Up-regulation of tumor necrosis factor-α pathway survival genes and of the receptor TNFR2 in gastric cancer

Table 1 Characterization of individuals with normal mucosa and gastric cancer

Variable	NM n (%)	GC n (%)
Gender
Female	3 (75.0)	6 (20.0)
Male	1 (25.0)	24 (80.0)
Total	4	30
Age (yr) Mean ± SD	30 ± 12.5	65 ± 13.8
	< 30, 3 (75)	< 65, 16 (53.3)
	³ 30, 1 (25)	³ 65, 14 (46.7)
Total	4	30
Smoking
Yes	0 (0)	18 (64.3)
No	4 (100)	10 (35.7)
Total	4	281
Drinking
Yes	0 (0)	14 (50.0)
No	4 (100)	14 (50.0)
Total	4	281
H. pylori
Positive	0 (0)	15 (50.0)
Negative	4 (100)	15 (50.0)
Total	4	30
Histological type
Intestinal	-	26 (86.7)
Diffuse	-	4 (13.3)
Total	-	30

¹Parameter not available for some individuals. SD: Standard deviation; NM: Normal mucosa; GC: Gastric cancer; H. pylori: Helicobacter pylori.

Table 2 Correlation analysis between mRNA expression and tumor necrosis factor-α pathway genes in gastric cancer

	TNF	TNFR1	TNFR2	TRADD	TRAF2	CFLIP	CASP8	CASP3	NFKB1
TNFR1	0.116
TNFR2	0.452b	0.530b
TRADD	0.603d	0.222	0.754d
TRAF2	0.610d	0.147	0.595d	0.801d
CFLIP	0.564b	0.367a	0.645d	0.866d	0.811d
CASP8	0.631d	0.158	0.616d	0.857d	0.822d	0.907d
CASP3	0.494b	0.398a	0.539b	0.540b	0.308	0.567b	0.526b
NFKB1	0.621d	0.390a	0.682d	0.790d	0.658d	0.736d	0.690d	0.556b
NFKB2	0.669d	0.115	0.512b	0.822d	0.724d	0.801d	0.796d	0.494b	0.760d

Data are presented as the Spearman correlation coefficient, with significant correlations:

^aP < 0.05;

^bP < 0.01;

^dP < 0.001.