Predictive role of XRCC5/XRCC6 genotypes in digestive system cancers

Table 1 Summary of the associations for digestive cancers and the polymorphic genotype of XRCC5 and XRCC6 genes

Cancer	Author	Gene	rs number	Location	Study subjects
					Ethnic area	Cases	Controls	Statistical significance	Brief description
Oral cancer	Hsu[28]	XRCC5	828907	Promoter	Taiwan	600	600	S	Allele C is of higher risk
			11685387	Promoter				NS
			9288518	Intron 19				NS
	Bau[27]	XRCC6	5751129	Promoter	Taiwan	318	318	S	Allele T is of higher risk, and interacted with betel quid chewing habits
			2267437	Promoter				NS
			132770	Promoter				NS
			132774	Intron 3				NS
Esophageal cancer	Dong[40]	XRCC5	Accession number: DQ7874341	Intron16	China mainland	329	631	S	Allele A is of higher risk
			Accession number: DQ7874341	Intron16				NS
Gastric cancer	Dong[40]	XRCC5	Accession number: DQ7874341	Intron16	China mainland	255	631	S	Allele A is of higher risk
			Accession number: DQ7874341	Intron16				S	Allele G is of higher risk
Colorectal cancer	Yang[51]	XRCC5	828907	Promoter	Taiwan mainland	362	362	S	Allele T is of higher risk, and interacted with smoking habits
			11685387	Promoter				NS
			9288518	Intron 19				NS

¹Accession number was provided instead for the rs number is not available. S: Statistically significant; NS: Not statistically significant.