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Demirel S. Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes. World J Diabetes 2024; 15:1122-1141. [PMID: 38983824 PMCID: PMC11229960 DOI: 10.4239/wjd.v15.i6.1122] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/30/2023] [Revised: 03/07/2024] [Accepted: 05/06/2024] [Indexed: 06/11/2024] Open
Abstract
Endothelial function plays a pivotal role in cardiovascular health, and dysfunction in this context diminishes vasorelaxation concomitant with endothelial activity. The nitric oxide-cyclic guanosine monophosphate pathway, prostacyclin-cyclic adenosine monophosphate pathway, inhibition of phosphodiesterase, and the opening of potassium channels, coupled with the reduction of calcium levels in the cell, constitute critical mechanisms governing vasorelaxation. Cardiovascular disease stands as a significant contributor to morbidity and mortality among individuals with diabetes, with adults afflicted by diabetes exhibiting a heightened cardiovascular risk compared to their non-diabetic counterparts. A plethora of medicinal plants, characterized by potent pharmacological effects and minimal side effects, holds promise in addressing these concerns. In this review, we delineate various medicinal plants and their respective biochemical constituents, showcasing concurrent vasorelaxant and anti-diabetic activities.
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Affiliation(s)
- Sadettin Demirel
- Medicine School, Physiology Department, Bursa Uludag University, Bursa 16059, Türkiye
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Réggami Y, Benkhaled A, Boudjelal A, Berredjem H, Amamra A, Benyettou H, Larabi N, Senator A, Siracusa L, Ruberto G. Artemisia herba-alba aqueous extract improves insulin sensitivity and hepatic steatosis in rodent model of fructose-induced metabolic syndrome. Arch Physiol Biochem 2021; 127:541-550. [PMID: 31464524 DOI: 10.1080/13813455.2019.1659825] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/13/2022]
Abstract
CONTEXT Fructose consumption is associated with the development of obesity and metabolic syndrome (MetS) in human and animal models. OBJECTIVE This study investigates the ability of an aqueous extract of Artemisia herba-alba Asso (AH) to ameliorate fructose-induced MetS in Male Wistar rats. METHODS AH extract at doses of 100, 200 and 400 mg/kg b.w./day was administered for six weeks to MetS animals. RESULTS Liquid fructose (10% w/v) intake did not vary total animal body weight, whereas, it produced moderate hyperglycemia associated with metabolic and histological alterations. Treating MetS rats with AH extract improved insulin sensitivity, alleviated atherogenic dyslipidaemia and decreased lipid deposition in their hepatic tissues. Additionally, AH extract was found to raise GSH level and antioxidant enzymes (GPx, GST and CAT) activities in rat livers homogenates. CONCLUSION The results here reported demonstrated, for the first time, that A. herba-alba have therapeutic proprieties against fructose-induced MetS in rodent model.
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Affiliation(s)
- Yassine Réggami
- Department of Microbiology and Biochemistry, Faculty of Sciences, Mohamed Boudiaf-M'sila University, M'sila, Algeria
- Laboratory of Biochemistry and Applied Microbiology, Department of Biochemistry, Faculty of Sciences, Badji Mokhtar-Annaba University, Annaba, Algeria
| | - Abderrahim Benkhaled
- Department of Microbiology and Biochemistry, Faculty of Sciences, Mohamed Boudiaf-M'sila University, M'sila, Algeria
| | - Amel Boudjelal
- Department of Microbiology and Biochemistry, Faculty of Sciences, Mohamed Boudiaf-M'sila University, M'sila, Algeria
| | - Hajira Berredjem
- Laboratory of Biochemistry and Applied Microbiology, Department of Biochemistry, Faculty of Sciences, Badji Mokhtar-Annaba University, Annaba, Algeria
| | - Amani Amamra
- Laboratory of Biochemistry and Applied Microbiology, Department of Biochemistry, Faculty of Sciences, Badji Mokhtar-Annaba University, Annaba, Algeria
| | - Halima Benyettou
- Department of Microbiology and Biochemistry, Faculty of Sciences, Mohamed Boudiaf-M'sila University, M'sila, Algeria
| | - Nadia Larabi
- Department of Microbiology and Biochemistry, Faculty of Sciences, Mohamed Boudiaf-M'sila University, M'sila, Algeria
| | - Abderrahmane Senator
- Laboratory of Applied Biochemistry, Faculty of Natural and Life Sciences, Ferhat Abbas-Setif University, Setif, Algeria
| | - Laura Siracusa
- Istituto di Chimica Biomolecolare del Consiglio Nazionale delle Ricerche (ICB-CNR), Catania, Italy
| | - Giuseppe Ruberto
- Istituto di Chimica Biomolecolare del Consiglio Nazionale delle Ricerche (ICB-CNR), Catania, Italy
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Henneh IT, Armah FA, Ameyaw EO, Biney RP, Obese E, Boakye-Gyasi E, Adakudugu EA, Ekor M. Analgesic Effect of Ziziphus abyssinica Involves Inhibition of Inflammatory Mediators and Modulation of K ATP Channels, Opioidergic and Nitrergic Pathways. Front Pharmacol 2021; 12:714722. [PMID: 34354595 PMCID: PMC8329242 DOI: 10.3389/fphar.2021.714722] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/25/2021] [Accepted: 07/01/2021] [Indexed: 11/13/2022] Open
Abstract
The diversity offered by natural products has timelessly positioned them as a good source for novel therapeutics for the management of diverse medical conditions, including pain. This study evaluated hydro-ethanolic root bark extract of Ziziphus abyssinica (ZAE) as well as β-amyrin and polpunonic acid isolated from the plant for analgesic property. The study also investigated the mechanism responsible for this action in the extract. The antinociceptive potential of ZAE (30, 100, and 300 mg/kg, p. o.) was assessed using the tail-immersion test (TIT), acetic acid-induced writhing test (AAT), and formalin test (FT). The extract’s effect on acute and chronic musculoskeletal pain was also assessed by administering carrageenan unilaterally into the rat gastrocnemius muscles and measuring pain at 12 h and 10 days for acute and chronic pain respectively. The involvement of pro-inflammatory mediators (prostaglandin E2, bradykinin, TNF-α, and IL-1β) was assessed. The possible pathways mediating the observed analgesic effect of ZAE were further assessed using the antagonists: naloxone, glibenclamide, NG-L-nitro-arginine methyl ester (L-NAME), atropine, nifedipine, and yohimbine in the FT. Also the analgesic effect of two triterpenoid compounds, β-amyrin and polpunonic acid, previously isolated from the plant was assessed using the TIT. The anti-nociceptive activity of ZAE was demonstrated in the TIT by the significant (p < 0.05) increase in tail withdrawal threshold in ZAE-treated mice. ZAE also markedly reduced writhing and paw licking responses in both AAT and FT and significantly (p < 0.05) attenuated both acute and chronic musculoskeletal pain. ZAE also significantly reversed hyperalgesia induced by intraplantar injection of PGE2, bradykinin, TNF-α, and IL-1β. Furthermore, data revealed the involvement of opioidergic, ATP-sensitive K+ channels and NO-cGMP pathways in the analgesic effect of ZAE. Both β-amyrin and polpunonic acid exhibited analgesic activity in the tail suspension test. Our study demonstrates ZAE as an important source of new therapeutic agents for pain management.
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Affiliation(s)
- Isaac Tabiri Henneh
- School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana
| | - Francis Ackah Armah
- Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana
| | - Elvis Ofori Ameyaw
- School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana
| | - Robert Peter Biney
- School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana
| | - Ernest Obese
- School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana
| | - Eric Boakye-Gyasi
- Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
| | | | - Martins Ekor
- Department of Pharmacology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana
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Singh V, Reddy R, Sinha A, Marturi V, Panditharadyula SS, Bala A. A Review on Phytopharmaceuticals having Concomitant Experimental Anti-diabetic and Anti-cancer Effects as Potential Sources for Targeted Therapies Against Insulin-mediated Breast Cancer Cell Invasion and Migration. CURRENT CANCER THERAPY REVIEWS 2021. [DOI: 10.2174/1573394716999200831113335] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/29/2022]
Abstract
Diabetes and breast cancer are pathophysiologically similar and clinically established
diseases that co-exist with a wider complex similar molecular signalling and having a similar set of
risk factors. Insulin plays a pivotal role in the invasion and migration of breast cancer cells. Several
ethnopharmacological evidences shed light on the concomitant anti-diabetic and anti-cancer activity
of medicinal plant and phytochemicals against breast tumors of patients with diabetes. This present
article reviewed the findings on medicinal plants and phytochemicals with concomitant antidiabetic
and anti-cancer effects reported in scientific literature to facilitate the development of dual-
acting therapies against diabetes and breast cancer. The schematic tabular form of published literature
on medicinal plants (63 plants belongs to 45 families) concluded the dynamics of phytochemicals
against diabetes and breast tumors that could be explored further for the discovery of therapies
for controlling of breast cancer cell invasion and migration in patients with diabetes.
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Affiliation(s)
- Vibhavana Singh
- Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, (NIPER) Hajipur, Export Promotion Industrial Park (EPIP) Hajipur, Bihar 844102, India
| | - Rakesh Reddy
- Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, (NIPER) Hajipur, Export Promotion Industrial Park (EPIP) Hajipur, Bihar 844102, India
| | - Antarip Sinha
- Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, (NIPER) Hajipur, Export Promotion Industrial Park (EPIP) Hajipur, Bihar 844102, India
| | - Venkatesh Marturi
- Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, (NIPER) Hajipur, Export Promotion Industrial Park (EPIP) Hajipur, Bihar 844102, India
| | - Shravani S. Panditharadyula
- Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, (NIPER) Hajipur, Export Promotion Industrial Park (EPIP) Hajipur, Bihar 844102, India
| | - Asis Bala
- Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, (NIPER) Hajipur, Export Promotion Industrial Park (EPIP) Hajipur, Bihar 844102, India
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Daoudi NE, Bouhrim M, Ouassou H, Bnouham M. Medicinal Plants as a Drug Alternative Source for the Antigout Therapy in Morocco. SCIENTIFICA 2020; 2020:8637583. [PMID: 33299636 PMCID: PMC7704184 DOI: 10.1155/2020/8637583] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 07/14/2020] [Revised: 11/04/2020] [Accepted: 11/10/2020] [Indexed: 06/12/2023]
Abstract
BACKGROUND The gout is a metabolic disease that is associated with a high level of uric acid in the blood. This disease is treated with some medications that aim to reduce serum urate levels. However, the use of various medicines leads to the appearance of some side effects, hence the importance of using other treatments based on natural resources. OBJECTIVE This study presents some medical treatments, their side effects, and some plants that are used for gout management in Morocco in the aim to valorize them. METHODS We have been consulting various English publications in PubMed, Web of Science, and ScienceDirect published between 1991 and 2019 using the following keywords "drugs," "gout," "Morocco," "medicinal plants," "in vitro," and "in vivo" terms. Then, we have classified the medicines, according to their action mechanisms, and we have cited some species that were reported in Moroccan pharmacopeia as antigout. RESULTS Three methods of the gout medical management were cited in this work: xanthine oxidase inhibitors, uric acid excretion enhancer, and uricase recombinant. However, it was found that these treatments had various side effects. We have described 23 species, and some of them showed experimentally an antigout effect by blocking the "xanthine oxidase" enzyme. These plants belong to 11 families. Lamiaceae represents the most dominant family with six species followed by Asteraceae with two species. Colchicine isolated from Colchicum autumnale is the most known compound for its efficiency towards gout. CONCLUSION This work summarized different treatments particularly medicinal plants that are used in Morocco to treat gout disease by blocking uric acid secretion. However, several studies are needed to valorize these antigout natural sources.
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Affiliation(s)
- Nour Elhouda Daoudi
- Laboratory of Bioresources Biotechnology Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohamed I, Oujda, Morocco
| | - Mohamed Bouhrim
- Laboratory of Bioresources Biotechnology Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohamed I, Oujda, Morocco
| | - Hayat Ouassou
- Laboratory of Bioresources Biotechnology Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohamed I, Oujda, Morocco
| | - Mohamed Bnouham
- Laboratory of Bioresources Biotechnology Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohamed I, Oujda, Morocco
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Lutgen P, Munyangi J, Idumbo M, Mupenda B. Five case reports on treatment of diabetes by Artemisia annua and Artemisia afra herbal tea. ACTA ACUST UNITED AC 2020. [DOI: 10.15406/ppij.2020.08.00283] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/06/2022]
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Al-Wahaibi LHN, Mahmood A, Khan M, Alkhathlan HZ. Comparative study on the essential oils of Artemisia judaica and A. herba-alba from Saudi Arabia. ARAB J CHEM 2020. [DOI: 10.1016/j.arabjc.2018.03.004] [Citation(s) in RCA: 15] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/17/2022] Open
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Salehi B, Ata A, V. Anil Kumar N, Sharopov F, Ramírez-Alarcón K, Ruiz-Ortega A, Abdulmajid Ayatollahi S, Valere Tsouh Fokou P, Kobarfard F, Amiruddin Zakaria Z, Iriti M, Taheri Y, Martorell M, Sureda A, N. Setzer W, Durazzo A, Lucarini M, Santini A, Capasso R, Adrian Ostrander E, -ur-Rahman A, Iqbal Choudhary M, C. Cho W, Sharifi-Rad J. Antidiabetic Potential of Medicinal Plants and Their Active Components. Biomolecules 2019; 9:551. [PMID: 31575072 PMCID: PMC6843349 DOI: 10.3390/biom9100551] [Citation(s) in RCA: 271] [Impact Index Per Article: 45.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/29/2019] [Revised: 09/17/2019] [Accepted: 09/25/2019] [Indexed: 12/11/2022] Open
Abstract
Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.
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Affiliation(s)
- Bahare Salehi
- Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran;
| | - Athar Ata
- Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada;
| | - Nanjangud V. Anil Kumar
- Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal 576104, India;
| | - Farukh Sharopov
- Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan;
| | - Karina Ramírez-Alarcón
- Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepción 4070386, Chile;
| | - Ana Ruiz-Ortega
- Facultad de Educación y Ciencias Sociales, Universidad Andrés Bello, Autopista Concepción—Talcahuano, Concepción 7100, Chile;
| | - Seyed Abdulmajid Ayatollahi
- Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran; (S.A.A.); (F.K.); (Y.T.)
- Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
| | - Patrick Valere Tsouh Fokou
- Department of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon;
| | - Farzad Kobarfard
- Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran; (S.A.A.); (F.K.); (Y.T.)
- Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
| | - Zainul Amiruddin Zakaria
- Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia;
- Integrative Pharmacogenomics Institute (iPROMISE), Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam Selangor 42300, Malaysia
| | - Marcello Iriti
- Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy
| | - Yasaman Taheri
- Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran; (S.A.A.); (F.K.); (Y.T.)
| | - Miquel Martorell
- Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepción 4070386, Chile;
- Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción 4070386, Chile
| | - Antoni Sureda
- Research Group on Community Nutrition and Oxidative Stress, Laboratory of Physical Activity Sciences, and CIBEROBN—Physiopathology of Obesity and Nutrition, CB12/03/30038, University of Balearic Islands, E-07122 Palma de Mallorca, Spain;
| | - William N. Setzer
- Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA;
| | - Alessandra Durazzo
- CREA—Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy; (A.D.); (M.L.)
| | - Massimo Lucarini
- CREA—Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy; (A.D.); (M.L.)
| | - Antonello Santini
- Department of Pharmacy, University of Napoli Federico II, Via D. Montesano, 49-80131 Napoli, Italy
| | - Raffaele Capasso
- Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy;
| | - Elise Adrian Ostrander
- Medical Illustration, Kendall College of Art and Design, Ferris State University, Grand Rapids, MI 49503, USA;
| | - Atta -ur-Rahman
- H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; (A.-u.-R.); (M.I.C.)
| | - Muhammad Iqbal Choudhary
- H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; (A.-u.-R.); (M.I.C.)
| | - William C. Cho
- Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China
| | - Javad Sharifi-Rad
- Department of Pharmacology, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft 7861756447, Iran
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Hamza N, Berke B, Umar A, Cheze C, Gin H, Moore N. A review of Algerian medicinal plants used in the treatment of diabetes. JOURNAL OF ETHNOPHARMACOLOGY 2019; 238:111841. [PMID: 30959140 DOI: 10.1016/j.jep.2019.111841] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/12/2018] [Revised: 03/26/2019] [Accepted: 03/26/2019] [Indexed: 05/27/2023]
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE Plants are traditionally used in Algeria to treat many disorders, including diabetes mellitus. Knowledge of the plants that are used may provide insight on their properties, for further exploration. This study reviewed all the available published and unpublished reports concerning the use of herbal medicines in the treatment of diabetes in Algeria. AIM OF THE STUDY To describe the plants used in Algeria to treat diabetes, as reported in the literature. MATERIAL AND METHODS Systematic review of ethnobotanical papers published in the medical literature, from literature databases (Pubmed, Web of Science), as well as Google, for English, French and Arabic -language publication, and a manual search of local libraries and bookshops, as well as the university repository of PhD and master's theses. The reference lists of the papers retrieved were also examined for further papers. RESULTS Many plants are cited in the ethnobotanical surveys, but only very few pharmacological studies were found. In the ethnobotanical surveys, 171 plants were reported, from 58 families of which the most often cited were Asteraceae, Lamiaceae and Apiaceae. The plants with the best evidence of use and activity are: Anabasis articulata (Forssk.) Moq., Trigonella foenum-graecum L., Centaurium erythraea Rafn, Artemisia herba-alba Asso, Marrubium vulgare L., Agathophora alopecuroides (Delile) Fenzl ex Bunge, Anabasis articulata (Forssk.) Moq., Hammada elegans (Bunge) Botsch., Helianthemum kahiricum Delile, Salsola baryosma (Schult.) Dandy, Salsola vermiculata L., Olea europaea L. CONCLUSION Traditional herbal medicines are still very much used in Algeria to control diabetes. However they are generally poorly characterized and none have been properly tested in man. There is a need for systematic evaluation of the more commonly used plants to confirm their antidiabetic activity, identify possible mechanimss of action, and recommend best use.
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Affiliation(s)
- Nawel Hamza
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, F33076, France; Département de Nutrition, Université des Frères Mentouri, INATAA, Constantine, 25000, Algeria.
| | - Bénédicte Berke
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, F33076, France
| | - Anwar Umar
- Department of Pharmacology, Xinjiang Medical University, Urumqi, 830011, China
| | - Catherine Cheze
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, F33076, France
| | - Henri Gin
- University of Bordeaux, Bordeaux University Hospital, France
| | - Nicholas Moore
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, F33076, France; Department of Pharmacology, Xinjiang Medical University, Urumqi, 830011, China.
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Aba PE, Asuzu IU. Glycosylated haemoglobin values of alloxan-induced diabetic rats treated with graded doses of Cussonia arborea extract. JOURNAL OF APPLIED ANIMAL RESEARCH 2018. [DOI: 10.1080/09712119.2018.1544902] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 10/27/2022]
Affiliation(s)
- Patrick Emeka Aba
- Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria
| | - Isaac Uzoma Asuzu
- Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria
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Abdelhalim A, Aburjai T, Hanrahan J, Abdel-Halim H. Medicinal Plants Used by Traditional Healers in Jordan, the Tafila Region. Pharmacogn Mag 2017; 13:S95-S101. [PMID: 28479733 PMCID: PMC5407123 DOI: 10.4103/0973-1296.203975] [Citation(s) in RCA: 27] [Impact Index Per Article: 3.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/21/2016] [Revised: 09/20/2016] [Indexed: 12/02/2022] Open
Abstract
Background: The reporting of the medicinal plants and their traditional uses is important in order to prevent this knowledge from being lost. The aims of this study were to collect information concerning the traditional use of medicinal plants in the region of Tafila; identify the most important medicinal plants; determine the relative importance of the species surveyed; and calculate the informant consensus factor (Fic) in relation to medicinal plant use. Materials and Methods: Data on the traditional medicinal uses of local plants were collected using qualitative tools. The informant consensus factor (Fic) for the category of aliments and the use value (UV) of the plant species were calculated. Results and Conclusions: The survey revealed that 41 plant species are still in use in Tafila for the treatments of various diseases. Problems of the digestive system had the highest Fic values, while Allium cepa L. and Matricaria aurea (Loefl.) Sch. Bip. scored the highest UV. SUMMARY
The medicinal plants used by local people of the Tafila area of Jordan their traditional uses were investigated. forty one plant species are still in use in Tafila for the traditional treatment of various diseases. The preservation of this knowledge is important not only for maintaining cultural and traditional resources but also as a resource for the future identification of leads for drug development. The use of Fic and the UV to identify plant species that are consistently used in the treatment of specific ailments assists in narrowing down the search for new effective plant-derived medicines and in validating the use of traditional medicines. Data on the traditional medicinal uses of local plants was collected using qualitative tools. The informant consensus factor (Fic) for category of aliments and the use value (UV) of the plant species were calculated. in the Tafila region, the Fic values are relatively low, indicating a low level of shared knowledge and that a number of different species are used to treat similar disorders. This may be a result of the great diversity of vegetation types found across the Tafila region, with the specific plant chosen being dependent on the species most readily available in the different vegetation zones. Interestingly, however, the UVs calculated for a number of species in the Tafila region are relatively high, compared with those recorded in other areas of Jordan. These high UVs indicate that despite the diversity of vegetation types across the Tafila region, a number of plants are highly valued for medicinal use throughout the whole region. This study contributes to the body of knowledge about the use of plants in traditional medicine, helping to document and maintain the knowledge that has been traditionally passed directly from person to person. The preservation of this knowledge is important not only for maintaining cultural and traditional resources but also as a resource for the future identification of leads for drug development. Problems of the digestive system had the highest Fic values, while Allium cepa L. and Matricaria aurea (Loefl.) Sch. Bip. scored the highest UV. Comparison with other ethnopharmacological studies in the region found consensus about many of the uses reported, and also identified localized uses of some species. Experimental evidence from the literature offered support for many of the reported uses. Abbreviations used: Fic: Informants consensus factor, nur: number of use reports per each category, nt: number of taxa used, UV: use value of a species, U: number of uses per species, n: number of informants
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Affiliation(s)
- Abeer Abdelhalim
- Faculty of Science, Taibah University, Almadinah Almunawarrah, Saudi Arabia
| | - Talal Aburjai
- Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan
| | - Jane Hanrahan
- Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
| | - Heba Abdel-Halim
- Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan
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Mahboubi M. Artemisia sieberi Besser essential oil and treatment of fungal infections. Biomed Pharmacother 2017; 89:1422-1430. [PMID: 28346993 DOI: 10.1016/j.biopha.2017.03.036] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/21/2017] [Revised: 03/11/2017] [Accepted: 03/14/2017] [Indexed: 11/15/2022] Open
Abstract
A. sieberi essential oil has been used for treatment of hardly curable infectious ulcers in Middle East Medicine and has been famous due to its wormicide effects. In this review, we evaluated the potency of A. sieberi essential oil in treatment of fungal infections. We searched in PubMed Central, Science direct, Wiley, Springer, SID, and accessible books, reports, thesis. There is a lot of mixed information on chemical compositions of A. sieberi essential oil, but most articles reported α, β-thujones as the main components of essential oils. In vitro studies confirmed the antifungal activity of A. sieberi essential oil against saprophytes fungi, dermatophytes, Malassezia sp. and Candida sp. and these results were confirmed in six clinical studies. The clinical studies confirmed the superiority of A. sieberi essential oil (5%) lotion in improvement of clinical signs of fungal superficial diseases, and mycological laboratory examinations of dermatophytosis and pityriasis versicolor diseases than clotrimazole (1%) topical treatment. The recurrence rate of superficial fungal infections with dermatophytosis and pityriasis versicolor was statistically lower in A. sieberi essential oil (5%) lotion than clotrimazole. There are no adverse effects due to the application of A. sieberi essential oil in clinical studies. Despite, the efficacy of A. sieberi essential oil against Candida sp., there is no clinical study about their related infections. Investigation about the effects of A. sieberi essential oil on fungal virulence factors in order to identifying the exact mechanism of antifungal activity and clinical trials on Candida related diseases are recommended.
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Affiliation(s)
- Mohaddese Mahboubi
- Department of Microbiology, Medicinal Plants Research Center of Barij, Kashan, Iran.
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Barkaoui M, Katiri A, Boubaker H, Msanda F. Ethnobotanical survey of medicinal plants used in the traditional treatment of diabetes in Chtouka Ait Baha and Tiznit (Western Anti-Atlas), Morocco. JOURNAL OF ETHNOPHARMACOLOGY 2017; 198:338-350. [PMID: 28109915 DOI: 10.1016/j.jep.2017.01.023] [Citation(s) in RCA: 77] [Impact Index Per Article: 9.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/19/2016] [Revised: 01/10/2017] [Accepted: 01/14/2017] [Indexed: 05/24/2023]
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE In Morocco, diabetes mellitus is a major public health problem with more than 1.5 million cases in 2014. Medicinal plants are widely used by the Moroccan population to treat the illness. AIM OF THE STUDY The aim of this work is to make an inventory of plant species used in folk medicine for the management of diabetes in Chtouka Ait Baha and Tiznit provinces. MATERIALS AND METHODS The survey was carried out by means of semi-structured questionnaires. A total of 380 interviews were conducted with traditional health practitioners and knowledgeable villagers. The data were analyzed through use value (UV), fidelity level (FL) and relative frequency of citation (RFC). RESULTS In total, 48 plant species belonging to 25 families were reported. Lamiaceae, Asteraceae and Apiaceae were reported as the most represented families. Six plants are reported for the first time as used in traditional treatment of diabetes and one plant species was previously unknown for its medicinal use to treat diabetes in Morocco. The most frequently cited plant species are Allium sativum L., Salvia officinalis L., Marrubium vulgare L. and Lavandula dentata L. Leaves were the most cited plant part used, decoction is the preferred mode of preparation. CONCLUSION This study showed the importance of folk medicine in the healthcare system for the local people living in the study area. The current study represents a useful documentation, which can contribute to preserving knowledge on the use of medicinal plants in this region and to explore the phytochemical and pharmacological potential of medicinal plants.
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Affiliation(s)
- M Barkaoui
- Laboratoire de Biotechnologies et Valorisation des Ressources Naturelles, Faculté des Sciences, Université Ibn Zohr, Agadir, Morocco
| | - A Katiri
- Laboratoire de Biotechnologies et Valorisation des Ressources Naturelles, Faculté des Sciences, Université Ibn Zohr, Agadir, Morocco
| | - H Boubaker
- Laboratoire de Biotechnologies et Valorisation des Ressources Naturelles, Faculté des Sciences, Université Ibn Zohr, Agadir, Morocco
| | - F Msanda
- Laboratoire de Biotechnologies et Valorisation des Ressources Naturelles, Faculté des Sciences, Université Ibn Zohr, Agadir, Morocco.
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Hamza N, Berke B, Cheze C, Marais S, Lorrain S, Abdouelfath A, Lassalle R, Carles D, Gin H, Moore N. Effect of Centaurium erythraea Rafn, Artemisia herba-alba Asso and Trigonella foenum-graecum L. on liver fat accumulation in C57BL/6J mice with high-fat diet-induced type 2 diabetes. JOURNAL OF ETHNOPHARMACOLOGY 2015; 171:4-11. [PMID: 26023031 DOI: 10.1016/j.jep.2015.05.027] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/13/2015] [Revised: 05/08/2015] [Accepted: 05/16/2015] [Indexed: 06/04/2023]
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE Centaurium erythraea Rafn (CE), Artemisia herba-alba Asso (AHA) and Trigonella foenum-graecum L. (TFG) are traditionally used to treat type 2 diabetes in Algeria, previous studies have found that extracts of these plants were effective to treat or prevent experimental diabetes induced by high-fat diet (HFD). AIM OF THE STUDY Describe the additional effects of these extracts on lipid tissue deposition in HFD. MATERIALS AND METHODS Male C57BL/6J mice were fed with HFD to induce type 2 Diabetes. Groups of mice were given plant extracts orally at 2g/kg/bodyweight daily for 20 weeks during establishment of diabetes, or for 18 weeks after confirmation of diabetes at the 17th week. Liver and other tissue samples were stained with Oil Red O. RESULTS Liver steatosis was confirmed with HFD. CE, AHA and TFG extracts improved liver steatosis by the end of the preventive (20 weeks) and curative periods (35 weeks). This was most marked for CE extract (p<0.05), less so with TFG and AHA. No steatosis was found in other tissues. CONCLUSION CE extract had a clear hepatoprotective effect in this mouse model of diet-induced type 2 diabetes. AHA and TFG had a minimal or no significant effect on steatosis. Beyond its effect as an antidiabetic agent, CE may also be promising to prevent or treat non-alcoholic liver steatosis.
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Affiliation(s)
- Nawel Hamza
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, France; Département de Nutrition, Université des frères Mentouri, INATAA, Constantine, Algerie.
| | - Bénédicte Berke
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, France
| | - Catherine Cheze
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, France
| | - Sébastien Marais
- Bordeaux Imaging Center, UMS 3420 CNRS, Université de Bordeaux, Bordeaux, France
| | - Simon Lorrain
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, France
| | | | - Regis Lassalle
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, France
| | - Dominique Carles
- Unité de pathologie fœtoplacentaire, Université de Bordeaux, CHU de Bordeaux, Hôpital Pellegrin, Bordeaux, France
| | - Henri Gin
- Service de Nutrition Diabétologie et Maladies Métaboliques, CHU de Bordeaux, Haut-Levèque, Bordeaux, France
| | - Nicholas Moore
- Département de Pharmacologie, Université de Bordeaux, Bordeaux, France.
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Moufid A, Eddouks M. Artemisia herba alba: a popular plant with potential medicinal properties. Pak J Biol Sci 2013; 15:1152-9. [PMID: 23755405 DOI: 10.3923/pjbs.2012.1152.1159] [Citation(s) in RCA: 24] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/15/2022]
Abstract
Artemisia herba alba (Asteraceae), commonly known as desert or white wormwood, is used in folk medicine for treatment of various diseases. Phytochemical studies of this plant revealed the existence of many beneficial compounds such as herbalbin, cis-chryanthenyl acetate, flavonoids (hispidulin and cirsilineol), monoterpenes, sesquiterpene. The aerial parts are characterized by a very low degree of toxicity. This study reviews the main reports of the pharmacological and toxicological properties of Artemisia herba alba in addition to the main constituents. It would appear that this plant exhibits many beneficial properties. Further studies are warranted to more integrate this popular plant in human health care system.
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Affiliation(s)
- Abderrahmane Moufid
- Faculty of Sciences and Techniques Errachidia, B.P 21, Errachidia 52000, Morocco
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Al-Aboudi A, Afifi FU. Plants used for the treatment of diabetes in Jordan: a review of scientific evidence. PHARMACEUTICAL BIOLOGY 2011; 49:221-239. [PMID: 20979537 DOI: 10.3109/13880209.2010.501802] [Citation(s) in RCA: 32] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/30/2023]
Abstract
CONTEXT Diabetes is a serious disease which has reached epidemic proportions in many parts of the world. Despite the tremendous developments in medicinal chemistry, traditional medicine is still a common practice for the treatment of diabetes. OBJECTIVES In Jordanian traditional medicine, 69 plant species are used by diabetic patients to reduce glucose levels in blood. The aim of the present study is to report these plants and link their traditional use with scientific evidence confirming their claimed activity. The plant part(s) used, method(s) of preparation, common Arabic names, and other ethnopharmacological uses are also listed. MATERIALS AND METHODS The literature and databases (SciFinder, PubMed, ScienceDirect and Scirus) have been thoroughly investigated and the plants used have been grouped according to the reported scientific evidence. RESULTS Results showed that 40 plants have been reported to possess hypoglycemic activities in in vivo/in vitro experiments. Five plant species did not exhibit in vivo hypoglycemic activity, while 24 plants had not been studied for such an activity. Twenty plants had been screened for their α-amylase/α-glucosidase inhibitory activities. DISCUSSION The reported in vivo and in vitro hypoglycemic as well as α-amylase/α-glucosidase inhibitory activities of these plants are discussed. CONCLUSION Additional in vitro and in vivo studies are needed to test the hypoglycemic activity of the plants with claimed antidiabetic activity which has not yet been evaluated. Identification of the active ingredients of potent plants might generate lead compounds in drug discovery and development.
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Affiliation(s)
- Amal Al-Aboudi
- Department of Chemistry, Faculty of Science, University of Jordan, Amman
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Bezza L, Mannarino A, Fattarsi K, Mikail C, Abou L, Hadji-Minaglou F, Kaloustian J. Composition chimique de l’huile essentielle d’Artemisia herba-alba provenant de la région de Biskra (Algérie). ACTA ACUST UNITED AC 2010. [DOI: 10.1007/s10298-010-0576-3] [Citation(s) in RCA: 17] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]
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Hamza N, Berke B, Cheze C, Agli AN, Robinson P, Gin H, Moore N. Prevention of type 2 diabetes induced by high fat diet in the C57BL/6J mouse by two medicinal plants used in traditional treatment of diabetes in the east of Algeria. JOURNAL OF ETHNOPHARMACOLOGY 2010; 128:513-518. [PMID: 20064599 DOI: 10.1016/j.jep.2010.01.004] [Citation(s) in RCA: 49] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/07/2009] [Revised: 12/02/2009] [Accepted: 01/03/2010] [Indexed: 05/28/2023]
Abstract
AIM OF THE STUDY The preventive effect of the hydro-alcoholic extracts of Artemisia herba-alba Asso (AHA), and Centaurium erythraea Rafn (CE), two medicinal plants used in traditional treatment of diabetes in the north-eastern Algeria, were evaluated in animal models of type 2 diabetic induced with a standardised high fat diet (HFD). MATERIALS AND METHODS Plant extracts were administered orally by gavage at a dose of 2g/kg bodyweight daily for 20 weeks to male C57BL/6J mice fed HFD. Animals were weighed and plasma glucose measured weekly and insulin at the end of study using standard ELISA methods. RESULTS After 6 weeks, blood glucose levels increased in HFD control mice. At end of study (20 weeks) in groups treated with AHA or CE extracts vs. HFD control group there was a significant reduction in mean (+/-SD) fasting blood glucose (respectively 108.0+/-42.0 and 120.4+/-45.1 vs. 183.1+/-19.1mg/dl, p<0.05), triglyceride concentrations (26.9+/-6.7 and 27.9+/-17.8 vs. 48.9+/-12.1mg/dl, p<0.05) and serum insulin levels (1.1+/-1.0 and 0.6+/-0.7 vs. 3.1+/-1.8 ng/ml, p<0.05). Plant extracts also markedly reduced insulin resistance as measured by the homeostasis model assessment (HOMA) compared to HFD controls (AHA: 4.4+/-5.3, CE: 3.0+/-3.3 vs. HFD control 38.3+/-26.6, p<0.05). The plant extracts had no effect on calorie intake or body weight. CONCLUSION AHA had been shown to have a hypoglycaemic effect in diabetes but this is the first demonstration of a preventive effect of AHA and CE on HFD-induced diabetes.
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Affiliation(s)
- Nawel Hamza
- Département de Pharmacologie, Université Victor Segalen Bordeaux 2, Bordeaux, France
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Musabayane CT, Xozwa K, Ojewole JAO. Effects ofHypoxis hemerocallidea(Fisch. & C.A. Mey.) [Hypoxidaceae] Corm (African Potato) Aqueous Extract on Renal Electrolyte and Fluid Handling in the Rat. Ren Fail 2009; 27:763-70. [PMID: 16350831 DOI: 10.1080/08860220500244807] [Citation(s) in RCA: 20] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/25/2022] Open
Abstract
Current biomedical evidence suggests that Hypoxis hemerocallidea (Fisch. & C.A. Mey.) [Hypoxidaceae] (African Potato [AP]) corm extract may be useful in the management of type 2 diabetes mellitus. However, more recent reports have also indicated that certain herbal extracts attenuate the deterioration of kidney function in diabetes mellitus. Accordingly, this study investigated the effects of short- (acute) and long-term (chronic) administration of H. hemerocallidea corm aqueous extract (APE) on renal fluid and electrolyte handling in male Wistar rats. Acute effects of APE were investigated in separate groups of anesthetized rats challenged with a continuous jugular infusion of 0.077 M NaCl at 9 mL x h(- 1). After a 3.5-h equilibration period, consecutive 30-min urine collections were made over the subsequent 4 h of 1-h control, 1.5-h treatment, and 1.5-h recovery periods for measurements of urine flow, Na+, and K+ excretion rates. To establish the effects of acute APE, the extract was added to the infusate at doses of 90, 180, or 360 microg x h (-1) in separate groups of rats during the treatment period. For chronic studies, individually caged rats were administered twice with APE (30 mg x kg (-1) PO) every third consecutive day at 09h00 and 17h00 for 5 weeks. Control rats received distilled water (3 mL x kg(-1)). Urine volume and total urinary outputs of creatinine, Na+, and K+ were determined from 24-h samples. Acute infusion of APE produced a dose-dependent, significant (p < 0.01) decrease in urine flow, K+, and Na+ excretion rates. Chronic APE treatment significantly reduced urinary Na+ output between weeks 2 and 5, without affecting either urine flow or K+ excretion rates. When compared with control animals, APE significantly reduced GFR (2.54+/-0.09 mL x min (-1) vs. 1.52+/-0.02 mL x min (-1)) and increased plasma creatinine concentration (55 +/- 3 micromol x L(-1) vs. 68 +/-6 micromol x L(-1)). The results from this study suggest that the H. hemerocallidea corm aqueous extract may impair kidney function.
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Affiliation(s)
- C T Musabayane
- Department of Human Physiology, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
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Musabayane CT, Gondwe M, Kamadyaapa DR, Chuturgoon AA, Ojewole JAO. Effects ofFicus thonningii(Blume) [Morarceae] Stem-Bark Ethanolic Extract on Blood Glucose, Cardiovascular and Kidney Functions of Rats, and on Kidney Cell Lines of the Proximal (LLC-PK1) and Distal Tubules (MDBK). Ren Fail 2009; 29:389-97. [PMID: 17497459 DOI: 10.1080/08860220701260735] [Citation(s) in RCA: 20] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2022] Open
Abstract
Previous observations indicate that Ficus thonningii (Blume) [Moraceae] stem-bark extracts may be useful in the control of diabetes mellitus. Accordingly, we investigated in some experimental animal paradigms the effects of F. thonningii stem-bark ethanolic extract (FTE) on renal and cardiovascular functions as complications of diabetes. Oral glucose tolerance tests were conducted in separate groups of non-diabetic and STZ-treated diabetic rats given glucose load (0.86 g x kg(-1), p.o.) after 18-h fast, followed by various FTE doses (60, 120, and 240 mg x kg(-1)). Rats treated with deionized water (3 mL x kg(-1) p.o.), or metformin (500 mg x kg(-1) p.o.) acted as untreated and treated positive controls, respectively. Blood glucose was monitored at 15-min intervals for the first hour, and hourly thereafter for 3 h. Acute effects of FTE on kidney function and mean arterial blood pressure (MAP) were investigated in anaesthetized rats challenged with hypotonic saline after a 3.5-h equilibration for 4 h of 1 h control, 1.5 h treatment, and 1.5 h recovery periods. FTE was added to the infusate during the treatment period. Chronic effects of FTE were studied in individually caged rats treated daily with FTE (120 mg x kg(-1), p.o.) for five weeks. Cytotoxicity of FTE was assessed by dye-reduction colorimetric (MTT) assay on MDBK and LLCPK1 kidney cell lines exposed for 24 h, 48 h, and 72 h to graded concentrations of the extract. Myocardial contractile performance was evaluated on rat isolated atrial muscle strips. FTE, like metformin, decreased blood glucose levels in non-diabetic and STZ-diabetic rats. Both acute and chronic FTE treatments did not affect renal function. In vitro studies demonstrated that FTE increased MDBK cell metabolic activity by an average of 15% (72 h), and LLCPK1 mirrored the controls. Acute intravenous infusion of FTE reduced the MAP from 119 +/- 1 mmHg to 98 +/- 4 mmHg. The MAP also was reduced throughout the five-week experimental study period. FTE also produced concentration-dependent, negative inotropic and chronotropic effects on rat isolated, electrically driven left-, and spontaneously beating right-, atrial muscle preparations. Our experimental findings suggest that FTE possesses reno- and cardio-protective effects in diabetes mellitus.
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Affiliation(s)
- C T Musabayane
- Discipline of Human Physiology, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
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Essential oil composition of Artemisia herba-alba from southern Tunisia. Molecules 2009; 14:1585-94. [PMID: 19384287 PMCID: PMC6254365 DOI: 10.3390/molecules14041585] [Citation(s) in RCA: 45] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/19/2009] [Revised: 02/27/2009] [Accepted: 03/09/2009] [Indexed: 11/16/2022] Open
Abstract
The composition of the essential oil hydrodistilled from the aerial parts of 18 individual Artemisia herba-alba Asso. plants collected in southern Tunisia was determined by GC and GCMS analysis. The oil yield varied between 0.68% v/w and 1.93% v/w. One hundred components were identified, 21 of of which are reported for the first time in Artemisia herba-alba oil. The oil contained 10 components with percentages higher than 10%. The main components were cineole, thujones, chrysanthenone, camphor, borneol, chrysanthenyl acetate, sabinyl acetate, davana ethers and davanone. Twelve samples had monoterpenes as major components, three had sesquiterpenes as major components and the last three samples had approximately the same percentage of monoterpenes and sesquiterpenes. The chemical compositions revealed that ten samples had compositions similar to those of other Artemisia herba-alba essential oils analyzed in other countries. The remaining eight samples had an original chemical composition.
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Abid ZB, Feki M, Hédhili A, Hamdaoui MH. Artemisia herba-alba Asso (Asteraceae) has equivalent effects to green and black tea decoctions on antioxidant processes and some metabolic parameters in rats. ANNALS OF NUTRITION AND METABOLISM 2007; 51:216-22. [PMID: 17587792 DOI: 10.1159/000104140] [Citation(s) in RCA: 17] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/20/2006] [Accepted: 12/12/2006] [Indexed: 12/16/2022]
Abstract
AIMS The objective was to compare the long-term effects of Artemisia herba-alba Asso decoction with a green or black tea decoction, prepared without sugar, on the antioxidant processes in rats. METHODS The direct parameters used in the control of antioxidant processes were total antioxidant status, glutathione peroxidase activity and conjugated dienes, as early markers of lipid peroxidation. However, the indirect parameters used in this control were the body weight gains, plasma glucose and lipid concentrations, iron, copper and zinc status. RESULTS After 9 weeks, artemisia or tea decoctions did not influence the daily food intake of the groups; however, they significantly decreased the weight gains. They significantly increased the total antioxidant status between 83.5 and 111% and the whole blood glutathione peroxidase activity between 23 and 38%. However, only the green tea and artemisia decoctions significantly decreased the plasma conjugated diene levels by 35 and 55.5%, respectively. Regarding the trace element status, artemisia, green or black tea decoctions significantly reduced the blood Fe by 28, 30 and 17%, respectively. Also, liver Fe tended to be lower in all treated groups as compared to the control group. In contrast, artemisia significantly increased both blood and liver Cu by 50 and 28% as compared to the control group. Moreover, they significantly decreased the plasma glucose and triglyceride levels between 29 and 40%. For the cholesterol, only the artemisia decoction significantly reduced the total blood cholesterol by 17%. CONCLUSION Artemisia as well as green tea decoctions increased the total antioxidant status, whole blood glutathione peroxidase activity and zinc and copper status, and prevented weight gains and increases in conjugated dienes, plasma glucose, lipids and iron status. The beneficial antioxidant effects were in descending order: artemisia decoction > or = green tea decoction > black tea decoction. So, artemisia could constitute a good adjuvant to combat obesity, hyperglycemia, hypertriglyceridemia, hypercholesterolemia and particularly oxidative stress.
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Affiliation(s)
- Zakia Ben Abid
- Unité de Recherche sur les Composés Antioxydants, Stress Oxydant, Eléments Traces et Maladies Métaboliques, Ecole Supérieure des Sciences et Techniques de la Santé de Tunis, Tunis, Tunisia
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Tahraoui A, El-Hilaly J, Israili ZH, Lyoussi B. Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). JOURNAL OF ETHNOPHARMACOLOGY 2007; 110:105-17. [PMID: 17052873 DOI: 10.1016/j.jep.2006.09.011] [Citation(s) in RCA: 283] [Impact Index Per Article: 15.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/08/2005] [Revised: 09/12/2006] [Accepted: 09/15/2006] [Indexed: 05/12/2023]
Abstract
This survey was undertaken in the Errachidia province in south-eastern Morocco in order to inventory the main medicinal plants used in folk medicine to treat arterial hypertension and diabetes mellitus. Four hundred individuals who knew about and/or had used the medicinal plants for the indicated diseases, including some herbal healers, were interviewed throughout different regions of the province. The inventory of medicinal plants is summarized in a synoptic table, which contains the scientific, vernacular and common name of the plant, its ecological distribution, the part of the plant and the preparation used and the therapeutic indication. Extensive investigations have brought to light 64 medicinal plants belonging to 33 families; of these, 45 are used for diabetes, 36 for hypertension, and 18 for both diseases. Of these plants, 34% grow in the wild, 44% are cultivated, and 22% are not indigenous to the area and are brought from other parts of Morocco or from outside the country. The survey shows that 78% of the patients regularly use these medicinal plants. In this region, the most frequently used plants to treat diabetes include Ajuga iva, Allium cepa, Artemisia herba-alba, Carum carvi, Lepidium sativum, Nigella sativa, Olea europaea, Peganum harmala, Phoenix dactylifera, Rosmarinus officinalis, and Zygophyllum gaetulum, and those to treat hypertension include Ajuga iva, Allium cepa, Allium sativum, Artemisia herba-alba Asso, Carum carvi, Nigella sativa, Olea europea, Rosmarinus officinalis, Origanum majorana, Peganum harmala, and Phoenix dactylifera. The local people recognize the toxic plants and are very careful in using such plants, which are Citrullus colocynthis, Datura stramonium, Nerium oleander, Nigella sativa, Peganum harmala and Zygophyllum gaetulum. Our survey shows that traditional medicine in the south-eastern Moroccan population has not only survived but has thrived in the transcultural environment and intermixture of many ethnic traditions and beliefs.
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Affiliation(s)
- A Tahraoui
- UFR Physiology-Pharmacology, Laboratory of Animal Physiology, Department of Biology, Faculty of Sciences, Dhar El Mehraz, USMBA, BP 1976 Atlas Fez, Morocco
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Houmani M, Houmani Z, Skoula M. Intérêt deArtemisia herba albaAsso dans l'alimentation du bétail des steppes algériennes. ACTA ACUST UNITED AC 2004. [DOI: 10.1080/12538078.2004.10516031] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/26/2022]
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Eddouks M, Maghrani M, Lemhadri A, Ouahidi ML, Jouad H. Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). JOURNAL OF ETHNOPHARMACOLOGY 2002; 82:97-103. [PMID: 12241983 DOI: 10.1016/s0378-8741(02)00164-2] [Citation(s) in RCA: 300] [Impact Index Per Article: 13.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/23/2023]
Abstract
In this study, the medicinal plants used in the treatment of diabetes mellitus, hypertension and cardiac diseases were inventoried based on the ethnopharmacological survey in south-eastern Morocco: Tafilalet region. Seven hundred persons including 320 diabetic patients and 380 patients with hypertension and cardiac disorders and 20 traditional herbal healers were interviewed in different areas of Tafilalet. The results indicated that 80% of patients interviewed used medicinal plants to treat diabetes, hypertension and cardiac diseases because they state that phytotherapy is cheaper (58%), more efficient (40%) and better (65%) than modern medicine. In this ethnobotanic enquiry, about 92 medicinal plants were cited. A lot of them are cited for the first time in Morocco. Many parameters have been evaluated such as knowledge of the toxic plants, doses, parts used, etc. Also, we have reported that 75% of type 2 diabetic patients used medicinal plants in association with modern drugs, while 10% of type 1 diabetic patients regularly used medicinal plants combined with insulin treatment. Some toxic plants have also been reported. In conclusion Tafilalet region disposes of a large phytotherapy knowledge which must be scientifically investigated especially in treating diabetes mellitus, hypertension and cardiac diseases.
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Affiliation(s)
- M Eddouks
- UFR Physiology of the Nutrition and Endocrinian Pharmacology, Faculty of Sciences and Techniques Errachidia, B.P. 509, Boutalamine, Errachidia, Morocco.
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Jouad H, Haloui M, Rhiouani H, El Hilaly J, Eddouks M. Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez-Boulemane). JOURNAL OF ETHNOPHARMACOLOGY 2001; 77:175-182. [PMID: 11535361 DOI: 10.1016/s0378-8741(01)00289-6] [Citation(s) in RCA: 240] [Impact Index Per Article: 10.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/23/2023]
Abstract
In order to make an inventory of herbal remedies commonly used in the treatment of diabetes, hypertension and renal diseases in the North centre region of Morocco, 1527 patients (1095 diabetic patients, 274 with renal disorders and 158 with cardiac disorders) and 25 traditional herbal healers were interviewed in four different areas of Fez-Boulemane region. More than 1153 of the total patients interviewed (76%) used regularly medicinal plants to treat diabetes, cardiac and renal diseases. These data showed that phytotherapy has always be practiced in this region. All the persons interviewed have indicated that the reasons of using phytotherapy is that the plant medicines are cheapest (54%) and more efficient (38%) than modern medicine. They also reported that the result of phytotherapy is better (72%). Our survey started at May 1997. About 90 plants were cited (54 plants for diabetes, 11 for cardiac diseases, 19 for hypertension and 33 for renal diseases). The plants reported have been identified and are presented in a table with the vernacular name, useful parts, ecological distribution and medicinal uses. Only 12% of the total patients have a relative knowledge of the toxic plants. The result indicated that nine plants are extremely toxic at high doses and chronic treatment. Fifty nine percent of the interviewers have indicated that they used medicinal plants from the experience of the other.
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Affiliation(s)
- H Jouad
- Laboratory of Endocrinian Physiology and Pharmacology, F.S.T.E. Boutalamine, BP 509, Errachidia, Morocco
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Abdel-Hassan IA, Abdel-Barry JA, Tariq Mohammeda S. The hypoglycaemic and antihyperglycaemic effect of citrullus colocynthis fruit aqueous extract in normal and alloxan diabetic rabbits. JOURNAL OF ETHNOPHARMACOLOGY 2000; 71:325-330. [PMID: 10904181 DOI: 10.1016/s0378-8741(99)00215-9] [Citation(s) in RCA: 69] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/23/2023]
Abstract
Effects of the aqueous, glycosidic, alkaloidal and saponin extracts of the rind of Citrullus colocynthis on the plasma glucose levels were investigated in normal rabbits, while the effects of saponin extract on the fasting plasma glucose levels were studied in alloxan induced diabetic rabbits. In normal rabbits, oral administration of aqueous extract (300 mg/kg) produced significant reduction in plasma glucose after 1 h and highly significant after 2,3 and 6 h. Phytochemical screening revealed that the rind of C. colocynthis and its aqueous extract contains tertiary and quaternary alkaloids, glycoside and saponin components. The hypoglycaemic effects of these components given orally at a dose (50 mg/kg) were studied in normoglycaemic rabbits. Result showed that the alkaloidal extract did not significantly lower the blood glucose levels from 132 mg/100 ml at 0 h to 120 mg/100 ml after 6 h, while the glycosidic extract significantly lowered the fasting glucose levels after 2 and 3 h and highly significant after 6 h. The effect was more pronounced with saponin extract, the saponin significantly lowered the fasting glucose levels after 1 and 2 h and highly significant (P<0.001) after 3 and 6 h. Graded doses (10, 15 and 20 mg/kg) of saponin extract, when given orally to alloxan diabetic rabbits, produced a significant reduction of plasma glucose concentration. These results suggest that the aqueous extract of the rind of C. colocynthis possesses a hypoglycaemic effect and its hypoglycaemic action could be attributed for more extent to the presence of saponin in addition to the presence of glycosidic components.
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Affiliation(s)
- I A Abdel-Hassan
- Chemistry Department, College of Science, University of Basrah, Basrah, Iraq
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Heinrich M, Robles M, West JE, Ortiz de Montellano BR, Rodriguez E. Ethnopharmacology of Mexican asteraceae (Compositae). Annu Rev Pharmacol Toxicol 1998; 38:539-65. [PMID: 9597165 DOI: 10.1146/annurev.pharmtox.38.1.539] [Citation(s) in RCA: 174] [Impact Index Per Article: 6.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/09/2022]
Abstract
Traditional herbal remedies have increased in popularity in Europe and the United States in recent years but have always been important to people living in rural Mexico and to their Mexican American/Chicano descendants in the United States. Mexican American patients will often be ingesting herbal teas at the same time that they are being treated for their ailments with antibiotics or antiinflammatory agents. The plant family Asteraceae (Compositae) has contributed the largest number of plants to this pharmacopoeia; the reasons for the importance of this family include its large number of species in Mexico and its wide array of natural products that are useful in the treatment of the maladies that have afflicted the inhabitants of rural Mexico. These natural products include sesquiterpene lactones, polyacetylenes, alkaloids, monoterpenes, and various phenolics such as flavonoids. In this review, we emphasize the sesquiterpene lactones, a large group of compounds with antiinflammatory properties and the ability to relax smooth muscles and thereby relieve gastrointestinal distress. These compounds also readily form adducts with glutathione or free thiols and can thereby affect the metabolism, activity, and toxicology of a wide array of pharmacological agents.
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Affiliation(s)
- M Heinrich
- Institute of Pharmaceutical Biology, Albert-Ludwigs University, Freiburg, Germany
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Ziyyat A, Legssyer A, Mekhfi H, Dassouli A, Serhrouchni M, Benjelloun W. Phytotherapy of hypertension and diabetes in oriental Morocco. JOURNAL OF ETHNOPHARMACOLOGY 1997; 58:45-54. [PMID: 9324004 DOI: 10.1016/s0378-8741(97)00077-9] [Citation(s) in RCA: 257] [Impact Index Per Article: 9.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/22/2023]
Abstract
In order to select the main medicinal plants used in folk medicine to treat arterial hypertension and/or diabetes, a survey was undertaken in different areas of oriental Morocco. The patients (370 women and 256 men) were divided into three groups: diabetics (61%), hypertensives (23%) and hypertensive diabetic persons (16%). On average, 67.51% of patients regularly use medicinal plants. This proportion is perceptibly the same in all groups and does not depend on sex, age and socio-cultural level. This result shows that phytotherapy is widely adopted in northeastern Morocco. For diabetes, 41 plants were cited, of which the most used were Trigonella foenum-graecum L. (Leguminosae), Globularia alypum L. (Globulariaceae), Artemisia herba-alba Asso. (Compositae), Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) and Tetraclinis articulata Benth. (Cupressaceae). In the hypertension's therapy 18 vegetal species were reported, of which the most used were Allium sativum L. (Liliaceae), Olea europea L. (Oleaceae), Arbutus unedo L. (Ericaceae), Urtica dioica L. (Urticaceae) and Petroselinum crispum A.W. Hill (Apiaceae). Among the 18 species used for hypertension, 14 were also employed for diabetes. Moreover, these two diseases were associated in 41% of hypertensives. These findings suggest that hypertension observed in this region would be in a large part related to diabetes.
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Affiliation(s)
- A Ziyyat
- Department of Biology, University Mohamed the First, Faculty of Sciences, Oujda, Morocco
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al-Shamaony L, al-Khazraji SM, Twaij HA. Hypoglycaemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals. JOURNAL OF ETHNOPHARMACOLOGY 1994; 43:167-171. [PMID: 7990489 DOI: 10.1016/0378-8741(94)90038-8] [Citation(s) in RCA: 203] [Impact Index Per Article: 6.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/22/2023]
Abstract
Artemisia herba alba is widely used in Iraqi folk medicine for the treatment of diabetes mellitus. However, very few scientific and medical studies were carried out to assess the efficacy and toxicity of A. herba alba. In this study feeding diabetic rats and rabbits with 0.39 g/kg body weight of the aqueous extract of the aerial parts of the plant for 2-4 weeks shows a significant reduction in blood glucose level, prevents elevation of glycosylated haemoglobin level and possesses a hypoliposis effect, in addition to the protection against body weight loss of diabetic animals.
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Affiliation(s)
- L al-Shamaony
- Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Iraq
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