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©The Author(s) 2023.
World J Gastrointest Oncol. Nov 15, 2023; 15(11): 1951-1973
Published online Nov 15, 2023. doi: 10.4251/wjgo.v15.i11.1951
Published online Nov 15, 2023. doi: 10.4251/wjgo.v15.i11.1951
Table 1 Clinical characteristics of the colorectal cancer patients included in this study
| Characteristics | TCGA-CRC (n = 537) | Clinical-CRC (n = 121) | ||
| All | High risk (n = 269) | Low risk (n = 268) | ||
| Age | ||||
| ≤ 65 | 234 (43.58%) | 114 (42.38%) | 120 (44.78%) | 53 (43.8%) |
| > 65 | 303 (56.42%) | 155 (57.62%) | 148 (55.22%) | 68 (56.2) |
| Sex | ||||
| Male | 287 (53.45%) | 141 (52.42%) | 146 (45.48%) | 61 (50.41%) |
| Female | 250 (46.55%) | 128 (47.58%) | 122 (45.52%) | 60 (49.29%) |
| T Stage | ||||
| T1 | 15 (2.94%) | 8 (2.97%) | 7 (2.61%) | 3 (2.48%) |
| T2 | 93 (17.32%) | 42 (15.61%) | 51 (19.03%) | 17 (14.05%) |
| T3 | 366 (68.16%) | 180 (66.91%) | 186 (69.40%) | 49 (40.5%) |
| T4 | 63 (11.73%) | 39 (14.50%) | 24 (8.96%) | 52 (42.98%) |
| N Stage | ||||
| N0 | 316 (58.85%) | 140 (52.04%) | 176 (65.67%) | 67 (55.37%) |
| N1 | 128 (23.84%) | 67 (24.91%) | 61 (22.76%) | 31 (25.62%) |
| N2 | 92 (17.13%) | 62 (23.05%) | 30 (11.19%) | 23 (19.01%) |
| Unknown | 1 (0.19%) | 0 | 1 (0.38%) | - |
| M Stage | ||||
| M0 | 400 (74.49%) | 190 (70.63%) | 210 (78.36%) | 102 (84.3%) |
| M1 | 75 (13.97%) | 46 (17.1%) | 29 (10.82%) | 19 (15.7%) |
| Unknown | 62 (11.55%) | 33 (12.27%) | 29 (10.82%) | - |
| Stage | ||||
| Stage I | 93 (17.32%) | 41 (15.24%) | 52 (19.40%) | 20 (16.53%) |
| Stage II | 209 (38.92%) | 91 (33.83%) | 118 (44.03%) | 42 (34.71%) |
| Stage III | 149 (27.75%) | 83 (30.86%) | 66 (24.63%) | 40 (33.06%) |
| Stage IV | 76 (14.15%) | 47 (17.47%) | 29 (10.82%) | 19 (15.7%) |
| Unknown | 10 (1.86%) | 7 (2.6%) | 3 (1.12%) | - |
Table 2 Univariate and multivariate Cox regression analysis of necroptosis-associated long noncoding RNAs in colorectal cancer
| Variables | Univariate analysis | Multivariate analysis | |||
| HR (95%CI) | P value | Coefficient | HR (95%CI) | P value | |
| AP001469.3 | 1.671 (1.045-2.673) | 0.032 | 0.396 | 1.485 (0.888-2.484) | 0.132 |
| AC007128.1 | 1.599 (1.016-2.516) | 0.043 | 0.500 | 1.648 (0.976-2.784) | 0.062 |
| LINC02381 | 1.619 (1.1.1-2.381) | 0.014 | 0.390 | 1.477 (0.934-2.337) | 0.095 |
| AC099850.3 | 0.747 (0.559-0.998) | 0.048 | -0.292 | 0.747 (0.536-1.041) | 0.085 |
| AC010973.2 | 2.285 (1.431-3.649) | 0.001 | 0.776 | 2.172 (1.3-3.629) | 0.003 |
| MIR4435-2HG | 1.766 (1.103-2.827) | 0.018 | 0.747 | 2.110 (1.192-3.736) | 0.010 |
| AC245100.7 | 2.084 (1.397-3.110) | 0.000 | 0.471 | 1.602 (1.046-2.455) | 0.030 |
| AL137782.1 | 0.384 (0.177-0.835) | 0.016 | -1.127 | 0.324 (0.153-0.688) | 0.003 |
- Citation: Chen ZH, Lin YL, Chen SQ, Yang XY. Identification of necroptosis-related lncRNAs for prognosis prediction and screening of potential drugs in patients with colorectal cancer. World J Gastrointest Oncol 2023; 15(11): 1951-1973
- URL: https://www.wjgnet.com/1948-5204/full/v15/i11/1951.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i11.1951