Integrated diagnostic model based on serum exosomal microRNAs and functional mechanism of miR-200b-3p in hepatocellular carcinoma

Table 1 Baseline status of enrolled cases

	TH-HebMU cohort-1			TH-HebMU cohort-2			TH-HebMU cohort-3
	Non-HCC (n = 131)	HCC (n = 68)	P value	Non-HCC (n = 135)	HCC (n = 66)	P value	Non-HCC (n = 5)	HCC (n = 5)	P value
Sex			0.002b			0.142			1.000
Male	85	58		93	52		4	4
Female	46	10		42	14		1	1
Age	43.13 ± 13.671	55.79 ± 10.74	< 0.001c	50.81 ± 11.31	59.98 ± 12.65	< 0.001c	47.00 ± 11.55	58.20 ± 9.07	> 0.05
miR-200b-3p	28.42 ± 23.21	61.75 ± 63.99	< 0.001c	-9.24 ± 1.03	-8.51 ± 0.78	< 0.001c	33369 ± 12333	15753 ± 7165	< 0.05a
miR-215-5p	942.51 ± 1422.19	3927.90 ± 6286.45	< 0.001c	-8.46 ± 0.83	-7.53 ± 0.78	< 0.001c	156.1 ± 103.5	754.8 ± 247.7	< 0.01b
miR-335-5p	35.96 ± 22.04	53.92 ± 33.97	< 0.001c	-9.41 ± 0.72	-8.78 ± 0.81	< 0.001c	35 ± 23.7	238.3 ± 52.6	< 0.01b
miR-378a-3p	818.66 ± 305.82	1063.99 ± 376.92	< 0.001c	-7.15 ± 0.84	-6.27 ± 0.95	< 0.001c	79340 ± 15325	66567 ± 27158	> 0.05
miR-452-5p	9.55 ± 10.45	24.62 ± 48.77	< 0.001c	-9.98 ± 1.07	-8.90 ± 1.27	< 0.001c	268.7 ± 184.4	1087 ± 1108	> 0.05
miR-501-3p	263.94 ± 123.31	410.85 ± 240.83	< 0.001c	-8.64 ± 0.79	-7.79 ± 0.82	< 0.001c	3226 ± 1680	1196 ± 199.7	< 0.05a

¹Age and microRNA expression values are presented as mean ± SD. For cohort-1, values are transcripts per million from next-generation sequencing; for cohort-2, values are -ΔCT from quantitative real-time polymerase chain reaction; for cohort-3, values are raw quantification cycle values or normalized counts.

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

TH-HebMU: Hebei Medical University Third Hospital; HCC: Hepatocellular carcinoma.