Comprehensive analysis of the protein phosphatase 2A regulatory subunit B56ε in pan-cancer and its role and mechanism in hepatocellular carcinoma

Table 1 Correlation between B56ε expression and hepatocellular carcinoma prognosis

Variables	n	Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Gender	373	1.261 (0.885-1.796)	0.204	1.052 (0.632-1.752)	0.845
Age	373	1.205 (0.850-1.708)	0.293	1.238 (0.768-1.997)	0.381
T	370	2.598 (1.826-3.697)	< 0.001a	8.023 (0.461-139.715)	0.153
N	258	2.029 (0.497-8.281)	0.375	4.476 (0.583-34.348)	0.149
M	272	4.077 (1.281-12.973)	0.050	1.865 (0.546-6.367)	0.320
Stage	349	2.504 (1.727-3.631)	< 0.001a	0.357 (0.020-6.488)	0.487
Grade	368	1.091 (0.761-1.564)	0.637	1.177 (0.735-1.885)	0.498
B56ε	373	1.587 (1.120-2.249)	0.009a	1.337 (0.829-2.156)	0.234

^aP < 0.05.

CI: Confidence interval; HR: Hazard ratio.

Table 2 Correlation analysis of B56ε expression with chemotherapy drugs

Drugs	Correlation	P value
Allopurinol	0.255	0.049
Fluorouracil	-0.324	0.011
Methylprednisolone	0.279	0.031
Chelerythrine	0.334	0.009
Ergenyl	-0.357	0.005
Ribavirin	0.307	0.017
Claritin	-0.312	0.015
RAF-265	-0.293	0.023
Nelarabine	0.264	0.042
PLX-4720	-0.271	0.036
Econazole nitrate	0.316	0.014
Rabusertib	-0.276	0.033
Vemurafenib	-0.304	0.018
Vertex ATR inhibitor Cpd 45	-0.265	0.041
Dabrafenib	-0.263	0.042