Citrullinated matrisome: An emerging stromal determinant in hepatocellular carcinoma prognostication

doi:10.4251/wjgo.117335

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 9

This Article

(8)

(9)

(0)

(25)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Editorial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 117335
Published online Sep 15, 2026. doi: 10.4251/wjgo.117335

Table 1 Comparison of citrullinated glial fibrillary acidic protein with other stromal biomarkers in hepatocellular carcinoma

Biomarker	Cellular source	Posttranslational modification	Prognostic value (HR)	Key feature	Current evidence level
α-SMA	Activated HSCs/CAFs	None	Approximately 1.5-2.5	Most widely used; marks myofibroblastic activation	Extensive validation
GFAP (total)	Quiescent/early HSCs	None	Not established	Marks early HSC activation; less prognostic	Limited
Desmin	HSCs	None	Approximately 1.6-2.0	HSC cytoskeletal marker	Moderate
cit-GFAP	Activated HSCs/CAFs	Citrullination	2.75	Posttranslational modification; independent of AFP	Hypothesisgenerating (single study)
Citrullinated fibronectin	ECM	Citrullination	Not reported in HCC	Promotes invasion in breast cancer	Preclinical only

HR: Hazard ratio; HSC: Hepatic stellate cell; α-SMA: Alpha-smooth muscle actin; CAF: Cancer-associated fibroblast; GFAP: Glial fibrillary acidic protein; cit-GFAP: Citrullinated glial fibrillary acidic protein; AFP: Alpha-fetoprotein; ECM: Extracellular matrix; HCC: Hepatocellular carcinoma.

Full Size Table

Citation: Xu ZF, Yao YR, Ye SY, Zhao CF. Citrullinated matrisome: An emerging stromal determinant in hepatocellular carcinoma prognostication. World J Gastrointest Oncol 2026; 18(9): 117335
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/117335.htm
DOI: https://dx.doi.org/10.4251/wjgo.117335

Xu ZF, Yao YR, Ye SY, Zhao CF. Citrullinated matrisome: An emerging stromal determinant in hepatocellular carcinoma prognostication. World J Gastrointest Oncol 2026; 18(9): 117335 [DOI: 10.4251/wjgo.117335]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.