Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk

Table 1 Details of the genome-wide association studies and datasets used in our analyses

Trait	Cases	Control	Ancestry	Ref.	GWAS ID
Inflammatory factors	14736	/	European	Zhao et al[22]	GCST90274758 to GCST90274848
ICC (training cohort)	832	475259	European	Sakaue et al[48]	ebi-a-GCST90018803
ICC (validation cohort)	104	456244	European	Jiang et al[23]	GCST90043859

ICC: Intrahepatic cholangiocarcinoma; GWAS: Genome-wide association study.

Table 2 Sensitive analysis of the causal association between two circulating inflammatory factors and risk of intrahepatic cholangiocarcinoma

Exposure	Outcome	Method	Heterogeneity		Pleiotropy		MR-PRESSO
			Q	P value	Egger intercept	P value	Outliers	P value
Artemin levels	ICC	MRE	12.173	0.878	-0.038	0.303	0	0.325
		IVW	13.294	0.864
MMP-10 levels	ICC	MRE	3.911	0.996	-0.032	0.265	0	0.695
		IVW	5.260	0.990

ICC: Intrahepatic cholangiocarcinoma; MRE: Mendelian randomization-Egger; MMP: Matrix metalloproteinase; IVW: Inverse-Variance weighted; MR: Mendelian randomization.