Anatomical vs nonanatomical liver resection for solitary hepatocellular carcinoma: A systematic review and meta-analysis

Table 1 Characteristics of the studies included in the meta-analysis

Ref.	Country	Enrollment of period	Design/center	Patients		Quality score
				AR	NAR
Cho et al[10], 2019	Korea	Jan 2008-Sep 2014	R/Single	59	59	8
Eguchi et al[27], 2008	Japan	1994-2001	R/Multiple	2267	3514	7
Hirokawa et al[23], 2015	Japan	Jan 2001-Dec 2005	R/Multiple	72	72	8
Hokuto et al[12], 2018	Japan	Jan 2007-Dec 2015	R/Single	20	20	8
Ishii et al[26], 2014	Japan	Jan 2002-Dec 2010	R/Single	44	44	8
Jung et al[18], 2019	Korea	Jan 2006-Dec 2014	R/Single	936	388	8
Kaibori et al[21], 2017	Japan	2003-2007	R/Multiple	355	355	7
Kim et al[22], 2016	Korea	Jan 2003-Dec 2009	R/Single	27	72	7
Kudo et al[25], 2014	Japan	Apr 2000-Mar 2012	R/Single	121	112	7
Okamura et al[24], 2014	Japan	Sep 2002-May 2013	R/Single	64	64	8
Shin et al[19], 2018	Korea	Jan 2006-Dec 2015	R/Single	53	63	7
Shindoh et al[52], 2020	Japan	Jan 2011-Oct 2017	R/Single	38	165	7
Yamamoto et al[28], 2001	Japan	1990-1994	R/Single	90	114	7
Zhao et al[20], 2017	China	Jan 2004-Dec 2013	R/Multiple	114	114	8

R: Retrospective; AR: Anatomical resection; NAR: Non-anatomical resection.

Table 2 Results of meta-analysis comparison of anatomical resection and non-anatomical resection

	Studies	Patients		MD/OR (95%CI)	P value	Study heterogeneity
		AR	NAR			χ2	df	I2, %	P value
Operating time (min)	9	782	954	47.08 (26.30-67.86)	< 0.001	60.82	8	87	< 0.001
Blood loss (mL)	8	749	921	169.29 (65.88-272.70)	0.001	110.72	7	94	< 0.001
Blood transfusion	8	749	921	1.16 (0.84-1.60)	0.36	8.75	6	31	0.19
Surgical margin (mm)	6	322	494	1.35 (0.06-2.64)	0.04	7.68	5	35	0.17
Complication	5	512	684	1.24 (0.91-1.70)	0.18	4.14	4	3	0.39
1-yr OS	10	929	975	1.08 (0.69-1.68)	0.73	3.17	8	0	0.92
1-yr DFS	10	929	975	1.21 (0.85-1.72)	0.29	16.92	9	47	0.05
5-yr OS	14	4260	5184	1.19 (1.08-1.30)	< 0.001	19.04	13	32	0.12
5-yr DFS	11	3113	4542	1.26 (1.15-1.39)	< 0.001	15.76	10	37	0.11

AR: Anatomical resection; NAR: Non-anatomical resection; OS: Overall survival; DFS: Disease-free survival; MD: Mean difference; OR: Odds ratio; CI: Confidence interval; df: Degrees of freedom.