Marked elevation of alpha fetoprotein caused by hepatoid adenocarcinoma of stomach: A case report

Table 1 Summary of reported cases on hepatoid adenocarcinoma with their alpha-fetoprotein levels before and after treatment

Ref.	Age, sex	Gastroscopy findings	AFP pre-treatment (ng/mL)	AFP post-treatment (ng/mL)	Pres-ence of PVT	Treatment	Prognosis (months)
Mahajan et al[19], 2014	60 male	Ulcerated mass - antrum	6590	125	-	Chemotherapy	12
Shen et al[20], 2016	70 male	Mass - antrum	14399	10	-	Chemotherapy, surgery	7
Quino-Florentin et al[21], 2021	44 female	Infiltrative mass - cardia	49800	-	-	Chemotherapy	0
Sun et al[23], 2022	60 male	Mass - body	1210	0	-	Chemotherapy	8
Zhang et al[14], 2022	57 male	Mass - antrum	6998	Normal	Yes	Chemotherapy	12
Bathobakae et al[24], 2024	49 female	Ulcerated mass - body	1252	-	-	Chemotherapy	6
Zhu et al[22], 2024	80 male	Infiltrative mass - body	22195	-	-	Chemotherapy	0.5
Zhong et al[25], 2026	68 male	Mass - antrum	919	8.2	-	Chemotherapy, surgery	14
Li et al[16], 2024	64 male	Mass - cardia	52951	9	-	Chemotherapy, immunotherapy, surgery	6
This case	75 male	Ulcerated mass - body	889200	-	Yes	Chemotherapy, immunotherapy	0.5

AFP: Alpha fetoprotein; PVT: Portal vein thrombosis.

Table 2 Serum alpha-fetoprotein levels and treatment response

Ref.	Initial AFP levels	Treatment and duration	Post-treatment AFP levels
Mahajan et al[19], 2014	6590	Radical gastrectomy, 6 months of chemotherapy: 5-fluorourcil and cisplatin	125
Shen et al[20], 2016	14399	Neoadjuvant therapy with 2 cycles of chemotherapy: Oxaliplatin and capecitabine, followed by gastrectomy and resection of left lobe of liver	10
Yoshizawa et al[26], 2017	1214	Emergency laparotomy with distal gastrectomy, cholecystectomy and reconstruction using Billroth II, followed by chemotherapy with S-1 (tegafur/gimeracil/oteracil)	Normalised (author didn’t specify the value)
Zhang et al[14], 2022	6998	6 cycles of docetaxel, oxaliplatin, tegafur gimeracil, followed by 3 cycles of oteracil potassium capecitabine	Normalised (author didn’t specify the value)
Sun et al[23], 2022	1210	One cycle of chemotherapy: Oxaliplatin and S-1. 11 cycles of sintilimab	0
Zhong et al[25], 2026	919	Billroth II gastrectomy, right hemihepatectomy, adjuvant chemoradiotherapy (capecitabine)	14
Li et al[16], 2024	52951	Neoadjuvant therapy with chemo-immunotherapy: Oxaliplatin, S-1, sintilimab and laparoscopic total gastrectomy with lymph node dissection	9

AFP: Alpha-fetoprotein.