Gastric submucosa-invasive carcinoma associated with Epstein-Barr virus and endoscopic submucosal dissection: A case report

Table 1 A summary of cases of Epstein-Barr virus-associated gastric cancer treated using endoscopic submucosal dissection

Study	Age (yr), Sex	Diameter (cm)	Lesions	Features	Biopsy diagnosis	ESD diagnosis	EBV	Depth	Additional surgery	Lymph node metasta-sis	Prognosis
Gromski et al[16], 2012	67, M	2 × 1.2	Lower body	Centrally depressed lesion	Chronic gastritis	Lymphoepithelioma-like gastric carcinoma	Positive	SM2	Not performed	ND	No recurrence for 12 M
Lee et al[17], 2012	43, M	NA	NA	Multiple elevated erosive lesions with mild central depressi-ons	Adenocarci-noma	Lymphoepithelioma-like gastric carcinoma with lymphoid-rich stroma	Positive	SM2 (1538 μm)	Not performed	ND	No recurrence for 24 M
Matsumoto et al[18], 2013	58, M	NA	Upper body	Submuco-sal tumor associated with a slightly depressed lesion	Adenocarci-noma	Gastric carcinoma with lymphoid stroma	Positive	SM2	Formal resection	Negative	NA
Lee et al[19], 2014	63, M	2.0	High body	Elevated lesion that displayed surface hyperemia	Moderately differentiat-ed adenocarci-noma	Lymphoepithelioma-like gastric carcinoma	Positive	SM2 (1800 μm)	Total gastrecto-my	Negative	No recurrence for 48 M
	65, M	1.0	Low body	Slightly elevated	Moderately differentiat-ed adenocarci-noma	Lymphoepithelioma-like gastric carcinoma	Positive	SM (1800 μm)	Not performed	ND	No recurrence for 32 M
	74, M	1.5	Low body	Slightly elevated lesion with central dimpling	A few markedly atypical cells	Lymphoepithelioma-like gastric carcinoma	Positive	SM2 (2500 μm)	Not performed	ND	No recurrence for 28 M
	84, M	1.5	Cardia	Large reddish and slightly depressed lesion	Moderately differentiated adenocarci-noma	Lymphoepithelioma-like gastric carcinoma	Positive	SM2 (2300 μm)	Not performed	ND	No recurrence for 27 M
Chen et al[20], 2016	50, M	2.5 × 2.5	Gastric body	A submuco-sal columnar lesion with surface erosion	Moderate chronic superficial gastritis	Lymphoepitheliomalike gastric carcinoma	Positive	SM	Total radical gastrecto-my	Negative	No recurrence for 12 M
Kato et al[21], 2018	53, M	2.0	Middle body	Subepithe-lial lesion with center depressed	Benign gastric mucosa	Gastric cancer with lymphoid stroma	Positive	SM2	Distal gastrecto-my	Negative	NA
Present cases	72, F	2.0	Middle body	Protruding lesions with central depression	No atypical cells	Gastric carcinoma with lymphoid stroma	Positive	SM2 (> 4000 μm)	Distal gastrecto-my	Negative	No recurrence for 14 M
	76, M	1.5	Lower body	Submuco-sal tumor	No atypical cells	Gastric carcinoma with lymphoid stroma	Positive	SM2 (5200 μm)	Not performed	ND	No recurrence for 12 M

ESD: Endoscopic submucosal dissection; EBV: Epstein-Barr virus; SM: Submucosa; ND: Not determined; NA: Not available; M: Male.