Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer

Table 1 Distribution of genotype, allelic frequencies and odds risk estimates in patients compared to control subjects

Genotype	Patients (n = 150)		Controls (n = 150)		Odds ratio	P value
	n	%	n	%	(95%CI)
T/T	3	2.00	22	14.67	Reference
T/C	12	8.00	29	19.33	3.034 (0.67-15.53)	0.136
C/C	135	90.00	99	66.00	10.00 (2.73-43.24)	0.000a
T/C + C/C	147	98.00	128	85.33	8.42 (2.32-36.2)	0.000a
T/T + T/C vs C/C	15	10.00	51	34.00	4.636 (2.37-9.17)	0.000a
Alleles
T	18	6.00	73	24.33	Reference
C	282	94.00	227	75.67	5.038 (2.841-9.026)	0.000a

^aP < 0.05.

Table 2 Distribution of genotype frequencies in patients and control subjects with regard to Helicobacter pylori infection

Characteristic	Controls n (%)	Cases n (%)	χ2	OR (95%CI)	P value
H. pylori infection
T/T genotype
+ve	1 (33.33)	0 (0.00)
-ve	2 (66.67)	22 (100.00)	1.424	-	0.120
T/C genotype
+ve	3 (25.00)	1 (3.45)
-ve	9 (75.00)	28 (96.55)	2.364	9.333 (0.699-267.06)	0.068
C/C genotype
+ve	10 (7.41)	1 (1.01)
-ve	125 (92.59)	98 (98.99)	3.887	7.840 (1.008-166.50)	0.027a

^aP < 0.05. H. pylori: Helicobacter pylori.

Table 3 Distribution of genotype frequencies in patients and control subjects with regard to addictions

Characteristic	Cases n (%)	Controls n (%)	χ2	OR (95%CI)	P value
Smoking status
T/T genotype
Smokers	2 (66.67)	4 (18.18)
Nonsmokers	1 (33.33)	18 (81.82)	1.263	9.000 (0.44-339.56)	0.133
T/C genotype
Smokers	7 (58.33)	5 (17.24)
Nonsmokers	5 (41.67)	24 (82.76)	5.080	6.720 (1.21-40.80)	0.020a
C/C genotype
Smokers	104 (77.04)	23 (23.23)
Nonsmokers	31 (22.96)	76 (76.77)	64.475	11.086 (5.74-21.58)	0.000b
Alcoholism
T/T genotype
Alcoholics	2 (66.67)	7 (31.82)
Non-alcoholics	1 (33.33)	15 (68.18)	0.290	4.286 (0.23-145.14)	0.530
T/C genotype
Alcoholics	10 (83.33)	9 (31.03)
Non-alcoholics	2 (16.67)	20 (68.97)	7.351	11.11 (1.68-93.07)	0.005b
C/C genotype
Alcoholics	113 (83.70)	48 (48.48)
Non-alcoholics	22 (16.30)	51 (51.52)	31.385	5.457 (2.86-10.46)	0.000b

^aP < 0.05,

^bP < 0.01.