Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases

doi:10.4251/wjgo.122608

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Oct 15, 2026; 18(10): 122608
Published online Oct 15, 2026. doi: 10.4251/wjgo.122608

Table 1 Correlation between CD66b+ polymorphonuclear neutrophils and CD117+ mast cells densities within non-tumor mucosa, primary colorectal cancer and liver metastasis in synchronous and metachronous groups

	Synchronous						Metachronous
	CD66b NM	CD66b pTC	CD66b pIM	CD66b pOM	CD66b pPT		CD66b NM	CD66b pTC	CD66b pIM	CD66b pOM	CD66b pPT
CD117 NM	0.11¹					CD117 NM	0.08
CD117 pTC		0.13				CD117 pTC		0.08
CD117 pIM			0.07			CD117 pIM			0.01
CD117 pOM				0.32^a		CD117 pOM				0.09
CD117 pPT					0.30^a	CD117 pPT					0.1
		CD66b mTC	CD66b mIM	CD66b mOM	CD66b mPT			CD66b mTC	CD66b mIM	CD66b mOM	CD66b mPT
CD117 mTC		-0.37^a				CD117 mTC		-0.03
CD117 mIM			-0.26			CD117 mIM			0.06
CD117 mOM				-0.13		CD117 mOM				0.15
CD117 mPT					0.06	CD117 mPT					0.12

¹Spearman rho.

^aP < 0.05.

NM: Non-tumor mucosa; pTC: Tumor center of primary colorectal cancer; mTC: Tumor center of liver metastasis; pIM: Inner margin of primary colorectal cancer; mIM: Inner margin of liver metastasis; pOM: Outer margin of primary colorectal cancer; mOM: Outer margin of liver metastasis; pPT: Peritumor zone of primary colorectal cancer; mPT: Peritumor zone of liver metastasis.

Full Size Table

Table 2 Hazard ratios for disease-free survival between high vs low densities of CD66b+ polymorphonuclear neutrophils in the non-tumor mucosa and per individual regions of interest of primary colorectal cancer and liver metastasis in colorectal cancer patients with synchronous and metachronous metastasis

	Synchronous		Metachronous
	n (%)	HR (95%CI), P value	n (%)	HR (95%CI), P value
NM	40 (74.1)	1.68 (0.85-3.31), 0.13	33 (75.0)	1.56 (0.73-3.35), 0.25
pTC	40 (75.5)	0.65 (0.34-1.24), 0.19	31 (73.8)	0.89 (0.41-1.93), 0.77
pIM	40 (75.5)	0.86 (0.45-1.64), 0.64	31 (73.8)	1.15 (0.54-2.46), 0.71
pOM	39 (75.0)	1.13 (0.57-2.24), 0.72	31 (73.8)	2.59 (1.11-6.02), 0.027^a
pIM/pOM	27 (51.9)	0.57 (0.31-1.03), 0.06	21 (50.0)	1.30 (0.67-2.51), 0.44
pPT	39 (75.0)	0.61 (0.31-1.18), 0.14	31 (73.8)	1.92 (0.87-4.25), 0.11
mTC	38 (74.5)	0.95 (0.49-1.85), 0.89	33 (75.0)	0.48 (0.24-0.99), 0.048^a
mIM	39 (75.0)	1.70 (0.84-3.46), 0.14	32 (74.4)	0.65 (0.31-1.36), 0.25
mOM	40 (75.5)	2.40 (1.14-5.04), 0.021^a	32 (74.4)	0.76 (0.36-1.58), 0.46
mIM/mOM	26 (49.1)	0.89 (0.50-1.59), 0.69	21 (48.8)	1.23 (0.64-2.36), 0.53
mPT	40 (75.5)	2.58 (1.22-5.46), 0.013^a	32 (74.4)	0.93 (0.44-1.99), 0.85

^aP < 0.05.

n shows the number of patients in “high” group. HR (95%CI) shows the relative risk compared with 1.00 for the “low” group. NM: Non-tumor mucosa; pTC: Tumor center of primary colorectal cancer; mTC: Tumor center of liver metastasis; pIM: Inner margin of primary colorectal cancer; mIM: Inner margin of liver metastasis; pOM: Outer margin of primary colorectal cancer; mOM: Outer margin of liver metastasis; pPT: Peritumor zone of primary colorectal cancer; mPT: Peritumor zone of liver metastasis.

Full Size Table

Table 3 Hazard ratios for disease-free survival between high vs low densities of CD117+ mast cells in the non-tumor mucosa and per individual regions of interest of primary colorectal cancer and liver metastasis in colorectal cancer patients with synchronous and metachronous metastasis

	Synchronous		Metachronous
	n (%)	HR (95%CI), P value	n (%)	HR (95%CI), P value
NM	40 (74.1)	1.51 (0.74-3.09), 0.26	32 (74.4)	0.85 (0.41-1.77), 0.67
pTC	40 (74.1)	0.69 (0.36-1.33), 0.27	31 (73.8)	2.34 (1.05-5.23), 0.038^a
pIM	40 (74.1)	1.04 (0.53-2.04), 0.91	31 (70.5)	0.96 (0.48-1.92), 0.92
pOM	40 (74.1)	0.98 (0.51-1.90), 0.96	31 (73.8)	0.67 (0.32-1.40), 0.28
pIM/pOM	27 (50.0)	1.54 (0.86-2.74), 0.14	21 (50.0)	1.66 (0.86-3.22), 0.13
pPT	40 (74.1)	1.02 (0.53-1.97), 0.95	31 (73.8)	0.86 (0.41-1.80), 0.69
mTC	39 (75.0)	0.69 (0.35-1.34), 0.27	33 (75.0)	1.20 (0.57-2.49), 0.63
mIM	39 (75.0)	0.91 (0.46-1.81), 0.80	32 (74.4)	0.83 (0.40-1.72), 0.62
mOM	40 (75.5)	1.15 (0.57-2.31), 0.71	32 (74.4)	1.61 (0.73-3.58), 0.24
mIM/mOM	27 (50.9)	0.65 (0.36-1.18), 0.16	22 (51.2)	0.93 (0.48-1.78), 0.82
mPT	40 (75.5)	0.74 (0.38-1.43), 0.37	32 (74.4)	1.35 (0.63-2.88), 0.44

^aP < 0.05.

Full Size Table

Citation: Ye WJ, Ali E, Pavlov S, Červenková L, Ambrozkiewicz F, Vyčítal O, Hošek P, Daum O, Liška V, Hemminki K, Trailin A. Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases. World J Gastrointest Oncol 2026; 18(10): 122608
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/122608.htm
DOI: https://dx.doi.org/10.4251/wjgo.122608

Ye WJ, Ali E, Pavlov S, Červenková L, Ambrozkiewicz F, Vyčítal O, Hošek P, Daum O, Liška V, Hemminki K, Trailin A. Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases. World J Gastrointest Oncol 2026; 18(10): 122608 [DOI: 10.4251/wjgo.122608]

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