Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan

doi:10.4251/wjgo.v2.i8.326

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Aug 15, 2010; 2(8): 326-331
Published online Aug 15, 2010. doi: 10.4251/wjgo.v2.i8.326

Table 1 Frequency distributions of characteristics among colorectal cancer patients and controls n (%)

Characteristics	Patients (n = 362)	Controls (n = 362)	P
Age (yr)
mean ± SD	64.4 (6.2)	63.8 (5.8)	0.149
Age group (yr)			0.932
≤ 60	93 (25.7)	95 (26.2)
> 60	269 (74.3)	267 (73.8)
Gender			0.707
Male	209 (57.7)	203 (56.0)
Female	153 (42.3)	159 (44.0)
Habits
Cigarette smokers	84 (23.2)	91 (25.1)	0.602
Alcohol drinkers	51 (14.1)	44 (12.2)	0.509
Primary tumor
Colon	239 (66.0)
Rectum	123 (34.0)
Histological differentiation
Well/moderate	319 (88.1)
Poorly/unknown	43 (11.9)
Extent of invasion
T1-2	134 (37.0)
T3-4	228 (63.0)
Lymph node involvement
N0	91 (25.1)
N1-3	271 (74.9)

^aPbased onχ²test.

Table 2 Distribution of Caveolin-1 genotypes among colorectal cancer patients and controls n (%)

Genotype	Controls	Patients	P^a
C239A rs1997623			0.3837
CC	355 (98.1)	357 (98.6)
AC	7 (1.9)	5 (1.4)
AA	0 (0.0)	0 (0.0)
G14713A rs3807987			1.6 × 10^-12
GG	234 (64.6)	135 (37.3)
AG	96 (26.5)	165 (45.6)
AA	32 (8.8)	62 (17.1)
G21985A rs12672038			0.9722
GG	211 (58.2)	214 (59.1)
AG	124 (34.3)	122 (33.7)
AA	27 (7.5)	26 (7.2)
T28608A rs3757733			0.8964
TT	209 (57.7)	214 (59.1)
AT	120 (33.2)	118 (32.6)
AA	33 (9.1)	30 (8.3)
T29107A rs7804372			0.0003
TT	179 (49.5)	216 (59.7)
AT	120 (33.1)	117 (32.3)
AA	63 (17.4)	29 (8.0)
G32124A rs3807992			0.8583
GG	179 (49.4)	172 (47.5)
AG	144 (39.8)	148 (40.9)
AA	39 (10.8)	42 (11.6)

^aPbased onχ²test.

Table 3 Distribution of Caveolin-1 alleles among colorectal cancer patients and controls n (%)

Allele	Controls	Patients	P^a
C239A rs1997623			0.5621
Allele C	717 (99.0)	719 (99.3)
Allele A	7 (1.0)	5 (0.7)
G14713A rs3807987			2.3 × 10^-13
Allele G	564 (77.9)	435 (60.1)
Allele A	160 (22.1)	289 (39.9)
G21985A rs12672038			0.8064
Allele G	546 (75.4)	550 (76.0)
Allele A	178 (24.6)	174 (24.0)
T28608A rs3757733			0.6279
Allele T	538 (74.3)	546 (75.4)
Allele A	186 (25.7)	178 (24.6)
T29107A rs7804372			4.0 × 10^-5
Allele T	478 (66.0)	549 (75.8)
Allele A	246 (34.0)	175 (24.2)
G32124A rs3807992			0.5711
Allele G	502 (69.3)	492 (68.0)
Allele A	222 (30.7)	232 (32.0)

^aPbased onχ²test.

Table 4 Distribution of Caveolin-1 G14713A/ T29107A haplotypes among colorectal cancer patients and controls n (%)

G14713A/T29107A haplotype	Controls	Patients	Crude odds ratio (95% CI)	Adjusted odds ratio (95% CI)^a
GG/TT	116 (32.0)	81 (22.4)	1.00 (Ref.)	1.00 (Ref.)
GG/AT or GG/AA	118 (32.6)	54 (14.9)	0.66 (0.43-1.01)	0.68 (0.48-0.98)^b
AG/TT	47 (13.0)	99 (27.3)	3.02 (1.93-4.72)^b	2.78 (2.04-4.22)^b
AG/AT or AG/AA	49 (13.5)	66 (18.2)	1.93 (1.21-3.07)^b	2.02 (1.28-2.94)^b
AA/TT	16 (4.4)	36 (9.9)	3.22 (1.68-6.20)^b	3.48 (1.86-5.59)^b
AA/AT or AA/AA	16 (4.4)	26 (7.2)	2.33 (1.17-4.61)^b	2.29 (1.49-3.06)^b

^aDate were calculated by unconditioned logistic regression and adjusted for age, gender, smoking, alcohol drinking and betel quid chewing behaviors; ^bStatistically significant.

Table 5 Distribution of Caveolin-1 G14713A and T29107A genotypes and colorectal cancer after stratification by smoking habit

	Overall			Never smokers			Ever smokers
SNP/Genotype	Controls	Cases	Adjusted^a	Controls	Cases	Adjusted^b	Controls	Cases	Adjusted^b
	n (%)	n (%)	OR (95% CI)	n (%)	n (%)	OR (95% CI)	n (%)	n (%)	OR (95% CI)
G14713A (rs3807987) GG AG AA	234 (64.6) 96 (26.5) 32 ( 8.8)	135 (37.3) 165 (45.6) 62 (17.1)	1.00 (Ref.) 2.98 (2.14-4.14) 3.36 (2.09-5.41)	171 (63.1) 75 (27.7) 25 (9.2)	107 (38.5) 124 (44.6) 47 (16.9)	1.00 (Ref.) 2.64 (1.81-3.84) 3.00 (1.75-5.17)	63 (69.2) 21 (23.1) 7 (7.7)	28 (33.3) 41 (48.8) 15 (17.9)	1.00 (Ref.) 4.39 (2.21-8.75) 4.82 (1.77-13.13)
T29107A (rs7804372) TT AT AA	179 (49.5) 120 (33.1) 63 (17.4)	216 (59.7) 117 (32.3) 29 (8.0)	1.00 (Ref.) 0.79 (0.57-1.11) 0.37 (0.23-0.58)	136 (50.2) 89 (32.8) 46 (17.0)	164 (59.0) 91 (32.7) 23 (8.3)	1.00 (Ref.) 0.84 (0.54-1.21) 0.40 (0.22-0.71)	43 (47.3) 52 (34.1) 17 (18.6)	52 (61.9) 26 (31.0) 6 (7.1)	1.00 (Ref.) 0.40 (0.22-0.76) 0.28 (0.21-0.79)

^aAdjusted for age, gender and smoking (pack-years); ^bAdjusted for age and gender; OR: Odds ratio; SNP: Single nucleotide polymorphism.

Citation: Yang MD, Tsai RY, Liu CS, Chang CH, Wang HC, Tsou YA, Wang CH, Lin CC, Shyue SK, Bau DT. Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan. World J Gastrointest Oncol 2010; 2(8): 326-331
URL: https://www.wjgnet.com/1948-5204/full/v2/i8/326.htm
DOI: https://dx.doi.org/10.4251/wjgo.v2.i8.326