Retrospective Study
Copyright ©The Author(s) 2020.
World J Gastrointest Oncol. Jan 15, 2020; 12(1): 101-112
Published online Jan 15, 2020. doi: 10.4251/wjgo.v12.i1.101
Table 1 Patient characteristics dichotomized by histological type before propensity score matching, n (%)
CharacteristicSRCASCTotalP value
n = 5968 (98.4)n = 95 (1.6)n = 6063 (100)
Age (yr)0.008
≤ 602823 (47.3)32 (33.7)2855 (47.1)
> 603145 (52.7)63 (66.3)3208 (52.9)
Gender< 0.001
Male3146 (52.7)71 (74.7)3217 (53.1)
Female2822 (47.3)24 (25.3)2846 (46.9)
Race0.045
White4147 (69.5)74 (77.9)4221 (69.6)
Black725 (12.1)13 (13.7)738 (12.2)
Others1096 (18.4)8 (8.4)1104 (18.2)
Marital status0.001
Not married2287 (38.3)21 (22.1)2308 (38.1)
Married3681 (61.7)74 (77.9)3755 (61.9)
Tumor size (mm)0.220
≤ 502271 (38.1)42 (44.2)2313 (38.1)
> 503697 (61.9)53 (55.8)3750 (61.9)
TNM Stage0.299
I1595 (26.7)21 (22.1)1616 (26.7)
II888 (14.9)20 (21.1)908 (15.0)
III1129 (18.9)15 (15.8)1144 (18.9)
IV2356 (39.5)39 (41.1)2395 (39.5)
Tumor depth0.139
T11398 (23.4)16 (16.8)1414 (23.3)
T22177 (36.5)45 (47.4)2222 (36.6)
T31384 (23.2)18 (18.9)1402 (23.1)
T41009 (16.9)16 (16.8)1025 (16.9)
LN metastasis0.011
N02472 (41.4)31 (32.6)2503 (41.3)
N12080 (34.9)46 (48.4)2126 (35.1)
N2926 (15.5)16 (16.8)942 (15.5)
N3490 (8.2)2 (2.1)492 (8.1)
Distant metastasis0.966
No4197 (70.3)67 (70.5)4264 (70.3)
Yes1771 (29.7)28 (29.5)1799 (29.7)
Radiotherapy0.006
No4553 (76.3)61 (64.2)4614 (76.1)
Yes1415 (23.7)34 (35.8)1449 (23.9)
Surgery0.231
No2047 (34.3)27 (28.4)2074 (34.2)
Yes3921 (65.7)68 (71.6)3989 (65.8)
Table 2 Patient characteristics dichotomized by histological type after propensity score matching, n (%)
CharacteristicSRC
ASC
Total
P value
n = 370 (79.6)n = 95 (20.4)n = 465 (100)
Age (yr)0.754
≤ 60131 (35.4)32 (33.7)163 (35.1)
> 60239 (64.6)63 (66.3)302 (64.9)
Gender0.809
Male272 (73.5)71 (74.7)343 (73.8)
Female98 (26.5)24 (25.3)122 (26.2)
Race0.845
White290 (78.4)74 (77.9)364 (78.3)
Black44 (11.9)13 (13.7)57 (12.3)
Others36 (9.7)8 (8.4)44 (9.5)
Marital status0.901
Not married84 (22.7)21 (22.1)105 (22.6)
Married286 (77.3)74 (77.9)360 (77.4)
Tumor size (mm)0.828
≤ 50159 (43.0)42 (44.2)201 (43.2)
> 50211 (57.0)53 (55.8)264 (56.8)
Stage0.365
I94 (25.4)21 (22.1)115 (24.7)
II55 (14.9)20 (21.1)75 (16.1)
III77 (20.8)15 (15.8)92 (19.8)
IV144 (38.9)39 (41.1)183 (39.4)
Tumor depth0.598
T177 (20.8)16 (16.8)93 (20.0)
T2156 (42.2)45 (47.4)201 (43.2)
T384 (22.7)18 (18.9)102 (21.9)
T453 (14.3)16 (16.8)69 (14.8)
LN metastasis0.151
N0151 (40.8)31 (32.6)182 (39.1)
N1134 (36.2)46 (48.4)180 (38.7)
N269 (18.6)16 (16.8)85 (18.3)
N316 (4.3)2 (2.1)18 (3.9)
Distant metastasis0.840
No257 (69.5)67 (70.5)324 (69.7)
Yes113 (30.5)28 (29.5)141 (30.3)
Radiotherapy0.786
No232 (62.7)61 (64.2)293 (63.0)
Yes138 (37.3)34 (35.8)172 (37.0)
Surgery0.883
No108 (29.2)27 (28.4)135 (29.0)
Yes262 (70.8)68 (71.6)330 (71.0)
Table 3 Comparison of median survival of the patients before and after propensity score matching
Patients, nMedian CSS 95%CI, moMedian OS 95%CI, mo
Before PSM
SRC596816.0 (15.2-16.8)15.0 (14.3-15.7)
ASC9513.0 (9.7-16.3)12.0 (9.5-14.5)
P value0.1010.084
After PSM
SRC37020.0 (15.7-24.3)19.0 (14.9-23.1)
ASC9513.0 (9.7-16.3)12.0 (9.5-14.5)
P value0.0270.017
Table 4 Cox regression analysis of cancer-specific survival (n = 465)
CharacteristicUnivariate CoxMultivariate Cox
HR (95%CI)P valueHR (95%CI)P value
Histological type
SRCReferenceReference
ASC1.343 (1.029-1.752)0.0301.316 (1.004-1.726)0.047
Age (yr)
≤ 60ReferenceNI
> 601.027 (0.819-1.288)0.815
Gender
MaleReferenceNI
Female0.952 (0.740-1.223)0.698
Race
WhiteReferenceNI
Black1.199 (0.870-1.652)0.268
Others0.883 (0.597-1.304)0.531
Marital status
Not marriedReferenceReference
Married0.768 (0.593-0.994)0.0450.709 (0.540-0.932)0.014
Tumor size (mm)
≤ 50ReferenceReference
> 501.994 (1.587-2.503)<0.0011.217 (0.947-1.564)0.125
Stage
IReferenceReference
II1.482 (0.993-2.212)0.0541.564 (1.021-2.394)0.040
III2.472 (1.714-3.564)< 0.0012.460 (1.601-3.780)< 0.001
IV5.179 (3.739-7.175)< 0.0012.884 (1.665-4.997)< 0.001
Tumor depth
T1ReferenceReference
T20.962(0.705-1.312)0.8051.296 (0.923-1.821)0.135
T31.478(1.051-2.077)0.0251.482 (0.986-2.228)0.058
T41.801 (1.243-2.609)0.0021.070 (0.699-1.638)0.757
LN metastasis
N0ReferenceNI
N10.978(0.760-1.258)0.863
N21.218 (0.901-1.647)0.200
N31.642 (0.985-2.737)0.057
Distant metastasis
NoReferenceReference
Yes4.303 (3.397-5.451)< 0.0011.278 (0.778-2.100)0.333
Radiotherapy
NoReferenceReference
Yes0.484(0.383-0.612)< 0.0010.587 (0.444-0.776)< 0.001
Surgery
NoReferenceReference
Yes0.244(0.192-0.311)< 0.0010.450 (0.319-0.635)< 0.001