Differences in Obsessive-Compulsive Disorder and Panic Disorder: Insights from Resting-State EEG with eLORETA. Brain Sci 2023; 13:1440. [PMID: 37891808 PMCID: PMC10605761 DOI: 10.3390/brainsci13101440] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/01/2023] [Revised: 09/29/2023] [Accepted: 10/05/2023] [Indexed: 10/29/2023] Open
Abstract
Background: Obsessive-compulsive disorder (OCD) and panic disorder (PD) are debilitating psychiatric conditions, yet their underlying neurobiological differences remain underexplored. This study aimed to directly compare resting-state EEGs in patients with OCD and PD, without a healthy control group, using the eLORETA method. Methods: We collected retrospective EEG data from 24 OCD patients and 22 PD patients who were hospitalized due to significant impairment in daily life functions. eLORETA was used to analyze the EEG data. Results: Heightened theta activity was observed in the anterior cingulate cortex (ACC) of OCD patients compared to PD patients (PD vs. OCD, t = -2.168, p < 0.05). Conversely, higher gamma activity was found in the medial frontal gyrus (MFG) and paracentral lobule (PCL) in PD patients (PD vs. OCD, t = 2.173, p < 0.05). Conclusions: Our findings highlight neurobiological differences between OCD and PD patients. Specifically, the increased theta activity in the ACC for OCD patients and elevated gamma activity in the MFG and PCL for PD patients offer preliminary insights into the neural mechanisms of these disorders. Further studies are essential to validate these results and delve deeper into the neural underpinnings.
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Affiliation(s)
- Ilju Lee
- Department of Psychology, Dankook University, 119 Dandar-ro, Dongnam-gu, Cheonan 31116, Republic of Korea;
- Department of Psychiatry, Dankook University Hospital, Cheonan 31116, Republic of Korea;
| | - Kyoung Min Kim
- Department of Psychiatry, Dankook University Hospital, Cheonan 31116, Republic of Korea;
- Department of Psychiatry, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea
| | - Myung Ho Lim
- Department of Psychology, Dankook University, 119 Dandar-ro, Dongnam-gu, Cheonan 31116, Republic of Korea;
- Department of Psychiatry, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea
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20
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Mishra B, Tarai S, Ratre V, Bit A. Processing of attentional and emotional stimuli depends on retrospective response of foot pressure: Conceptualizing neuron-cognitive distribution in human brain. Comput Biol Med 2023; 164:107186. [PMID: 37480678 DOI: 10.1016/j.compbiomed.2023.107186] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/24/2023] [Revised: 06/08/2023] [Accepted: 06/13/2023] [Indexed: 07/24/2023]
Abstract
Cognitive function of human brain requires temporal execution of emotional or attentional tasks, or their inter-dependence influences. Smooth execution of such tasks requires spontaneous distribution of cognitive load at specific regions of brain based on its classification. A strong connectivity between peripheral sensors and central nervous system is thought to assist the cognitive load distribution effectively. Novelty of current study evaluates the modulation of foot pressure and its mapping with distributed cognitive load while executing attentional biased emotional tasks. Emotional stimulus in form of happy and sad faces with attentional paradigm drawn on them were used in the study. Behavioral results were measured with respect to the analysis of response time (RT) and response accuracy (%). Neurological signals were acquired using 10-channel EEG data acquisition system, whereas, another 6 channels were used to measure foot pressure in the left and right feet at three different locations of foot. Acquired signals were further analyzed in time and frequency domains to interpret the cognitive load distribution, and the influence of foot pressure on distribution of cognitive loads. We found that the foot pressure accelerated the response accuracy rate in attending the local scope of attention, which was not in the case of global scope of attention. This means that the global attention does not require any pressure from peripheral sensory neurons. Our event related potential (ERP) results revealed that the early sensory negative N100 characterized the processing of global scope of attention coupled with high-foot pressure. However, the late positive peak of P300 and P600 associated with local scope of attention along with high-foot pressure. The global scope of attention with low-foot pressure modulates delta and theta oscillations. These results largely contribute to the literature on cognitive neuroscience of attention and it corelation with the peripheral sensory foot pressure.
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Affiliation(s)
- Bharti Mishra
- Department of Biomedical Engineering, National Institute of Technology, Raipur, India
| | - Shashikanta Tarai
- Department of Humanities and Social Sciences, National Institute of Technology, Raipur, India
| | - Vinod Ratre
- Department of Biomedical Engineering, National Institute of Technology, Raipur, India
| | - Arindam Bit
- Department of Biomedical Engineering, National Institute of Technology, Raipur, India.
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Choi S, Chen Y, Zeng H, Biswal B, Yu X. Identifying the distinct spectral dynamics of laminar-specific interhemispheric connectivity with bilateral line-scanning fMRI. J Cereb Blood Flow Metab 2023; 43:1115-1129. [PMID: 36803280 PMCID: PMC10291453 DOI: 10.1177/0271678x231158434] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/02/2022] [Revised: 11/30/2022] [Accepted: 12/12/2022] [Indexed: 02/23/2023]
Abstract
Despite extensive efforts to identify interhemispheric functional connectivity (FC) with resting-state (rs-) fMRI, correlated low-frequency rs-fMRI signal fluctuation across homotopic cortices originates from multiple sources. It remains challenging to differentiate circuit-specific FC from global regulation. Here, we developed a bilateral line-scanning fMRI method to detect laminar-specific rs-fMRI signals from homologous forepaw somatosensory cortices with high spatial and temporal resolution in rat brains. Based on spectral coherence analysis, two distinct bilateral fluctuation spectral features were identified: ultra-slow fluctuation (<0.04 Hz) across all cortical laminae versus Layer (L) 2/3-specific evoked BOLD at 0.05 Hz based on 4 s on/16 s off block design and resting-state fluctuations at 0.08-0.1 Hz. Based on the measurements of evoked BOLD signal at corpus callosum (CC), this L2/3-specific 0.05 Hz signal is likely associated with neuronal circuit-specific activity driven by the callosal projection, which dampened ultra-slow oscillation less than 0.04 Hz. Also, the rs-fMRI power variability clustering analysis showed that the appearance of L2/3-specific 0.08-0.1 Hz signal fluctuation is independent of the ultra-slow oscillation across different trials. Thus, distinct laminar-specific bilateral FC patterns at different frequency ranges can be identified by the bilateral line-scanning fMRI method.
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Affiliation(s)
- Sangcheon Choi
- Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA
- Max Planck Institute for Biological Cybernetics, Tübingen, Germany
| | - Yi Chen
- Max Planck Institute for Biological Cybernetics, Tübingen, Germany
| | - Hang Zeng
- Max Planck Institute for Biological Cybernetics, Tübingen, Germany
- Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, Germany
| | - Bharat Biswal
- Department of Biomedical Engineering, NJIT, Newark, NJ, USA
| | - Xin Yu
- Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA
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22
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Norata D, Broggi S, Alvisi L, Lattanzi S, Brigo F, Tinuper P. The EEG pen-on-paper sound: History and recent advances. Seizure 2023; 107:67-70. [PMID: 36965379 DOI: 10.1016/j.seizure.2023.03.011] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/19/2022] [Revised: 03/02/2023] [Accepted: 03/14/2023] [Indexed: 03/17/2023] Open
Abstract
The electroencephalogram (EEG) is one of the most useful technologies for brain research and clinical neurology, characterized by non-invasiveness and high time resolution. The acquired traces are visibly displayed, but various studies investigate the translation of brain waves in sound (i.e., a process called sonification). Several articles have been published since 1934 about the sonification of EEG traces, in the attempt to identify the "brain-sound." However, for a long time this sonification technique was not used for clinical purposes. The analog EEG was in fact already equipped with an auditory output, although rarely mentioned in scientific papers: the pen-on-paper noise made by the writer unit. EEG technologists often relied on the sound that pens made on paper to facilitate the diagnosis. This article provides a sample of analog video-EEG recordings with audio support representing the strengths of a combined visual-and-auditory detection of different types of seizures. The purpose of the present article is to illustrate how the analog EEG "sounded," as well as to highlight the advantages of this pen-writing noise. It was considered so useful that early digital EEG devices could be equipped with special software to duplicate it digitally. Even in the present days, the sonification can be considered as an attempt to modify the EEG practice using auditory neurofeedback with applications in therapeutic interventions, cognitive improvement, and basic research.
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Affiliation(s)
- Davide Norata
- Neurological Clinic and Stroke Unit, Department of Experimental and Clinical Medicine (DiMSC), Marche Polytechnic University, Via Conca 71, Ancona 60020, Italy.
| | - Serena Broggi
- Neurological Clinic and Stroke Unit, Department of Experimental and Clinical Medicine (DiMSC), Marche Polytechnic University, Via Conca 71, Ancona 60020, Italy
| | - Lara Alvisi
- Dipartimento di Scienze Biomediche e Neuromotorie, University of Bologna, Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna, Epilepsy Center (full member of the European Reference Network EpiCARE), Bologna, Italy
| | - Simona Lattanzi
- Neurological Clinic and Stroke Unit, Department of Experimental and Clinical Medicine (DiMSC), Marche Polytechnic University, Via Conca 71, Ancona 60020, Italy
| | - Francesco Brigo
- Department of Neurology, Hospital of Merano (SABES-ASDAA), Merano-Meran, Italy
| | - Paolo Tinuper
- Dipartimento di Scienze Biomediche e Neuromotorie, University of Bologna, Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna, Epilepsy Center (full member of the European Reference Network EpiCARE), Bologna, Italy
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Neuroprotective Efficacy of Europinidin in Streptozotocin-Induced Memory Impairment by Modulation of Oxidative Stress, Inflammatory Mediators, and Cholinesterase Activity in Rats. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2023; 2023:5248127. [PMID: 36760351 PMCID: PMC9904885 DOI: 10.1155/2023/5248127] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 09/02/2022] [Revised: 10/30/2022] [Accepted: 11/24/2022] [Indexed: 02/04/2023]
Abstract
Materials and Methods Oral acute toxicity studies were performed to evaluate the toxicological effects of europinidin in animals. In this study, four different animal groups (n = 6) were used. Group I was the normal control, group II was the STZ-induced diabetes control, group III was STZ + europinidin-treated (10 mg/kg), and group IV was STZ + europinidin-treated (10 mg/kg). The efficacy of europinidin at a dose of 10 mg/kg and 20 mg/kg was studied with single-dose administration of streptozotocin, which experimentally induced memory impairments in Wistar male rats for 38 days. The mean body weight and blood glucose levels were recorded at the initial and end of the study. The two behavioural paradigms (Y-maze and Morris water maze) were performed to evaluate spatial and working memory in rats. The biochemical parameters such as acetylcholinesterase, choline acetyltransferase, superoxide dismutase, glutathione transferase, malonaldehyde, catalase, and nitric oxide level as hallmarks of oxidative stress were measured. Additionally, the proinflammatory parameters were also determined to evaluate the neuroinflammatory responses associated with streptozotocin such as tumor necrosis factor-alpha (TNF-α) interleukin-1β (IL-1β), interleukin (IL-6), nuclear factor-kappa B (NF-ƙB), interleukin (IL-10), and nuclear factor-erythroid factor 2-related factor 2 (Nrf2) in the perfused brain. Results The rats in the europinidin-treated group exhibited a significant restoration of body weight and blood glucose level as compared with the streptozotocin control group. Furthermore, europinidin significantly modulated the spatial and working memory in rats, when assessed through behavioural paradigms. Streptozotocin caused a significant alteration in biochemical, neuronal enzymatic, and neuroinflammatory parameters, which were significantly restored to normal levels by europinidin. Conclusion The present study attributed the neuroprotective efficacy of europinidin in experimental animal models by subsiding the several biomarkers of oxidative stress, neuroinflammation, and neuronal enzymatic activities.
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Smit D, Trevino L, Mohamed SMH, Enriquez-Geppert S. Theta power and functional connectivity as neurophysiological markers of executive functions in individuals with cognitive complaints in daily life. Biol Psychol 2023; 178:108503. [PMID: 36681295 DOI: 10.1016/j.biopsycho.2023.108503] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/04/2022] [Revised: 01/11/2023] [Accepted: 01/14/2023] [Indexed: 01/20/2023]
Abstract
Impairments in executive functions (EFs) are common across psychological disorders. Research into the neural oscillations underlying EFs has the potential to help understand these impairments and contribute to the development of interventions. The aim of this study is to assess theta power and functional theta connectivity in the sensor space of the regions of the superordinate network for the core EFs: conflict monitoring, response inhibition, set-shifting, and working memory updating. We recruited adults with self-reported everyday EFs complaints and formed two groups: one with attention deficit hyperactivity disorder (ADHD) (n=27) and another without any diagnosis (n=22), and compared them to controls (n=21) on the Stroop, Stop-signal, Switching, and N-back task using EEG. Power and functional connectivity analyses were conducted for four regions of interest: frontal-midline, frontolateral left and right, and parietal region. For all four EFs, the groups showed a dynamical increase in theta power over time in the four regions of interest, as well as in functional theta connectivity between these regions. Group differences were found especially for conflict monitoring, with differences in theta power in the frontal-midline and frontolateral right region. These neural markers are also associated with behavioural performance and complaints in daily life. For set-shifting, group differences were less pronounced and for response inhibition and working memory updating no group differences were observed.
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Affiliation(s)
- Diede Smit
- Department of Clinical and Developmental Neuropsychology, University of Groningen, the Netherlands; Research School of Behavioural and Cognitive Neurosciences, University of Groningen, the Netherlands
| | - Lorena Trevino
- Department of Clinical and Developmental Neuropsychology, University of Groningen, the Netherlands
| | - Saleh M H Mohamed
- Department of Clinical and Developmental Neuropsychology, University of Groningen, the Netherlands
| | - Stefanie Enriquez-Geppert
- Department of Clinical and Developmental Neuropsychology, University of Groningen, the Netherlands; Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, the Netherlands.
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Başar-Eroğlu C, Küçük KM, Rürup L, Schmiedt-Fehr C, Mathes B. Oscillatory Activities in Multiple Frequency Bands in Patients with Schizophrenia During Motion Perception. Clin EEG Neurosci 2022:15500594221141825. [PMID: 36437602 DOI: 10.1177/15500594221141825] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]
Abstract
Patients with schizophrenia show impairment in binding stimulus features into coherent objects, which are reflected in disturbed oscillatory activities. This study aimed to identify disturbances in multiple oscillatory bands during perceptual organization of motion perception in patients with schizophrenia. EEG was recorded from healthy controls and patients with schizophrenia during continuous presentation of a motion stimulus which induces reversals between two exogenously generated perceptions. This stimulus was used to investigate differences in motion binding processes between healthy controls and patients with schizophrenia. EEG signals were transformed into frequency components by means of the Morlet wavelet transformation in order to analyse inter-trial coherences (ITC) in the delta (1-4 Hz), theta (4-7 Hz), alpha (8-12 Hz), and gamma (28-48 Hz) frequency bands during exogenous motion binding. Patients showed decreased delta-ITC in occipital and theta-ITC in central and parietal areas, while no significant differences were found for neither alpha nor gamma-ITCs. The present study provides one of the first insights on the oscillatory synchronizations related with the motion perception in schizophrenia. The ITC differences revealed alterations in the consistency of large-scale integration and transfer functions in patients with schizophrenia.
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Affiliation(s)
- C Başar-Eroğlu
- Department of Psychology, 52973İzmir University of Economics, Izmir, Turkey
| | - K M Küçük
- Department of Psychology, 52973İzmir University of Economics, Izmir, Turkey
| | - L Rürup
- 62546Hospital Bremen-East, Bremen, Germany
| | - C Schmiedt-Fehr
- Institute of Psychology, 9168University of Bremen, Bremen, Germany
| | - B Mathes
- Bremen Initiative to Foster Early Childhood Development, 9168University of Bremen, Bremen, Germany
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26
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REDUCED POWER AND PHASE-LOCKING VALUES WERE ACCOMPANIED BY THALAMUS, PUTAMEN AND HIPPOCAMPUS ATROPHY IN PARKINSON'S DISEASE WITH MILD COGNITIVE IMPAIRMENT: AN EVENT-RELATED OSCILLATION STUDY. Neurobiol Aging 2022; 121:88-106. [DOI: 10.1016/j.neurobiolaging.2022.10.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/03/2022] [Revised: 09/30/2022] [Accepted: 10/05/2022] [Indexed: 11/07/2022]
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Wu J, Aton SJ, Booth V, Zochowski M. Heterogeneous mechanisms for synchronization of networks of resonant neurons under different E/I balance regimes. FRONTIERS IN NETWORK PHYSIOLOGY 2022; 2:975951. [PMID: 36926113 PMCID: PMC10013004 DOI: 10.3389/fnetp.2022.975951] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/22/2022] [Accepted: 09/12/2022] [Indexed: 11/13/2022]
Abstract
Rhythmic synchronization of neuronal firing patterns is a widely present phenomenon in the brain-one that seems to be essential for many cognitive processes. A variety of mechanisms contribute to generation and synchronization of network oscillations, ranging from intrinsic cellular excitability to network mediated effects. However, it is unclear how these mechanisms interact together. Here, using computational modeling of excitatory-inhibitory neural networks, we show that different synchronization mechanisms dominate network dynamics at different levels of excitation and inhibition (i.e. E/I levels) as synaptic strength is systematically varied. Our results show that with low synaptic strength networks are sensitive to external oscillatory drive as a synchronizing mechanism-a hallmark of resonance. In contrast, in a strongly-connected regime, synchronization is driven by network effects via the direct interaction between excitation and inhibition, and spontaneous oscillations and cross-frequency coupling emerge. Unexpectedly, we find that while excitation dominates network synchrony at low excitatory coupling strengths, inhibition dominates at high excitatory coupling strengths. Together, our results provide novel insights into the oscillatory modulation of firing patterns in different excitation/inhibition regimes.
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Affiliation(s)
- Jiaxing Wu
- Applied Physics Program, University of Michigan, Ann Arbor, MI, United States
| | - Sara J. Aton
- Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, United States
| | - Victoria Booth
- Department of Mathematics, University of Michigan, Ann Arbor, MI, United States
- Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, United States
| | - Michal Zochowski
- Applied Physics Program, University of Michigan, Ann Arbor, MI, United States
- Department of Physics, University of Michigan, Ann Arbor, MI, United States
- Biophysics Program, University of Michigan, Ann Arbor, MI, United States
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Lu Z, Wang H, Gu J, Gao F. Association between abnormal brain oscillations and cognitive performance in patients with bipolar disorder; Molecular mechanisms and clinical evidence. Synapse 2022; 76:e22247. [PMID: 35849784 DOI: 10.1002/syn.22247] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/20/2022] [Revised: 05/23/2022] [Accepted: 06/20/2022] [Indexed: 11/10/2022]
Abstract
Brain oscillations have gained great attention in neuroscience during recent decades as functional building blocks of cognitive-sensory processes. Research has shown that oscillations in "alpha," "beta," "gamma," "delta," and "theta" frequency windows are highly modified in brain pathology, including in patients with cognitive impairment like bipolar disorder (BD). The study of changes in brain oscillations can provide fundamental knowledge for exploring neurophysiological biomarkers in cognitive impairment. The present article reviews findings from the role and molecular basis of abnormal neural oscillation and synchronization in the symptoms of patients with BD. An overview of the results clearly demonstrates that, in cognitive-sensory processes, resting and evoked/event-related electroencephalogram (EEG) spectra in the delta, theta, alpha, beta, and gamma bands are abnormally changed in patients with BD showing psychotic features. Abnormal oscillations have been found to be associated with several neural dysfunctions and abnormalities contributing to BD, including abnormal GABAergic neurotransmission signaling, hippocampal cell discharge, abnormal hippocampal neurogenesis, impaired cadherin and synaptic contact-based cell adhesion processes, extended lateral ventricles, decreased prefrontal cortical gray matter, and decreased hippocampal volume. Mechanistically, impairment in calcium voltage-gated channel subunit alpha1 I, neurotrophic tyrosine receptor kinase proteins, genes involved in brain neurogenesis and synaptogenesis like WNT3 and ACTG2, genes involved in the cell adhesion process like CDH12 and DISC1, and gamma-aminobutyric acid (GABA) signaling have been reported as the main molecular contributors to the abnormalities in resting-state low-frequency oscillations in BD patients. Findings also showed the association of impaired synaptic connections and disrupted membrane potential with abnormal beta/gamma oscillatory activity in patients with BD. Of note, the synaptic GABA neurotransmitter has been found to be a fundamental requirement for the occurrence of long-distance synchronous gamma oscillations necessary for coordinating the activity of neural networks between various brain regions. This article is protected by copyright. All rights reserved.
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Affiliation(s)
- Zhou Lu
- Department of Neurosurgery, The Affiliated People's Hospital of NingBo University, NingBo, 315000, China
| | - Huixiao Wang
- Department of Neurosurgery, The Affiliated People's Hospital of NingBo University, NingBo, 315000, China
| | - Jiajie Gu
- Department of Neurosurgery, The Affiliated People's Hospital of NingBo University, NingBo, 315000, China
| | - Feng Gao
- Department of Neurosurgery, The Affiliated People's Hospital of NingBo University, NingBo, 315000, China
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Chen-Engerer HJ, Jaeger S, Bondarenko R, Sprengel R, Hengerer B, Rosenbrock H, Mack V, Schuelert N. Increasing the Excitatory Drive Rescues Excitatory/Inhibitory Imbalance and Mismatch Negativity Deficit Caused by Parvalbumin Specific GluA1 Deletion. Neuroscience 2022; 496:190-204. [PMID: 35750109 DOI: 10.1016/j.neuroscience.2022.06.027] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/28/2022] [Revised: 05/02/2022] [Accepted: 06/15/2022] [Indexed: 11/25/2022]
Abstract
Disturbance in synaptic excitatory and inhibitory (E/I) transmission in the prefrontal cortex is considered a critical factor for cognitive dysfunction, a core symptom in schizophrenia. However, the cortical network pathophysiology induced by E/I imbalance is not well characterized, and an effective therapeutic strategy is lacking. In this study, we simulated imbalanced cortical network by using mice with parvalbumin neuron (PV) specific knockout of GluA1 (AMPA receptor subunit 1) (Gria1-PV KO) as an experimental model. Applying high-content confocal imaging and electrophysiological recordings in the medial prefrontal cortex (mPFC), we found structural and functional alterations in the local network of Gria1-PV KO mice. Additionally, we applied electroencephalography (EEG) to assess potential deficits in mismatch negativity (MMN), the standard readout in the clinic for measuring deviance detection and sensory information processing. Gria1-PV KO animals exhibited abnormal theta oscillation and MMN, which is consistent with clinical findings in cognitively impaired patients. Remarkably, we demonstrated that the glycine transporter 1 (GlyT1) inhibitor, Bitopertin, ameliorates E/I imbalance, hyperexcitability, and sensory processing malfunction in Gria1-PV KO mice. Our results suggest that PV-specific deletion of GluA1 might be an experimental approach for back translating the E/I imbalance observed in schizophrenic patients. Our work offers a systematic workflow to understand the effect of GlyT1 inhibition in restoring cortical network activity from single cells to local brain circuitry. This study highlights that selectively boosting NMDA receptor-mediated excitatory drive to enhance the network inhibitory transmission from interneurons to pyramidal neurons (PYs) is a potential therapeutic strategy for restoring E/I imbalance-associated cognitive-related abnormality.
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Affiliation(s)
- Hsing-Jung Chen-Engerer
- Central Nervous System Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstr. 65, 88397 Biberach Riß, Germany.
| | - Stefan Jaeger
- Central Nervous System Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstr. 65, 88397 Biberach Riß, Germany
| | - Rimma Bondarenko
- Central Nervous System Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstr. 65, 88397 Biberach Riß, Germany
| | - Rolf Sprengel
- Max Planck Institute for Medical Research at the Institute for Anatomy and Cell Biology at Heidelberg University, Germany
| | - Bastian Hengerer
- Central Nervous System Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstr. 65, 88397 Biberach Riß, Germany
| | - Holger Rosenbrock
- Central Nervous System Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstr. 65, 88397 Biberach Riß, Germany
| | - Volker Mack
- CardioMetabolic Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstr. 65, 88397 Biberach Riß, Germany
| | - Niklas Schuelert
- Central Nervous System Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstr. 65, 88397 Biberach Riß, Germany
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30
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Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease. Int J Psychophysiol 2022; 177:179-201. [PMID: 35588964 DOI: 10.1016/j.ijpsycho.2022.05.008] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/30/2021] [Revised: 05/11/2022] [Accepted: 05/12/2022] [Indexed: 11/23/2022]
Abstract
Alzheimer's disease dementia (ADD) is the most diffuse neurodegenerative disorder belonging to mild cognitive impairment (MCI) and dementia in old persons. This disease is provoked by an abnormal accumulation of amyloid-beta and tauopathy proteins in the brain. Very recently, the first disease-modifying drug has been licensed with reserve (i.e., Aducanumab). Therefore, there is a need to identify and use biomarkers probing the neurophysiological underpinnings of human cognitive functions to test the clinical efficacy of that drug. In this regard, event-related electroencephalographic potentials (ERPs) and oscillations (EROs) are promising candidates. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer's Association and Global Brain Consortium reviewed the field literature on the effects of the most used symptomatic drug against ADD (i.e., Acetylcholinesterase inhibitors) on ERPs and EROs in ADD patients with MCI and dementia at the group level. The most convincing results were found in ADD patients. In those patients, Acetylcholinesterase inhibitors partially normalized ERP P300 peak latency and amplitude in oddball paradigms using visual stimuli. In these same paradigms, those drugs partially normalize ERO phase-locking at the theta band (4-7 Hz) and spectral coherence between electrode pairs at the gamma (around 40 Hz) band. These results are of great interest and may motivate multicentric, double-blind, randomized, and placebo-controlled clinical trials in MCI and ADD patients for final cross-validation.
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31
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Ten Oever S, van der Werf OJ, Schuhmann T, Sack AT. Absence of behavioral rhythms: noise or unexplained neuronal mechanisms? (response to Fiebelkorn, 2021). Eur J Neurosci 2022; 55:3121-3124. [PMID: 35193154 PMCID: PMC9545739 DOI: 10.1111/ejn.15628] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/23/2021] [Accepted: 02/17/2022] [Indexed: 11/30/2022]
Affiliation(s)
- Sanne Ten Oever
- Language and Computation in Neural Systems group, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.,Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands.,Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
| | - Olof J van der Werf
- Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.,Maastricht Brain Imaging Centre (MBIC), Maastricht University, Maastricht, The Netherlands
| | - Teresa Schuhmann
- Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.,Maastricht Brain Imaging Centre (MBIC), Maastricht University, Maastricht, The Netherlands
| | - Alexander T Sack
- Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.,Maastricht Brain Imaging Centre (MBIC), Maastricht University, Maastricht, The Netherlands.,Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Brain and Nerve Centre, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands
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32
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Karakaş S. A comparative review of the psychophysiology of attention in typically developing children and children with attention deficit hyperactivity disorder. Int J Psychophysiol 2022; 177:43-60. [DOI: 10.1016/j.ijpsycho.2022.02.007] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/10/2021] [Revised: 01/10/2022] [Accepted: 02/15/2022] [Indexed: 11/17/2022]
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Chen B, Ciria LF, Hu C, Ivanov PC. Ensemble of coupling forms and networks among brain rhythms as function of states and cognition. Commun Biol 2022; 5:82. [PMID: 35064204 PMCID: PMC8782865 DOI: 10.1038/s42003-022-03017-4] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/26/2021] [Accepted: 12/23/2021] [Indexed: 01/02/2023] Open
Abstract
The current paradigm in brain research focuses on individual brain rhythms, their spatiotemporal organization, and specific pairwise interactions in association with physiological states, cognitive functions, and pathological conditions. Here we propose a conceptually different approach to understanding physiologic function as emerging behavior from communications among distinct brain rhythms. We hypothesize that all brain rhythms coordinate as a network to generate states and facilitate functions. We analyze healthy subjects during rest, exercise, and cognitive tasks and show that synchronous modulation in the micro-architecture of brain rhythms mediates their cross-communications. We discover that brain rhythms interact through an ensemble of coupling forms, universally observed across cortical areas, uniquely defining each physiological state. We demonstrate that a dynamic network regulates the collective behavior of brain rhythms and that network topology and links strength hierarchically reorganize with transitions across states, indicating that brain-rhythm interactions play an essential role in generating physiological states and cognition.
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Affiliation(s)
- Bolun Chen
- Keck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, MA, 02215, USA
| | - Luis F Ciria
- Keck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, MA, 02215, USA
- Mind, Brain and Behaviour Research Center, Department of Experimental Psychology, Faculty of Psychology, University of Granada, Campus de la Cartuja, Granada, 18071, Spain
| | - Congtai Hu
- Keck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, MA, 02215, USA
| | - Plamen Ch Ivanov
- Keck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, MA, 02215, USA.
- Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
- Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str. Block 21, Sofia, 1113, Bulgaria.
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Mokhothu TM, Tanaka KZ. Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy. Front Behav Neurosci 2021; 15:785328. [PMID: 34899205 PMCID: PMC8656355 DOI: 10.3389/fnbeh.2021.785328] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/29/2021] [Accepted: 10/29/2021] [Indexed: 01/01/2023] Open
Abstract
Temporal Lobe Epilepsy (TLE) is a neurological condition characterized by focal brain hyperexcitability, resulting in abnormal neuronal discharge and uncontrollable seizures. The hippocampus, with its inherently highly synchronized firing patterns and relatively high excitability, is prone to epileptic seizures, and it is usually the focus of TLE. Researchers have identified hippocampal high-frequency oscillations (HFOs) as a salient feature in people with TLE and animal models of this disease, arising before or at the onset of the epileptic event. To a certain extent, these pathological HFOs have served as a marker and a potential target for seizure attenuation using electrical or optogenetic interventions. However, many questions remain about whether we can reliably distinguish pathological from non-pathological HFOs and whether they can tell us about the development of the disease. While this would be an arduous task to perform in humans, animal models of TLE provide an excellent opportunity to study the characteristics of HFOs in predicting how epilepsy evolves. This minireview will (1) summarize what we know about the oscillatory disruption in TLE, (2) summarize knowledge about oscillatory changes in the latent period and their role in predicting seizures, and (3) propose future studies essential to uncovering potential treatments based on early detection of pathological HFOs.
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Affiliation(s)
- Thato Mary Mokhothu
- Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
| | - Kazumasa Zen Tanaka
- Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
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35
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Analysis of electroencephalography (EEG) signals and adapting to systems theory principles. JOURNAL OF COMPLEXITY IN HEALTH SCIENCES 2021. [DOI: 10.21595/chs.2021.22038] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/18/2022] Open
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Maciel LÍL, Rodrigues Feitosa Ramalho R, Izidoro Ribeiro R, Cunha Xavier Pinto M, Pereira I, Vaz BG. Combining the Katritzky Reaction and Paper Spray Ionization Mass Spectrometry for Enhanced Detection of Amino Acid Neurotransmitters in Mouse Brain Sections. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 2021; 32:2513-2518. [PMID: 34464122 DOI: 10.1021/jasms.1c00153] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/13/2023]
Abstract
This work describes the development of a system that combines a derivatization protocol based on the Katritzky reaction with paper spray ionization mass spectrometry (PSI-MS) for the analysis of amino acid neurotransmitters in mouse brain tissues. The system is relatively simple, consisting of spraying the derivatization solution onto a mouse brain section mounted on a glass slide, applying a small volume of solvent to moisten the sample, pressing a triangular paper onto the sample surface to transfer the sample constituents to the paper surface, and using the paper as a substrate for PSI-MS analysis. The Katritzky reaction facilitated the ionization of the amino acids by reacting a pyrylium salt with the amino group of the analytes, forming very stable pyridinium cations, which greatly increased the sensitivity of the PSI-MS analysis. Most of the intensities of the amino acids modified by the Katritzky reaction were more than 10 times greater than the nonderivatized ones. The system was applied for the analysis of brain sections obtained from mice with Parkinson's disease, and the amino acids gamma-aminobutyric acid (GABA) and glycine (Gly), two compounds very well-known in studies of Parkinson's disease, were readily detected. The results suggest that the Katritzky reaction combined with PSI-MS might offer a significant advance in the knowledge on protocols that improve the sensitivity of detection of crucial biological compounds.
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Affiliation(s)
| | | | - Raul Izidoro Ribeiro
- Institute of Biological Sciences, Federal University of Goiás, 74690-900, Goiânia, Brazil
| | | | - Igor Pereira
- Chemistry Institute, Federal University of Goiás, 74690-900, Goiânia, Brazil
| | - Boniek Gontijo Vaz
- Chemistry Institute, Federal University of Goiás, 74690-900, Goiânia, Brazil
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Arroyo-García LE, Isla AG, Andrade-Talavera Y, Balleza-Tapia H, Loera-Valencia R, Alvarez-Jimenez L, Pizzirusso G, Tambaro S, Nilsson P, Fisahn A. Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the App NL-G-F mouse model of Alzheimer's disease. Mol Psychiatry 2021; 26:5557-5567. [PMID: 34385602 PMCID: PMC8758494 DOI: 10.1038/s41380-021-01257-0] [Citation(s) in RCA: 33] [Impact Index Per Article: 8.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/18/2020] [Revised: 07/19/2021] [Accepted: 07/30/2021] [Indexed: 02/07/2023]
Abstract
In Alzheimer's disease (AD) the accumulation of amyloid-β (Aβ) correlates with degradation of cognition-relevant gamma oscillations. The gamma rhythm relies on proper neuronal spike-gamma coupling, specifically of fast-spiking interneurons (FSN). Here we tested the hypothesis that decrease in gamma power and FSN synchrony precede amyloid plaque deposition and cognitive impairment in AppNL-G-F knock-in mice (AppNL-G-F). The aim of the study was to evaluate the amyloidogenic pathology progression in the novel AppNL-G-F mouse model using in vitro electrophysiological network analysis. Using patch clamp of FSNs and pyramidal cells (PCs) with simultaneous gamma oscillation recordings, we compared the activity of the hippocampal network of wild-type mice (WT) and the AppNL-G-F mice at four disease stages (1, 2, 4, and 6 months of age). We found a severe degradation of gamma oscillation power that is independent of, and precedes Aβ plaque formation, and the cognitive impairment reported previously in this animal model. The degradation correlates with increased Aβ1-42 concentration in the brain. Analysis on the cellular level showed an impaired spike-gamma coupling of FSN from 2 months of age that correlates with the degradation of gamma oscillations. From 6 months of age PC firing becomes desynchronized also, correlating with reports in the literature of robust Aβ plaque pathology and cognitive impairment in the AppNL-G-F mice. This study provides evidence that impaired FSN spike-gamma coupling is one of the earliest functional impairment caused by the amyloidogenic pathology progression likely is the main cause for the degradation of gamma oscillations and consequent cognitive impairment. Our data suggests that therapeutic approaches should be aimed at restoring normal FSN spike-gamma coupling and not just removal of Aβ.
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Affiliation(s)
- Luis Enrique Arroyo-García
- Neuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
| | - Arturo G Isla
- Neuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden
| | - Yuniesky Andrade-Talavera
- Neuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden
| | - Hugo Balleza-Tapia
- Neuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden
| | - Raúl Loera-Valencia
- Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden
| | - Laura Alvarez-Jimenez
- Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden
| | - Giusy Pizzirusso
- Neuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden
| | - Simone Tambaro
- Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden
| | - Per Nilsson
- Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden
| | - André Fisahn
- Neuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
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Almalki AH, Naguib IA, Alshehri FS, Alghamdi BS, Alsaab HO, Althobaiti YS, Alshehri S, Abdallah FF. Application of Three Ecological Assessment Tools in Examining Chromatographic Methods for the Green Analysis of a Mixture of Dopamine, Serotonin, Glutamate and GABA: A Comparative Study. Molecules 2021; 26:5436. [PMID: 34576907 PMCID: PMC8467375 DOI: 10.3390/molecules26185436] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/06/2021] [Revised: 07/13/2021] [Accepted: 07/16/2021] [Indexed: 12/28/2022] Open
Abstract
The assessment of greenness of analytical protocols is of great importance now to preserve the environment. Some studies have analyzed either only the neurotransmitters, dopamine, serotonin, glutamate, and gamma-aminobutyric acid (GABA), together or with other neurotransmitters and biomarkers. However, these methods have not been investigated for their greenness and were not compared with each other to find the optimum one. Therefore, this study aims to compare seven published chromatographic methods that analyzed the four neurotransmitters and their mixtures using the National Environmental Method Index, Analytical Eco-Scale Assessment (ESA), and Green Analytical Procedure Index (GAPI). As these methods cover both qualitative and quantitative aspects, they offer better transparency. Overall, GAPI showed maximum greenness throughout the analysis. Method 6 was proven to be the method of choice for analyzing the mixture, owing to its greenness, according to NEMI, ESA, and GAPI. Additionally, method 6 has a wide scope of application (13 components can be analyzed), high sensitivity (low LOQ values), and fast analysis (low retention times, especially for glutamate and GABA).
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Affiliation(s)
- Atiah H. Almalki
- Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia;
- Addiction and Neuroscience Research Unit, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia; (H.O.A.); (Y.S.A.)
| | - Ibrahim A. Naguib
- Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia;
| | - Fahad S. Alshehri
- Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia;
| | - Badrah S. Alghamdi
- Neuroscience Unit, Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah 22252, Saudi Arabia;
- Pre-Clinical Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 22252, Saudi Arabia
| | - Hashem O. Alsaab
- Addiction and Neuroscience Research Unit, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia; (H.O.A.); (Y.S.A.)
- Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia;
| | - Yusuf S. Althobaiti
- Addiction and Neuroscience Research Unit, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia; (H.O.A.); (Y.S.A.)
- Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
| | - Sameer Alshehri
- Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia;
| | - Fatma F. Abdallah
- Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt;
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Bruegger D, Abegg M. Prediction of cortical theta oscillations in humans for phase-locked visual stimulation. J Neurosci Methods 2021; 361:109288. [PMID: 34274403 DOI: 10.1016/j.jneumeth.2021.109288] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/08/2020] [Revised: 07/09/2021] [Accepted: 07/10/2021] [Indexed: 11/17/2022]
Abstract
BACKGROUND The timing of an event within an oscillatory phase is considered to be one of the key strategies used by the brain to code and process neural information. Whereas existing methods of studying this phenomenon are chiefly based on retrospective analysis of electroencephalography (EEG) data, we now present a method to study it prospectively. New method: We present a system that allows for the delivery of visual stimuli at a specific phase of the cortical theta oscillation by fitting a sine to raw surface EEG data to estimate and predict the phase. One noteworthy feature of the method is that it can minimize potentially confounding effects of previous trials by using only a short sequence of past data. RESULTS In a trial with 10 human participants we achieved a significant phase locking with an inter-trial phase coherence of 0.39. We demonstrated successful phase locking on synthetic signals with a signal-to-noise ratio of less than - 20 dB. Comparison with existing method(s): We compared the new method to an autoregressive method published in the literature and found the new method was superior in mean phase offset, circular standard deviation, and prediction latency. CONCLUSIONS By fitting sine waves to raw EEG traces, we locked visual stimuli to arbitrary phases within the theta oscillatory cycle of healthy humans.
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Affiliation(s)
- D Bruegger
- Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Switzerland.
| | - M Abegg
- Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
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Babiloni C, Arakaki X, Bonanni L, Bujan A, Carrillo MC, Del Percio C, Edelmayer RM, Egan G, Elahh FM, Evans A, Ferri R, Frisoni GB, Güntekin B, Hainsworth A, Hampel H, Jelic V, Jeong J, Kim DK, Kramberger M, Kumar S, Lizio R, Nobili F, Noce G, Puce A, Ritter P, Smit DJA, Soricelli A, Teipel S, Tucci F, Sachdev P, Valdes-Sosa M, Valdes-Sosa P, Vergallo A, Yener G. EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel. Neurobiol Aging 2021; 103:78-97. [PMID: 33845399 DOI: 10.1016/j.neurobiolaging.2021.03.003] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/15/2020] [Revised: 02/17/2021] [Accepted: 03/05/2021] [Indexed: 11/22/2022]
Abstract
Vascular contribution to cognitive impairment (VCI) and dementia is related to etiologies that may affect the neurophysiological mechanisms regulating brain arousal and generating electroencephalographic (EEG) activity. A multidisciplinary expert panel reviewed the clinical literature and reached consensus about the EEG measures consistently found as abnormal in VCI patients with dementia. As compared to cognitively unimpaired individuals, those VCI patients showed (1) smaller amplitude of resting state alpha (8-12 Hz) rhythms dominant in posterior regions; (2) widespread increases in amplitude of delta (< 4 Hz) and theta (4-8 Hz) rhythms; and (3) delayed N200/P300 peak latencies in averaged event-related potentials, especially during the detection of auditory rare target stimuli requiring participants' responses in "oddball" paradigms. The expert panel formulated the following recommendations: (1) the above EEG measures are not specific for VCI and should not be used for its diagnosis; (2) they may be considered as "neural synchronization" biomarkers to enlighten the relationships between features of the VCI-related cerebrovascular lesions and abnormalities in neurophysiological brain mechanisms; and (3) they may be tested in future clinical trials as prognostic biomarkers and endpoints of interventions aimed at normalizing background brain excitability and vigilance in wakefulness.
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Affiliation(s)
- Claudio Babiloni
- Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy; San Raffaele Cassino, Cassino, FR, Italy.
| | | | - Laura Bonanni
- Department of Neuroscience Imaging and Clinical Sciences and CESI, University G D'Annunzio of Chieti-Pescara, Chieti, Italy
| | - Ana Bujan
- Psychological Neuroscience Lab, School of Psychology, University of Minho, Portugal
| | | | - Claudio Del Percio
- Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy
| | | | - Gary Egan
- Foundation Director of the Monash Biomedical Imaging (MBI) research facilities, Monash University, Clayton, Australia
| | - Fanny M Elahh
- Memory and Aging Center, University of California, San Francisco
| | - Alan Evans
- Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
| | | | - Giovanni B Frisoni
- Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland; Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
| | - Bahar Güntekin
- Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey; REMER, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey
| | - Atticus Hainsworth
- University of London St George's Molecular and Clinical Sciences Research Institute, London, UK
| | - Harald Hampel
- Sorbonne University, GRC No. 21, Alzheimer Precision Medicine, Pitié-Salpêtrière Hospital, Paris, France
| | - Vesna Jelic
- Division of Clinical Geriatrics, NVS Department, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
| | - Jaeseung Jeong
- Department of Bio and Brain Engineering/Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea
| | - Doh Kwan Kim
- Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, South Korea
| | - Milica Kramberger
- Center for cognitive and movement disorders, Department of neurology, University Medical Center Ljubljana, Slovenia
| | - Sanjeev Kumar
- Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada
| | | | - Flavio Nobili
- Clinica neurologica, IRCCS Ospedale Policlinico San Martino, Genova, Italy; Dipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-infantili (DiNOGMI)
| | | | - Aina Puce
- Department of Psychological and Brain Sciences at Indiana University in Bloomington, Indiana, USA
| | - Petra Ritter
- Brain Simulation Section, Department of Neurology, Charité Universitätsmedizin and Berlin Institute of Health, Berlin, Germany; Bernstein Center for Computational Neuroscience, Berlin, Germany
| | - Dirk J A Smit
- Department of Psychiatry Academisch Medisch Centrum Universiteit van Amsterdam, Amsterdam, the Netherlands
| | - Andrea Soricelli
- IRCCS SDN, Naples, Italy; Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy
| | - Stefan Teipel
- Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; German Center for Neurodegenerative Diseases (DZNE) - Rostock/Greifswald, Rostock, Germany
| | - Federico Tucci
- Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy
| | - Perminder Sachdev
- Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales; Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia
| | | | - Pedro Valdes-Sosa
- Cuban Neuroscience Center, Havana, Cuba; Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
| | - Andrea Vergallo
- Sorbonne University, GRC No. 21, Alzheimer Precision Medicine, Pitié-Salpêtrière Hospital, Paris, France
| | - Görsev Yener
- Izmir Biomedicine and Genome Center. Dokuz Eylul University Health Campus, Izmir, Turkey
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Côté V, Knoth IS, Agbogba K, Vannasing P, Côté L, Major P, Michaud JL, Barlaam F, Lippé S. Differential auditory brain response abnormalities in two intellectual disability conditions: SYNGAP1 mutations and Down syndrome. Clin Neurophysiol 2021; 132:1802-1812. [PMID: 34130248 DOI: 10.1016/j.clinph.2021.03.054] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/25/2020] [Revised: 03/06/2021] [Accepted: 03/31/2021] [Indexed: 10/21/2022]
Abstract
OBJECTIVE Altered sensory processing is common in intellectual disability (ID). Here, we study electroencephalographic responses to auditory stimulation in human subjects presenting a rare condition (mutations in SYNGAP1) which causes ID, epilepsy and autism. METHODS Auditory evoked potentials, time-frequency and inter-trial coherence analyses were used to compare subjects with SYNGAP1 mutations with Down syndrome (DS) and neurotypical (NT) participants (N = 61 ranging from three to 19 years of age). RESULTS Altered synchronization in the brain responses to sound were found in both ID groups. The SYNGAP1 mutations group showed less phase-locking in early time windows and lower frequency bands compared to NT, and in later time windows compared to NT and DS. Time-frequency analysis showed more power in beta-gamma in the SYNGAP1 group compared to NT participants. CONCLUSIONS This study indicated reduced synchronization as well as more high frequencies power in SYNGAP1 mutations, while maintained synchronization was found in the DS group. These results might reflect dysfunctional sensory information processing caused by excitation/inhibition imbalance, or an imperfect compensatory mechanism in SYNGAP1 mutations individuals. SIGNIFICANCE Our study is the first to reveal brain response abnormalities in auditory sensory processing in SYNGAP1 mutations individuals, that are distinct from DS, another ID condition.
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Affiliation(s)
- Valérie Côté
- Department of Psychology, University of Montreal, Montreal, Québec, Canada; CHU Sainte-Justine Research Center, Montreal, Quebec, Canada
| | - Inga S Knoth
- CHU Sainte-Justine Research Center, Montreal, Quebec, Canada
| | | | | | - Lucie Côté
- CHU Sainte-Justine Research Center, Montreal, Quebec, Canada
| | - Philippe Major
- CHU Sainte-Justine Research Center, Montreal, Quebec, Canada; Department of Pediatrics and Neurosciences, University of Montreal, Montreal, Quebec, Canada
| | - Jacques L Michaud
- CHU Sainte-Justine Research Center, Montreal, Quebec, Canada; Department of Pediatrics and Neurosciences, University of Montreal, Montreal, Quebec, Canada
| | - Fanny Barlaam
- CHU Sainte-Justine Research Center, Montreal, Quebec, Canada
| | - Sarah Lippé
- Department of Psychology, University of Montreal, Montreal, Québec, Canada; CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.
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Zhang G, Cui Y, Zhang Y, Cao H, Zhou G, Shu H, Yao D, Xia Y, Chen K, Guo D. Computational exploration of dynamic mechanisms of steady state visual evoked potentials at the whole brain level. Neuroimage 2021; 237:118166. [PMID: 34000401 DOI: 10.1016/j.neuroimage.2021.118166] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/05/2021] [Revised: 05/05/2021] [Accepted: 05/11/2021] [Indexed: 01/23/2023] Open
Abstract
Periodic visual stimulation can induce stable steady-state visual evoked potentials (SSVEPs) distributed in multiple brain regions and has potential applications in both neural engineering and cognitive neuroscience. However, the underlying dynamic mechanisms of SSVEPs at the whole-brain level are still not completely understood. Here, we addressed this issue by simulating the rich dynamics of SSVEPs with a large-scale brain model designed with constraints of neuroimaging data acquired from the human brain. By eliciting activity of the occipital areas using an external periodic stimulus, our model was capable of replicating both the spatial distributions and response features of SSVEPs that were observed in experiments. In particular, we confirmed that alpha-band (8-12 Hz) stimulation could evoke stronger SSVEP responses; this frequency sensitivity was due to nonlinear entrainment and resonance, and could be modulated by endogenous factors in the brain. Interestingly, the stimulus-evoked brain networks also exhibited significant superiority in topological properties near this frequency-sensitivity range, and stronger SSVEP responses were demonstrated to be supported by more efficient functional connectivity at the neural activity level. These findings not only provide insights into the mechanistic understanding of SSVEPs at the whole-brain level but also indicate a bright future for large-scale brain modeling in characterizing the complicated dynamics and functions of the brain.
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Affiliation(s)
- Ge Zhang
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035, Chengdu, China
| | - Yan Cui
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035, Chengdu, China
| | - Yangsong Zhang
- School of Computer Science and Technology, Southwest University of Science and Technology, Mianyang 621010, China
| | - Hefei Cao
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035, Chengdu, China
| | - Guanyu Zhou
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035, Chengdu, China
| | - Haifeng Shu
- Department of Neurosurgery, The General Hospital of Western Theater Command, Chengdu 610083, China
| | - Dezhong Yao
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035, Chengdu, China; School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, China.
| | - Yang Xia
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035, Chengdu, China
| | - Ke Chen
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035, Chengdu, China
| | - Daqing Guo
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035, Chengdu, China.
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Figueiro MG, Leggett S. Intermittent Light Exposures in Humans: A Case for Dual Entrainment in the Treatment of Alzheimer's Disease. Front Neurol 2021; 12:625698. [PMID: 33767659 PMCID: PMC7985540 DOI: 10.3389/fneur.2021.625698] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/03/2020] [Accepted: 02/15/2021] [Indexed: 12/26/2022] Open
Abstract
Circadian sleep disorders are common among American adults and can become especially acute among older adults, especially those living with Alzheimer's disease (AD) and mild cognitive impairment (MCI), leading to the exacerbation of symptoms and contributing to the development and advancement of the diseases. This review explores the connections between circadian sleep disorders, cognition, and neurodegenerative disease, offering insights on rapidly developing therapeutic interventions employing intermittent light stimuli for improving sleep and cognition in persons with AD and MCI. Light therapy has the potential to affect sleep and cognition via at least two pathways: (1) a regular and robust light-dark pattern reaching the retina that promotes circadian phase shifting, which can promote entrainment and (2) 40 Hz flickering light that promotes gamma-wave entrainment. While this is a new area of research, preliminary evidence shows the potential of dual circadian and gamma-wave entrainment as an important therapy not only for those with AD, but for others with cognitive impairment.
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Affiliation(s)
- Mariana G. Figueiro
- Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, United States
| | - Sagan Leggett
- Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, United States
- Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, United States
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Meyer L, Lakatos P, He Y. Language Dysfunction in Schizophrenia: Assessing Neural Tracking to Characterize the Underlying Disorder(s)? Front Neurosci 2021; 15:640502. [PMID: 33692672 PMCID: PMC7937925 DOI: 10.3389/fnins.2021.640502] [Citation(s) in RCA: 14] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/11/2020] [Accepted: 02/03/2021] [Indexed: 12/19/2022] Open
Abstract
Deficits in language production and comprehension are characteristic of schizophrenia. To date, it remains unclear whether these deficits arise from dysfunctional linguistic knowledge, or dysfunctional predictions derived from the linguistic context. Alternatively, the deficits could be a result of dysfunctional neural tracking of auditory information resulting in decreased auditory information fidelity and even distorted information. Here, we discuss possible ways for clinical neuroscientists to employ neural tracking methodology to independently characterize deficiencies on the auditory-sensory and abstract linguistic levels. This might lead to a mechanistic understanding of the deficits underlying language related disorder(s) in schizophrenia. We propose to combine naturalistic stimulation, measures of speech-brain synchronization, and computational modeling of abstract linguistic knowledge and predictions. These independent but likely interacting assessments may be exploited for an objective and differential diagnosis of schizophrenia, as well as a better understanding of the disorder on the functional level-illustrating the potential of neural tracking methodology as translational tool in a range of psychotic populations.
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Affiliation(s)
- Lars Meyer
- Research Group Language Cycles, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
- Clinic for Phoniatrics and Pedaudiology, University Hospital Münster, Münster, Germany
| | - Peter Lakatos
- Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, United States
| | - Yifei He
- Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany
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Basso JC, Satyal MK, Rugh R. Dance on the Brain: Enhancing Intra- and Inter-Brain Synchrony. Front Hum Neurosci 2021; 14:584312. [PMID: 33505255 PMCID: PMC7832346 DOI: 10.3389/fnhum.2020.584312] [Citation(s) in RCA: 32] [Impact Index Per Article: 8.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/16/2020] [Accepted: 12/03/2020] [Indexed: 12/11/2022] Open
Abstract
Dance has traditionally been viewed from a Eurocentric perspective as a mode of self-expression that involves the human body moving through space, performed for the purposes of art, and viewed by an audience. In this Hypothesis and Theory article, we synthesize findings from anthropology, sociology, psychology, dance pedagogy, and neuroscience to propose The Synchronicity Hypothesis of Dance, which states that humans dance to enhance both intra- and inter-brain synchrony. We outline a neurocentric definition of dance, which suggests that dance involves neurobehavioral processes in seven distinct areas including sensory, motor, cognitive, social, emotional, rhythmic, and creative. We explore The Synchronicity Hypothesis of Dance through several avenues. First, we examine evolutionary theories of dance, which suggest that dance drives interpersonal coordination. Second, we examine fundamental movement patterns, which emerge throughout development and are omnipresent across cultures of the world. Third, we examine how each of the seven neurobehaviors increases intra- and inter-brain synchrony. Fourth, we examine the neuroimaging literature on dance to identify the brain regions most involved in and affected by dance. The findings presented here support our hypothesis that we engage in dance for the purpose of intrinsic reward, which as a result of dance-induced increases in neural synchrony, leads to enhanced interpersonal coordination. This hypothesis suggests that dance may be helpful to repattern oscillatory activity, leading to clinical improvements in autism spectrum disorder and other disorders with oscillatory activity impairments. Finally, we offer suggestions for future directions and discuss the idea that our consciousness can be redefined not just as an individual process but as a shared experience that we can positively influence by dancing together.
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Affiliation(s)
- Julia C Basso
- Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, United States.,Center for Transformative Research on Health Behaviors, Fralin Biomedical Research Institute, Virginia Tech, Blacksburg, VA, United States.,School of Neuroscience, Virginia Tech, Blacksburg, VA, United States
| | - Medha K Satyal
- Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA, United States
| | - Rachel Rugh
- Center for Communicating Science, Virginia Tech, Blacksburg, VA, United States.,School of Performing Arts, Virginia Tech, Blacksburg, VA, United States
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Völker JM, Arguissain FG, Manresa JB, Andersen OK. Characterization of Source-Localized EEG Activity During Sustained Deep-Tissue Pain. Brain Topogr 2021; 34:192-206. [PMID: 33403561 DOI: 10.1007/s10548-020-00815-z] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/22/2020] [Accepted: 12/16/2020] [Indexed: 02/06/2023]
Abstract
Musculoskeletal pain is a clinical condition that is characterized by ongoing pain and discomfort in the deep tissues such as muscle, bones, ligaments, nerves, and tendons. In the last decades, it was subject to extensive research due to its high prevalence. Still, a quantitative description of the electrical brain activity during musculoskeletal pain is lacking. This study aimed to characterize intracranial current source density (CSD) estimations during sustained deep-tissue experimental pain. Twenty-three healthy volunteers received three types of tonic stimuli for three minutes each: computer-controlled cuff pressure (1) below pain threshold (sustained deep-tissue no-pain, SDTnP), (2) above pain threshold (sustained deep-tissue pain, SDTP) and (3) vibrotactile stimulation (VT). The CSD in response to these stimuli was calculated in seven regions of interest (ROIs) likely involved in pain processing: contralateral anterior cingulate cortex, contralateral primary somatosensory cortex, bilateral anterior insula, contralateral dorsolateral prefrontal cortex, posterior parietal cortex and contralateral premotor cortex. Results showed that participants exhibited an overall increase in spectral power during SDTP in all seven ROIs compared to both SDTnP and VT, likely reflecting the differences in the salience of these stimuli. Moreover, we observed a difference is CSD due to the type of stimulus, likely reflecting somatosensory discrimination of stimulus intensity. These results describe the different contributions of neural oscillations within these brain regions in the processing of sustained deep-tissue pain.
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Affiliation(s)
- Juan Manuel Völker
- Department of Health Science and Technology, Integrative Neuroscience Group, Center for Neuroplasticity and Pain (CNAP), Aalborg University, Aalborg, Denmark.
| | - Federico Gabriel Arguissain
- Department of Health Science and Technology, Integrative Neuroscience Group, Center for Neuroplasticity and Pain (CNAP), Aalborg University, Aalborg, Denmark
| | - José Biurrun Manresa
- Department of Health Science and Technology, Integrative Neuroscience Group, Center for Neuroplasticity and Pain (CNAP), Aalborg University, Aalborg, Denmark.,Institute for Research and Development in Bioengineering and Bioinformatics (IBB), CONICET-UNER, Oro Verde, Argentina
| | - Ole Kæseler Andersen
- Department of Health Science and Technology, Integrative Neuroscience Group, Center for Neuroplasticity and Pain (CNAP), Aalborg University, Aalborg, Denmark
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47
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The Necessity of Leave One Subject Out (LOSO) Cross Validation for EEG Disease Diagnosis. Brain Inform 2021. [DOI: 10.1007/978-3-030-86993-9_50] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022] Open
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48
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Erol Başar and the scientific revolution in nonlinear brain dynamics: A selective review. Int J Psychophysiol 2020; 158:419-431. [DOI: 10.1016/j.ijpsycho.2020.08.011] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/23/2020] [Revised: 08/15/2020] [Accepted: 08/24/2020] [Indexed: 11/23/2022]
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49
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Lejko N, Larabi DI, Herrmann CS, Aleman A, Ćurčić-Blake B. Alpha Power and Functional Connectivity in Cognitive Decline: A Systematic Review and Meta-Analysis. J Alzheimers Dis 2020; 78:1047-1088. [PMID: 33185607 PMCID: PMC7739973 DOI: 10.3233/jad-200962] [Citation(s) in RCA: 36] [Impact Index Per Article: 7.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/31/2022]
Abstract
Background: Mild cognitive impairment (MCI) is a stage between expected age-related cognitive decline and dementia. Dementias have been associated with changes in neural oscillations across the frequency spectrum, including the alpha range. Alpha is the most prominent rhythm in human EEG and is best detected during awake resting state (RS). Though several studies measured alpha power and synchronization in MCI, findings have not yet been integrated. Objective: To consolidate findings on power and synchronization of alpha oscillations across stages of cognitive decline. Methods: We included studies published until January 2020 that compared power or functional connectivity between 1) people with MCI and cognitively healthy older adults (OA) or people with a neurodegenerative dementia, and 2) people with progressive and stable MCI. Random-effects meta-analyses were performed when enough data was available. Results: Sixty-eight studies were included in the review. Global RS alpha power was lower in AD than in MCI (ES = –0.30; 95% CI = –0.51, –0.10; k = 6), and in MCI than in OA (ES = –1.49; 95% CI = –2.69, –0.29; k = 5). However, the latter meta-analysis should be interpreted cautiously due to high heterogeneity. The review showed lower RS alpha power in progressive than in stable MCI, and lower task-related alpha reactivity in MCI than in OA. People with MCI had both lower and higher functional connectivity than OA. Publications lacked consistency in MCI diagnosis and EEG measures. Conclusion: Research indicates that RS alpha power decreases with increasing impairment, and could—combined with measures from other frequency bands—become a biomarker of early cognitive decline.
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Affiliation(s)
- Nena Lejko
- University of Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells & Systems, Cognitive Neuroscience Center, Groningen, The Netherlands
| | - Daouia I Larabi
- University of Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells & Systems, Cognitive Neuroscience Center, Groningen, The Netherlands.,Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.,Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
| | | | - André Aleman
- University of Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells & Systems, Cognitive Neuroscience Center, Groningen, The Netherlands
| | - Branislava Ćurčić-Blake
- University of Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells & Systems, Cognitive Neuroscience Center, Groningen, The Netherlands
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50
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Karakaş S. A review of theta oscillation and its functional correlates. Int J Psychophysiol 2020; 157:82-99. [DOI: 10.1016/j.ijpsycho.2020.04.008] [Citation(s) in RCA: 33] [Impact Index Per Article: 6.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2019] [Revised: 04/06/2020] [Accepted: 04/09/2020] [Indexed: 12/29/2022]
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