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Publication Name
World Journal of Gastrointestinal Oncology
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1948-5204
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis
Copyright: ©Author(s) 2026.
World J Gastrointest Oncol. Nov 15, 2026; 18(11): 124040
Published online Nov 15, 2026. doi: 10.4251/wjgo.124040
Table 1 Characteristics of the included studies
Ref.
Tumor type
Sample size
Research type
Endpoint
NLR cut-off
PLR cut-off
Cut-off derivation method
Wang et al[15], 2026Distal cholangiocarcinoma208Retrospective cohortOSNRNRNR
Li et al[16], 2025hCCA112Retrospective cohortOS2.98155.47NR
Fukushi et al[17], 2026CCA103Retrospective studyOS5148NR
Matsumoto et al[18], 2026CCA29Retrospective studyPFS5NRNR
Guo et al[11], 2026hCCA373Retrospective studyRFS3.3114.83NR
Chindaprasirt et al[7], 2026CCA213Retrospective studyDFS/OS2.4NRNR
Mii et al[19], 2025CCA54Retrospective studyPFS/OS3NRNR
Ge et al[20], 2022pCCA333Retrospective studyOS/RFS1.68113.1NR
Li et al[21], 2022eCCA140Retrospective studyOS2.66125.82NR
Lin et al[22], 2022pCCA76Retrospective studyOS2NRNR
Yang et al[23], 2022iCCA73Retrospective studyOS3.56222.52NR
Zhang et al[24], 2022iCCA162Retrospective studyOS3.7376.51NR
Catalano et al[25], 2024iCCA758Retrospective studyOS2.57172.5NR
Fu et al[26], 2024pCCA139Retrospective cohort studyOS3.19NRNR
Jin et al[27], 2024CCA120Retrospective cohort studyOS1.08204.62NR
Lang et al[9], 2025iCCA286Retrospective cohort studyOS2.65167.8NR
Zhao et al[28], 2021iCCA468Retrospective cohort studyOS3143.5NR
Ma et al[29], 2021iCCA174Retrospective cohortOS/DFS390NR
Zhang et al[30], 2020iCCA128Retrospective studyOS/DFS3156.8NR
Tsilimigras et al[31], 2020iCCA688Retrospective studyOS5190NR
Ohira et al[32], 2020iCCA52Retrospective studyOS1.9398NR
Ji et al[33], 2020eCCA59Retrospective studyOS2.93268.9NR
Huh et al[34], 2020iCCA137Retrospective studyOS/DFS5148NR
Filippi et al[35], 2020iCCA20Retrospective studyOS2.7NRNR
Zhang et al[36], 2019iCCA322Retrospective studyOS/DFS3NRNR
Wu et al[37], 2019iCCA123Retrospective studyOS2.05157.3NR
Sellers et al[38], 2019iCCA131Retrospective studyOS3.96156.4NR
Lin et al[39], 2019iCCA218Retrospective studyOS2.94130.6NR
Hu et al[40], 2019eCCA134Retrospective studyOS3150NR
Hoshimoto et al[41], 2019eCCA53Retrospective cohort studyOS/DFS1.97187.8NR
Buettner et al[42], 2018iCCA991Retrospective cohort studyOS5190NR
Yoh et al[43], 2017iCCA141Retrospective studyOS5120NR
Omichi et al[44], 2017iCCA119Retrospective studyOS/DFS3NRNR
Nam et al[45], 2017iCCA377Retrospective studyOS2.7NRNR
Kitano et al[46], 2017eCCA120Retrospective studyOS/DFS2.8185NR
Cho et al[47], 2018iCCA305Retrospective studyOS/DFS2.8128.3NR
Okuno et al[48], 2016eCCA219Retrospective studyOS5NRNR
Okuno et al[49], 2016eCCA534Retrospective studyOS3150NR
Lin et al[50], 2016iCCA102Retrospective studyOS/DFS3NRNR
Lee et al[51], 2016CCA221Retrospective studyOS/DFS5NRNR
Ha et al[52], 2016CCA534Retrospective studyOS3.49NRNR
Beal et al[53], 2016eCCA525Retrospective studyOS/DFS5NRNR
Chen et al[54], 2015iCCA322Retrospective studyOS/DFS2.49NRNR
Chen et al[55], 2015iCCA322Retrospective studyOS/DFSNR123NR
McNamara et al[56], 2014CCA864Retrospective studyOS3NRNR
Iwaku et al[57], 2014CCA52Retrospective studyOS4NRNR
Dumitrascu et al[58], 2013eCCA90Retrospective studyOS/DFS3.3NRNR
Gomez et al[59], 2008iCCA27Retrospective studyOS/DFS5NRNR
NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; OS: Overall survival; NR: Not reported; hCCA: Hilar cholangiocarcinoma; CCA: Cholangiocarcinoma; PFS: Progression-free survival; RFS: Recurrence-free survival; DFS: Disease-free survival; pCCA: Perihilar cholangiocarcinoma; eCCA: Extrahepatic cholangiocarcinoma; iCCA: Intrahepatic cholangiocarcinoma.
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