MicroRNA in rectal cancer

Table 1 Association of microRNA expression and clinical parameters

microRNA	Clinical parameter	Change of expression	Ref.
miR-17-5p	Association with rectal cancer survival	No further explanation	Slattery et al[59]
miR-20a/20b-5p
miR-21-3p/5p
miR-25-3p
miR-29a/29c-3p
miR-31-5p	Association with advanced tumor stage	Increased expression level in advanced tumor stage	Slattery et al[59]
miR-135b	Correlation with disease-free and cancer-specific survival	Patients with a high expression level of miR-135b had a better disease-free and cancer-specific survival	Gaedcke et al[38]
miR-135b	Correlation with Duke stage IV	Upregulated with the highest fold-change (17.7-fold) among 9 upregulated miRNAs	Xu et al[58]
miR-141-3p	Association with rectal cancer survival	No further explanation	Slattery et al[59]
miR-145	Correlation with Duke stage II, III, IV	Downregulated with a -18.15, -18.9, -23.8-fold change in stage II, III and IV CRC respectively	Xu et al[58]
miR-145-5p	Correlation with advanced tumor stage	Increased expression level in advanced tumor stage	Slattery et al[59]
miR-155	Correlation with nodal stage and Duke stage	Discrimination of nodal positive from negative cases as well as Duke A/B stages from Duke C/D stages	Yang et al[61]
miR-200b-3p	Association with advanced tumor stage and survival	Decreased expression level in advanced tumor stage	Slattery et al[59]
miR-215	Association with advanced tumor stage and survival	Decreased expression level in advanced tumor stage	Slattery et al[59]
miR-335-5p	Association between any miRNA expression and survival	The expression of miR-335-5p is associated with a better survival	Slattery et al[59]
miR-374a	Correlation with metastasis stage	Decreased expression of miR-374a in tumor of patients without metastasis	Xu et al[58]
miR-425-5p	Association with rectal cancer survival	No further explanation	Slattery et al[59]
miR-451a	Association with advanced tumor stage	Decreased expression level in advanced tumor stage	Slattery et al[59]

CRC: Colorectal carcinoma.