Case Report
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Aug 15, 2014; 6(8): 301-310
Published online Aug 15, 2014. doi: 10.4251/wjgo.v6.i8.301
Table 1 Clinical data of patients with neuroendocrine tumors
Patient (age, yr/sex)Initial evaluationSiteDiagnostic studiesOutcome
65/FHematochezia, IBD epigastric painDuodenal bulb12 21 05 EGD duodenal bulb polyp; path: neuroendocrine tumor 12 30 05 repeat EGD, no residual, path: neuroendocrine tumor 11 24 08 repeat EGD no recurrence, COL mucosal prolapse syndromeAlive and well
59/MGERD with break-through symptomsDuodenal bulb11 11 08 EGD duodenal bulb polyp, path: neuroendocrine tumor 12 22 08 EGD, no residual tumor 12 30 08 PET scan negativeAlive and well
50/F2nd opinion for liver metastatic diseaseLiver02 09 04 EGD chronic esophagitis, HH, fundic nodularity, path: benign lymphoid aggregates 03 16 04 PET/CT innumberable larg hepatic lesions replacing R and L lobes consistent with neuroendocrine tumorExpired 12 04
70/MEpigastric pain and 15 lb weight lossIntra-abdominal04 15 08 EGD chronic esophagitis, HH, acute and chronic gastritis; path: reactive gastropathy; COL: 1 adenomatous/2 hyperplastic polyps 04 16 08 CT Abd/Pelvis mesen-teric mass 04 24 08 CT guided bx: path: neuroendocrine tumor05 08 treated with sandostatin
46/FNausea, vomiting, abdominal painIntra-abdominal01 02 10 CT Abd/Pelvis ascites small bowel and colonic obstruction 01 04 10 Gastrografin emema sigmoid Obstruction 01 04 10 exploratory laparotomy desmoplastic reaction, sigmoid colon with liver metastases and intraperitoneal implants; bx of implants positive for chromogranin and synapotophysin 01 19 10 COL 3 cm stenosis at 30 cm due to extrinsic pressure; stent placed 01 26 10 serum CGA, 27 nmole/LDischarge To hospice
40/MRecurrent perianal abscess r/o IBDTerminal ileum12 05 06 COL 10 mm sessile polyp in terminal ileum, path: neuroendocrine tumorLost to follow-up
50/FGERD and CRCSSigmoid04 04 08 EGD chronic esophagitis, HH, path: mild reactive gastropathy, COL 4 mm sigmoid neuroendocrine tumor resected 04 30 08 normal octreotide scan 03 30 09 COL negative bx at prior polypectomy siteAlive and well
75/FBreast cancer and CRCSSigmoid02 06 08 COL 7 mm sigmoid submucosal nodule resected; cells positive for synaptophysin, but negative for chromogranin 03 11 08 Urinary 5-HIAA negative 04 22 08 Repeat COL with resection of remaining neuroendocrine tumor 05 19 09 COL negative for recurrenceAlive and well
55/MLLQ tenderness, CRCSRectum08 22 06 COL sigmoid tubulovillous adenoma and 6 mm rectal neuro-endocrine tumor 09 01 09 COL hyperplastic polyp, no recurrence of neuroendocrine tumorAlive and well
55/FCRCSRectum05 01 09 COL 8 mm neuroendocrine tumor COL 1 yr later no recurrenceAlive and well
60/FCRCSRectum11 29 07 COL submucosal nodule neuroendocrine tumor 01 28 08 COL no recurrenceAlive and well
Table 2 Hormone production by tumor location[15,9,31,43]
LocationHormones
StomachHistamine, Gastrin, Serotonin, Somatostatin, Gastrin Releasing Peptide
Duodenum/Upper JejunumGastrin, Serotonin, Somatostatin, Gastrin Releasing Peptide
Ileum/CecumEnteroglucagon, Serotonin, Substance P, Tachykinins
AppendixEnteroglucagon, Peptide YY, Serotonin, Somatostatin
Colon/RectumEnteroglucagon, Serotonin, Somatostatin
PancreasACTH, Calcitonin, Cholecystokinin, Corticotropin-Releasing Hormone, Gastrin, Glucagon, Growth Hormone-Releasing Hormone, Growth Hormone-Releasing Factor, Insulin, Neurotensin, Pancreatic Polypeptide, Parathyroid Hormone-Related Peptide, Prolactin, Somatostatin, Vasoactive Intestinal Peptide